RNASE1 (ribonuclease A family member 1, pancreatic)

2007-02-01  

Identity

HGNC
RNASE1
LOCATION
14q11.2
LOCUSID
6035
ALIAS
RAC1,RIB1,RNS1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6035
MIM: 180440
HGNC: 10044
Ensembl: ENSG00000129538

Variants:

dbSNP: 6035
ClinVar: 6035
TCGA: ENSG00000129538
COSMIC: RNASE1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129538ENST00000340900P07998
ENSG00000129538ENST00000340900W0UV93
ENSG00000129538ENST00000397967P07998
ENSG00000129538ENST00000397967W0UV93
ENSG00000129538ENST00000397970P07998
ENSG00000129538ENST00000397970W0UV93
ENSG00000129538ENST00000412779P07998
ENSG00000129538ENST00000412779W0UV93
ENSG00000129538ENST00000555698G3V357

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
173506502007Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein.57
155283502004Human ribonuclease A superfamily members, eosinophil-derived neurotoxin and pancreatic ribonuclease, induce dendritic cell maturation and activation.51
120220382002Analysis of the RNASEL gene in familial and sporadic prostate cancer.28
177055072007Cytotoxic ribonucleases: the dichotomy of Coulombic forces.27
171095152006Comparison of gene expression profiles between primary tumor and metastatic lesions in gastric cancer patients using laser microdissection and cDNA microarray.25
122107602002Human endothelial cells selectively express large amounts of pancreatic-type ribonuclease (RNase 1).20
211036612011Expression and localisation of vascular ribonucleases in endothelial cells.20
231352722012Conservation of flexible residue clusters among structural and functional enzyme homologues.19
160545672005Arg462Gln sequence variation in the prostate-cancer-susceptibility gene RNASEL and age of onset of hereditary non-polyposis colorectal cancer: a case-control study.16
161140552006Association of hereditary prostate cancer gene polymorphic variants with sporadic aggressive prostate carcinoma.11

Citation

Dessen P

RNASE1 (ribonuclease A family member 1, pancreatic)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46115/rnase1