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RNF128 (ring finger protein 128)

Identity

Alias (NCBI)GRAIL
HGNC (Hugo) RNF128
HGNC Alias symbFLJ23516
GRAIL
HGNC Previous namering finger protein 128, E3 ubiquitin protein ligase
LocusID (NCBI) 79589
Atlas_Id 47371
Location Xq22.3  [Link to chromosome band Xq22]
Location_base_pair Starts at 106726701 and ends at 106797016 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RNF128 (Xq22.3) / THSD4 (15q23)TBC1D8B (Xq22.3) / RNF128 (Xq22.3)TBC1D8B Xq22.3 / RNF128 Xq22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)RNF128   21153
Cards
Entrez_Gene (NCBI)RNF128    ring finger protein 128
AliasesGRAIL
GeneCards (Weizmann)RNF128
Ensembl hg19 (Hinxton)ENSG00000133135 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133135 [Gene_View]  ENSG00000133135 [Sequence]  chrX:106726701-106797016 [Contig_View]  RNF128 [Vega]
ICGC DataPortalENSG00000133135
TCGA cBioPortalRNF128
AceView (NCBI)RNF128
Genatlas (Paris)RNF128
SOURCE (Princeton)RNF128
Genetics Home Reference (NIH)RNF128
Genomic and cartography
GoldenPath hg38 (UCSC)RNF128  -     chrX:106726701-106797016 +  Xq22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RNF128  -     Xq22.3   [Description]    (hg19-Feb_2009)
GoldenPathRNF128 - Xq22.3 [CytoView hg19]  RNF128 - Xq22.3 [CytoView hg38]
ImmunoBaseENSG00000133135
Genome Data Viewer NCBIRNF128 [Mapview hg19]  
OMIM300439   
Gene and transcription
Genbank (Entrez)AF394689 AK027169 AK074264 AK126553 BC012931
RefSeq transcript (Entrez)NM_024539 NM_194463
Consensus coding sequences : CCDS (NCBI)RNF128
Gene ExpressionRNF128 [ NCBI-GEO ]   RNF128 [ EBI - ARRAY_EXPRESS ]   RNF128 [ SEEK ]   RNF128 [ MEM ]
Gene Expression Viewer (FireBrowse)RNF128 [ Firebrowse - Broad ]
GenevisibleExpression of RNF128 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79589
GTEX Portal (Tissue expression)RNF128
Human Protein AtlasENSG00000133135-RNF128 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TEB7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TEB7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TEB7
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ8TEB7
Domaine pattern : Prosite (Expaxy)ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)PA_domain    Znf_RING    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)PA (PF02225)    zf-RING_2 (PF13639)   
Domain families : Pfam (NCBI)pfam02225    pfam13639   
Domain families : Smart (EMBL)RING (SM00184)  
Conserved Domain (NCBI)RNF128
PDB (RSDB)3ICU   
PDB Europe3ICU   
PDB (PDBSum)3ICU   
PDB (IMB)3ICU   
Structural Biology KnowledgeBase3ICU   
SCOP (Structural Classification of Proteins)3ICU   
CATH (Classification of proteins structures)3ICU   
SuperfamilyQ8TEB7
AlphaFold pdb e-kbQ8TEB7   
Human Protein Atlas [tissue]ENSG00000133135-RNF128 [tissue]
HPRD02340
Protein Interaction databases
DIP (DOE-UCLA)Q8TEB7
IntAct (EBI)Q8TEB7
BioGRIDRNF128
STRING (EMBL)RNF128
ZODIACRNF128
Ontologies - Pathways
QuickGOQ8TEB7
Ontology : AmiGOnegative regulation of cytokine production  protein binding  cytoplasm  late endosome  endoplasmic reticulum  Golgi apparatus  cytosol  cytoskeleton  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  integral component of membrane  protein ubiquitination  protein deubiquitination  regulation of protein stability  metal ion binding  perinuclear region of cytoplasm  protein localization to lysosome  ubiquitin protein ligase activity  ubiquitin protein ligase activity  positive regulation of protein catabolic process in the vacuole  
Ontology : EGO-EBInegative regulation of cytokine production  protein binding  cytoplasm  late endosome  endoplasmic reticulum  Golgi apparatus  cytosol  cytoskeleton  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  integral component of membrane  protein ubiquitination  protein deubiquitination  regulation of protein stability  metal ion binding  perinuclear region of cytoplasm  protein localization to lysosome  ubiquitin protein ligase activity  ubiquitin protein ligase activity  positive regulation of protein catabolic process in the vacuole  
NDEx NetworkRNF128
Atlas of Cancer Signalling NetworkRNF128
Wikipedia pathwaysRNF128
Orthology - Evolution
OrthoDB79589
GeneTree (enSembl)ENSG00000133135
Phylogenetic Trees/Animal Genes : TreeFamRNF128
Homologs : HomoloGeneRNF128
Homology/Alignments : Family Browser (UCSC)RNF128
Gene fusions - Rearrangements
Fusion : MitelmanTBC1D8B/RNF128 [Xq22.3/Xq22.3]  
Fusion : QuiverRNF128
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRNF128 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNF128
dbVarRNF128
ClinVarRNF128
MonarchRNF128
1000_GenomesRNF128 
Exome Variant ServerRNF128
GNOMAD BrowserENSG00000133135
Varsome BrowserRNF128
ACMGRNF128 variants
VarityQ8TEB7
Genomic Variants (DGV)RNF128 [DGVbeta]
DECIPHERRNF128 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRNF128 
Mutations
ICGC Data PortalRNF128 
TCGA Data PortalRNF128 
Broad Tumor PortalRNF128
OASIS PortalRNF128 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRNF128  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRNF128
Mutations and Diseases : HGMDRNF128
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRNF128
DgiDB (Drug Gene Interaction Database)RNF128
DoCM (Curated mutations)RNF128
CIViC (Clinical Interpretations of Variants in Cancer)RNF128
Cancer3DRNF128
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300439   
Orphanet
DisGeNETRNF128
MedgenRNF128
Genetic Testing Registry RNF128
NextProtQ8TEB7 [Medical]
GENETestsRNF128
Target ValidationRNF128
Huge Navigator RNF128 [HugePedia]
ClinGenRNF128
Clinical trials, drugs, therapy
MyCancerGenomeRNF128
Protein Interactions : CTDRNF128
Pharm GKB GenePA134868457
PharosQ8TEB7
Clinical trialRNF128
Miscellaneous
canSAR (ICR)RNF128
HarmonizomeRNF128
DataMed IndexRNF128
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRNF128
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:29:09 CEST 2021

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