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RNF135 (ring finger protein 135)

Identity

Alias (NCBI)L13
MMFD
REUL
Riplet
HGNC (Hugo) RNF135
HGNC Alias symbMGC13061
HGNC Alias nameriplet
LocusID (NCBI) 84282
Atlas_Id 42128
Location 17q11.2  [Link to chromosome band 17q11]
Location_base_pair Starts at 30971039 and ends at 30999911 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADAP2 (17q11.2) / RNF135 (17q11.2)ANKRD11 (16q24.3) / RNF135 (17q11.2)MYO18A (17q11.2) / RNF135 (17q11.2)
PIK3R5 (17p13.1) / RNF135 (17q11.2)RNF135 (17q11.2) / C17orf78 (17q12)MYO18A 17q11.2 / RNF135 17q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)RNF135   21158
Cards
Entrez_Gene (NCBI)RNF135    ring finger protein 135
AliasesL13; MMFD; REUL; Riplet
GeneCards (Weizmann)RNF135
Ensembl hg19 (Hinxton)ENSG00000181481 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000181481 [Gene_View]  ENSG00000181481 [Sequence]  chr17:30971039-30999911 [Contig_View]  RNF135 [Vega]
ICGC DataPortalENSG00000181481
TCGA cBioPortalRNF135
AceView (NCBI)RNF135
Genatlas (Paris)RNF135
SOURCE (Princeton)RNF135
Genetics Home Reference (NIH)RNF135
Genomic and cartography
GoldenPath hg38 (UCSC)RNF135  -     chr17:30971039-30999911 +  17q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RNF135  -     17q11.2   [Description]    (hg19-Feb_2009)
GoldenPathRNF135 - 17q11.2 [CytoView hg19]  RNF135 - 17q11.2 [CytoView hg38]
ImmunoBaseENSG00000181481
Genome Data Viewer NCBIRNF135 [Mapview hg19]  
OMIM611358   
Gene and transcription
Genbank (Entrez)AB470605 AI634044 AJ496729 AK122646 AK122709
RefSeq transcript (Entrez)NM_001184992 NM_032322 NM_197939
Consensus coding sequences : CCDS (NCBI)RNF135
Gene ExpressionRNF135 [ NCBI-GEO ]   RNF135 [ EBI - ARRAY_EXPRESS ]   RNF135 [ SEEK ]   RNF135 [ MEM ]
Gene Expression Viewer (FireBrowse)RNF135 [ Firebrowse - Broad ]
GenevisibleExpression of RNF135 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84282
GTEX Portal (Tissue expression)RNF135
Human Protein AtlasENSG00000181481-RNF135 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IUD6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IUD6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IUD6
PhosPhoSitePlusQ8IUD6
Domaine pattern : Prosite (Expaxy)B302_SPRY (PS50188)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)B30.2/SPRY    B30.2/SPRY_sf    Butyrophylin_SPRY    ConA-like_dom_sf    PRY    RNF135_SPRY_PRY_dom    SPRY_dom    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)SPRY (PF00622)   
Domain families : Pfam (NCBI)pfam00622   
Domain families : Smart (EMBL)PRY (SM00589)  RING (SM00184)  SPRY (SM00449)  
Conserved Domain (NCBI)RNF135
SuperfamilyQ8IUD6
AlphaFold pdb e-kbQ8IUD6   
Human Protein Atlas [tissue]ENSG00000181481-RNF135 [tissue]
HPRD11506
Protein Interaction databases
DIP (DOE-UCLA)Q8IUD6
IntAct (EBI)Q8IUD6
BioGRIDRNF135
STRING (EMBL)RNF135
ZODIACRNF135
Ontologies - Pathways
QuickGOQ8IUD6
Ontology : AmiGOprotein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  cytoplasm  cytoplasm  cytosol  cytoplasmic stress granule  free ubiquitin chain polymerization  protein ubiquitination  negative regulation of type I interferon production  positive regulation of interferon-beta production  RIG-I signaling pathway  RIG-I signaling pathway  RIG-I binding  identical protein binding  ribonucleoprotein complex binding  ribonucleoprotein complex binding  ribonucleoprotein complex binding  innate immune response  regulation of innate immune response  regulation of innate immune response  metal ion binding  protein homooligomerization  ubiquitin protein ligase activity  protein K63-linked ubiquitination  antiviral innate immune response  ribonucleoprotein complex  
Ontology : EGO-EBIprotein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  cytoplasm  cytoplasm  cytosol  cytoplasmic stress granule  free ubiquitin chain polymerization  protein ubiquitination  negative regulation of type I interferon production  positive regulation of interferon-beta production  RIG-I signaling pathway  RIG-I signaling pathway  RIG-I binding  identical protein binding  ribonucleoprotein complex binding  ribonucleoprotein complex binding  ribonucleoprotein complex binding  innate immune response  regulation of innate immune response  regulation of innate immune response  metal ion binding  protein homooligomerization  ubiquitin protein ligase activity  protein K63-linked ubiquitination  antiviral innate immune response  ribonucleoprotein complex  
NDEx NetworkRNF135
Atlas of Cancer Signalling NetworkRNF135
Wikipedia pathwaysRNF135
Orthology - Evolution
OrthoDB84282
GeneTree (enSembl)ENSG00000181481
Phylogenetic Trees/Animal Genes : TreeFamRNF135
Homologs : HomoloGeneRNF135
Homology/Alignments : Family Browser (UCSC)RNF135
Gene fusions - Rearrangements
Fusion : MitelmanMYO18A/RNF135 [17q11.2/17q11.2]  
Fusion : QuiverRNF135
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRNF135 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNF135
dbVarRNF135
ClinVarRNF135
MonarchRNF135
1000_GenomesRNF135 
Exome Variant ServerRNF135
GNOMAD BrowserENSG00000181481
Varsome BrowserRNF135
ACMGRNF135 variants
VarityQ8IUD6
Genomic Variants (DGV)RNF135 [DGVbeta]
DECIPHERRNF135 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRNF135 
Mutations
ICGC Data PortalRNF135 
TCGA Data PortalRNF135 
Broad Tumor PortalRNF135
OASIS PortalRNF135 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRNF135  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRNF135
Mutations and Diseases : HGMDRNF135
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRNF135
DgiDB (Drug Gene Interaction Database)RNF135
DoCM (Curated mutations)RNF135
CIViC (Clinical Interpretations of Variants in Cancer)RNF135
Cancer3DRNF135
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611358   
Orphanet16697   
DisGeNETRNF135
MedgenRNF135
Genetic Testing Registry RNF135
NextProtQ8IUD6 [Medical]
GENETestsRNF135
Target ValidationRNF135
Huge Navigator RNF135 [HugePedia]
ClinGenRNF135 (curated)
Clinical trials, drugs, therapy
MyCancerGenomeRNF135
Protein Interactions : CTDRNF135
Pharm GKB GenePA134978537
PharosQ8IUD6
Clinical trialRNF135
Miscellaneous
canSAR (ICR)RNF135
HarmonizomeRNF135
DataMed IndexRNF135
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRNF135
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:29:10 CEST 2021

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