Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

RIPK3 (receptor interacting serine/threonine kinase 3)

Identity

Alias_namesreceptor-interacting serine-threonine kinase 3
Alias_symbol (synonym)RIP3
Other alias
HGNC (Hugo) RIPK3
LocusID (NCBI) 11035
Atlas_Id 42121
Location 14q12  [Link to chromosome band 14q12]
Location_base_pair Starts at 24336021 and ends at 24340036 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RIPK3   10021
Cards
Entrez_Gene (NCBI)RIPK3  11035  receptor interacting serine/threonine kinase 3
AliasesRIP3
GeneCards (Weizmann)RIPK3
Ensembl hg19 (Hinxton)ENSG00000129465 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000129465 [Gene_View]  chr14:24336021-24340036 [Contig_View]  RIPK3 [Vega]
ICGC DataPortalENSG00000129465
TCGA cBioPortalRIPK3
AceView (NCBI)RIPK3
Genatlas (Paris)RIPK3
WikiGenes11035
SOURCE (Princeton)RIPK3
Genetics Home Reference (NIH)RIPK3
Genomic and cartography
GoldenPath hg38 (UCSC)RIPK3  -     chr14:24336021-24340036 -  14q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RIPK3  -     14q12   [Description]    (hg19-Feb_2009)
EnsemblRIPK3 - 14q12 [CytoView hg19]  RIPK3 - 14q12 [CytoView hg38]
Mapping of homologs : NCBIRIPK3 [Mapview hg19]  RIPK3 [Mapview hg38]
OMIM605817   
Gene and transcription
Genbank (Entrez)AF156884 AK075275 AK296140 AK296309 AY453693
RefSeq transcript (Entrez)NM_006871
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RIPK3
Cluster EST : UnigeneHs.268551 [ NCBI ]
CGAP (NCI)Hs.268551
Alternative Splicing GalleryENSG00000129465
Gene ExpressionRIPK3 [ NCBI-GEO ]   RIPK3 [ EBI - ARRAY_EXPRESS ]   RIPK3 [ SEEK ]   RIPK3 [ MEM ]
Gene Expression Viewer (FireBrowse)RIPK3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11035
GTEX Portal (Tissue expression)RIPK3
Human Protein AtlasENSG00000129465-RIPK3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y572   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y572  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y572
Splice isoforms : SwissVarQ9Y572
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ9Y572
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    RHIM_dom    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)    RHIM (PF12721)   
Domain families : Pfam (NCBI)pfam00069    pfam12721   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)RIPK3
DMDM Disease mutations11035
Blocks (Seattle)RIPK3
SuperfamilyQ9Y572
Human Protein Atlas [tissue]ENSG00000129465-RIPK3 [tissue]
Peptide AtlasQ9Y572
HPRD09315
IPIIPI00847572   IPI00896383   IPI00940090   IPI01026037   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y572
IntAct (EBI)Q9Y572
FunCoupENSG00000129465
BioGRIDRIPK3
STRING (EMBL)RIPK3
ZODIACRIPK3
Ontologies - Pathways
QuickGOQ9Y572
Ontology : AmiGOregulation of T cell mediated cytotoxicity  regulation of adaptive immune response  transcription coactivator activity  protein kinase activity  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  NF-kappaB-inducing kinase activity  protein binding  ATP binding  mitochondrion  cytosol  cytosol  plasma membrane  cellular protein modification process  signal transduction  I-kappaB kinase/NF-kappaB signaling  positive regulation of phosphatase activity  activation of protein kinase activity  protein complex binding  regulation of interferon-gamma production  T cell differentiation in thymus  NIK/NF-kappaB signaling  identical protein binding  T cell homeostasis  regulation of activated T cell proliferation  protein autophosphorylation  lymph node development  spleen development  thymus development  positive regulation of NF-kappaB transcription factor activity  protein homooligomerization  protein heterooligomerization  positive regulation of ligase activity  positive regulation of oxidoreductase activity  positive regulation of necroptotic process  positive regulation of necroptotic process  regulation of activation-induced cell death of T cells  necroptotic process  necroptotic process  positive regulation of protein deacetylation  apoptotic signaling pathway  ripoptosome  amyloid fibril formation  positive regulation of reactive oxygen species metabolic process  regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation  positive regulation of intrinsic apoptotic signaling pathway  
Ontology : EGO-EBIregulation of T cell mediated cytotoxicity  regulation of adaptive immune response  transcription coactivator activity  protein kinase activity  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  NF-kappaB-inducing kinase activity  protein binding  ATP binding  mitochondrion  cytosol  cytosol  plasma membrane  cellular protein modification process  signal transduction  I-kappaB kinase/NF-kappaB signaling  positive regulation of phosphatase activity  activation of protein kinase activity  protein complex binding  regulation of interferon-gamma production  T cell differentiation in thymus  NIK/NF-kappaB signaling  identical protein binding  T cell homeostasis  regulation of activated T cell proliferation  protein autophosphorylation  lymph node development  spleen development  thymus development  positive regulation of NF-kappaB transcription factor activity  protein homooligomerization  protein heterooligomerization  positive regulation of ligase activity  positive regulation of oxidoreductase activity  positive regulation of necroptotic process  positive regulation of necroptotic process  regulation of activation-induced cell death of T cells  necroptotic process  necroptotic process  positive regulation of protein deacetylation  apoptotic signaling pathway  ripoptosome  amyloid fibril formation  positive regulation of reactive oxygen species metabolic process  regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation  positive regulation of intrinsic apoptotic signaling pathway  
Pathways : KEGGCytosolic DNA-sensing pathway    TNF signaling pathway   
NDEx NetworkRIPK3
Atlas of Cancer Signalling NetworkRIPK3
Wikipedia pathwaysRIPK3
Orthology - Evolution
OrthoDB11035
GeneTree (enSembl)ENSG00000129465
Phylogenetic Trees/Animal Genes : TreeFamRIPK3
HOVERGENQ9Y572
HOGENOMQ9Y572
Homologs : HomoloGeneRIPK3
Homology/Alignments : Family Browser (UCSC)RIPK3
Gene fusions - Rearrangements
Tumor Fusion PortalRIPK3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRIPK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RIPK3
dbVarRIPK3
ClinVarRIPK3
1000_GenomesRIPK3 
Exome Variant ServerRIPK3
ExAC (Exome Aggregation Consortium)ENSG00000129465
GNOMAD BrowserENSG00000129465
Genetic variants : HAPMAP11035
Genomic Variants (DGV)RIPK3 [DGVbeta]
DECIPHERRIPK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRIPK3 
Mutations
ICGC Data PortalRIPK3 
TCGA Data PortalRIPK3 
Broad Tumor PortalRIPK3
OASIS PortalRIPK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRIPK3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRIPK3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RIPK3
DgiDB (Drug Gene Interaction Database)RIPK3
DoCM (Curated mutations)RIPK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RIPK3 (select a term)
intoGenRIPK3
Cancer3DRIPK3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605817   
Orphanet
DisGeNETRIPK3
MedgenRIPK3
Genetic Testing Registry RIPK3
NextProtQ9Y572 [Medical]
TSGene11035
GENETestsRIPK3
Target ValidationRIPK3
Huge Navigator RIPK3 [HugePedia]
snp3D : Map Gene to Disease11035
BioCentury BCIQRIPK3
ClinGenRIPK3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11035
Chemical/Pharm GKB GenePA34396
Clinical trialRIPK3
Miscellaneous
canSAR (ICR)RIPK3 (select the gene name)
Probes
Litterature
PubMed81 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRIPK3
EVEXRIPK3
GoPubMedRIPK3
iHOPRIPK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:32:29 CET 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.