RNF114 (ring finger protein 114)

2014-11-01  

Identity

HGNC
LOCATION
20q13.13
LOCUSID
ALIAS
PSORS12,ZNF313
FUSION GENES

Other Information

Locus ID:

NCBI: 55905
MIM: 612451
HGNC: 13094
Ensembl: ENSG00000124226

Variants:

dbSNP: 55905
ClinVar: 55905
TCGA: ENSG00000124226
COSMIC: RNF114

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124226ENST00000244061Q9Y508
ENSG00000124226ENST00000622920A0A096LP02
ENSG00000124226ENST00000622999A0A096LNT1
ENSG00000124226ENST00000623528A0A096LNN8
ENSG00000124226ENST00000623732A0A096LPF9
ENSG00000124226ENST00000625177A0A096LNV3

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
209531892010Genome-wide association analysis identifies three psoriasis susceptibility loci.106
183643902008Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene.64
183643902008Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene.64
215717842011Functional analysis of the RNF114 psoriasis susceptibility gene implicates innate immune responses to double-stranded RNA in disease pathogenesis.23
236452062013ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.).13
251658852014The RING ubiquitin E3 RNF114 interacts with A20 and modulates NF-κB activity and T-cell activation.11
253130372014XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313.11
246313322014Identification of RNF114 as a novel positive regulatory protein for T cell activation.4
205154462010Sp1 plays an important role in regulating the transcription of ZNF313.0
222053042012Identification of rare, disease-associated variants in the promoter region of the RNF114 psoriasis susceptibility gene.0

Citation

Dessen P

RNF114 (ring finger protein 114)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72684/rnf114