Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

RIT2 (Ras like without CAAX 2)

Identity

Alias_namesRIN
Ric (Drosophila)-like
Alias_symbol (synonym)RIBA
Other aliasROC2
HGNC (Hugo) RIT2
LocusID (NCBI) 6014
Atlas_Id 42123
Location 18q12.3  [Link to chromosome band 18q12]
Location_base_pair Starts at 42743218 and ends at 43115692 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CDC45 (22q11.21) / RIT2 (18q12.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)RIT2   10017
Cards
Entrez_Gene (NCBI)RIT2  6014  Ras like without CAAX 2
AliasesRIBA; RIN; ROC2
GeneCards (Weizmann)RIT2
Ensembl hg19 (Hinxton)ENSG00000152214 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000152214 [Gene_View]  chr18:42743218-43115692 [Contig_View]  RIT2 [Vega]
ICGC DataPortalENSG00000152214
TCGA cBioPortalRIT2
AceView (NCBI)RIT2
Genatlas (Paris)RIT2
WikiGenes6014
SOURCE (Princeton)RIT2
Genetics Home Reference (NIH)RIT2
Genomic and cartography
GoldenPath hg38 (UCSC)RIT2  -     chr18:42743218-43115692 -  18q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RIT2  -     18q12.3   [Description]    (hg19-Feb_2009)
EnsemblRIT2 - 18q12.3 [CytoView hg19]  RIT2 - 18q12.3 [CytoView hg38]
Mapping of homologs : NCBIRIT2 [Mapview hg19]  RIT2 [Mapview hg38]
OMIM609592   
Gene and transcription
Genbank (Entrez)AF493922 AK313823 AY563951 BC018060 BG188523
RefSeq transcript (Entrez)NM_001272077 NM_002930
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RIT2
Cluster EST : UnigeneHs.464985 [ NCBI ]
CGAP (NCI)Hs.464985
Alternative Splicing GalleryENSG00000152214
Gene ExpressionRIT2 [ NCBI-GEO ]   RIT2 [ EBI - ARRAY_EXPRESS ]   RIT2 [ SEEK ]   RIT2 [ MEM ]
Gene Expression Viewer (FireBrowse)RIT2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6014
GTEX Portal (Tissue expression)RIT2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99578   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99578  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99578
Splice isoforms : SwissVarQ99578
PhosPhoSitePlusQ99578
Domaine pattern : Prosite (Expaxy)RAS (PS51421)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase    Small_GTPase_Ras   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Conserved Domain (NCBI)RIT2
DMDM Disease mutations6014
Blocks (Seattle)RIT2
SuperfamilyQ99578
Human Protein AtlasENSG00000152214
Peptide AtlasQ99578
HPRD15253
IPIIPI00163763   IPI00289566   
Protein Interaction databases
DIP (DOE-UCLA)Q99578
IntAct (EBI)Q99578
FunCoupENSG00000152214
BioGRIDRIT2
STRING (EMBL)RIT2
ZODIACRIT2
Ontologies - Pathways
QuickGOQ99578
Ontology : AmiGOMAPK cascade  chromatin binding  GTPase activity  GTPase activity  protein binding  calmodulin binding  calmodulin binding  GTP binding  nucleus  nucleus  cytoplasm  plasma membrane  plasma membrane  plasma membrane  small GTPase mediated signal transduction  Ras protein signal transduction  chemical synaptic transmission  positive regulation of neuron projection development  positive regulation of neuron projection development  negative regulation of neuron projection development  regulation of endocytosis  semaphorin receptor binding  regulation of Cdc42 protein signal transduction  maintenance of protein location in cell  intracellular signal transduction  identical protein binding  neuron projection  positive regulation of MAPK cascade  cell body  membrane raft  positive regulation of adenylate cyclase activity  positive regulation of transcription from RNA polymerase II promoter  regulation of calcium-mediated signaling  dendritic tree  
Ontology : EGO-EBIMAPK cascade  chromatin binding  GTPase activity  GTPase activity  protein binding  calmodulin binding  calmodulin binding  GTP binding  nucleus  nucleus  cytoplasm  plasma membrane  plasma membrane  plasma membrane  small GTPase mediated signal transduction  Ras protein signal transduction  chemical synaptic transmission  positive regulation of neuron projection development  positive regulation of neuron projection development  negative regulation of neuron projection development  regulation of endocytosis  semaphorin receptor binding  regulation of Cdc42 protein signal transduction  maintenance of protein location in cell  intracellular signal transduction  identical protein binding  neuron projection  positive regulation of MAPK cascade  cell body  membrane raft  positive regulation of adenylate cyclase activity  positive regulation of transcription from RNA polymerase II promoter  regulation of calcium-mediated signaling  dendritic tree  
NDEx NetworkRIT2
Atlas of Cancer Signalling NetworkRIT2
Wikipedia pathwaysRIT2
Orthology - Evolution
OrthoDB6014
GeneTree (enSembl)ENSG00000152214
Phylogenetic Trees/Animal Genes : TreeFamRIT2
HOVERGENQ99578
HOGENOMQ99578
Homologs : HomoloGeneRIT2
Homology/Alignments : Family Browser (UCSC)RIT2
Gene fusions - Rearrangements
Fusion : MitelmanCDC45/RIT2 [22q11.21/18q12.3]  [t(18;22)(q12;q11)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRIT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RIT2
dbVarRIT2
ClinVarRIT2
1000_GenomesRIT2 
Exome Variant ServerRIT2
ExAC (Exome Aggregation Consortium)RIT2 (select the gene name)
Genetic variants : HAPMAP6014
Genomic Variants (DGV)RIT2 [DGVbeta]
DECIPHERRIT2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRIT2 
Mutations
ICGC Data PortalRIT2 
TCGA Data PortalRIT2 
Broad Tumor PortalRIT2
OASIS PortalRIT2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRIT2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRIT2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RIT2
DgiDB (Drug Gene Interaction Database)RIT2
DoCM (Curated mutations)RIT2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RIT2 (select a term)
intoGenRIT2
Cancer3DRIT2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609592   
Orphanet
MedgenRIT2
Genetic Testing Registry RIT2
NextProtQ99578 [Medical]
TSGene6014
GENETestsRIT2
Target ValidationRIT2
Huge Navigator RIT2 [HugePedia]
snp3D : Map Gene to Disease6014
BioCentury BCIQRIT2
ClinGenRIT2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6014
Chemical/Pharm GKB GenePA35527
Clinical trialRIT2
Miscellaneous
canSAR (ICR)RIT2 (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRIT2
EVEXRIT2
GoPubMedRIT2
iHOPRIT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:53:22 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.