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RNF135 (ring finger protein 135)

Identity

Other namesL13
MMFD
REUL
Riplet
HGNC (Hugo) RNF135
LocusID (NCBI) 84282
Atlas_Id 42128
Location 17q11.2  [Link to chromosome band 17q11]
Location_base_pair Starts at 29297956 and ends at 29326929 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ADAP2 (17q11.2) / RNF135 (17q11.2)ANKRD11 (16q24.3) / RNF135 (17q11.2)MYO18A (17q11.2) / RNF135 (17q11.2)
PIK3R5 (17p13.1) / RNF135 (17q11.2)RNF135 (17q11.2) / C17orf78 (17q12)MYO18A 17q11.2 / RNF135 17q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RNF135   21158
Cards
Entrez_Gene (NCBI)RNF135  84282  ring finger protein 135
AliasesL13; MMFD; REUL; Riplet
GeneCards (Weizmann)RNF135
Ensembl hg19 (Hinxton)ENSG00000181481 [Gene_View]  chr17:29297956-29326929 [Contig_View]  RNF135 [Vega]
Ensembl hg38 (Hinxton)ENSG00000181481 [Gene_View]  chr17:29297956-29326929 [Contig_View]  RNF135 [Vega]
ICGC DataPortalENSG00000181481
TCGA cBioPortalRNF135
AceView (NCBI)RNF135
Genatlas (Paris)RNF135
WikiGenes84282
SOURCE (Princeton)RNF135
Genomic and cartography
GoldenPath hg19 (UCSC)RNF135  -     chr17:29297956-29326929 +  17q11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RNF135  -     17q11.2   [Description]    (hg38-Dec_2013)
EnsemblRNF135 - 17q11.2 [CytoView hg19]  RNF135 - 17q11.2 [CytoView hg38]
Mapping of homologs : NCBIRNF135 [Mapview hg19]  RNF135 [Mapview hg38]
OMIM611358   614192   
Gene and transcription
Genbank (Entrez)AB470605 AI634044 AJ496729 AK122646 AK122709
RefSeq transcript (Entrez)NM_001184992 NM_032322 NM_197939
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_011701 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)RNF135
Cluster EST : UnigeneHs.29874 [ NCBI ]
CGAP (NCI)Hs.29874
Alternative Splicing GalleryENSG00000181481
Gene ExpressionRNF135 [ NCBI-GEO ]   RNF135 [ EBI - ARRAY_EXPRESS ]   RNF135 [ SEEK ]   RNF135 [ MEM ]
Gene Expression Viewer (FireBrowse)RNF135 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84282
GTEX Portal (Tissue expression)RNF135
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IUD6 (Uniprot)
NextProtQ8IUD6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IUD6
Splice isoforms : SwissVarQ8IUD6 (Swissvar)
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
PhosPhoSitePlusQ8IUD6
Domaine pattern : Prosite (Expaxy)B302_SPRY (PS50188)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)B30.2/SPRY    Butyrophylin    ConA-like_dom    PRY    SPRY_dom    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)SPRY (PF00622)   
Domain families : Pfam (NCBI)pfam00622   
Domain families : Smart (EMBL)PRY (SM00589)  RING (SM00184)  
DMDM Disease mutations84282
Blocks (Seattle)RNF135
SuperfamilyQ8IUD6
Human Protein AtlasENSG00000181481
Peptide AtlasQ8IUD6
HPRD11506
IPIIPI00216721   IPI00335645   IPI01011416   IPI00981506   IPI00796911   IPI00798220   
Protein Interaction databases
DIP (DOE-UCLA)Q8IUD6
IntAct (EBI)Q8IUD6
FunCoupENSG00000181481
BioGRIDRNF135
STRING (EMBL)RNF135
ZODIACRNF135
Ontologies - Pathways
QuickGOQ8IUD6
Ontology : AmiGOubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  cytoplasm  cytosol  zinc ion binding  protein ubiquitination  protein ubiquitination  ligase activity  negative regulation of type I interferon production  positive regulation of interferon-beta production  ribonucleoprotein complex binding  innate immune response  regulation of innate immune response  
Ontology : EGO-EBIubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  cytoplasm  cytosol  zinc ion binding  protein ubiquitination  protein ubiquitination  ligase activity  negative regulation of type I interferon production  positive regulation of interferon-beta production  ribonucleoprotein complex binding  innate immune response  regulation of innate immune response  
NDEx NetworkRNF135
Atlas of Cancer Signalling NetworkRNF135
Wikipedia pathwaysRNF135
Orthology - Evolution
OrthoDB84282
GeneTree (enSembl)ENSG00000181481
Phylogenetic Trees/Animal Genes : TreeFamRNF135
Homologs : HomoloGeneRNF135
Homology/Alignments : Family Browser (UCSC)RNF135
Gene fusions - Rearrangements
Fusion: TCGAMYO18A 17q11.2 RNF135 17q11.2 BLCA
Polymorphisms : SNP, variants
NCBI Variation ViewerRNF135 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNF135
dbVarRNF135
ClinVarRNF135
1000_GenomesRNF135 
Exome Variant ServerRNF135
ExAC (Exome Aggregation Consortium)RNF135 (select the gene name)
Genetic variants : HAPMAP84282
Genomic Variants (DGV)RNF135 [DGVbeta]
Mutations
ICGC Data PortalRNF135 
TCGA Data PortalRNF135 
Broad Tumor PortalRNF135
OASIS PortalRNF135 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRNF135 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch RNF135
DgiDB (Drug Gene Interaction Database)RNF135
DoCM (Curated mutations)RNF135 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RNF135 (select a term)
intoGenRNF135
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)17:29297956-29326929  ENSG00000181481
CONAN: Copy Number AnalysisRNF135 
Mutations and Diseases : HGMDRNF135
OMIM611358    614192   
MedgenRNF135
Genetic Testing Registry RNF135
NextProtQ8IUD6 [Medical]
TSGene84282
GENETestsRNF135
Huge Navigator RNF135 [HugePedia]
snp3D : Map Gene to Disease84282
BioCentury BCIQRNF135
ClinGenRNF135
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84282
Chemical/Pharm GKB GenePA134978537
Clinical trialRNF135
Miscellaneous
canSAR (ICR)RNF135 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRNF135
EVEXRNF135
GoPubMedRNF135
iHOPRNF135
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 19 19:11:07 CEST 2016

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