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RNF170 (ring finger protein 170)

Identity

Alias_namesSNAX1
sensory ataxia 1 (autosomal dominant)
Alias_symbol (synonym)DKFZP564A022
ADSA
Other alias
HGNC (Hugo) RNF170
LocusID (NCBI) 81790
Atlas_Id 54584
Location 8p11.21  [Link to chromosome band 8p11]
Location_base_pair Starts at 42853295 and ends at 42896723 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ADAM9 (8p11.22) / RNF170 (8p11.21)CRIM1 (2p22.3) / RNF170 (8p11.21)RNF170 (8p11.21) / CSMD1 (8p23.2)
RNF170 (8p11.21) / FNTA (8p11.21)RNF170 (8p11.21) / GOLGA7 (8p11.21)RNF170 (8p11.21) / HOOK3 (8p11.21)
RNF170 (8p11.21) / SFRP1 (8p11.21)ADAM9 8p11.22 / RNF170 8p11.21RNF170 8p11.21 / CSMD1 8p23.2
RNF170 8p11.21 / GOLGA7 8p11.21RNF170 8p11.21 / HOOK3 8p11.21RNF170 8p11.21 / SFRP1 8p11.21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)RNF170   25358
Cards
Entrez_Gene (NCBI)RNF170  81790  ring finger protein 170
AliasesADSA; SNAX1
GeneCards (Weizmann)RNF170
Ensembl hg19 (Hinxton)ENSG00000120925 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120925 [Gene_View]  chr8:42853295-42896723 [Contig_View]  RNF170 [Vega]
ICGC DataPortalENSG00000120925
TCGA cBioPortalRNF170
AceView (NCBI)RNF170
Genatlas (Paris)RNF170
WikiGenes81790
SOURCE (Princeton)RNF170
Genetics Home Reference (NIH)RNF170
Genomic and cartography
GoldenPath hg38 (UCSC)RNF170  -     chr8:42853295-42896723 -  8p11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RNF170  -     8p11.21   [Description]    (hg19-Feb_2009)
EnsemblRNF170 - 8p11.21 [CytoView hg19]  RNF170 - 8p11.21 [CytoView hg38]
Mapping of homologs : NCBIRNF170 [Mapview hg19]  RNF170 [Mapview hg38]
OMIM608984   614649   
Gene and transcription
Genbank (Entrez)AA973979 AF209504 AK027748 AK090864 AK095625
RefSeq transcript (Entrez)NM_001160223 NM_001160224 NM_001160225 NM_030954
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RNF170
Cluster EST : UnigeneHs.491626 [ NCBI ]
CGAP (NCI)Hs.491626
Alternative Splicing GalleryENSG00000120925
Gene ExpressionRNF170 [ NCBI-GEO ]   RNF170 [ EBI - ARRAY_EXPRESS ]   RNF170 [ SEEK ]   RNF170 [ MEM ]
Gene Expression Viewer (FireBrowse)RNF170 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)81790
GTEX Portal (Tissue expression)RNF170
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96K19   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96K19  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96K19
Splice isoforms : SwissVarQ96K19
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   
PhosPhoSitePlusQ96K19
Domaine pattern : Prosite (Expaxy)ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)DUF1232    Znf_C3HC4_RING-type    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)DUF1232 (PF06803)    zf-C3HC4 (PF00097)   
Domain families : Pfam (NCBI)pfam06803    pfam00097   
Domain families : Smart (EMBL)RING (SM00184)  
Conserved Domain (NCBI)RNF170
DMDM Disease mutations81790
Blocks (Seattle)RNF170
SuperfamilyQ96K19
Human Protein AtlasENSG00000120925
Peptide AtlasQ96K19
HPRD13165
IPIIPI00742872   IPI00829735   IPI00166853   IPI00830124   IPI00829763   IPI00976275   IPI00977024   IPI00980141   
Protein Interaction databases
DIP (DOE-UCLA)Q96K19
IntAct (EBI)Q96K19
FunCoupENSG00000120925
BioGRIDRNF170
STRING (EMBL)RNF170
ZODIACRNF170
Ontologies - Pathways
QuickGOQ96K19
Ontology : AmiGOprotein binding  endoplasmic reticulum membrane  zinc ion binding  integral component of membrane  protein ubiquitination  transferase activity  
Ontology : EGO-EBIprotein binding  endoplasmic reticulum membrane  zinc ion binding  integral component of membrane  protein ubiquitination  transferase activity  
NDEx NetworkRNF170
Atlas of Cancer Signalling NetworkRNF170
Wikipedia pathwaysRNF170
Orthology - Evolution
OrthoDB81790
GeneTree (enSembl)ENSG00000120925
Phylogenetic Trees/Animal Genes : TreeFamRNF170
HOVERGENQ96K19
HOGENOMQ96K19
Homologs : HomoloGeneRNF170
Homology/Alignments : Family Browser (UCSC)RNF170
Gene fusions - Rearrangements
Fusion : MitelmanADAM9/RNF170 [8p11.22/8p11.21]  [t(8;8)(p11;p11)]  
Fusion : MitelmanRNF170/CSMD1 [8p11.21/8p23.2]  [t(8;8)(p11;p23)]  
Fusion : MitelmanRNF170/GOLGA7 [8p11.21/8p11.21]  [t(8;8)(p11;p11)]  
Fusion : MitelmanRNF170/HOOK3 [8p11.21/8p11.21]  [t(8;8)(p11;p11)]  
Fusion : MitelmanRNF170/SFRP1 [8p11.21/8p11.21]  [t(8;8)(p11;p11)]  
Fusion: TCGAADAM9 8p11.22 RNF170 8p11.21 LUAD LUSC
Fusion: TCGARNF170 8p11.21 CSMD1 8p23.2 PRAD
Fusion: TCGARNF170 8p11.21 GOLGA7 8p11.21 BRCA
Fusion: TCGARNF170 8p11.21 HOOK3 8p11.21 BRCA
Fusion: TCGARNF170 8p11.21 SFRP1 8p11.21 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRNF170 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNF170
dbVarRNF170
ClinVarRNF170
1000_GenomesRNF170 
Exome Variant ServerRNF170
ExAC (Exome Aggregation Consortium)RNF170 (select the gene name)
Genetic variants : HAPMAP81790
Genomic Variants (DGV)RNF170 [DGVbeta]
DECIPHERRNF170 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRNF170 
Mutations
ICGC Data PortalRNF170 
TCGA Data PortalRNF170 
Broad Tumor PortalRNF170
OASIS PortalRNF170 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRNF170  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRNF170
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RNF170
DgiDB (Drug Gene Interaction Database)RNF170
DoCM (Curated mutations)RNF170 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RNF170 (select a term)
intoGenRNF170
Cancer3DRNF170(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608984    614649   
Orphanet
MedgenRNF170
Genetic Testing Registry RNF170
NextProtQ96K19 [Medical]
TSGene81790
GENETestsRNF170
Target ValidationRNF170
Huge Navigator RNF170 [HugePedia]
snp3D : Map Gene to Disease81790
BioCentury BCIQRNF170
ClinGenRNF170
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD81790
Chemical/Pharm GKB GenePA134922560
Clinical trialRNF170
Miscellaneous
canSAR (ICR)RNF170 (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRNF170
EVEXRNF170
GoPubMedRNF170
iHOPRNF170
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 14:06:01 CEST 2017

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