Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

RNF169 (ring finger protein 169)

Identity

Alias (NCBI)-
HGNC (Hugo) RNF169
HGNC Alias symbKIAA1991
LocusID (NCBI) 254225
Atlas_Id 52763
Location 11q13.4  [Link to chromosome band 11q13]
Location_base_pair Starts at 74748849 and ends at 74842413 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BCAS3 (17q23.2)::RNF169 (11q13.4)C2CD3 (11q13.4)::RNF169 (11q13.4)FCHSD2 (11q13.4)::RNF169 (11q13.4)
FOXG1 (14q12)::RNF169 (11q13.4)MLLT10 (10p12.31)::RNF169 (11q13.4)MPP7 (10p12.1)::RNF169 (11q13.4)
NRBF2 (10q21.3)::RNF169 (11q13.4)RNF169 (11q13.4)::ANAPC15 (11q13.4)RNF169 (11q13.4)::CALCOCO2 (17q21.32)
RNF169 (11q13.4)::CBX1 (17q21.32)RNF169 (11q13.4)::MYO18A (17q11.2)USP35 (11q14.1)::RNF169 (11q13.4)
BCAS3 17q23.2::RNF169 11q13.4C2CD3 11q13.4::RNF169 11q13.4FCHSD2 11q13.4::RNF169 11q13.4
MPP7 10p12.1::RNF169 11q13.4RNF169 11q13.4 C11orf51RNF169 11q13.4::CALCOCO2 17q21.32
RNF169 11q13.4::CBX1 17q21.32USP35 11q14.1::RNF169 11q13.4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(10;11)(p12;q13) MLLT10::RNF169

External links

 

Nomenclature
HGNC (Hugo)RNF169   26961
Cards
Entrez_Gene (NCBI)RNF169    ring finger protein 169
Aliases
GeneCards (Weizmann)RNF169
Ensembl hg19 (Hinxton)ENSG00000166439 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166439 [Gene_View]  ENSG00000166439 [Sequence]  chr11:74748849-74842413 [Contig_View]  RNF169 [Vega]
ICGC DataPortalENSG00000166439
TCGA cBioPortalRNF169
AceView (NCBI)RNF169
Genatlas (Paris)RNF169
SOURCE (Princeton)RNF169
Genetics Home Reference (NIH)RNF169
Genomic and cartography
GoldenPath hg38 (UCSC)RNF169  -     chr11:74748849-74842413 +  11q13.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RNF169  -     11q13.4   [Description]    (hg19-Feb_2009)
GoldenPathRNF169 - 11q13.4 [CytoView hg19]  RNF169 - 11q13.4 [CytoView hg38]
ImmunoBaseENSG00000166439
Genome Data Viewer NCBIRNF169 [Mapview hg19]  
OMIM618650   
Gene and transcription
Genbank (Entrez)AB082522 BU735906 BX640750 DQ580376 DQ600280
RefSeq transcript (Entrez)NM_001098638
Consensus coding sequences : CCDS (NCBI)RNF169
Gene ExpressionRNF169 [ NCBI-GEO ]   RNF169 [ EBI - ARRAY_EXPRESS ]   RNF169 [ SEEK ]   RNF169 [ MEM ]
Gene Expression Viewer (FireBrowse)RNF169 [ Firebrowse - Broad ]
GenevisibleExpression of RNF169 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)254225
GTEX Portal (Tissue expression)RNF169
Human Protein AtlasENSG00000166439-RNF169 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NCN4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NCN4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NCN4
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ8NCN4
Domaine pattern : Prosite (Expaxy)ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)RING (SM00184)  
Conserved Domain (NCBI)RNF169
PDB (RSDB)5GG4    5VEY   
PDB Europe5GG4    5VEY   
PDB (PDBSum)5GG4    5VEY   
PDB (IMB)5GG4    5VEY   
Structural Biology KnowledgeBase5GG4    5VEY   
SCOP (Structural Classification of Proteins)5GG4    5VEY   
CATH (Classification of proteins structures)5GG4    5VEY   
SuperfamilyQ8NCN4
AlphaFold pdb e-kbQ8NCN4   
Human Protein Atlas [tissue]ENSG00000166439-RNF169 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q8NCN4
IntAct (EBI)Q8NCN4
BioGRIDRNF169
STRING (EMBL)RNF169
ZODIACRNF169
Ontologies - Pathways
QuickGOQ8NCN4
Ontology : AmiGOubiquitin-protein transferase activity  protein binding  nucleus  nucleus  nucleoplasm  nucleolus  cytosol  double-strand break repair  cellular response to DNA damage stimulus  cellular response to DNA damage stimulus  protein ubiquitination  nuclear body  transferase activity  nucleosome binding  nucleosome binding  site of double-strand break  site of double-strand break  metal ion binding  K63-linked polyubiquitin modification-dependent protein binding  negative regulation of double-strand break repair  negative regulation of double-strand break repair  
Ontology : EGO-EBIubiquitin-protein transferase activity  protein binding  nucleus  nucleus  nucleoplasm  nucleolus  cytosol  double-strand break repair  cellular response to DNA damage stimulus  cellular response to DNA damage stimulus  protein ubiquitination  nuclear body  transferase activity  nucleosome binding  nucleosome binding  site of double-strand break  site of double-strand break  metal ion binding  K63-linked polyubiquitin modification-dependent protein binding  negative regulation of double-strand break repair  negative regulation of double-strand break repair  
NDEx NetworkRNF169
Atlas of Cancer Signalling NetworkRNF169
Wikipedia pathwaysRNF169
Orthology - Evolution
OrthoDB254225
GeneTree (enSembl)ENSG00000166439
Phylogenetic Trees/Animal Genes : TreeFamRNF169
Homologs : HomoloGeneRNF169
Homology/Alignments : Family Browser (UCSC)RNF169
Gene fusions - Rearrangements
Fusion : MitelmanBCAS3::RNF169 [17q23.2/11q13.4]  
Fusion : MitelmanC2CD3::RNF169 [11q13.4/11q13.4]  
Fusion : MitelmanFCHSD2::RNF169 [11q13.4/11q13.4]  
Fusion : MitelmanMLLT10::RNF169 [10p12.31/11q13.4]  
Fusion : MitelmanMPP7::RNF169 [10p12.1/11q13.4]  
Fusion : MitelmanRNF169::ANAPC15 [11q13.4/11q13.4]  
Fusion : MitelmanRNF169::CALCOCO2 [11q13.4/17q21.32]  
Fusion : MitelmanRNF169::CBX1 [11q13.4/17q21.32]  
Fusion : MitelmanUSP35::RNF169 [11q14.1/11q13.4]  
Fusion : QuiverRNF169
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRNF169 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNF169
dbVarRNF169
ClinVarRNF169
MonarchRNF169
1000_GenomesRNF169 
Exome Variant ServerRNF169
GNOMAD BrowserENSG00000166439
Varsome BrowserRNF169
ACMGRNF169 variants
VarityQ8NCN4
Genomic Variants (DGV)RNF169 [DGVbeta]
DECIPHERRNF169 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRNF169 
Mutations
ICGC Data PortalRNF169 
TCGA Data PortalRNF169 
Broad Tumor PortalRNF169
OASIS PortalRNF169 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRNF169  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRNF169
Mutations and Diseases : HGMDRNF169
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRNF169
DgiDB (Drug Gene Interaction Database)RNF169
DoCM (Curated mutations)RNF169
CIViC (Clinical Interpretations of Variants in Cancer)RNF169
Cancer3DRNF169
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM618650   
Orphanet
DisGeNETRNF169
MedgenRNF169
Genetic Testing Registry RNF169
NextProtQ8NCN4 [Medical]
GENETestsRNF169
Target ValidationRNF169
Huge Navigator RNF169 [HugePedia]
ClinGenRNF169
Clinical trials, drugs, therapy
MyCancerGenomeRNF169
Protein Interactions : CTDRNF169
Pharm GKB GenePA142671054
PharosQ8NCN4
Clinical trialRNF169
Miscellaneous
canSAR (ICR)RNF169
HarmonizomeRNF169
ARCHS4RNF169
DataMed IndexRNF169
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRNF169
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 20 12:56:26 CET 2022
Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.