RNASE3 (ribonuclease A family member 3)

2016-10-01  

Identity

HGNC
RNASE3
LOCATION
14q11.2
LOCUSID
6037
ALIAS
ECP,RAF1,RNS3

Other Information

Locus ID:

NCBI: 6037
MIM: 131398
HGNC: 10046
Ensembl: ENSG00000169397

Variants:

dbSNP: 6037
ClinVar: 6037
TCGA: ENSG00000169397
COSMIC: RNASE3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169397ENST00000304639P12724

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
AsthmaKEGGko05310
AsthmaKEGGhsa05310
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Antimicrobial peptidesREACTOMER-HSA-6803157
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
182939322008Eosinophil cationic protein high-affinity binding to bacteria-wall lipopolysaccharides and peptidoglycans.37
237160472013Two human host defense ribonucleases against mycobacteria, the eosinophil cationic protein (RNase 3) and RNase 7.28
194502312009Bactericidal and membrane disruption activities of the eosinophil cationic protein are largely retained in an N-terminal fragment.23
193665932009Comparison of the membrane interaction mechanism of two antimicrobial RNases: RNase 3/ECP and RNase 7.21
180876742008The cytotoxicity of eosinophil cationic protein/ribonuclease 3 on eukaryotic cell lines takes place through its aggregation on the cell membrane.19
231352722012Conservation of flexible residue clusters among structural and functional enzyme homologues.19
172236932007Topography studies on the membrane interaction mechanism of the eosinophil cationic protein.18
176755272007Neutrophils as a novel source of eosinophil cationic protein in IgE-mediated processes.18
175070192007The 434(G>C) polymorphism within the coding sequence of Eosinophil Cationic Protein (ECP) correlates with the natural course of Schistosoma mansoni infection.17
179448072007A heparan sulfate-facilitated and raft-dependent macropinocytosis of eosinophil cationic protein.17

Citation

Dessen P

RNASE3 (ribonuclease A family member 3)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56394/rnase3