Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

RNASE2 (ribonuclease A family member 2)

Identity

Alias_namesRNS2
ribonuclease
Alias_symbol (synonym)EDN
RAF3
Other alias
HGNC (Hugo) RNASE2
LocusID (NCBI) 6036
Atlas_Id 46157
Location 14q11.2  [Link to chromosome band 14q11]
Location_base_pair Starts at 21423630 and ends at 21424594 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
RNASE2 (14q11.2) / MMP9 (20q13.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RNASE2   10045
Cards
Entrez_Gene (NCBI)RNASE2  6036  ribonuclease A family member 2
AliasesEDN; RAF3; RNS2
GeneCards (Weizmann)RNASE2
Ensembl hg19 (Hinxton)ENSG00000169385 [Gene_View]  chr14:21423630-21424594 [Contig_View]  RNASE2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000169385 [Gene_View]  chr14:21423630-21424594 [Contig_View]  RNASE2 [Vega]
ICGC DataPortalENSG00000169385
TCGA cBioPortalRNASE2
AceView (NCBI)RNASE2
Genatlas (Paris)RNASE2
WikiGenes6036
SOURCE (Princeton)RNASE2
Genetics Home Reference (NIH)RNASE2
Genomic and cartography
GoldenPath hg19 (UCSC)RNASE2  -     chr14:21423630-21424594 +  14q11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RNASE2  -     14q11.2   [Description]    (hg38-Dec_2013)
EnsemblRNASE2 - 14q11.2 [CytoView hg19]  RNASE2 - 14q11.2 [CytoView hg38]
Mapping of homologs : NCBIRNASE2 [Mapview hg19]  RNASE2 [Mapview hg38]
OMIM131410   
Gene and transcription
Genbank (Entrez)BC093678 BC093680 BC096059 M24157 M28129
RefSeq transcript (Entrez)NM_002934
RefSeq genomic (Entrez)NC_000014 NC_018925 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)RNASE2
Cluster EST : UnigeneHs.728 [ NCBI ]
CGAP (NCI)Hs.728
Alternative Splicing GalleryENSG00000169385
Gene ExpressionRNASE2 [ NCBI-GEO ]   RNASE2 [ EBI - ARRAY_EXPRESS ]   RNASE2 [ SEEK ]   RNASE2 [ MEM ]
Gene Expression Viewer (FireBrowse)RNASE2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6036
GTEX Portal (Tissue expression)RNASE2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10153   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP10153  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP10153
Splice isoforms : SwissVarP10153
Catalytic activity : Enzyme3.1.27.5 [ Enzyme-Expasy ]   3.1.27.53.1.27.5 [ IntEnz-EBI ]   3.1.27.5 [ BRENDA ]   3.1.27.5 [ KEGG ]   
PhosPhoSitePlusP10153
Domaine pattern : Prosite (Expaxy)RNASE_PANCREATIC (PS00127)   
Domains : Interpro (EBI)RNaseA    RNaseA_AS    RNaseA_domain   
Domain families : Pfam (Sanger)RnaseA (PF00074)   
Domain families : Pfam (NCBI)pfam00074   
Domain families : Smart (EMBL)RNAse_Pc (SM00092)  
Domain structure : Prodom (Prabi Lyon)RNaseA (PD000535)   
Conserved Domain (NCBI)RNASE2
DMDM Disease mutations6036
Blocks (Seattle)RNASE2
PDB (SRS)1GQV    1HI2    1HI3    1HI4    1HI5    1K2A    2BEX    2BZZ    2C01    2C02    2C05    5E13   
PDB (PDBSum)1GQV    1HI2    1HI3    1HI4    1HI5    1K2A    2BEX    2BZZ    2C01    2C02    2C05    5E13   
PDB (IMB)1GQV    1HI2    1HI3    1HI4    1HI5    1K2A    2BEX    2BZZ    2C01    2C02    2C05    5E13   
PDB (RSDB)1GQV    1HI2    1HI3    1HI4    1HI5    1K2A    2BEX    2BZZ    2C01    2C02    2C05    5E13   
Structural Biology KnowledgeBase1GQV    1HI2    1HI3    1HI4    1HI5    1K2A    2BEX    2BZZ    2C01    2C02    2C05    5E13   
SCOP (Structural Classification of Proteins)1GQV    1HI2    1HI3    1HI4    1HI5    1K2A    2BEX    2BZZ    2C01    2C02    2C05    5E13   
CATH (Classification of proteins structures)1GQV    1HI2    1HI3    1HI4    1HI5    1K2A    2BEX    2BZZ    2C01    2C02    2C05    5E13   
SuperfamilyP10153
Human Protein AtlasENSG00000169385
Peptide AtlasP10153
HPRD00577
IPIIPI00019449   
Protein Interaction databases
DIP (DOE-UCLA)P10153
IntAct (EBI)P10153
FunCoupENSG00000169385
BioGRIDRNASE2
STRING (EMBL)RNASE2
ZODIACRNASE2
Ontologies - Pathways
QuickGOP10153
Ontology : AmiGOnucleic acid binding  endonuclease activity  ribonuclease A activity  ribonuclease activity  extracellular region  lysosome  RNA catabolic process  chemotaxis  extracellular exosome  nucleic acid phosphodiester bond hydrolysis  RNA phosphodiester bond hydrolysis  RNA phosphodiester bond hydrolysis, endonucleolytic  positive regulation of protein targeting to mitochondrion  
Ontology : EGO-EBInucleic acid binding  endonuclease activity  ribonuclease A activity  ribonuclease activity  extracellular region  lysosome  RNA catabolic process  chemotaxis  extracellular exosome  nucleic acid phosphodiester bond hydrolysis  RNA phosphodiester bond hydrolysis  RNA phosphodiester bond hydrolysis, endonucleolytic  positive regulation of protein targeting to mitochondrion  
NDEx NetworkRNASE2
Atlas of Cancer Signalling NetworkRNASE2
Wikipedia pathwaysRNASE2
Orthology - Evolution
OrthoDB6036
GeneTree (enSembl)ENSG00000169385
Phylogenetic Trees/Animal Genes : TreeFamRNASE2
HOVERGENP10153
HOGENOMP10153
Homologs : HomoloGeneRNASE2
Homology/Alignments : Family Browser (UCSC)RNASE2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRNASE2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNASE2
dbVarRNASE2
ClinVarRNASE2
1000_GenomesRNASE2 
Exome Variant ServerRNASE2
ExAC (Exome Aggregation Consortium)RNASE2 (select the gene name)
Genetic variants : HAPMAP6036
Genomic Variants (DGV)RNASE2 [DGVbeta]
DECIPHER (Syndromes)14:21423630-21424594  ENSG00000169385
CONAN: Copy Number AnalysisRNASE2 
Mutations
ICGC Data PortalRNASE2 
TCGA Data PortalRNASE2 
Broad Tumor PortalRNASE2
OASIS PortalRNASE2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRNASE2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRNASE2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RNASE2
DgiDB (Drug Gene Interaction Database)RNASE2
DoCM (Curated mutations)RNASE2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RNASE2 (select a term)
intoGenRNASE2
Cancer3DRNASE2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM131410   
Orphanet
MedgenRNASE2
Genetic Testing Registry RNASE2
NextProtP10153 [Medical]
TSGene6036
GENETestsRNASE2
Huge Navigator RNASE2 [HugePedia]
snp3D : Map Gene to Disease6036
BioCentury BCIQRNASE2
ClinGenRNASE2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6036
Chemical/Pharm GKB GenePA34413
Clinical trialRNASE2
Miscellaneous
canSAR (ICR)RNASE2 (select the gene name)
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRNASE2
EVEXRNASE2
GoPubMedRNASE2
iHOPRNASE2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:17:34 CEST 2017

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.