RNF125 (ring finger protein 125)

2007-04-01  

Identity

HGNC
LOCATION
18q12.1
LOCUSID
ALIAS
TNORS,TRAC-1,TRAC1
FUSION GENES

Other Information

Locus ID:

NCBI: 54941
MIM: 610432
HGNC: 21150
Ensembl: ENSG00000101695

Variants:

dbSNP: 54941
ClinVar: 54941
TCGA: ENSG00000101695
COSMIC: RNF125

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101695ENST00000217740Q96EQ8
ENSG00000101695ENST00000580209J3QQW8

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
Negative regulators of RIG-I/MDA5 signalingREACTOMER-HSA-936440

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
262029832015MicroRNA-15b Modulates Japanese Encephalitis Virus-Mediated Inflammation via Targeting RNF125.41
179909822008T-cell regulator RNF125/TRAC-1 belongs to a novel family of ubiquitin ligases with zinc fingers and a ubiquitin-binding domain.24
260279342015Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation.18
237720262013Human bocavirus VP2 upregulates IFN-β pathway by inhibiting ring finger protein 125-mediated ubiquitination of retinoic acid-inducible gene-I.14
176434632007The RING finger ubiquitin ligase RNF125/TRAC-1 down-modulates HIV-1 replication in primary human peripheral blood mononuclear cells.10
284769342017The Ubiquitin Ligase RNF125 Targets Innate Immune Adaptor Protein TRIM14 for Ubiquitination and Degradation.9
251965412014A new overgrowth syndrome is due to mutations in RNF125.7
274113752016A C2HC zinc finger is essential for the RING-E2 interaction of the ubiquitin ligase RNF125.5
241319852013Expression levels of the innate response gene RIG-I and its regulators RNF125 and TRIM25 in HIV-1-infected adult and pediatric individuals.4
286112922017Ring finger protein 125, as a potential highly aggressive and unfavorable prognostic biomarker, promotes the invasion and metastasis of human gallbladder cancers via activating the TGF- β1-SMAD3-ID1 signaling pathway.0

Citation

Dessen P

RNF125 (ring finger protein 125)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47479/rnf125