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RNASEH2B (ribonuclease H2 subunit B)

Identity

Other namesAGS2
DLEU8
HGNC (Hugo) RNASEH2B
LocusID (NCBI) 79621
Atlas_Id 43055
Location 13q14.3  [Link to chromosome band 13q14]
Location_base_pair Starts at 51483814 and ends at 51544596 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
HLA-B (6p21.33) / RNASEH2B (13q14.3)RNASEH2B (13q14.3) / PNRC1 (6q15)HLA-B 6p21.33 / RNASEH2B 13q14.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RNASEH2B   25671
Cards
Entrez_Gene (NCBI)RNASEH2B  79621  ribonuclease H2 subunit B
AliasesAGS2; DLEU8
GeneCards (Weizmann)RNASEH2B
Ensembl hg19 (Hinxton)ENSG00000136104 [Gene_View]  chr13:51483814-51544596 [Contig_View]  RNASEH2B [Vega]
Ensembl hg38 (Hinxton)ENSG00000136104 [Gene_View]  chr13:51483814-51544596 [Contig_View]  RNASEH2B [Vega]
ICGC DataPortalENSG00000136104
TCGA cBioPortalRNASEH2B
AceView (NCBI)RNASEH2B
Genatlas (Paris)RNASEH2B
WikiGenes79621
SOURCE (Princeton)RNASEH2B
Genomic and cartography
GoldenPath hg19 (UCSC)RNASEH2B  -     chr13:51483814-51544596 +  13q14.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RNASEH2B  -     13q14.3   [Description]    (hg38-Dec_2013)
EnsemblRNASEH2B - 13q14.3 [CytoView hg19]  RNASEH2B - 13q14.3 [CytoView hg38]
Mapping of homologs : NCBIRNASEH2B [Mapview hg19]  RNASEH2B [Mapview hg38]
OMIM610181   610326   
Gene and transcription
Genbank (Entrez)AK021774 AK022667 AK124228 AK223340 AY764036
RefSeq transcript (Entrez)NM_001142279 NM_024570
RefSeq genomic (Entrez)NC_000013 NC_018924 NG_009055 NT_024524 NW_004929388
Consensus coding sequences : CCDS (NCBI)RNASEH2B
Cluster EST : UnigeneHs.306291 [ NCBI ]
CGAP (NCI)Hs.306291
Alternative Splicing GalleryENSG00000136104
Gene ExpressionRNASEH2B [ NCBI-GEO ]   RNASEH2B [ EBI - ARRAY_EXPRESS ]   RNASEH2B [ SEEK ]   RNASEH2B [ MEM ]
Gene Expression Viewer (FireBrowse)RNASEH2B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79621
GTEX Portal (Tissue expression)RNASEH2B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5TBB1 (Uniprot)
NextProtQ5TBB1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5TBB1
Splice isoforms : SwissVarQ5TBB1 (Swissvar)
PhosPhoSitePlusQ5TBB1
Domains : Interpro (EBI)RNase_H2_suB   
Domain families : Pfam (Sanger)RNase_H2-Ydr279 (PF09468)   
Domain families : Pfam (NCBI)pfam09468   
DMDM Disease mutations79621
Blocks (Seattle)RNASEH2B
PDB (SRS)3P56    3P87    3PUF   
PDB (PDBSum)3P56    3P87    3PUF   
PDB (IMB)3P56    3P87    3PUF   
PDB (RSDB)3P56    3P87    3PUF   
Structural Biology KnowledgeBase3P56    3P87    3PUF   
SCOP (Structural Classification of Proteins)3P56    3P87    3PUF   
CATH (Classification of proteins structures)3P56    3P87    3PUF   
SuperfamilyQ5TBB1
Human Protein AtlasENSG00000136104
Peptide AtlasQ5TBB1
IPIIPI01010943   IPI00245135   IPI00915437   
Protein Interaction databases
DIP (DOE-UCLA)Q5TBB1
IntAct (EBI)Q5TBB1
FunCoupENSG00000136104
BioGRIDRNASEH2B
STRING (EMBL)RNASEH2B
ZODIACRNASEH2B
Ontologies - Pathways
QuickGOQ5TBB1
Ontology : AmiGOin utero embryonic development  RNA-DNA hybrid ribonuclease activity  nucleus  RNA catabolic process  ribonucleotide metabolic process  regulation of G2/M transition of mitotic cell cycle  negative regulation of gene expression  ribonuclease H2 complex  positive regulation of fibroblast proliferation  RNA phosphodiester bond hydrolysis, endonucleolytic  regulation of DNA damage checkpoint  
Ontology : EGO-EBIin utero embryonic development  RNA-DNA hybrid ribonuclease activity  nucleus  RNA catabolic process  ribonucleotide metabolic process  regulation of G2/M transition of mitotic cell cycle  negative regulation of gene expression  ribonuclease H2 complex  positive regulation of fibroblast proliferation  RNA phosphodiester bond hydrolysis, endonucleolytic  regulation of DNA damage checkpoint  
Pathways : KEGGDNA replication   
NDEx Network
Atlas of Cancer Signalling NetworkRNASEH2B
Wikipedia pathwaysRNASEH2B
Orthology - Evolution
OrthoDB79621
GeneTree (enSembl)ENSG00000136104
Phylogenetic Trees/Animal Genes : TreeFamRNASEH2B
Homologs : HomoloGeneRNASEH2B
Homology/Alignments : Family Browser (UCSC)RNASEH2B
Gene fusions - Rearrangements
Fusion: TCGAHLA-B 6p21.33 RNASEH2B 13q14.3 THCA
Polymorphisms : SNP, variants
NCBI Variation ViewerRNASEH2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNASEH2B
dbVarRNASEH2B
ClinVarRNASEH2B
1000_GenomesRNASEH2B 
Exome Variant ServerRNASEH2B
ExAC (Exome Aggregation Consortium)RNASEH2B (select the gene name)
Genetic variants : HAPMAP79621
Genomic Variants (DGV)RNASEH2B [DGVbeta]
Mutations
ICGC Data PortalRNASEH2B 
TCGA Data PortalRNASEH2B 
Broad Tumor PortalRNASEH2B
OASIS PortalRNASEH2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRNASEH2B 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch RNASEH2B
DgiDB (Drug Gene Interaction Database)RNASEH2B
DoCM (Curated mutations)RNASEH2B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RNASEH2B (select a term)
intoGenRNASEH2B
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)13:51483814-51544596  ENSG00000136104
CONAN: Copy Number AnalysisRNASEH2B 
Mutations and Diseases : HGMDRNASEH2B
OMIM610181    610326   
MedgenRNASEH2B
Genetic Testing Registry RNASEH2B
NextProtQ5TBB1 [Medical]
TSGene79621
GENETestsRNASEH2B
Huge Navigator RNASEH2B [HugePedia]
snp3D : Map Gene to Disease79621
BioCentury BCIQRNASEH2B
ClinGenRNASEH2B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79621
Chemical/Pharm GKB GenePA162401418
Clinical trialRNASEH2B
Miscellaneous
canSAR (ICR)RNASEH2B (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRNASEH2B
EVEXRNASEH2B
GoPubMedRNASEH2B
iHOPRNASEH2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 9 19:27:18 CEST 2016

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