Atlas of Genetics and Cytogenetics in Oncology and Haematology


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RIPPLY2 (ripply transcriptional repressor 2)

Identity

Alias_namesC6orf159
chromosome 6 open reading frame 159
ripply2 homolog (zebrafish)
Alias_symbol (synonym)dJ237I15.1
Other aliasSCDO6
HGNC (Hugo) RIPPLY2
LocusID (NCBI) 134701
Atlas_Id 51381
Location 6q14.2  [Link to chromosome band 6q14]
Location_base_pair Starts at 83853266 and ends at 83857516 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ENPP1 (6q23.2) / RIPPLY2 (6q14.2)ENPP1 6q23.2 / RIPPLY2 6q14.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(q14;q23) ENPP1/RIPPLY2


External links

Nomenclature
HGNC (Hugo)RIPPLY2   21390
Cards
Entrez_Gene (NCBI)RIPPLY2  134701  ripply transcriptional repressor 2
AliasesC6orf159; SCDO6; dJ237I15.1
GeneCards (Weizmann)RIPPLY2
Ensembl hg19 (Hinxton)ENSG00000203877 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000203877 [Gene_View]  ENSG00000203877 [Sequence]  chr6:83853266-83857516 [Contig_View]  RIPPLY2 [Vega]
ICGC DataPortalENSG00000203877
TCGA cBioPortalRIPPLY2
AceView (NCBI)RIPPLY2
Genatlas (Paris)RIPPLY2
WikiGenes134701
SOURCE (Princeton)RIPPLY2
Genetics Home Reference (NIH)RIPPLY2
Genomic and cartography
GoldenPath hg38 (UCSC)RIPPLY2  -     chr6:83853266-83857516 +  6q14.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RIPPLY2  -     6q14.2   [Description]    (hg19-Feb_2009)
EnsemblRIPPLY2 - 6q14.2 [CytoView hg19]  RIPPLY2 - 6q14.2 [CytoView hg38]
Mapping of homologs : NCBIRIPPLY2 [Mapview hg19]  RIPPLY2 [Mapview hg38]
OMIM609891   616566   
Gene and transcription
Genbank (Entrez)AI279191 AK124105 AW511485 BC130460 BC132968
RefSeq transcript (Entrez)NM_001009994
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RIPPLY2
Cluster EST : UnigeneHs.149454 [ NCBI ]
CGAP (NCI)Hs.149454
Alternative Splicing GalleryENSG00000203877
Gene ExpressionRIPPLY2 [ NCBI-GEO ]   RIPPLY2 [ EBI - ARRAY_EXPRESS ]   RIPPLY2 [ SEEK ]   RIPPLY2 [ MEM ]
Gene Expression Viewer (FireBrowse)RIPPLY2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)134701
GTEX Portal (Tissue expression)RIPPLY2
Human Protein AtlasENSG00000203877-RIPPLY2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5TAB7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5TAB7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5TAB7
Splice isoforms : SwissVarQ5TAB7
PhosPhoSitePlusQ5TAB7
Domains : Interpro (EBI)Ripply_fam   
Domain families : Pfam (Sanger)Ripply (PF14998)   
Domain families : Pfam (NCBI)pfam14998   
Conserved Domain (NCBI)RIPPLY2
DMDM Disease mutations134701
Blocks (Seattle)RIPPLY2
SuperfamilyQ5TAB7
Human Protein Atlas [tissue]ENSG00000203877-RIPPLY2 [tissue]
Peptide AtlasQ5TAB7
HPRD16658
IPIIPI00047815   IPI00645279   IPI00915834   
Protein Interaction databases
DIP (DOE-UCLA)Q5TAB7
IntAct (EBI)Q5TAB7
FunCoupENSG00000203877
BioGRIDRIPPLY2
STRING (EMBL)RIPPLY2
ZODIACRIPPLY2
Ontologies - Pathways
QuickGOQ5TAB7
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  ossification  somitogenesis  protein binding  nucleus  Notch signaling pathway  determination of left/right symmetry  somite rostral/caudal axis specification  post-anal tail morphogenesis  bone morphogenesis  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  ossification  somitogenesis  protein binding  nucleus  Notch signaling pathway  determination of left/right symmetry  somite rostral/caudal axis specification  post-anal tail morphogenesis  bone morphogenesis  
NDEx NetworkRIPPLY2
Atlas of Cancer Signalling NetworkRIPPLY2
Wikipedia pathwaysRIPPLY2
Orthology - Evolution
OrthoDB134701
GeneTree (enSembl)ENSG00000203877
Phylogenetic Trees/Animal Genes : TreeFamRIPPLY2
HOVERGENQ5TAB7
HOGENOMQ5TAB7
Homologs : HomoloGeneRIPPLY2
Homology/Alignments : Family Browser (UCSC)RIPPLY2
Gene fusions - Rearrangements
Fusion : MitelmanENPP1/RIPPLY2 [6q23.2/6q14.2]  [t(6;6)(q14;q23)]  
Fusion PortalENPP1 6q23.2 RIPPLY2 6q14.2 BRCA
Fusion : QuiverRIPPLY2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRIPPLY2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RIPPLY2
dbVarRIPPLY2
ClinVarRIPPLY2
1000_GenomesRIPPLY2 
Exome Variant ServerRIPPLY2
ExAC (Exome Aggregation Consortium)ENSG00000203877
GNOMAD BrowserENSG00000203877
Varsome BrowserRIPPLY2
Genetic variants : HAPMAP134701
Genomic Variants (DGV)RIPPLY2 [DGVbeta]
DECIPHERRIPPLY2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRIPPLY2 
Mutations
ICGC Data PortalRIPPLY2 
TCGA Data PortalRIPPLY2 
Broad Tumor PortalRIPPLY2
OASIS PortalRIPPLY2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRIPPLY2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRIPPLY2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RIPPLY2
DgiDB (Drug Gene Interaction Database)RIPPLY2
DoCM (Curated mutations)RIPPLY2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RIPPLY2 (select a term)
intoGenRIPPLY2
Cancer3DRIPPLY2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609891    616566   
Orphanet1042   
DisGeNETRIPPLY2
MedgenRIPPLY2
Genetic Testing Registry RIPPLY2
NextProtQ5TAB7 [Medical]
TSGene134701
GENETestsRIPPLY2
Target ValidationRIPPLY2
Huge Navigator RIPPLY2 [HugePedia]
snp3D : Map Gene to Disease134701
BioCentury BCIQRIPPLY2
ClinGenRIPPLY2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD134701
Chemical/Pharm GKB GenePA162401349
Clinical trialRIPPLY2
Miscellaneous
canSAR (ICR)RIPPLY2 (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRIPPLY2
EVEXRIPPLY2
GoPubMedRIPPLY2
iHOPRIPPLY2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:35:43 CET 2018

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