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RNF169 (ring finger protein 169)

Identity

Alias_symbol (synonym)KIAA1991
Other alias-
HGNC (Hugo) RNF169
LocusID (NCBI) 254225
Atlas_Id 52763
Location 11q13.4  [Link to chromosome band 11q13]
Location_base_pair Starts at 74748868 and ends at 74842413 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BCAS3 (17q23.2) / RNF169 (11q13.4)C2CD3 (11q13.4) / RNF169 (11q13.4)FCHSD2 (11q13.4) / RNF169 (11q13.4)
FOXG1 (14q12) / RNF169 (11q13.4)MLLT10 (10p12.31) / RNF169 (11q13.4)MPP7 (10p12.1) / RNF169 (11q13.4)
NRBF2 (10q21.3) / RNF169 (11q13.4)RNF169 (11q13.4) / ANAPC15 (11q13.4)RNF169 (11q13.4) / CALCOCO2 (17q21.32)
RNF169 (11q13.4) / CBX1 (17q21.32)RNF169 (11q13.4) / MYO18A (17q11.2)USP35 (11q14.1) / RNF169 (11q13.4)
BCAS3 17q23.2 / RNF169 11q13.4C2CD3 11q13.4 / RNF169 11q13.4FCHSD2 11q13.4 / RNF169 11q13.4
MPP7 10p12.1 / RNF169 11q13.4RNF169 11q13.4 C11orf51RNF169 11q13.4 / CALCOCO2 17q21.32
RNF169 11q13.4 / CBX1 17q21.32USP35 11q14.1 / RNF169 11q13.4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(10;11)(p12;q13) MLLT10/RNF169


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 7 ]
  t(10;11)(p12;q13) MPP7/RNF169
t(11;11)(q13;q13) C2CD3/RNF169
t(11;11)(q13;q13) FCHSD2/RNF169
t(11;11)(q13;q13) RNF169/ANAPC15
t(11;17)(q13;q21) RNF169/CALCOCO2
t(11;17)(q13;q21) RNF169/CBX1
t(11;17)(q13;q23) BCAS3/RNF169


External links

Nomenclature
HGNC (Hugo)RNF169   26961
Cards
Entrez_Gene (NCBI)RNF169  254225  ring finger protein 169
Aliases
GeneCards (Weizmann)RNF169
Ensembl hg19 (Hinxton)ENSG00000166439 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166439 [Gene_View]  chr11:74748868-74842413 [Contig_View]  RNF169 [Vega]
ICGC DataPortalENSG00000166439
TCGA cBioPortalRNF169
AceView (NCBI)RNF169
Genatlas (Paris)RNF169
WikiGenes254225
SOURCE (Princeton)RNF169
Genetics Home Reference (NIH)RNF169
Genomic and cartography
GoldenPath hg38 (UCSC)RNF169  -     chr11:74748868-74842413 +  11q13.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RNF169  -     11q13.4   [Description]    (hg19-Feb_2009)
EnsemblRNF169 - 11q13.4 [CytoView hg19]  RNF169 - 11q13.4 [CytoView hg38]
Mapping of homologs : NCBIRNF169 [Mapview hg19]  RNF169 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB082522 BU735906 BX640750 DQ580376 DQ600280
RefSeq transcript (Entrez)NM_001098638
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RNF169
Cluster EST : UnigeneHs.745050 [ NCBI ]
CGAP (NCI)Hs.745050
Alternative Splicing GalleryENSG00000166439
Gene ExpressionRNF169 [ NCBI-GEO ]   RNF169 [ EBI - ARRAY_EXPRESS ]   RNF169 [ SEEK ]   RNF169 [ MEM ]
Gene Expression Viewer (FireBrowse)RNF169 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)254225
GTEX Portal (Tissue expression)RNF169
Human Protein AtlasENSG00000166439-RNF169 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NCN4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NCN4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NCN4
Splice isoforms : SwissVarQ8NCN4
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   
PhosPhoSitePlusQ8NCN4
Domaine pattern : Prosite (Expaxy)ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)RING (SM00184)  
Conserved Domain (NCBI)RNF169
DMDM Disease mutations254225
Blocks (Seattle)RNF169
SuperfamilyQ8NCN4
Human Protein Atlas [tissue]ENSG00000166439-RNF169 [tissue]
Peptide AtlasQ8NCN4
IPIIPI00456899   IPI00981515   
Protein Interaction databases
DIP (DOE-UCLA)Q8NCN4
IntAct (EBI)Q8NCN4
FunCoupENSG00000166439
BioGRIDRNF169
STRING (EMBL)RNF169
ZODIACRNF169
Ontologies - Pathways
QuickGOQ8NCN4
Ontology : AmiGOnucleus  nucleoplasm  cellular response to DNA damage stimulus  cellular response to DNA damage stimulus  protein ubiquitination  nuclear speck  transferase activity  nucleosome binding  site of double-strand break  metal ion binding  K63-linked polyubiquitin modification-dependent protein binding  negative regulation of double-strand break repair  negative regulation of double-strand break repair  
Ontology : EGO-EBInucleus  nucleoplasm  cellular response to DNA damage stimulus  cellular response to DNA damage stimulus  protein ubiquitination  nuclear speck  transferase activity  nucleosome binding  site of double-strand break  metal ion binding  K63-linked polyubiquitin modification-dependent protein binding  negative regulation of double-strand break repair  negative regulation of double-strand break repair  
NDEx NetworkRNF169
Atlas of Cancer Signalling NetworkRNF169
Wikipedia pathwaysRNF169
Orthology - Evolution
OrthoDB254225
GeneTree (enSembl)ENSG00000166439
Phylogenetic Trees/Animal Genes : TreeFamRNF169
HOVERGENQ8NCN4
HOGENOMQ8NCN4
Homologs : HomoloGeneRNF169
Homology/Alignments : Family Browser (UCSC)RNF169
Gene fusions - Rearrangements
Fusion : MitelmanBCAS3/RNF169 [17q23.2/11q13.4]  [t(11;17)(q13;q23)]  
Fusion : MitelmanC2CD3/RNF169 [11q13.4/11q13.4]  [t(11;11)(q13;q13)]  
Fusion : MitelmanFCHSD2/RNF169 [11q13.4/11q13.4]  [t(11;11)(q13;q13)]  
Fusion : MitelmanMLLT10/RNF169 [10p12.31/11q13.4]  [t(10;11)(p12;q13)]  
Fusion : MitelmanMPP7/RNF169 [10p12.1/11q13.4]  [t(10;11)(p12;q13)]  
Fusion : MitelmanRNF169/ANAPC15 [11q13.4/11q13.4]  [t(11;11)(q13;q13)]  
Fusion : MitelmanRNF169/CALCOCO2 [11q13.4/17q21.32]  [t(11;17)(q13;q21)]  
Fusion : MitelmanRNF169/CBX1 [11q13.4/17q21.32]  [t(11;17)(q13;q21)]  
Fusion : MitelmanUSP35/RNF169 [11q14.1/11q13.4]  [t(11;11)(q13;q14)]  
Fusion: TCGA_MDACCBCAS3 17q23.2 RNF169 11q13.4 BRCA
Fusion: TCGA_MDACCC2CD3 11q13.4 RNF169 11q13.4 BRCA
Fusion: TCGA_MDACCFCHSD2 11q13.4 RNF169 11q13.4 BRCA
Fusion: TCGA_MDACCMPP7 10p12.1 RNF169 11q13.4 LUAD
Fusion: TCGA_MDACCRNF169 11q13.4 C11orf51 BRCA
Fusion: TCGA_MDACCRNF169 11q13.4 CALCOCO2 17q21.32 BRCA
Fusion: TCGA_MDACCRNF169 11q13.4 CBX1 17q21.32 BRCA
Fusion: TCGA_MDACCUSP35 11q14.1 RNF169 11q13.4 BRCA
Fusion PortalBCAS3 17q23.2 RNF169 11q13.4 BRCA
Fusion PortalC2CD3 11q13.4 RNF169 11q13.4 BRCA
Fusion PortalFCHSD2 11q13.4 RNF169 11q13.4 BRCA
Fusion PortalMPP7 10p12.1 RNF169 11q13.4 LUAD
Fusion PortalRNF169 11q13.4 C11orf51 BRCA
Fusion PortalRNF169 11q13.4 CALCOCO2 17q21.32 BRCA
Fusion PortalRNF169 11q13.4 CBX1 17q21.32 BRCA
Fusion PortalUSP35 11q14.1 RNF169 11q13.4 BRCA
Fusion : QuiverRNF169
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRNF169 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNF169
dbVarRNF169
ClinVarRNF169
1000_GenomesRNF169 
Exome Variant ServerRNF169
ExAC (Exome Aggregation Consortium)ENSG00000166439
GNOMAD BrowserENSG00000166439
Genetic variants : HAPMAP254225
Genomic Variants (DGV)RNF169 [DGVbeta]
DECIPHERRNF169 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRNF169 
Mutations
ICGC Data PortalRNF169 
TCGA Data PortalRNF169 
Broad Tumor PortalRNF169
OASIS PortalRNF169 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRNF169  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRNF169
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RNF169
DgiDB (Drug Gene Interaction Database)RNF169
DoCM (Curated mutations)RNF169 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RNF169 (select a term)
intoGenRNF169
Cancer3DRNF169(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETRNF169
MedgenRNF169
Genetic Testing Registry RNF169
NextProtQ8NCN4 [Medical]
TSGene254225
GENETestsRNF169
Target ValidationRNF169
Huge Navigator RNF169 [HugePedia]
snp3D : Map Gene to Disease254225
BioCentury BCIQRNF169
ClinGenRNF169
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD254225
Chemical/Pharm GKB GenePA142671054
Clinical trialRNF169
Miscellaneous
canSAR (ICR)RNF169 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRNF169
EVEXRNF169
GoPubMedRNF169
iHOPRNF169
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Feb 28 13:35:10 CET 2018

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