RNF135 (ring finger protein 135)

2003-05-01 Affiliation

Identity

HGNC

RNF135

LOCATION

17q11.2

LOCUSID

84282

ALIAS

L13,MMFD,REUL,Riplet

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 84282
MIM: 611358
HGNC: 21158
Ensembl: ENSG00000181481

Variants:

dbSNP: 84282
ClinVar: 84282
TCGA: ENSG00000181481
COSMIC: RNF135

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000181481	ENST00000324689	Q8IUD6
ENSG00000181481	ENST00000328381	Q8IUD6
ENSG00000181481	ENST00000434242	K7EQF1
ENSG00000181481	ENST00000443677	H7C3H8
ENSG00000181481	ENST00000535306	Q8IUD6
ENSG00000181481	ENST00000580444	J3QS68

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways	REACTOME	R-HSA-168928
TRAF3-dependent IRF activation pathway	REACTOME	R-HSA-918233
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	REACTOME	R-HSA-933543
TRAF6 mediated IRF7 activation	REACTOME	R-HSA-933541
TRAF6 mediated NF-kB activation	REACTOME	R-HSA-933542
Negative regulators of RIG-I/MDA5 signaling	REACTOME	R-HSA-936440
Deubiquitination	REACTOME	R-HSA-5688426
Ovarian tumor domain proteases	REACTOME	R-HSA-5689896

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19017631	2009	Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection.	130
23950712	2013	A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses.	71
19484123	2009	REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I.	54
17632510	2007	Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth.	25
20546612	2010	The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.	19
28469175	2017	Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity.	19
31006531	2019	Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity.	17
26368817	2015	Mutation screening of the ubiquitin ligase gene RNF135 in French patients with autism.	7
31335993	2019	RIPLET, and not TRIM25, is required for endogenous RIG-I-dependent antiviral responses.	7
26856755	2016	RNF135, RING finger protein, promotes the proliferation of human glioblastoma cells in vivo and in vitro via the ERK pathway.	6

Citation

Dessen P

RNF135 (ring finger protein 135)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42128/rnf135