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RNASE1 (ribonuclease A family member 1, pancreatic)

Identity

Alias (NCBI)RAC1
RIB1
RNS1
HGNC (Hugo) RNASE1
HGNC Alias symbRAC1
HGNC Previous nameRNS1
HGNC Previous nameribonuclease, RNase A family, 1 (pancreatic)
LocusID (NCBI) 6035
Atlas_Id 46115
Location 14q11.2  [Link to chromosome band 14q11]
Location_base_pair Starts at 20801228 and ends at 20802844 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ESF1 (20p12.1) / RNASE1 (14q11.2)RNASE1 (14q11.2) / B2M (15q21.1)RNASE1 (14q11.2) / FOXRED1 (11q24.2)
RNASE1 (14q11.2) / KCTD12 (13q22.3)RNASE1 (14q11.2) / LOC728730 (2p22.1)RNASE1 (14q11.2) / SPR (2p13.2)
RNASE1 (14q11.2) / UBL3 (13q12.3)SPR (2p13.2) / RNASE1 (14q11.2)TEP1 (14q11.2) / RNASE1 (14q11.2)
TJP1 (15q13.1) / RNASE1 (14q11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)RNASE1   10044
Cards
Entrez_Gene (NCBI)RNASE1    ribonuclease A family member 1, pancreatic
AliasesRAC1; RIB1; RNS1
GeneCards (Weizmann)RNASE1
Ensembl hg19 (Hinxton)ENSG00000129538 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000129538 [Gene_View]  ENSG00000129538 [Sequence]  chr14:20801228-20802844 [Contig_View]  RNASE1 [Vega]
ICGC DataPortalENSG00000129538
TCGA cBioPortalRNASE1
AceView (NCBI)RNASE1
Genatlas (Paris)RNASE1
SOURCE (Princeton)RNASE1
Genetics Home Reference (NIH)RNASE1
Genomic and cartography
GoldenPath hg38 (UCSC)RNASE1  -     chr14:20801228-20802844 -  14q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RNASE1  -     14q11.2   [Description]    (hg19-Feb_2009)
GoldenPathRNASE1 - 14q11.2 [CytoView hg19]  RNASE1 - 14q11.2 [CytoView hg38]
ImmunoBaseENSG00000129538
Genome Data Viewer NCBIRNASE1 [Mapview hg19]  
OMIM180440   
Gene and transcription
Genbank (Entrez)AI400223 AK098375 AK129871 AK312100 AV710596
RefSeq transcript (Entrez)NM_002933 NM_198232 NM_198234 NM_198235
Consensus coding sequences : CCDS (NCBI)RNASE1
Gene ExpressionRNASE1 [ NCBI-GEO ]   RNASE1 [ EBI - ARRAY_EXPRESS ]   RNASE1 [ SEEK ]   RNASE1 [ MEM ]
Gene Expression Viewer (FireBrowse)RNASE1 [ Firebrowse - Broad ]
GenevisibleExpression of RNASE1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6035
GTEX Portal (Tissue expression)RNASE1
Human Protein AtlasENSG00000129538-RNASE1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07998   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP07998  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP07998
Catalytic activity : Enzyme4.6.1.18 [ Enzyme-Expasy ]   4.6.1.184.6.1.18 [ IntEnz-EBI ]   4.6.1.18 [ BRENDA ]   4.6.1.18 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP07998
Domaine pattern : Prosite (Expaxy)RNASE_PANCREATIC (PS00127)   
Domains : Interpro (EBI)RNaseA    RNaseA-like_dom_sf    RNaseA_AS    RNaseA_domain   
Domain families : Pfam (Sanger)RnaseA (PF00074)   
Domain families : Pfam (NCBI)pfam00074   
Domain families : Smart (EMBL)RNAse_Pc (SM00092)  
Conserved Domain (NCBI)RNASE1
PDB (RSDB)1DZA    1E21    1H8X    1Z7X    2E0J    2E0L    2E0M    2E0O    2K11    2Q4G    3F8G    4KXH   
PDB Europe1DZA    1E21    1H8X    1Z7X    2E0J    2E0L    2E0M    2E0O    2K11    2Q4G    3F8G    4KXH   
PDB (PDBSum)1DZA    1E21    1H8X    1Z7X    2E0J    2E0L    2E0M    2E0O    2K11    2Q4G    3F8G    4KXH   
PDB (IMB)1DZA    1E21    1H8X    1Z7X    2E0J    2E0L    2E0M    2E0O    2K11    2Q4G    3F8G    4KXH   
Structural Biology KnowledgeBase1DZA    1E21    1H8X    1Z7X    2E0J    2E0L    2E0M    2E0O    2K11    2Q4G    3F8G    4KXH   
SCOP (Structural Classification of Proteins)1DZA    1E21    1H8X    1Z7X    2E0J    2E0L    2E0M    2E0O    2K11    2Q4G    3F8G    4KXH   
CATH (Classification of proteins structures)1DZA    1E21    1H8X    1Z7X    2E0J    2E0L    2E0M    2E0O    2K11    2Q4G    3F8G    4KXH   
SuperfamilyP07998
AlphaFold pdb e-kbP07998   
Human Protein Atlas [tissue]ENSG00000129538-RNASE1 [tissue]
HPRD01591
Protein Interaction databases
DIP (DOE-UCLA)P07998
IntAct (EBI)P07998
BioGRIDRNASE1
STRING (EMBL)RNASE1
ZODIACRNASE1
Ontologies - Pathways
QuickGOP07998
Ontology : AmiGOnucleic acid binding  ribonuclease A activity  ribonuclease activity  ribonuclease activity  protein binding  lyase activity  defense response to virus  extracellular exosome  RNA phosphodiester bond hydrolysis  RNA phosphodiester bond hydrolysis  RNA phosphodiester bond hydrolysis, endonucleolytic  
Ontology : EGO-EBInucleic acid binding  ribonuclease A activity  ribonuclease activity  ribonuclease activity  protein binding  lyase activity  defense response to virus  extracellular exosome  RNA phosphodiester bond hydrolysis  RNA phosphodiester bond hydrolysis  RNA phosphodiester bond hydrolysis, endonucleolytic  
NDEx NetworkRNASE1
Atlas of Cancer Signalling NetworkRNASE1
Wikipedia pathwaysRNASE1
Orthology - Evolution
OrthoDB6035
GeneTree (enSembl)ENSG00000129538
Phylogenetic Trees/Animal Genes : TreeFamRNASE1
Homologs : HomoloGeneRNASE1
Homology/Alignments : Family Browser (UCSC)RNASE1
Gene fusions - Rearrangements
Fusion : MitelmanTEP1/RNASE1 [14q11.2/14q11.2]  
Fusion : QuiverRNASE1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRNASE1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNASE1
dbVarRNASE1
ClinVarRNASE1
MonarchRNASE1
1000_GenomesRNASE1 
Exome Variant ServerRNASE1
GNOMAD BrowserENSG00000129538
Varsome BrowserRNASE1
ACMGRNASE1 variants
VarityP07998
Genomic Variants (DGV)RNASE1 [DGVbeta]
DECIPHERRNASE1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRNASE1 
Mutations
ICGC Data PortalRNASE1 
TCGA Data PortalRNASE1 
Broad Tumor PortalRNASE1
OASIS PortalRNASE1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRNASE1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRNASE1
Mutations and Diseases : HGMDRNASE1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRNASE1
DgiDB (Drug Gene Interaction Database)RNASE1
DoCM (Curated mutations)RNASE1
CIViC (Clinical Interpretations of Variants in Cancer)RNASE1
Cancer3DRNASE1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM180440   
Orphanet
DisGeNETRNASE1
MedgenRNASE1
Genetic Testing Registry RNASE1
NextProtP07998 [Medical]
GENETestsRNASE1
Target ValidationRNASE1
Huge Navigator RNASE1 [HugePedia]
ClinGenRNASE1
Clinical trials, drugs, therapy
MyCancerGenomeRNASE1
Protein Interactions : CTDRNASE1
Pharm GKB GenePA34412
PharosP07998
Clinical trialRNASE1
Miscellaneous
canSAR (ICR)RNASE1
HarmonizomeRNASE1
DataMed IndexRNASE1
Probes
Litterature
PubMed68 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRNASE1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:29:05 CEST 2021

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