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RNASE6 (ribonuclease A family member k6)

Identity

Alias_namesRNS6
ribonuclease, RNase A family, k6
Alias_symbol (synonym)RAD1
RNaseK6
Other aliasRNasek6
HGNC (Hugo) RNASE6
LocusID (NCBI) 6039
Atlas_Id 72669
Location 14q11.2  [Link to chromosome band 14q11]
Location_base_pair Starts at 20781051 and ends at 20782467 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RNASE6   10048
Cards
Entrez_Gene (NCBI)RNASE6  6039  ribonuclease A family member k6
AliasesRAD1; RNS6; RNasek6
GeneCards (Weizmann)RNASE6
Ensembl hg19 (Hinxton)ENSG00000169413 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000169413 [Gene_View]  chr14:20781051-20782467 [Contig_View]  RNASE6 [Vega]
ICGC DataPortalENSG00000169413
TCGA cBioPortalRNASE6
AceView (NCBI)RNASE6
Genatlas (Paris)RNASE6
WikiGenes6039
SOURCE (Princeton)RNASE6
Genetics Home Reference (NIH)RNASE6
Genomic and cartography
GoldenPath hg38 (UCSC)RNASE6  -     chr14:20781051-20782467 +  14q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RNASE6  -     14q11.2   [Description]    (hg19-Feb_2009)
EnsemblRNASE6 - 14q11.2 [CytoView hg19]  RNASE6 - 14q11.2 [CytoView hg38]
Mapping of homologs : NCBIRNASE6 [Mapview hg19]  RNASE6 [Mapview hg38]
OMIM601981   
Gene and transcription
Genbank (Entrez)AI151384 AK313580 BC020848 CR456965 HM005479
RefSeq transcript (Entrez)NM_005615
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RNASE6
Cluster EST : UnigeneHs.23262 [ NCBI ]
CGAP (NCI)Hs.23262
Alternative Splicing GalleryENSG00000169413
Gene ExpressionRNASE6 [ NCBI-GEO ]   RNASE6 [ EBI - ARRAY_EXPRESS ]   RNASE6 [ SEEK ]   RNASE6 [ MEM ]
Gene Expression Viewer (FireBrowse)RNASE6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6039
GTEX Portal (Tissue expression)RNASE6
Human Protein AtlasENSG00000169413-RNASE6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ93091   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ93091  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ93091
Splice isoforms : SwissVarQ93091
Catalytic activity : Enzyme3.1.27.- [ Enzyme-Expasy ]   3.1.27.-3.1.27.- [ IntEnz-EBI ]   3.1.27.- [ BRENDA ]   3.1.27.- [ KEGG ]   
PhosPhoSitePlusQ93091
Domaine pattern : Prosite (Expaxy)RNASE_PANCREATIC (PS00127)   
Domains : Interpro (EBI)RNaseA    RNaseA_AS    RNaseA_domain   
Domain families : Pfam (Sanger)RnaseA (PF00074)   
Domain families : Pfam (NCBI)pfam00074   
Domain families : Smart (EMBL)RNAse_Pc (SM00092)  
Domain structure : Prodom (Prabi Lyon)RNaseA (PD000535)   
Conserved Domain (NCBI)RNASE6
DMDM Disease mutations6039
Blocks (Seattle)RNASE6
PDB (SRS)4X09   
PDB (PDBSum)4X09   
PDB (IMB)4X09   
PDB (RSDB)4X09   
Structural Biology KnowledgeBase4X09   
SCOP (Structural Classification of Proteins)4X09   
CATH (Classification of proteins structures)4X09   
SuperfamilyQ93091
Human Protein Atlas [tissue]ENSG00000169413-RNASE6 [tissue]
Peptide AtlasQ93091
HPRD03581
IPIIPI00004114   
Protein Interaction databases
DIP (DOE-UCLA)Q93091
IntAct (EBI)Q93091
FunCoupENSG00000169413
BioGRIDRNASE6
STRING (EMBL)RNASE6
ZODIACRNASE6
Ontologies - Pathways
QuickGOQ93091
Ontology : AmiGOnucleic acid binding  endonuclease activity  ribonuclease activity  extracellular region  RNA catabolic process  defense response  antimicrobial humoral response  extracellular exosome  RNA phosphodiester bond hydrolysis  
Ontology : EGO-EBInucleic acid binding  endonuclease activity  ribonuclease activity  extracellular region  RNA catabolic process  defense response  antimicrobial humoral response  extracellular exosome  RNA phosphodiester bond hydrolysis  
NDEx NetworkRNASE6
Atlas of Cancer Signalling NetworkRNASE6
Wikipedia pathwaysRNASE6
Orthology - Evolution
OrthoDB6039
GeneTree (enSembl)ENSG00000169413
Phylogenetic Trees/Animal Genes : TreeFamRNASE6
HOVERGENQ93091
HOGENOMQ93091
Homologs : HomoloGeneRNASE6
Homology/Alignments : Family Browser (UCSC)RNASE6
Gene fusions - Rearrangements
Fusion: Tumor Portal RNASE6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRNASE6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNASE6
dbVarRNASE6
ClinVarRNASE6
1000_GenomesRNASE6 
Exome Variant ServerRNASE6
ExAC (Exome Aggregation Consortium)ENSG00000169413
GNOMAD BrowserENSG00000169413
Genetic variants : HAPMAP6039
Genomic Variants (DGV)RNASE6 [DGVbeta]
DECIPHERRNASE6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRNASE6 
Mutations
ICGC Data PortalRNASE6 
TCGA Data PortalRNASE6 
Broad Tumor PortalRNASE6
OASIS PortalRNASE6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRNASE6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRNASE6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RNASE6
DgiDB (Drug Gene Interaction Database)RNASE6
DoCM (Curated mutations)RNASE6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RNASE6 (select a term)
intoGenRNASE6
Cancer3DRNASE6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601981   
Orphanet
MedgenRNASE6
Genetic Testing Registry RNASE6
NextProtQ93091 [Medical]
TSGene6039
GENETestsRNASE6
Target ValidationRNASE6
Huge Navigator RNASE6 [HugePedia]
snp3D : Map Gene to Disease6039
BioCentury BCIQRNASE6
ClinGenRNASE6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6039
Chemical/Pharm GKB GenePA34416
Clinical trialRNASE6
Miscellaneous
canSAR (ICR)RNASE6 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRNASE6
EVEXRNASE6
GoPubMedRNASE6
iHOPRNASE6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 12:25:09 CET 2017

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