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RNASE3 (ribonuclease A family member 3)

Identity

Alias_namesRNS3
ribonuclease
Alias_symbol (synonym)ECP
RAF1
Other alias
HGNC (Hugo) RNASE3
LocusID (NCBI) 6037
Atlas_Id 56394
Location 14q11.2  [Link to chromosome band 14q11]
Location_base_pair Starts at 20891403 and ends at 20892348 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RNASE3   10046
Cards
Entrez_Gene (NCBI)RNASE3  6037  ribonuclease A family member 3
AliasesECP; RAF1; RNS3
GeneCards (Weizmann)RNASE3
Ensembl hg19 (Hinxton)ENSG00000169397 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000169397 [Gene_View]  chr14:20891403-20892348 [Contig_View]  RNASE3 [Vega]
ICGC DataPortalENSG00000169397
TCGA cBioPortalRNASE3
AceView (NCBI)RNASE3
Genatlas (Paris)RNASE3
WikiGenes6037
SOURCE (Princeton)RNASE3
Genetics Home Reference (NIH)RNASE3
Genomic and cartography
GoldenPath hg38 (UCSC)RNASE3  -     chr14:20891403-20892348 +  14q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RNASE3  -     14q11.2   [Description]    (hg19-Feb_2009)
EnsemblRNASE3 - 14q11.2 [CytoView hg19]  RNASE3 - 14q11.2 [CytoView hg38]
Mapping of homologs : NCBIRNASE3 [Mapview hg19]  RNASE3 [Mapview hg38]
OMIM131398   
Gene and transcription
Genbank (Entrez)BC096060 BC096061 BC096062 BX280390 M28128
RefSeq transcript (Entrez)NM_002935
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RNASE3
Cluster EST : UnigeneHs.73839 [ NCBI ]
CGAP (NCI)Hs.73839
Alternative Splicing GalleryENSG00000169397
Gene ExpressionRNASE3 [ NCBI-GEO ]   RNASE3 [ EBI - ARRAY_EXPRESS ]   RNASE3 [ SEEK ]   RNASE3 [ MEM ]
Gene Expression Viewer (FireBrowse)RNASE3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6037
GTEX Portal (Tissue expression)RNASE3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP12724   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP12724  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP12724
Splice isoforms : SwissVarP12724
Catalytic activity : Enzyme3.1.27.- [ Enzyme-Expasy ]   3.1.27.-3.1.27.- [ IntEnz-EBI ]   3.1.27.- [ BRENDA ]   3.1.27.- [ KEGG ]   
PhosPhoSitePlusP12724
Domaine pattern : Prosite (Expaxy)RNASE_PANCREATIC (PS00127)   
Domains : Interpro (EBI)RNaseA    RNaseA_AS    RNaseA_domain   
Domain families : Pfam (Sanger)RnaseA (PF00074)   
Domain families : Pfam (NCBI)pfam00074   
Domain families : Smart (EMBL)RNAse_Pc (SM00092)  
Domain structure : Prodom (Prabi Lyon)RNaseA (PD000535)   
Conserved Domain (NCBI)RNASE3
DMDM Disease mutations6037
Blocks (Seattle)RNASE3
PDB (SRS)1DYT    1H1H    1QMT    2KB5    2LVZ    4A2O    4A2Y    4OWZ    4OXB    4OXF    4X08   
PDB (PDBSum)1DYT    1H1H    1QMT    2KB5    2LVZ    4A2O    4A2Y    4OWZ    4OXB    4OXF    4X08   
PDB (IMB)1DYT    1H1H    1QMT    2KB5    2LVZ    4A2O    4A2Y    4OWZ    4OXB    4OXF    4X08   
PDB (RSDB)1DYT    1H1H    1QMT    2KB5    2LVZ    4A2O    4A2Y    4OWZ    4OXB    4OXF    4X08   
Structural Biology KnowledgeBase1DYT    1H1H    1QMT    2KB5    2LVZ    4A2O    4A2Y    4OWZ    4OXB    4OXF    4X08   
SCOP (Structural Classification of Proteins)1DYT    1H1H    1QMT    2KB5    2LVZ    4A2O    4A2Y    4OWZ    4OXB    4OXF    4X08   
CATH (Classification of proteins structures)1DYT    1H1H    1QMT    2KB5    2LVZ    4A2O    4A2Y    4OWZ    4OXB    4OXF    4X08   
SuperfamilyP12724
Human Protein AtlasENSG00000169397
Peptide AtlasP12724
HPRD00575
IPIIPI00025427   
Protein Interaction databases
DIP (DOE-UCLA)P12724
IntAct (EBI)P12724
FunCoupENSG00000169397
BioGRIDRNASE3
STRING (EMBL)RNASE3
ZODIACRNASE3
Ontologies - Pathways
QuickGOP12724
Ontology : AmiGOinnate immune response in mucosa  nucleic acid binding  endonuclease activity  ribonuclease activity  extracellular region  extracellular space  RNA catabolic process  antimicrobial humoral response  antibacterial humoral response  azurophil granule lumen  neutrophil degranulation  defense response to Gram-positive bacterium  extracellular exosome  RNA phosphodiester bond hydrolysis  
Ontology : EGO-EBIinnate immune response in mucosa  nucleic acid binding  endonuclease activity  ribonuclease activity  extracellular region  extracellular space  RNA catabolic process  antimicrobial humoral response  antibacterial humoral response  azurophil granule lumen  neutrophil degranulation  defense response to Gram-positive bacterium  extracellular exosome  RNA phosphodiester bond hydrolysis  
Pathways : KEGGAsthma   
NDEx NetworkRNASE3
Atlas of Cancer Signalling NetworkRNASE3
Wikipedia pathwaysRNASE3
Orthology - Evolution
OrthoDB6037
GeneTree (enSembl)ENSG00000169397
Phylogenetic Trees/Animal Genes : TreeFamRNASE3
HOVERGENP12724
HOGENOMP12724
Homologs : HomoloGeneRNASE3
Homology/Alignments : Family Browser (UCSC)RNASE3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRNASE3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNASE3
dbVarRNASE3
ClinVarRNASE3
1000_GenomesRNASE3 
Exome Variant ServerRNASE3
ExAC (Exome Aggregation Consortium)RNASE3 (select the gene name)
Genetic variants : HAPMAP6037
Genomic Variants (DGV)RNASE3 [DGVbeta]
DECIPHERRNASE3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRNASE3 
Mutations
ICGC Data PortalRNASE3 
TCGA Data PortalRNASE3 
Broad Tumor PortalRNASE3
OASIS PortalRNASE3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRNASE3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRNASE3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RNASE3
DgiDB (Drug Gene Interaction Database)RNASE3
DoCM (Curated mutations)RNASE3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RNASE3 (select a term)
intoGenRNASE3
Cancer3DRNASE3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM131398   
Orphanet
MedgenRNASE3
Genetic Testing Registry RNASE3
NextProtP12724 [Medical]
TSGene6037
GENETestsRNASE3
Target ValidationRNASE3
Huge Navigator RNASE3 [HugePedia]
snp3D : Map Gene to Disease6037
BioCentury BCIQRNASE3
ClinGenRNASE3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6037
Chemical/Pharm GKB GenePA34414
Clinical trialRNASE3
Miscellaneous
canSAR (ICR)RNASE3 (select the gene name)
Probes
Litterature
PubMed109 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRNASE3
EVEXRNASE3
GoPubMedRNASE3
iHOPRNASE3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:28:58 CEST 2017

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