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RIT1 (Ras-like without CAAX 1)

Identity

Other namesNS8
RIBB
RIT
ROC1
HGNC (Hugo) RIT1
LocusID (NCBI) 6016
Atlas_Id 42122
Location 1q22
Location_base_pair Starts at 155867599 and ends at 155881193 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ASH1L (1q22) / RIT1 (1q22)RIT1 (1q22) / SPATA13 (13q12.12)SLC35F3 (1q42.2) / RIT1 (1q22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Noonan syndrome

External links

Nomenclature
HGNC (Hugo)RIT1   10023
Cards
Entrez_Gene (NCBI)RIT1  6016  Ras-like without CAAX 1
AliasesNS8; RIBB; RIT; ROC1
GeneCards (Weizmann)RIT1
Ensembl hg19 (Hinxton)ENSG00000143622 [Gene_View]  chr1:155867599-155881193 [Contig_View]  RIT1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000143622 [Gene_View]  chr1:155867599-155881193 [Contig_View]  RIT1 [Vega]
ICGC DataPortalENSG00000143622
TCGA cBioPortalRIT1
AceView (NCBI)RIT1
Genatlas (Paris)RIT1
WikiGenes6016
SOURCE (Princeton)RIT1
Genomic and cartography
GoldenPath hg19 (UCSC)RIT1  -     chr1:155867599-155881193 -  1q22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RIT1  -     1q22   [Description]    (hg38-Dec_2013)
EnsemblRIT1 - 1q22 [CytoView hg19]  RIT1 - 1q22 [CytoView hg38]
Mapping of homologs : NCBIRIT1 [Mapview hg19]  RIT1 [Mapview hg38]
OMIM609591   615355   
Gene and transcription
Genbank (Entrez)AF084462 AF493923 AK298768 AK314239 BC104186
RefSeq transcript (Entrez)NM_001256820 NM_001256821 NM_006912
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_033885 NT_004487 NW_004929293
Consensus coding sequences : CCDS (NCBI)RIT1
Cluster EST : UnigeneHs.491234 [ NCBI ]
CGAP (NCI)Hs.491234
Alternative Splicing GalleryENSG00000143622
Gene ExpressionRIT1 [ NCBI-GEO ]   RIT1 [ EBI - ARRAY_EXPRESS ]   RIT1 [ SEEK ]   RIT1 [ MEM ]
Gene Expression Viewer (FireBrowse)RIT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6016
GTEX Portal (Tissue expression)RIT1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92963 (Uniprot)
NextProtQ92963  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92963
Splice isoforms : SwissVarQ92963 (Swissvar)
PhosPhoSitePlusQ92963
Domaine pattern : Prosite (Expaxy)RAS (PS51421)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase    Small_GTPase_Ras   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Domain families : Smart (EMBL)RAS (SM00173)  
DMDM Disease mutations6016
Blocks (Seattle)RIT1
PDB (SRS)4KLZ   
PDB (PDBSum)4KLZ   
PDB (IMB)4KLZ   
PDB (RSDB)4KLZ   
Structural Biology KnowledgeBase4KLZ   
SCOP (Structural Classification of Proteins)4KLZ   
CATH (Classification of proteins structures)4KLZ   
SuperfamilyQ92963
Human Protein AtlasENSG00000143622
Peptide AtlasQ92963
HPRD10195
IPIIPI00144289   IPI01012532   IPI00639824   
Protein Interaction databases
DIP (DOE-UCLA)Q92963
IntAct (EBI)Q92963
FunCoupENSG00000143622
BioGRIDRIT1
STRING (EMBL)RIT1
ZODIACRIT1
Ontologies - Pathways
QuickGOQ92963
Ontology : AmiGOGTPase activity  protein binding  calmodulin binding  GTP binding  intracellular  plasma membrane  intracellular protein transport  nucleocytoplasmic transport  signal transduction  Ras protein signal transduction  metabolic process  
Ontology : EGO-EBIGTPase activity  protein binding  calmodulin binding  GTP binding  intracellular  plasma membrane  intracellular protein transport  nucleocytoplasmic transport  signal transduction  Ras protein signal transduction  metabolic process  
NDEx Network
Atlas of Cancer Signalling NetworkRIT1
Wikipedia pathwaysRIT1
Orthology - Evolution
OrthoDB6016
GeneTree (enSembl)ENSG00000143622
Phylogenetic Trees/Animal Genes : TreeFamRIT1
Homologs : HomoloGeneRIT1
Homology/Alignments : Family Browser (UCSC)RIT1
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerRIT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RIT1
dbVarRIT1
ClinVarRIT1
1000_GenomesRIT1 
Exome Variant ServerRIT1
ExAC (Exome Aggregation Consortium)RIT1 (select the gene name)
Genetic variants : HAPMAP6016
Genomic Variants (DGV)RIT1 [DGVbeta]
Mutations
ICGC Data PortalRIT1 
TCGA Data PortalRIT1 
Broad Tumor PortalRIT1
OASIS PortalRIT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRIT1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RIT1
DgiDB (Drug Gene Interaction Database)RIT1
DoCM (Curated mutations)RIT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RIT1 (select a term)
intoGenRIT1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:155867599-155881193  ENSG00000143622
CONAN: Copy Number AnalysisRIT1 
Mutations and Diseases : HGMDRIT1
OMIM609591    615355   
MedgenRIT1
Genetic Testing Registry RIT1
NextProtQ92963 [Medical]
TSGene6016
GENETestsRIT1
Huge Navigator RIT1 [HugePedia]
snp3D : Map Gene to Disease6016
BioCentury BCIQRIT1
ClinGenRIT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6016
Chemical/Pharm GKB GenePA35528
Clinical trialRIT1
Miscellaneous
canSAR (ICR)RIT1 (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRIT1
EVEXRIT1
GoPubMedRIT1
iHOPRIT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat May 28 11:19:01 CEST 2016

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