RIPK3 (receptor interacting serine/threonine kinase 3)

2004-04-01  

Identity

HGNC
RIPK3
LOCATION
14q12
LOCUSID
11035
ALIAS
RIP3

Other Information

Locus ID:

NCBI: 11035
MIM: 605817
HGNC: 10021
Ensembl: ENSG00000129465

Variants:

dbSNP: 11035
ClinVar: 11035
TCGA: ENSG00000129465
COSMIC: RIPK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129465ENST00000216274Q9Y572
ENSG00000129465ENST00000554569H0YJN5
ENSG00000129465ENST00000554756Q9Y572

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Cytosolic DNA-sensing pathwayKEGGko04623
Cytosolic DNA-sensing pathwayKEGGhsa04623
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 3 (TLR3) CascadeREACTOMER-HSA-168164
MyD88-independent TLR3/TLR4 cascadeREACTOMER-HSA-166166
TRIF-mediated TLR3/TLR4 signalingREACTOMER-HSA-937061
IKK complex recruitment mediated by RIP1REACTOMER-HSA-937041
TRIF-mediated programmed cell deathREACTOMER-HSA-2562578
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
Cytosolic sensors of pathogen-associated DNAREACTOMER-HSA-1834949
ZBP1(DAI) mediated induction of type I IFNsREACTOMER-HSA-1606322
RIP-mediated NFkB activation via ZBP1REACTOMER-HSA-1810476
Programmed Cell DeathREACTOMER-HSA-5357801
Regulated NecrosisREACTOMER-HSA-5218859
RIPK1-mediated regulated necrosisREACTOMER-HSA-5213460

References

Pubmed IDYearTitleCitations
195245122009Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha.729
247039472014Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3.378
228178962012The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis.335
224214392012Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis.237
203542262010The role of the kinases RIP1 and RIP3 in TNF-induced necrosis.180
254598802014RIP3 induces apoptosis independent of pronecrotic kinase activity.160
253267522014RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway.92
259526682015Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics.82
236129632013Diverse sequence determinants control human and mouse receptor interacting protein 3 (RIP3) and mixed lineage kinase domain-like (MLKL) interaction in necroptotic signaling.77
256749832015Herpes simplex virus suppresses necroptosis in human cells.73

Citation

Dessen P

RIPK3 (receptor interacting serine/threonine kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2004-04-01

Online version: http://atlasgeneticsoncology.org/gene/42121/ripk3