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RNASE1 (ribonuclease A family member 1, pancreatic)

Identity

Alias_namesRNS1
ribonuclease
Alias_symbol (synonym)RAC1
Other aliasRIB1
HGNC (Hugo) RNASE1
LocusID (NCBI) 6035
Atlas_Id 46115
Location 14q11.2  [Link to chromosome band 14q11]
Location_base_pair Starts at 21269515 and ends at 21271036 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ESF1 (20p12.1) / RNASE1 (14q11.2)RNASE1 (14q11.2) / B2M (15q21.1)RNASE1 (14q11.2) / FOXRED1 (11q24.2)
RNASE1 (14q11.2) / KCTD12 (13q22.3)RNASE1 (14q11.2) / LOC728730 (2p22.1)RNASE1 (14q11.2) / SPR (2p13.2)
RNASE1 (14q11.2) / UBL3 (13q12.3)SPR (2p13.2) / RNASE1 (14q11.2)TEP1 (14q11.2) / RNASE1 (14q11.2)
TJP1 (15q13.1) / RNASE1 (14q11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RNASE1   10044
Cards
Entrez_Gene (NCBI)RNASE1  6035  ribonuclease A family member 1, pancreatic
AliasesRAC1; RIB1; RNS1
GeneCards (Weizmann)RNASE1
Ensembl hg19 (Hinxton)ENSG00000129538 [Gene_View]  chr14:21269515-21271036 [Contig_View]  RNASE1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000129538 [Gene_View]  chr14:21269515-21271036 [Contig_View]  RNASE1 [Vega]
ICGC DataPortalENSG00000129538
TCGA cBioPortalRNASE1
AceView (NCBI)RNASE1
Genatlas (Paris)RNASE1
WikiGenes6035
SOURCE (Princeton)RNASE1
Genetics Home Reference (NIH)RNASE1
Genomic and cartography
GoldenPath hg19 (UCSC)RNASE1  -     chr14:21269515-21271036 -  14q11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RNASE1  -     14q11.2   [Description]    (hg38-Dec_2013)
EnsemblRNASE1 - 14q11.2 [CytoView hg19]  RNASE1 - 14q11.2 [CytoView hg38]
Mapping of homologs : NCBIRNASE1 [Mapview hg19]  RNASE1 [Mapview hg38]
OMIM180440   
Gene and transcription
Genbank (Entrez)AI400223 AK098375 AK129871 AK312100 AV710596
RefSeq transcript (Entrez)NM_002933 NM_198232 NM_198234 NM_198235
RefSeq genomic (Entrez)NC_000014 NC_018925 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)RNASE1
Cluster EST : UnigeneHs.78224 [ NCBI ]
CGAP (NCI)Hs.78224
Alternative Splicing GalleryENSG00000129538
Gene ExpressionRNASE1 [ NCBI-GEO ]   RNASE1 [ EBI - ARRAY_EXPRESS ]   RNASE1 [ SEEK ]   RNASE1 [ MEM ]
Gene Expression Viewer (FireBrowse)RNASE1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6035
GTEX Portal (Tissue expression)RNASE1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07998   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP07998  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP07998
Splice isoforms : SwissVarP07998
Catalytic activity : Enzyme3.1.27.5 [ Enzyme-Expasy ]   3.1.27.53.1.27.5 [ IntEnz-EBI ]   3.1.27.5 [ BRENDA ]   3.1.27.5 [ KEGG ]   
PhosPhoSitePlusP07998
Domaine pattern : Prosite (Expaxy)RNASE_PANCREATIC (PS00127)   
Domains : Interpro (EBI)RNaseA    RNaseA_AS    RNaseA_domain   
Domain families : Pfam (Sanger)RnaseA (PF00074)   
Domain families : Pfam (NCBI)pfam00074   
Domain families : Smart (EMBL)RNAse_Pc (SM00092)  
Domain structure : Prodom (Prabi Lyon)RNaseA (PD000535)   
Conserved Domain (NCBI)RNASE1
DMDM Disease mutations6035
Blocks (Seattle)RNASE1
PDB (SRS)1DZA    1E21    1H8X    1Z7X    2E0J    2E0L    2E0M    2E0O    2K11    2Q4G    3F8G    4KXH   
PDB (PDBSum)1DZA    1E21    1H8X    1Z7X    2E0J    2E0L    2E0M    2E0O    2K11    2Q4G    3F8G    4KXH   
PDB (IMB)1DZA    1E21    1H8X    1Z7X    2E0J    2E0L    2E0M    2E0O    2K11    2Q4G    3F8G    4KXH   
PDB (RSDB)1DZA    1E21    1H8X    1Z7X    2E0J    2E0L    2E0M    2E0O    2K11    2Q4G    3F8G    4KXH   
Structural Biology KnowledgeBase1DZA    1E21    1H8X    1Z7X    2E0J    2E0L    2E0M    2E0O    2K11    2Q4G    3F8G    4KXH   
SCOP (Structural Classification of Proteins)1DZA    1E21    1H8X    1Z7X    2E0J    2E0L    2E0M    2E0O    2K11    2Q4G    3F8G    4KXH   
CATH (Classification of proteins structures)1DZA    1E21    1H8X    1Z7X    2E0J    2E0L    2E0M    2E0O    2K11    2Q4G    3F8G    4KXH   
SuperfamilyP07998
Human Protein AtlasENSG00000129538
Peptide AtlasP07998
HPRD01591
IPIIPI00014048   IPI01025088   
Protein Interaction databases
DIP (DOE-UCLA)P07998
IntAct (EBI)P07998
FunCoupENSG00000129538
BioGRIDRNASE1
STRING (EMBL)RNASE1
ZODIACRNASE1
Ontologies - Pathways
QuickGOP07998
Ontology : AmiGOnucleic acid binding  ribonuclease A activity  protein binding  extracellular exosome  RNA phosphodiester bond hydrolysis, endonucleolytic  RNA phosphodiester bond hydrolysis, endonucleolytic  
Ontology : EGO-EBInucleic acid binding  ribonuclease A activity  protein binding  extracellular exosome  RNA phosphodiester bond hydrolysis, endonucleolytic  RNA phosphodiester bond hydrolysis, endonucleolytic  
NDEx NetworkRNASE1
Atlas of Cancer Signalling NetworkRNASE1
Wikipedia pathwaysRNASE1
Orthology - Evolution
OrthoDB6035
GeneTree (enSembl)ENSG00000129538
Phylogenetic Trees/Animal Genes : TreeFamRNASE1
HOVERGENP07998
HOGENOMP07998
Homologs : HomoloGeneRNASE1
Homology/Alignments : Family Browser (UCSC)RNASE1
Gene fusions - Rearrangements
Fusion : MitelmanTEP1/RNASE1 [14q11.2/14q11.2]  [t(14;14)(q11;q11)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRNASE1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNASE1
dbVarRNASE1
ClinVarRNASE1
1000_GenomesRNASE1 
Exome Variant ServerRNASE1
ExAC (Exome Aggregation Consortium)RNASE1 (select the gene name)
Genetic variants : HAPMAP6035
Genomic Variants (DGV)RNASE1 [DGVbeta]
DECIPHER (Syndromes)14:21269515-21271036  ENSG00000129538
CONAN: Copy Number AnalysisRNASE1 
Mutations
ICGC Data PortalRNASE1 
TCGA Data PortalRNASE1 
Broad Tumor PortalRNASE1
OASIS PortalRNASE1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRNASE1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRNASE1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RNASE1
DgiDB (Drug Gene Interaction Database)RNASE1
DoCM (Curated mutations)RNASE1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RNASE1 (select a term)
intoGenRNASE1
Cancer3DRNASE1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM180440   
Orphanet
MedgenRNASE1
Genetic Testing Registry RNASE1
NextProtP07998 [Medical]
TSGene6035
GENETestsRNASE1
Huge Navigator RNASE1 [HugePedia]
snp3D : Map Gene to Disease6035
BioCentury BCIQRNASE1
ClinGenRNASE1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6035
Chemical/Pharm GKB GenePA34412
Clinical trialRNASE1
Miscellaneous
canSAR (ICR)RNASE1 (select the gene name)
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRNASE1
EVEXRNASE1
GoPubMedRNASE1
iHOPRNASE1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:17:34 CEST 2017

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