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RIPK4 (receptor interacting serine/threonine kinase 4)

Identity

Alias_namesANKRD3
ankyrin repeat domain 3
receptor-interacting serine-threonine kinase 4
Alias_symbol (synonym)DIK
ANKK2
RIP4
PKK
Other aliasNKRD3
PPS2
HGNC (Hugo) RIPK4
LocusID (NCBI) 54101
Atlas_Id 47632
Location 21q22.3  [Link to chromosome band 21q22]
Location_base_pair Starts at 41739369 and ends at 41767089 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NEB (2q23.3) / RIPK4 (21q22.3)RIPK4 (21q22.3) / NEB (2q23.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RIPK4   496
Cards
Entrez_Gene (NCBI)RIPK4  54101  receptor interacting serine/threonine kinase 4
AliasesANKK2; ANKRD3; DIK; NKRD3; 
PKK; PPS2; RIP4
GeneCards (Weizmann)RIPK4
Ensembl hg19 (Hinxton)ENSG00000183421 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000183421 [Gene_View]  chr21:41739369-41767089 [Contig_View]  RIPK4 [Vega]
ICGC DataPortalENSG00000183421
TCGA cBioPortalRIPK4
AceView (NCBI)RIPK4
Genatlas (Paris)RIPK4
WikiGenes54101
SOURCE (Princeton)RIPK4
Genetics Home Reference (NIH)RIPK4
Genomic and cartography
GoldenPath hg38 (UCSC)RIPK4  -     chr21:41739369-41767089 -  21q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RIPK4  -     21q22.3   [Description]    (hg19-Feb_2009)
EnsemblRIPK4 - 21q22.3 [CytoView hg19]  RIPK4 - 21q22.3 [CytoView hg38]
Mapping of homologs : NCBIRIPK4 [Mapview hg19]  RIPK4 [Mapview hg38]
OMIM263650   605706   
Gene and transcription
Genbank (Entrez)AB047783 AF308292 AJ278016 AK027424 AK296685
RefSeq transcript (Entrez)NM_020639
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RIPK4
Cluster EST : UnigeneHs.517310 [ NCBI ]
CGAP (NCI)Hs.517310
Alternative Splicing GalleryENSG00000183421
Gene ExpressionRIPK4 [ NCBI-GEO ]   RIPK4 [ EBI - ARRAY_EXPRESS ]   RIPK4 [ SEEK ]   RIPK4 [ MEM ]
Gene Expression Viewer (FireBrowse)RIPK4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54101
GTEX Portal (Tissue expression)RIPK4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP57078   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP57078  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP57078
Splice isoforms : SwissVarP57078
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusP57078
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Ank_2 (PF12796)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam12796    pfam00069   
Domain families : Smart (EMBL)ANK (SM00248)  S_TKc (SM00220)  
Conserved Domain (NCBI)RIPK4
DMDM Disease mutations54101
Blocks (Seattle)RIPK4
SuperfamilyP57078
Human Protein AtlasENSG00000183421
Peptide AtlasP57078
HPRD10419
IPIIPI00025714   IPI00215935   IPI01011254   IPI00040874   
Protein Interaction databases
DIP (DOE-UCLA)P57078
IntAct (EBI)P57078
FunCoupENSG00000183421
BioGRIDRIPK4
STRING (EMBL)RIPK4
ZODIACRIPK4
Ontologies - Pathways
QuickGOP57078
Ontology : AmiGOmorphogenesis of an epithelium  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  protein phosphorylation  membrane  positive regulation of NF-kappaB transcription factor activity  
Ontology : EGO-EBImorphogenesis of an epithelium  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  protein phosphorylation  membrane  positive regulation of NF-kappaB transcription factor activity  
NDEx NetworkRIPK4
Atlas of Cancer Signalling NetworkRIPK4
Wikipedia pathwaysRIPK4
Orthology - Evolution
OrthoDB54101
GeneTree (enSembl)ENSG00000183421
Phylogenetic Trees/Animal Genes : TreeFamRIPK4
HOVERGENP57078
HOGENOMP57078
Homologs : HomoloGeneRIPK4
Homology/Alignments : Family Browser (UCSC)RIPK4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRIPK4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RIPK4
dbVarRIPK4
ClinVarRIPK4
1000_GenomesRIPK4 
Exome Variant ServerRIPK4
ExAC (Exome Aggregation Consortium)RIPK4 (select the gene name)
Genetic variants : HAPMAP54101
Genomic Variants (DGV)RIPK4 [DGVbeta]
DECIPHERRIPK4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRIPK4 
Mutations
ICGC Data PortalRIPK4 
TCGA Data PortalRIPK4 
Broad Tumor PortalRIPK4
OASIS PortalRIPK4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRIPK4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRIPK4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RIPK4
DgiDB (Drug Gene Interaction Database)RIPK4
DoCM (Curated mutations)RIPK4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RIPK4 (select a term)
intoGenRIPK4
Cancer3DRIPK4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM263650    605706   
Orphanet1478   
MedgenRIPK4
Genetic Testing Registry RIPK4
NextProtP57078 [Medical]
TSGene54101
GENETestsRIPK4
Target ValidationRIPK4
Huge Navigator RIPK4 [HugePedia]
snp3D : Map Gene to Disease54101
BioCentury BCIQRIPK4
ClinGenRIPK4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54101
Chemical/Pharm GKB GenePA24805
Clinical trialRIPK4
Miscellaneous
canSAR (ICR)RIPK4 (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRIPK4
EVEXRIPK4
GoPubMedRIPK4
iHOPRIPK4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:28:54 CEST 2017

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