Atlas of Genetics and Cytogenetics in Oncology and Haematology


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RIPK3 (receptor interacting serine/threonine kinase 3)

Identity

Alias (NCBI)RIP3
HGNC (Hugo) RIPK3
HGNC Alias symbRIP3
HGNC Previous namereceptor-interacting serine-threonine kinase 3
LocusID (NCBI) 11035
Atlas_Id 42121
Location 14q12  [Link to chromosome band 14q12]
Location_base_pair Starts at 24336025 and ends at 24339991 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)RIPK3   10021
Cards
Entrez_Gene (NCBI)RIPK3    receptor interacting serine/threonine kinase 3
AliasesRIP3
GeneCards (Weizmann)RIPK3
Ensembl hg19 (Hinxton)ENSG00000129465 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000129465 [Gene_View]  ENSG00000129465 [Sequence]  chr14:24336025-24339991 [Contig_View]  RIPK3 [Vega]
ICGC DataPortalENSG00000129465
TCGA cBioPortalRIPK3
AceView (NCBI)RIPK3
Genatlas (Paris)RIPK3
SOURCE (Princeton)RIPK3
Genetics Home Reference (NIH)RIPK3
Genomic and cartography
GoldenPath hg38 (UCSC)RIPK3  -     chr14:24336025-24339991 -  14q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RIPK3  -     14q12   [Description]    (hg19-Feb_2009)
GoldenPathRIPK3 - 14q12 [CytoView hg19]  RIPK3 - 14q12 [CytoView hg38]
ImmunoBaseENSG00000129465
Genome Data Viewer NCBIRIPK3 [Mapview hg19]  
OMIM605817   
Gene and transcription
Genbank (Entrez)AF156884 AK075275 AK296140 AK296309 AY453693
RefSeq transcript (Entrez)NM_006871
Consensus coding sequences : CCDS (NCBI)RIPK3
Gene ExpressionRIPK3 [ NCBI-GEO ]   RIPK3 [ EBI - ARRAY_EXPRESS ]   RIPK3 [ SEEK ]   RIPK3 [ MEM ]
Gene Expression Viewer (FireBrowse)RIPK3 [ Firebrowse - Broad ]
GenevisibleExpression of RIPK3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11035
GTEX Portal (Tissue expression)RIPK3
Human Protein AtlasENSG00000129465-RIPK3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y572   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y572  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y572
PhosPhoSitePlusQ9Y572
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    RHIM_dom    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)    RHIM (PF12721)   
Domain families : Pfam (NCBI)pfam00069    pfam12721   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)RIPK3
PDB (RSDB)5V7Z    5ZCK   
PDB Europe5V7Z    5ZCK   
PDB (PDBSum)5V7Z    5ZCK   
PDB (IMB)5V7Z    5ZCK   
Structural Biology KnowledgeBase5V7Z    5ZCK   
SCOP (Structural Classification of Proteins)5V7Z    5ZCK   
CATH (Classification of proteins structures)5V7Z    5ZCK   
SuperfamilyQ9Y572
AlphaFold pdb e-kbQ9Y572   
Human Protein Atlas [tissue]ENSG00000129465-RIPK3 [tissue]
HPRD09315
Protein Interaction databases
DIP (DOE-UCLA)Q9Y572
IntAct (EBI)Q9Y572
BioGRIDRIPK3
STRING (EMBL)RIPK3
ZODIACRIPK3
Ontologies - Pathways
QuickGOQ9Y572
Ontology : AmiGOregulation of T cell mediated cytotoxicity  regulation of adaptive immune response  transcription coactivator activity  protein kinase activity  protein kinase activity  protein kinase activity  protein serine/threonine kinase activity  NF-kappaB-inducing kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  cytosol  cellular protein modification process  signal transduction  I-kappaB kinase/NF-kappaB signaling  positive regulation of phosphatase activity  modulation by virus of host cellular process  activation of protein kinase activity  regulation of interferon-gamma production  protein-containing complex  T cell differentiation in thymus  NIK/NF-kappaB signaling  identical protein binding  regulation of apoptotic process  T cell homeostasis  protein-containing complex binding  positive regulation of transcription, DNA-templated  regulation of activated T cell proliferation  protein autophosphorylation  lymph node development  spleen development  thymus development  positive regulation of NF-kappaB transcription factor activity  positive regulation of ligase activity  positive regulation of oxidoreductase activity  defense response to virus  regulation of necroptotic process  positive regulation of necroptotic process  positive regulation of necroptotic process  negative regulation of programmed necrotic cell death  regulation of activation-induced cell death of T cells  necroptotic process  necroptotic process  cellular response to hydrogen peroxide  apoptotic signaling pathway  programmed necrotic cell death  necroptotic signaling pathway  execution phase of necroptosis  protein serine kinase activity  protein threonine kinase activity  amyloid fibril formation  positive regulation of reactive oxygen species metabolic process  regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation  positive regulation of intrinsic apoptotic signaling pathway  
Ontology : EGO-EBIregulation of T cell mediated cytotoxicity  regulation of adaptive immune response  transcription coactivator activity  protein kinase activity  protein kinase activity  protein kinase activity  protein serine/threonine kinase activity  NF-kappaB-inducing kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  cytosol  cellular protein modification process  signal transduction  I-kappaB kinase/NF-kappaB signaling  positive regulation of phosphatase activity  modulation by virus of host cellular process  activation of protein kinase activity  regulation of interferon-gamma production  protein-containing complex  T cell differentiation in thymus  NIK/NF-kappaB signaling  identical protein binding  regulation of apoptotic process  T cell homeostasis  protein-containing complex binding  positive regulation of transcription, DNA-templated  regulation of activated T cell proliferation  protein autophosphorylation  lymph node development  spleen development  thymus development  positive regulation of NF-kappaB transcription factor activity  positive regulation of ligase activity  positive regulation of oxidoreductase activity  defense response to virus  regulation of necroptotic process  positive regulation of necroptotic process  positive regulation of necroptotic process  negative regulation of programmed necrotic cell death  regulation of activation-induced cell death of T cells  necroptotic process  necroptotic process  cellular response to hydrogen peroxide  apoptotic signaling pathway  programmed necrotic cell death  necroptotic signaling pathway  execution phase of necroptosis  protein serine kinase activity  protein threonine kinase activity  amyloid fibril formation  positive regulation of reactive oxygen species metabolic process  regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation  positive regulation of intrinsic apoptotic signaling pathway  
Pathways : KEGGCytosolic DNA-sensing pathway    TNF signaling pathway   
NDEx NetworkRIPK3
Atlas of Cancer Signalling NetworkRIPK3
Wikipedia pathwaysRIPK3
Orthology - Evolution
OrthoDB11035
GeneTree (enSembl)ENSG00000129465
Phylogenetic Trees/Animal Genes : TreeFamRIPK3
Homologs : HomoloGeneRIPK3
Homology/Alignments : Family Browser (UCSC)RIPK3
Gene fusions - Rearrangements
Fusion : QuiverRIPK3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRIPK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RIPK3
dbVarRIPK3
ClinVarRIPK3
MonarchRIPK3
1000_GenomesRIPK3 
Exome Variant ServerRIPK3
GNOMAD BrowserENSG00000129465
Varsome BrowserRIPK3
ACMGRIPK3 variants
VarityQ9Y572
Genomic Variants (DGV)RIPK3 [DGVbeta]
DECIPHERRIPK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRIPK3 
Mutations
ICGC Data PortalRIPK3 
TCGA Data PortalRIPK3 
Broad Tumor PortalRIPK3
OASIS PortalRIPK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRIPK3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRIPK3
Mutations and Diseases : HGMDRIPK3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRIPK3
DgiDB (Drug Gene Interaction Database)RIPK3
DoCM (Curated mutations)RIPK3
CIViC (Clinical Interpretations of Variants in Cancer)RIPK3
Cancer3DRIPK3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605817   
Orphanet
DisGeNETRIPK3
MedgenRIPK3
Genetic Testing Registry RIPK3
NextProtQ9Y572 [Medical]
GENETestsRIPK3
Target ValidationRIPK3
Huge Navigator RIPK3 [HugePedia]
ClinGenRIPK3
Clinical trials, drugs, therapy
MyCancerGenomeRIPK3
Protein Interactions : CTDRIPK3
Pharm GKB GenePA34396
PharosQ9Y572
Clinical trialRIPK3
Miscellaneous
canSAR (ICR)RIPK3
HarmonizomeRIPK3
DataMed IndexRIPK3
Probes
Litterature
PubMed149 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRIPK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:29:01 CEST 2021

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