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RNF125 (ring finger protein 125)

Identity

Alias (NCBI)TNORS
TRAC-1
TRAC1
HGNC (Hugo) RNF125
HGNC Alias symbFLJ20456
HGNC Previous namering finger protein 125, E3 ubiquitin protein ligase
LocusID (NCBI) 54941
Atlas_Id 47479
Location 18q12.1  [Link to chromosome band 18q12]
Location_base_pair Starts at 32018825 and ends at 32073219 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RNF138 (18q12.1) / RNF125 (18q12.1)TRAPPC8 (18q12.1) / RNF125 (18q12.1)RNF138 18q12.1 / RNF125 18q12.1
TRAPPC8 18q12.1 / RNF125 18q12.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)RNF125   21150
Cards
Entrez_Gene (NCBI)RNF125    ring finger protein 125
AliasesTNORS; TRAC-1; TRAC1
GeneCards (Weizmann)RNF125
Ensembl hg19 (Hinxton)ENSG00000101695 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101695 [Gene_View]  ENSG00000101695 [Sequence]  chr18:32018825-32073219 [Contig_View]  RNF125 [Vega]
ICGC DataPortalENSG00000101695
TCGA cBioPortalRNF125
AceView (NCBI)RNF125
Genatlas (Paris)RNF125
SOURCE (Princeton)RNF125
Genetics Home Reference (NIH)RNF125
Genomic and cartography
GoldenPath hg38 (UCSC)RNF125  -     chr18:32018825-32073219 +  18q12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RNF125  -     18q12.1   [Description]    (hg19-Feb_2009)
GoldenPathRNF125 - 18q12.1 [CytoView hg19]  RNF125 - 18q12.1 [CytoView hg38]
ImmunoBaseENSG00000101695
Genome Data Viewer NCBIRNF125 [Mapview hg19]  
OMIM610432   616260   
Gene and transcription
Genbank (Entrez)AK000463 AK027134 AK225518 BC012021 BI666910
RefSeq transcript (Entrez)NM_017831
Consensus coding sequences : CCDS (NCBI)RNF125
Gene ExpressionRNF125 [ NCBI-GEO ]   RNF125 [ EBI - ARRAY_EXPRESS ]   RNF125 [ SEEK ]   RNF125 [ MEM ]
Gene Expression Viewer (FireBrowse)RNF125 [ Firebrowse - Broad ]
GenevisibleExpression of RNF125 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54941
GTEX Portal (Tissue expression)RNF125
Human Protein AtlasENSG00000101695-RNF125 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96EQ8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96EQ8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96EQ8
PhosPhoSitePlusQ96EQ8
Domaine pattern : Prosite (Expaxy)ZF_C2HC_RNF (PS51803)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)Di19_Zn-bd    ZF_C2HC_RNF    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)zf-Di19 (PF05605)    zf_C2HC_14 (PF18574)   
Domain families : Pfam (NCBI)pfam05605    pfam18574   
Domain families : Smart (EMBL)RING (SM00184)  
Conserved Domain (NCBI)RNF125
PDB (RSDB)5DKA   
PDB Europe5DKA   
PDB (PDBSum)5DKA   
PDB (IMB)5DKA   
Structural Biology KnowledgeBase5DKA   
SCOP (Structural Classification of Proteins)5DKA   
CATH (Classification of proteins structures)5DKA   
SuperfamilyQ96EQ8
AlphaFold pdb e-kbQ96EQ8   
Human Protein Atlas [tissue]ENSG00000101695-RNF125 [tissue]
HPRD11500
Protein Interaction databases
DIP (DOE-UCLA)Q96EQ8
IntAct (EBI)Q96EQ8
BioGRIDRNF125
STRING (EMBL)RNF125
ZODIACRNF125
Ontologies - Pathways
QuickGOQ96EQ8
Ontology : AmiGOGolgi membrane  protein polyubiquitination  protein polyubiquitination  p53 binding  adaptive immune response  protein binding  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  zinc ion binding  ubiquitin conjugating enzyme binding  negative regulation of type I interferon production  VCP-NPL4-UFD1 AAA ATPase complex  VCP-NPL4-UFD1 AAA ATPase complex  negative regulation of RIG-I signaling pathway  intracellular membrane-bounded organelle  ubiquitin protein ligase activity  ubiquitin protein ligase activity  cellular response to leukemia inhibitory factor  
Ontology : EGO-EBIGolgi membrane  protein polyubiquitination  protein polyubiquitination  p53 binding  adaptive immune response  protein binding  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  zinc ion binding  ubiquitin conjugating enzyme binding  negative regulation of type I interferon production  VCP-NPL4-UFD1 AAA ATPase complex  VCP-NPL4-UFD1 AAA ATPase complex  negative regulation of RIG-I signaling pathway  intracellular membrane-bounded organelle  ubiquitin protein ligase activity  ubiquitin protein ligase activity  cellular response to leukemia inhibitory factor  
Pathways : KEGGRIG-I-like receptor signaling pathway   
NDEx NetworkRNF125
Atlas of Cancer Signalling NetworkRNF125
Wikipedia pathwaysRNF125
Orthology - Evolution
OrthoDB54941
GeneTree (enSembl)ENSG00000101695
Phylogenetic Trees/Animal Genes : TreeFamRNF125
Homologs : HomoloGeneRNF125
Homology/Alignments : Family Browser (UCSC)RNF125
Gene fusions - Rearrangements
Fusion : MitelmanRNF138/RNF125 [18q12.1/18q12.1]  
Fusion : MitelmanTRAPPC8/RNF125 [18q12.1/18q12.1]  
Fusion : QuiverRNF125
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRNF125 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNF125
dbVarRNF125
ClinVarRNF125
MonarchRNF125
1000_GenomesRNF125 
Exome Variant ServerRNF125
GNOMAD BrowserENSG00000101695
Varsome BrowserRNF125
ACMGRNF125 variants
VarityQ96EQ8
Genomic Variants (DGV)RNF125 [DGVbeta]
DECIPHERRNF125 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRNF125 
Mutations
ICGC Data PortalRNF125 
TCGA Data PortalRNF125 
Broad Tumor PortalRNF125
OASIS PortalRNF125 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRNF125  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRNF125
Mutations and Diseases : HGMDRNF125
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRNF125
DgiDB (Drug Gene Interaction Database)RNF125
DoCM (Curated mutations)RNF125
CIViC (Clinical Interpretations of Variants in Cancer)RNF125
Cancer3DRNF125
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610432    616260   
Orphanet
DisGeNETRNF125
MedgenRNF125
Genetic Testing Registry RNF125
NextProtQ96EQ8 [Medical]
GENETestsRNF125
Target ValidationRNF125
Huge Navigator RNF125 [HugePedia]
ClinGenRNF125
Clinical trials, drugs, therapy
MyCancerGenomeRNF125
Protein Interactions : CTDRNF125
Pharm GKB GenePA134950383
PharosQ96EQ8
Clinical trialRNF125
Miscellaneous
canSAR (ICR)RNF125
HarmonizomeRNF125
DataMed IndexRNF125
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRNF125
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:29:09 CEST 2021

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