RNF128 (ring finger protein 128)

2007-04-01  

Identity

HGNC
RNF128
LOCATION
Xq22.3
LOCUSID
79589
ALIAS
GRAIL
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79589
MIM: 300439
HGNC: 21153
Ensembl: ENSG00000133135

Variants:

dbSNP: 79589
ClinVar: 79589
TCGA: ENSG00000133135
COSMIC: RNF128

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133135ENST00000255499Q8TEB7
ENSG00000133135ENST00000324342Q8TEB7
ENSG00000133135ENST00000418562Q5JSK4

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880
Ovarian tumor domain proteasesREACTOMER-HSA-5689896

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
172591782007GRAIL is up-regulated in CD4+ CD25+ T regulatory cells and is sufficient for conversion of T cells to a regulatory phenotype.31
187137302008The single subunit transmembrane E3 ligase gene related to anergy in lymphocytes (GRAIL) captures and then ubiquitinates transmembrane proteins across the cell membrane.28
194147432009Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAIL expression.18
195424552009The transmembrane E3 ligase GRAIL ubiquitinates and degrades CD83 on CD4 T cells.17
233702712013Grail as a molecular determinant for the functions of the tumor suppressor p53 in tumorigenesis.17
174758422007Up-regulation of gene related to anergy in lymphocytes is associated with Notch-mediated human T cell suppression.11
308326922019Downregulation of RNF128 activates Wnt/β-catenin signaling to induce cellular EMT and stemness via CD44 and CTTN ubiquitination in melanoma.10
184674992008Upregulation of GRAIL is associated with remission of ulcerative colitis.5
243568102014Regulation of anergy-related ubiquitin E3 ligase, GRAIL, in murine models of colitis and patients with Crohn's disease.2
304673242018Grail attenuates influenza A virus infection and pathogenesis by inhibiting viral nucleoprotein.1

Citation

Dessen P

RNF128 (ring finger protein 128)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47371/rnf128