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RNF128 (ring finger protein 128, E3 ubiquitin protein ligase)

Identity

Alias_namesring finger protein 128
Alias_symbol (synonym)FLJ23516
GRAIL
Other alias
HGNC (Hugo) RNF128
LocusID (NCBI) 79589
Atlas_Id 47371
Location Xq22.3  [Link to chromosome band Xq22]
Location_base_pair Starts at 106693838 and ends at 106797016 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
RNF128 (Xq22.3) / THSD4 (15q23)TBC1D8B (Xq22.3) / RNF128 (Xq22.3)TBC1D8B Xq22.3 / RNF128 Xq22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RNF128   21153
Cards
Entrez_Gene (NCBI)RNF128  79589  ring finger protein 128, E3 ubiquitin protein ligase
AliasesGRAIL
GeneCards (Weizmann)RNF128
Ensembl hg19 (Hinxton)ENSG00000133135 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133135 [Gene_View]  chrX:106693838-106797016 [Contig_View]  RNF128 [Vega]
ICGC DataPortalENSG00000133135
TCGA cBioPortalRNF128
AceView (NCBI)RNF128
Genatlas (Paris)RNF128
WikiGenes79589
SOURCE (Princeton)RNF128
Genetics Home Reference (NIH)RNF128
Genomic and cartography
GoldenPath hg38 (UCSC)RNF128  -     chrX:106693838-106797016 +  Xq22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RNF128  -     Xq22.3   [Description]    (hg19-Feb_2009)
EnsemblRNF128 - Xq22.3 [CytoView hg19]  RNF128 - Xq22.3 [CytoView hg38]
Mapping of homologs : NCBIRNF128 [Mapview hg19]  RNF128 [Mapview hg38]
OMIM300439   
Gene and transcription
Genbank (Entrez)AF394689 AK027169 AK074264 AK126553 BC012931
RefSeq transcript (Entrez)NM_024539 NM_194463
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RNF128
Cluster EST : UnigeneHs.496542 [ NCBI ]
CGAP (NCI)Hs.496542
Alternative Splicing GalleryENSG00000133135
Gene ExpressionRNF128 [ NCBI-GEO ]   RNF128 [ EBI - ARRAY_EXPRESS ]   RNF128 [ SEEK ]   RNF128 [ MEM ]
Gene Expression Viewer (FireBrowse)RNF128 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79589
GTEX Portal (Tissue expression)RNF128
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TEB7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TEB7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TEB7
Splice isoforms : SwissVarQ8TEB7
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   
PhosPhoSitePlusQ8TEB7
Domaine pattern : Prosite (Expaxy)ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)PA_domain    Znf_RING    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)PA (PF02225)    zf-RING_2 (PF13639)   
Domain families : Pfam (NCBI)pfam02225    pfam13639   
Domain families : Smart (EMBL)RING (SM00184)  
Conserved Domain (NCBI)RNF128
DMDM Disease mutations79589
Blocks (Seattle)RNF128
PDB (SRS)3ICU   
PDB (PDBSum)3ICU   
PDB (IMB)3ICU   
PDB (RSDB)3ICU   
Structural Biology KnowledgeBase3ICU   
SCOP (Structural Classification of Proteins)3ICU   
CATH (Classification of proteins structures)3ICU   
SuperfamilyQ8TEB7
Human Protein AtlasENSG00000133135
Peptide AtlasQ8TEB7
HPRD02340
IPIIPI00152698   IPI00376602   IPI00647651   
Protein Interaction databases
DIP (DOE-UCLA)Q8TEB7
IntAct (EBI)Q8TEB7
FunCoupENSG00000133135
BioGRIDRNF128
STRING (EMBL)RNF128
ZODIACRNF128
Ontologies - Pathways
QuickGOQ8TEB7
Ontology : AmiGOprotein binding  late endosome  endoplasmic reticulum  Golgi apparatus  cytosol  cytoskeleton  zinc ion binding  integral component of membrane  protein deubiquitination  regulation of protein stability  negative regulation of cytokine biosynthetic process  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  perinuclear region of cytoplasm  protein localization to lysosome  ubiquitin protein ligase activity  positive regulation of protein catabolic process in the vacuole  
Ontology : EGO-EBIprotein binding  late endosome  endoplasmic reticulum  Golgi apparatus  cytosol  cytoskeleton  zinc ion binding  integral component of membrane  protein deubiquitination  regulation of protein stability  negative regulation of cytokine biosynthetic process  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  perinuclear region of cytoplasm  protein localization to lysosome  ubiquitin protein ligase activity  positive regulation of protein catabolic process in the vacuole  
NDEx NetworkRNF128
Atlas of Cancer Signalling NetworkRNF128
Wikipedia pathwaysRNF128
Orthology - Evolution
OrthoDB79589
GeneTree (enSembl)ENSG00000133135
Phylogenetic Trees/Animal Genes : TreeFamRNF128
HOVERGENQ8TEB7
HOGENOMQ8TEB7
Homologs : HomoloGeneRNF128
Homology/Alignments : Family Browser (UCSC)RNF128
Gene fusions - Rearrangements
Fusion : MitelmanTBC1D8B/RNF128 [Xq22.3/Xq22.3]  [t(X;X)(q22;q22)]  
Fusion: TCGATBC1D8B Xq22.3 RNF128 Xq22.3 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRNF128 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNF128
dbVarRNF128
ClinVarRNF128
1000_GenomesRNF128 
Exome Variant ServerRNF128
ExAC (Exome Aggregation Consortium)RNF128 (select the gene name)
Genetic variants : HAPMAP79589
Genomic Variants (DGV)RNF128 [DGVbeta]
DECIPHERRNF128 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRNF128 
Mutations
ICGC Data PortalRNF128 
TCGA Data PortalRNF128 
Broad Tumor PortalRNF128
OASIS PortalRNF128 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRNF128  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRNF128
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch RNF128
DgiDB (Drug Gene Interaction Database)RNF128
DoCM (Curated mutations)RNF128 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RNF128 (select a term)
intoGenRNF128
Cancer3DRNF128(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300439   
Orphanet
MedgenRNF128
Genetic Testing Registry RNF128
NextProtQ8TEB7 [Medical]
TSGene79589
GENETestsRNF128
Target ValidationRNF128
Huge Navigator RNF128 [HugePedia]
snp3D : Map Gene to Disease79589
BioCentury BCIQRNF128
ClinGenRNF128
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79589
Chemical/Pharm GKB GenePA134868457
Clinical trialRNF128
Miscellaneous
canSAR (ICR)RNF128 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRNF128
EVEXRNF128
GoPubMedRNF128
iHOPRNF128
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:05:58 CEST 2017

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