RLN3 (relaxin 3)

2014-11-01 Affiliation

Identity

HGNC

RLN3

LOCATION

19p13.12

LOCUSID

117579

ALIAS

H3,RXN3,ZINS4,insl7

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 117579
MIM: 606855
HGNC: 17135
Ensembl: ENSG00000171136

Variants:

dbSNP: 117579
ClinVar: 117579
TCGA: ENSG00000171136
COSMIC: RLN3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000171136	ENST00000431365	Q8WXF3
ENSG00000171136	ENST00000585987	K7ENX1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Peptide ligand-binding receptors	REACTOME	R-HSA-375276
Relaxin receptors	REACTOME	R-HSA-444821
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (s) signalling events	REACTOME	R-HSA-418555
G alpha (i) signalling events	REACTOME	R-HSA-418594

References

Pubmed ID	Year	Title	Citations
14522968	2003	Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135.	56
14522967	2003	Identification of relaxin-3/INSL7 as a ligand for GPCR142.	35
15465925	2005	Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7.	26
18434306	2008	The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors.	26
16365033	2006	Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3.	24
21693186	2011	Relaxin-3 systems in the brain--the first 10 years.	20
21229994	2011	H3 relaxin demonstrates antifibrotic properties via the RXFP1 receptor.	11
15956730	2005	Responses of GPCR135 to human gene 3 (H3) relaxin in CHO-K1 cells determined by microphysiometry.	7
27193232	2016	Identification of hydrophobic interactions between relaxin-3 and its receptor RXFP3: implication for a conformational change in the B-chain C-terminus during receptor binding.	7
19778557	2010	Relaxin-3 and receptors in the human and rhesus brain and reproductive tissues.	6

Citation

Dessen P

RLN3 (relaxin 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72655/rln3