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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret jlhuret@AtlasGeneticsOncology.org
Donations are also welcome
If each casual visitor gives 3 Euros or Dollars, the Atlas is saved in a week !
If each professional gives 100 Euros or Dollars once a year (now), the Atlas is saved in 2 weeks !
Don't let the Atlas imminent demise
Note: we send fiscal receipts for donations equal or above 50 Euros or Dollars

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RNASEH2B (ribonuclease H2, subunit B)

Identity

Other namesAGS2
DLEU8
HGNC (Hugo) RNASEH2B
LocusID (NCBI) 79621
Location 13q14.3
Location_base_pair Starts at 51483814 and ends at 51544596 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)RNASEH2B   25671
Cards
Entrez_Gene (NCBI)RNASEH2B  79621  ribonuclease H2, subunit B
GeneCards (Weizmann)RNASEH2B
Ensembl hg19 (Hinxton)ENSG00000136104 [Gene_View]  chr13:51483814-51544596 [Contig_View]  RNASEH2B [Vega]
Ensembl hg38 (Hinxton)ENSG00000136104 [Gene_View]  chr13:51483814-51544596 [Contig_View]  RNASEH2B [Vega]
ICGC DataPortalENSG00000136104
cBioPortalRNASEH2B
AceView (NCBI)RNASEH2B
Genatlas (Paris)RNASEH2B
WikiGenes79621
SOURCE (Princeton)RNASEH2B
Genomic and cartography
GoldenPath hg19 (UCSC)RNASEH2B  -     chr13:51483814-51544596 +  13q14.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RNASEH2B  -     13q14.3   [Description]    (hg38-Dec_2013)
EnsemblRNASEH2B - 13q14.3 [CytoView hg19]  RNASEH2B - 13q14.3 [CytoView hg38]
Mapping of homologs : NCBIRNASEH2B [Mapview hg19]  RNASEH2B [Mapview hg38]
OMIM610181   610326   
Gene and transcription
Genbank (Entrez)AK021774 AK022667 AK124228 AK223340 AY764036
RefSeq transcript (Entrez)NM_001142279 NM_024570
RefSeq genomic (Entrez)NC_000013 NC_018924 NG_009055 NT_024524 NW_004929388
Consensus coding sequences : CCDS (NCBI)RNASEH2B
Cluster EST : UnigeneHs.306291 [ NCBI ]
CGAP (NCI)Hs.306291
Alternative Splicing : Fast-db (Paris)GSHG0008124
Alternative Splicing GalleryENSG00000136104
Gene ExpressionRNASEH2B [ NCBI-GEO ]     RNASEH2B [ SEEK ]   RNASEH2B [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5TBB1 (Uniprot)
NextProtQ5TBB1  [Medical]
With graphics : InterProQ5TBB1
Splice isoforms : SwissVarQ5TBB1 (Swissvar)
Domains : Interpro (EBI)RNase_H2_suB   
Related proteins : CluSTrQ5TBB1
Domain families : Pfam (Sanger)RNase_H2-Ydr279 (PF09468)   
Domain families : Pfam (NCBI)pfam09468   
DMDM Disease mutations79621
Blocks (Seattle)Q5TBB1
PDB (SRS)3P56    3P87    3PUF   
PDB (PDBSum)3P56    3P87    3PUF   
PDB (IMB)3P56    3P87    3PUF   
PDB (RSDB)3P56    3P87    3PUF   
Human Protein AtlasENSG00000136104
Peptide AtlasQ5TBB1
IPIIPI01010943   IPI00245135   IPI00915437   
Protein Interaction databases
DIP (DOE-UCLA)Q5TBB1
IntAct (EBI)Q5TBB1
FunCoupENSG00000136104
BioGRIDRNASEH2B
IntegromeDBRNASEH2B
STRING (EMBL)RNASEH2B
Ontologies - Pathways
QuickGOQ5TBB1
Ontology : AmiGOin utero embryonic development  RNA-DNA hybrid ribonuclease activity  nucleus  nucleoplasm  RNA catabolic process  ribonucleotide metabolic process  regulation of G2/M transition of mitotic cell cycle  negative regulation of gene expression  ribonuclease H2 complex  positive regulation of fibroblast proliferation  RNA phosphodiester bond hydrolysis, endonucleolytic  regulation of DNA damage checkpoint  
Ontology : EGO-EBIin utero embryonic development  RNA-DNA hybrid ribonuclease activity  nucleus  nucleoplasm  RNA catabolic process  ribonucleotide metabolic process  regulation of G2/M transition of mitotic cell cycle  negative regulation of gene expression  ribonuclease H2 complex  positive regulation of fibroblast proliferation  RNA phosphodiester bond hydrolysis, endonucleolytic  regulation of DNA damage checkpoint  
Pathways : KEGGDNA replication   
Protein Interaction DatabaseRNASEH2B
DoCM (Curated mutations)RNASEH2B
Wikipedia pathwaysRNASEH2B
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerRNASEH2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNASEH2B
dbVarRNASEH2B
ClinVarRNASEH2B
1000_GenomesRNASEH2B 
Exome Variant ServerRNASEH2B
SNP (GeneSNP Utah)RNASEH2B
SNP : HGBaseRNASEH2B
Genetic variants : HAPMAPRNASEH2B
Genomic Variants (DGV)RNASEH2B [DGVbeta]
Mutations
ICGC Data PortalENSG00000136104 
Somatic Mutations in Cancer : COSMICRNASEH2B 
CONAN: Copy Number AnalysisRNASEH2B 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)13:51483814-51544596
Mutations and Diseases : HGMDRNASEH2B
OMIM610181    610326   
MedgenRNASEH2B
NextProtQ5TBB1 [Medical]
GENETestsRNASEH2B
Disease Genetic AssociationRNASEH2B
Huge Navigator RNASEH2B [HugePedia]  RNASEH2B [HugeCancerGEM]
snp3D : Map Gene to Disease79621
DGIdb (Drug Gene Interaction db)RNASEH2B
General knowledge
Homologs : HomoloGeneRNASEH2B
Homology/Alignments : Family Browser (UCSC)RNASEH2B
Phylogenetic Trees/Animal Genes : TreeFamRNASEH2B
Chemical/Protein Interactions : CTD79621
Chemical/Pharm GKB GenePA162401418
Clinical trialRNASEH2B
Cancer Resource (Charite)ENSG00000136104
Other databases
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
CoreMineRNASEH2B
GoPubMedRNASEH2B
iHOPRNASEH2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Mar 28 17:08:46 CET 2015

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jlhuret@AtlasGeneticsOncology.org.