RNF111 (ring finger protein 111)

2004-02-01  

Identity

HGNC
LOCATION
15q22.1
LOCUSID
ALIAS
ARK,hRNF111
FUSION GENES

Other Information

Locus ID:

NCBI: 54778
MIM: 605840
HGNC: 17384
Ensembl: ENSG00000157450

Variants:

dbSNP: 54778
ClinVar: 54778
TCGA: ENSG00000157450
COSMIC: RNF111

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000157450ENST00000348370Q6ZNA4
ENSG00000157450ENST00000348370A0A024R5T5
ENSG00000157450ENST00000557998Q6ZNA4
ENSG00000157450ENST00000559160H0YKK5
ENSG00000157450ENST00000559209Q6ZNA4
ENSG00000157450ENST00000559592H0YLK9
ENSG00000157450ENST00000559757H0YKS2
ENSG00000157450ENST00000561186Q6ZNA4

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Signal TransductionREACTOMER-HSA-162582
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerREACTOMER-HSA-2173793
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionREACTOMER-HSA-2173796
Downregulation of SMAD2/3:SMAD4 transcriptional activityREACTOMER-HSA-2173795
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
DNA RepairREACTOMER-HSA-73894
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
Formation of Incision Complex in GG-NERREACTOMER-HSA-5696395

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
146570192003Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7.71
175916952007Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation.69
237514932013RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response.61
175100632007Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling.57
233949992013RNF111-dependent neddylation activates DNA damage-induced ubiquitination.44
261514772015SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair.39
235300562013Arkadia, a novel SUMO-targeted ubiquitin ligase involved in PML degradation.33
112984522001Induction of the mammalian node requires Arkadia function in the extraembryonic lineages.29
112984532001Arkadia enhances nodal-related signalling to induce mesendoderm.23
217957122011RB1CC1 protein positively regulates transforming growth factor-beta signaling through the modulation of Arkadia E3 ubiquitin ligase activity.18

Citation

Dessen P

RNF111 (ring finger protein 111)

Atlas Genet Cytogenet Oncol Haematol. 2004-02-01

Online version: http://atlasgeneticsoncology.org/gene/42126/rnf111