RNASEL (ribonuclease L)

2003-02-01  

Identity

HGNC
LOCATION
1q25.3
LOCUSID
ALIAS
PRCA1,RNS4

Other Information

Locus ID:

NCBI: 6041
MIM: 180435
HGNC: 10050
Ensembl: ENSG00000135828

Variants:

dbSNP: 6041
ClinVar: 6041
TCGA: ENSG00000135828
COSMIC: RNASEL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135828ENST00000367559Q05823
ENSG00000135828ENST00000539397Q05823

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733
Transmembrane transport of small moleculesREACTOMER-HSA-382551
ABC-family proteins mediated transportREACTOMER-HSA-382556

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
166276182006The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: Inhibiting the 2'-5' oligo (A) synthetase/RNase L pathway.204
124152692002RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases.100
268584072016Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses.57
197600272009Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer.54
119415392002Germline alterations of the RNASEL gene, a candidate HPC1 gene at 1q25, in patients and families with prostate cancer.53
119415392002Germline alterations of the RNASEL gene, a candidate HPC1 gene at 1q25, in patients and families with prostate cancer.53
162039932005A transcriptional signaling pathway in the IFN system mediated by 2'-5'-oligoadenylate activation of RNase L.52
192673702009Association of IL10 and other immune response- and obesity-related genes with prostate cancer in CLUE II.52
125905672003Implications for RNase L in prostate cancer biology.51
145709082004An apoptotic signaling pathway in the interferon antiviral response mediated by RNase L and c-Jun NH2-terminal kinase.51

Citation

Dessen P

RNASEL (ribonuclease L)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/407/rnasel