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RNASEL (ribonuclease L)

Identity

Alias_namesRNS4
PRCA1
prostate cancer 1
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
Other alias
HGNC (Hugo) RNASEL
LocusID (NCBI) 6041
Atlas_Id 407
Location 1q25.3  [Link to chromosome band 1q25]
Location_base_pair Starts at 182573634 and ends at 182589259 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Prostate tumors: an overview


Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Hereditary prostate cancer


External links

Nomenclature
HGNC (Hugo)RNASEL   10050
Cards
Entrez_Gene (NCBI)RNASEL  6041  ribonuclease L
AliasesPRCA1; RNS4
GeneCards (Weizmann)RNASEL
Ensembl hg19 (Hinxton)ENSG00000135828 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135828 [Gene_View]  chr1:182573634-182589259 [Contig_View]  RNASEL [Vega]
ICGC DataPortalENSG00000135828
TCGA cBioPortalRNASEL
AceView (NCBI)RNASEL
Genatlas (Paris)RNASEL
WikiGenes6041
SOURCE (Princeton)RNASEL
Genetics Home Reference (NIH)RNASEL
Genomic and cartography
GoldenPath hg38 (UCSC)RNASEL  -     chr1:182573634-182589259 -  1q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RNASEL  -     1q25.3   [Description]    (hg19-Feb_2009)
EnsemblRNASEL - 1q25.3 [CytoView hg19]  RNASEL - 1q25.3 [CytoView hg38]
Mapping of homologs : NCBIRNASEL [Mapview hg19]  RNASEL [Mapview hg38]
OMIM180435   601518   
Gene and transcription
Genbank (Entrez)AK315231 AW968304 BC090934 BC114433 BC115697
RefSeq transcript (Entrez)NM_021133
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RNASEL
Cluster EST : UnigeneHs.518545 [ NCBI ]
CGAP (NCI)Hs.518545
Alternative Splicing GalleryENSG00000135828
Gene ExpressionRNASEL [ NCBI-GEO ]   RNASEL [ EBI - ARRAY_EXPRESS ]   RNASEL [ SEEK ]   RNASEL [ MEM ]
Gene Expression Viewer (FireBrowse)RNASEL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6041
GTEX Portal (Tissue expression)RNASEL
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ05823   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ05823  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ05823
Splice isoforms : SwissVarQ05823
Catalytic activity : Enzyme3.1.26.- [ Enzyme-Expasy ]   3.1.26.-3.1.26.- [ IntEnz-EBI ]   3.1.26.- [ BRENDA ]   3.1.26.- [ KEGG ]   
PhosPhoSitePlusQ05823
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)    KEN (PS51392)    PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    KEN_dom    Kinase-like_dom    Prot_kinase_dom    PUB_domain   
Domain families : Pfam (Sanger)Ank_2 (PF12796)    Pkinase (PF00069)    Ribonuc_2-5A (PF06479)   
Domain families : Pfam (NCBI)pfam12796    pfam00069    pfam06479   
Domain families : Smart (EMBL)ANK (SM00248)  PUG (SM00580)  S_TKc (SM00220)  
Conserved Domain (NCBI)RNASEL
DMDM Disease mutations6041
Blocks (Seattle)RNASEL
PDB (SRS)1WDY    4G8K    4G8L    4OAU    4OAV   
PDB (PDBSum)1WDY    4G8K    4G8L    4OAU    4OAV   
PDB (IMB)1WDY    4G8K    4G8L    4OAU    4OAV   
PDB (RSDB)1WDY    4G8K    4G8L    4OAU    4OAV   
Structural Biology KnowledgeBase1WDY    4G8K    4G8L    4OAU    4OAV   
SCOP (Structural Classification of Proteins)1WDY    4G8K    4G8L    4OAU    4OAV   
CATH (Classification of proteins structures)1WDY    4G8K    4G8L    4OAU    4OAV   
SuperfamilyQ05823
Human Protein AtlasENSG00000135828
Peptide AtlasQ05823
HPRD01590
IPIIPI00015864   IPI01014430   IPI01015665   
Protein Interaction databases
DIP (DOE-UCLA)Q05823
IntAct (EBI)Q05823
FunCoupENSG00000135828
BioGRIDRNASEL
STRING (EMBL)RNASEL
ZODIACRNASEL
Ontologies - Pathways
QuickGOQ05823
Ontology : AmiGORNA binding  endoribonuclease activity  protein kinase activity  protein binding  ATP binding  cellular_component  mitochondrial matrix  cytosol  rRNA processing  mRNA processing  protein phosphorylation  nuclear matrix  rRNA binding  ribonucleoprotein complex binding  regulation of mRNA stability  negative regulation of viral genome replication  fat cell differentiation  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  defense response to virus  transmembrane transport  type I interferon signaling pathway  RNA phosphodiester bond hydrolysis, endonucleolytic  positive regulation of glucose import in response to insulin stimulus  
Ontology : EGO-EBIRNA binding  endoribonuclease activity  protein kinase activity  protein binding  ATP binding  cellular_component  mitochondrial matrix  cytosol  rRNA processing  mRNA processing  protein phosphorylation  nuclear matrix  rRNA binding  ribonucleoprotein complex binding  regulation of mRNA stability  negative regulation of viral genome replication  fat cell differentiation  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  defense response to virus  transmembrane transport  type I interferon signaling pathway  RNA phosphodiester bond hydrolysis, endonucleolytic  positive regulation of glucose import in response to insulin stimulus  
Pathways : KEGGHepatitis C    Influenza A    Herpes simplex infection   
NDEx NetworkRNASEL
Atlas of Cancer Signalling NetworkRNASEL
Wikipedia pathwaysRNASEL
Orthology - Evolution
OrthoDB6041
GeneTree (enSembl)ENSG00000135828
Phylogenetic Trees/Animal Genes : TreeFamRNASEL
HOVERGENQ05823
HOGENOMQ05823
Homologs : HomoloGeneRNASEL
Homology/Alignments : Family Browser (UCSC)RNASEL
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRNASEL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNASEL
dbVarRNASEL
ClinVarRNASEL
1000_GenomesRNASEL 
Exome Variant ServerRNASEL
ExAC (Exome Aggregation Consortium)RNASEL (select the gene name)
Genetic variants : HAPMAP6041
Genomic Variants (DGV)RNASEL [DGVbeta]
DECIPHERRNASEL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRNASEL 
Mutations
ICGC Data PortalRNASEL 
TCGA Data PortalRNASEL 
Broad Tumor PortalRNASEL
OASIS PortalRNASEL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRNASEL  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRNASEL
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Zhejiang University Center for Genetic and Genomic Medicine (ZJU-CGGM)
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch RNASEL
DgiDB (Drug Gene Interaction Database)RNASEL
DoCM (Curated mutations)RNASEL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RNASEL (select a term)
intoGenRNASEL
Cancer3DRNASEL(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM180435    601518   
Orphanet903   
MedgenRNASEL
Genetic Testing Registry RNASEL
NextProtQ05823 [Medical]
TSGene6041
GENETestsRNASEL
Target ValidationRNASEL
Huge Navigator RNASEL [HugePedia]
snp3D : Map Gene to Disease6041
BioCentury BCIQRNASEL
ClinGenRNASEL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6041
Chemical/Pharm GKB GenePA34418
Clinical trialRNASEL
Miscellaneous
canSAR (ICR)RNASEL (select the gene name)
Probes
Litterature
PubMed132 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRNASEL
EVEXRNASEL
GoPubMedRNASEL
iHOPRNASEL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:53:26 CEST 2017

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