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RNF144B (ring finger protein 144B)

Identity

Alias_namesIBRDC2
IBR domain containing 2
Alias_symbol (synonym)bA528A10.3
Other aliasPIR2
p53RFP
HGNC (Hugo) RNF144B
LocusID (NCBI) 255488
Atlas_Id 46739
Location 6p22.3  [Link to chromosome band 6p22]
Location_base_pair Starts at 18387350 and ends at 18468874 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CSGALNACT1 (8p21.3) / RNF144B (6p22.3)DIMT1 (5q12.1) / RNF144B (6p22.3)RNF144B (6p22.3) / LYRM4 (6p25.1)
RNF144B 6p22.3 / LYRM4 6p25.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(p22;p25) RNF144B/LYRM4


External links

Nomenclature
HGNC (Hugo)RNF144B   21578
Cards
Entrez_Gene (NCBI)RNF144B  255488  ring finger protein 144B
AliasesIBRDC2; PIR2; bA528A10.3; p53RFP
GeneCards (Weizmann)RNF144B
Ensembl hg19 (Hinxton)ENSG00000137393 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137393 [Gene_View]  ENSG00000137393 [Sequence]  chr6:18387350-18468874 [Contig_View]  RNF144B [Vega]
ICGC DataPortalENSG00000137393
TCGA cBioPortalRNF144B
AceView (NCBI)RNF144B
Genatlas (Paris)RNF144B
WikiGenes255488
SOURCE (Princeton)RNF144B
Genetics Home Reference (NIH)RNF144B
Genomic and cartography
GoldenPath hg38 (UCSC)RNF144B  -     chr6:18387350-18468874 +  6p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RNF144B  -     6p22.3   [Description]    (hg19-Feb_2009)
EnsemblRNF144B - 6p22.3 [CytoView hg19]  RNF144B - 6p22.3 [CytoView hg38]
Mapping of homologs : NCBIRNF144B [Mapview hg19]  RNF144B [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB076367 AJ420555 AK096832 AK302935 AL832329
RefSeq transcript (Entrez)NM_182757
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RNF144B
Cluster EST : UnigeneHs.148741 [ NCBI ]
CGAP (NCI)Hs.148741
Alternative Splicing GalleryENSG00000137393
Gene ExpressionRNF144B [ NCBI-GEO ]   RNF144B [ EBI - ARRAY_EXPRESS ]   RNF144B [ SEEK ]   RNF144B [ MEM ]
Gene Expression Viewer (FireBrowse)RNF144B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)255488
GTEX Portal (Tissue expression)RNF144B
Human Protein AtlasENSG00000137393-RNF144B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z419   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z419  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z419
Splice isoforms : SwissVarQ7Z419
PhosPhoSitePlusQ7Z419
Domaine pattern : Prosite (Expaxy)ZF_RING_1 (PS00518)   
Domains : Interpro (EBI)E3_UB_ligase_RBR    IBR_dom    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)IBR (PF01485)   
Domain families : Pfam (NCBI)pfam01485   
Domain families : Smart (EMBL)IBR (SM00647)  RING (SM00184)  
Conserved Domain (NCBI)RNF144B
DMDM Disease mutations255488
Blocks (Seattle)RNF144B
SuperfamilyQ7Z419
Human Protein Atlas [tissue]ENSG00000137393-RNF144B [tissue]
Peptide AtlasQ7Z419
HPRD17126
IPIIPI00296533   IPI00909358   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z419
IntAct (EBI)Q7Z419
FunCoupENSG00000137393
BioGRIDRNF144B
STRING (EMBL)RNF144B
ZODIACRNF144B
Ontologies - Pathways
QuickGOQ7Z419
Ontology : AmiGOubiquitin ligase complex  ubiquitin ligase complex  protein polyubiquitination  protein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  cytoplasm  cytosol  apoptotic process  integral component of membrane  ubiquitin conjugating enzyme binding  mitochondrial membrane  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  negative regulation of apoptotic process  metal ion binding  ubiquitin protein ligase activity  
Ontology : EGO-EBIubiquitin ligase complex  ubiquitin ligase complex  protein polyubiquitination  protein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  cytoplasm  cytosol  apoptotic process  integral component of membrane  ubiquitin conjugating enzyme binding  mitochondrial membrane  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  negative regulation of apoptotic process  metal ion binding  ubiquitin protein ligase activity  
Pathways : KEGGTryptophan metabolism   
NDEx NetworkRNF144B
Atlas of Cancer Signalling NetworkRNF144B
Wikipedia pathwaysRNF144B
Orthology - Evolution
OrthoDB255488
GeneTree (enSembl)ENSG00000137393
Phylogenetic Trees/Animal Genes : TreeFamRNF144B
HOVERGENQ7Z419
HOGENOMQ7Z419
Homologs : HomoloGeneRNF144B
Homology/Alignments : Family Browser (UCSC)RNF144B
Gene fusions - Rearrangements
Fusion : MitelmanRNF144B/LYRM4 [6p22.3/6p25.1]  
Fusion PortalRNF144B 6p22.3 LYRM4 6p25.1 BRCA
Fusion : QuiverRNF144B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRNF144B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNF144B
dbVarRNF144B
ClinVarRNF144B
1000_GenomesRNF144B 
Exome Variant ServerRNF144B
ExAC (Exome Aggregation Consortium)ENSG00000137393
GNOMAD BrowserENSG00000137393
Genetic variants : HAPMAP255488
Genomic Variants (DGV)RNF144B [DGVbeta]
DECIPHERRNF144B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRNF144B 
Mutations
ICGC Data PortalRNF144B 
TCGA Data PortalRNF144B 
Broad Tumor PortalRNF144B
OASIS PortalRNF144B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRNF144B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRNF144B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RNF144B
DgiDB (Drug Gene Interaction Database)RNF144B
DoCM (Curated mutations)RNF144B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RNF144B (select a term)
intoGenRNF144B
Cancer3DRNF144B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETRNF144B
MedgenRNF144B
Genetic Testing Registry RNF144B
NextProtQ7Z419 [Medical]
TSGene255488
GENETestsRNF144B
Target ValidationRNF144B
Huge Navigator RNF144B [HugePedia]
snp3D : Map Gene to Disease255488
BioCentury BCIQRNF144B
ClinGenRNF144B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD255488
Chemical/Pharm GKB GenePA162401565
Clinical trialRNF144B
Miscellaneous
canSAR (ICR)RNF144B (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRNF144B
EVEXRNF144B
GoPubMedRNF144B
iHOPRNF144B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:47:24 CEST 2018

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