RNF123 (ring finger protein 123)

2007-04-01 Affiliation

Identity

HGNC

RNF123

LOCATION

3p21.31

LOCUSID

63891

ALIAS

FP1477,KPC1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 63891
MIM: 614472
HGNC: 21148
Ensembl: ENSG00000164068

Variants:

dbSNP: 63891
ClinVar: 63891
TCGA: ENSG00000164068
COSMIC: RNF123

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000164068	ENST00000327697	Q5XPI4
ENSG00000164068	ENST00000432042	C9J266
ENSG00000164068	ENST00000433785	C9JI97
ENSG00000164068	ENST00000443204	F8WB91
ENSG00000164068	ENST00000444689	H7C3U1
ENSG00000164068	ENST00000454491	C9JN91
ENSG00000164068	ENST00000457726	C9JS59
ENSG00000164068	ENST00000629802	F8WB91

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradation	REACTOME	R-HSA-983168
Deubiquitination	REACTOME	R-HSA-5688426
Ub-specific processing proteases	REACTOME	R-HSA-5689880

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
15531880	2004	Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase.	155
21355095	2011	miR-221 and miR-155 regulate human dendritic cell development, apoptosis, and IL-12 production through targeting of p27kip1, KPC1, and SOCS-1.	100
21982424	2012	High dimensional endophenotype ranking in the search for major depression risk genes.	78
22688066	2012	Distribution of moyamoya disease susceptibility polymorphism p.R4810K in RNF213 in East and Southeast Asian populations.	32
25860612	2015	KPC1-mediated ubiquitination and proteasomal processing of NF-κB1 p105 to p50 restricts tumor growth.	32
26126547	2015	Biochemical and Functional Characterization of RNF213 (Mysterin) R4810K, a Susceptibility Mutation of Moyamoya Disease, in Angiogenesis In Vitro and In Vivo.	26
15746103	2005	Molecular dissection of the interaction between p27 and Kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in G1 phase.	25
28389511	2017	Epigenetic Regulation of KPC1 Ubiquitin Ligase Affects the NF-κB Pathway in Melanoma.	8
29676528	2018	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	6
23077635	2012	Ubiquitin ligase RNF123 mediates degradation of heterochromatin protein 1α and β in lamin A/C knock-down cells.	5

Citation

Dessen P

RNF123 (ring finger protein 123)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47473/rnf123