RNASE6 (ribonuclease A family member k6)

2014-11-01  

Identity

HGNC
LOCATION
14q11.2
LOCUSID
ALIAS
RAD1,RNS6,RNasek6

Other Information

Locus ID:

NCBI: 6039
MIM: 601981
HGNC: 10048
Ensembl: ENSG00000169413

Variants:

dbSNP: 6039
ClinVar: 6039
TCGA: ENSG00000169413
COSMIC: RNASE6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169413ENST00000304677Q93091
ENSG00000169413ENST00000304677Q6IB39

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Antimicrobial peptidesREACTOMER-HSA-6803157

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
250757722015Ribonucleases 6 and 7 have antimicrobial function in the human and murine urinary tract.33
270893202016Insights into the Antimicrobial Mechanism of Action of Human RNase6: Structural Determinants for Bacterial Cell Agglutination and Membrane Permeation.13
302872442019Characterization of an RNase with two catalytic centers. Human RNase6 catalytic and phosphate-binding site arrangement favors the endonuclease cleavage of polymeric substrates.6

Citation

Dessen P

RNASE6 (ribonuclease A family member k6)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72669/rnase6