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RNASE8 (ribonuclease A family member 8)

Identity

Alias_namesribonuclease, RNase A family, 8
Alias_symbol (synonym)RAE2
Other alias
HGNC (Hugo) RNASE8
LocusID (NCBI) 122665
Atlas_Id 72671
Location 14q11.2  [Link to chromosome band 14q11]
Location_base_pair Starts at 21057822 and ends at 21058455 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RNASE8   19277
Cards
Entrez_Gene (NCBI)RNASE8  122665  ribonuclease A family member 8
AliasesRAE2
GeneCards (Weizmann)RNASE8
Ensembl hg19 (Hinxton)ENSG00000173431 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000173431 [Gene_View]  chr14:21057822-21058455 [Contig_View]  RNASE8 [Vega]
ICGC DataPortalENSG00000173431
TCGA cBioPortalRNASE8
AceView (NCBI)RNASE8
Genatlas (Paris)RNASE8
WikiGenes122665
SOURCE (Princeton)RNASE8
Genetics Home Reference (NIH)RNASE8
Genomic and cartography
GoldenPath hg38 (UCSC)RNASE8  -     chr14:21057822-21058455 +  14q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RNASE8  -     14q11.2   [Description]    (hg19-Feb_2009)
EnsemblRNASE8 - 14q11.2 [CytoView hg19]  RNASE8 - 14q11.2 [CytoView hg38]
Mapping of homologs : NCBIRNASE8 [Mapview hg19]  RNASE8 [Mapview hg38]
OMIM612485   
Gene and transcription
Genbank (Entrez)BC137537 BC137538 JQ353679
RefSeq transcript (Entrez)NM_138331
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RNASE8
Cluster EST : UnigeneHs.553572 [ NCBI ]
CGAP (NCI)Hs.553572
Alternative Splicing GalleryENSG00000173431
Gene ExpressionRNASE8 [ NCBI-GEO ]   RNASE8 [ EBI - ARRAY_EXPRESS ]   RNASE8 [ SEEK ]   RNASE8 [ MEM ]
Gene Expression Viewer (FireBrowse)RNASE8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)122665
GTEX Portal (Tissue expression)RNASE8
Human Protein AtlasENSG00000173431-RNASE8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TDE3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TDE3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TDE3
Splice isoforms : SwissVarQ8TDE3
Catalytic activity : Enzyme3.1.27.- [ Enzyme-Expasy ]   3.1.27.-3.1.27.- [ IntEnz-EBI ]   3.1.27.- [ BRENDA ]   3.1.27.- [ KEGG ]   
PhosPhoSitePlusQ8TDE3
Domaine pattern : Prosite (Expaxy)RNASE_PANCREATIC (PS00127)   
Domains : Interpro (EBI)RNaseA    RNaseA_AS    RNaseA_domain   
Domain families : Pfam (Sanger)RnaseA (PF00074)   
Domain families : Pfam (NCBI)pfam00074   
Domain families : Smart (EMBL)RNAse_Pc (SM00092)  
Domain structure : Prodom (Prabi Lyon)RNaseA (PD000535)   
Conserved Domain (NCBI)RNASE8
DMDM Disease mutations122665
Blocks (Seattle)RNASE8
SuperfamilyQ8TDE3
Human Protein Atlas [tissue]ENSG00000173431-RNASE8 [tissue]
Peptide AtlasQ8TDE3
HPRD17982
IPIIPI00152516   
Protein Interaction databases
DIP (DOE-UCLA)Q8TDE3
IntAct (EBI)Q8TDE3
FunCoupENSG00000173431
BioGRIDRNASE8
STRING (EMBL)RNASE8
ZODIACRNASE8
Ontologies - Pathways
QuickGOQ8TDE3
Ontology : AmiGOnucleic acid binding  ribonuclease A activity  extracellular region  RNA phosphodiester bond hydrolysis, endonucleolytic  
Ontology : EGO-EBInucleic acid binding  ribonuclease A activity  extracellular region  RNA phosphodiester bond hydrolysis, endonucleolytic  
NDEx NetworkRNASE8
Atlas of Cancer Signalling NetworkRNASE8
Wikipedia pathwaysRNASE8
Orthology - Evolution
OrthoDB122665
GeneTree (enSembl)ENSG00000173431
Phylogenetic Trees/Animal Genes : TreeFamRNASE8
HOVERGENQ8TDE3
HOGENOMQ8TDE3
Homologs : HomoloGeneRNASE8
Homology/Alignments : Family Browser (UCSC)RNASE8
Gene fusions - Rearrangements
Tumor Fusion PortalRNASE8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRNASE8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNASE8
dbVarRNASE8
ClinVarRNASE8
1000_GenomesRNASE8 
Exome Variant ServerRNASE8
ExAC (Exome Aggregation Consortium)ENSG00000173431
GNOMAD BrowserENSG00000173431
Genetic variants : HAPMAP122665
Genomic Variants (DGV)RNASE8 [DGVbeta]
DECIPHERRNASE8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRNASE8 
Mutations
ICGC Data PortalRNASE8 
TCGA Data PortalRNASE8 
Broad Tumor PortalRNASE8
OASIS PortalRNASE8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRNASE8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRNASE8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RNASE8
DgiDB (Drug Gene Interaction Database)RNASE8
DoCM (Curated mutations)RNASE8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RNASE8 (select a term)
intoGenRNASE8
Cancer3DRNASE8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612485   
Orphanet
DisGeNETRNASE8
MedgenRNASE8
Genetic Testing Registry RNASE8
NextProtQ8TDE3 [Medical]
TSGene122665
GENETestsRNASE8
Target ValidationRNASE8
Huge Navigator RNASE8 [HugePedia]
snp3D : Map Gene to Disease122665
BioCentury BCIQRNASE8
ClinGenRNASE8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD122665
Chemical/Pharm GKB GenePA134930162
Clinical trialRNASE8
Miscellaneous
canSAR (ICR)RNASE8 (select the gene name)
Probes
Litterature
PubMed5 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRNASE8
EVEXRNASE8
GoPubMedRNASE8
iHOPRNASE8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 13:30:23 CET 2017

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