Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

RNF180 (ring finger protein 180)

Identity

Alias (NCBI)RINES
HGNC (Hugo) RNF180
LocusID (NCBI) 285671
Atlas_Id 52691
Location 5q12.3  [Link to chromosome band 5q12]
Location_base_pair Starts at 64165843 and ends at 64217786 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CASC2 () / RNF180 (5q12.3)CWC27 (5q12.3) / RNF180 (5q12.3)RNF180 (5q12.3) / AKAP13 (15q25.3)
RNF180 (5q12.3) / CASC2 ()

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(5;12)(q12;p13) ZNF384/RNF180
t(5;15)(q12;q25) RNF180/AKAP13


External links

 

Nomenclature
HGNC (Hugo)RNF180   27752
Cards
Entrez_Gene (NCBI)RNF180    ring finger protein 180
AliasesRINES
GeneCards (Weizmann)RNF180
Ensembl hg19 (Hinxton)ENSG00000164197 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164197 [Gene_View]  ENSG00000164197 [Sequence]  chr5:64165843-64217786 [Contig_View]  RNF180 [Vega]
ICGC DataPortalENSG00000164197
TCGA cBioPortalRNF180
AceView (NCBI)RNF180
Genatlas (Paris)RNF180
SOURCE (Princeton)RNF180
Genetics Home Reference (NIH)RNF180
Genomic and cartography
GoldenPath hg38 (UCSC)RNF180  -     chr5:64165843-64217786 +  5q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RNF180  -     5q12.3   [Description]    (hg19-Feb_2009)
GoldenPathRNF180 - 5q12.3 [CytoView hg19]  RNF180 - 5q12.3 [CytoView hg38]
ImmunoBaseENSG00000164197
Genome Data Viewer NCBIRNF180 [Mapview hg19]  
OMIM616015   
Gene and transcription
Genbank (Entrez)AK090756 AL832580 BC101277 BC101278 BC101279
RefSeq transcript (Entrez)NM_001113561 NM_001323291 NM_001323292 NM_178532
Consensus coding sequences : CCDS (NCBI)RNF180
Gene ExpressionRNF180 [ NCBI-GEO ]   RNF180 [ EBI - ARRAY_EXPRESS ]   RNF180 [ SEEK ]   RNF180 [ MEM ]
Gene Expression Viewer (FireBrowse)RNF180 [ Firebrowse - Broad ]
GenevisibleExpression of RNF180 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)285671
GTEX Portal (Tissue expression)RNF180
Human Protein AtlasENSG00000164197-RNF180 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86T96   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86T96  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86T96
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ86T96
Domaine pattern : Prosite (Expaxy)ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)RNF180    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)RING (SM00184)  
Conserved Domain (NCBI)RNF180
SuperfamilyQ86T96
AlphaFold pdb e-kbQ86T96   
Human Protein Atlas [tissue]ENSG00000164197-RNF180 [tissue]
HPRD15263
Protein Interaction databases
DIP (DOE-UCLA)Q86T96
IntAct (EBI)Q86T96
BioGRIDRNF180
STRING (EMBL)RNF180
ZODIACRNF180
Ontologies - Pathways
QuickGOQ86T96
Ontology : AmiGOprotein polyubiquitination  nuclear envelope  integral component of membrane  adult behavior  intrinsic component of endoplasmic reticulum membrane  positive regulation of protein ubiquitination  ubiquitin conjugating enzyme binding  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  norepinephrine metabolic process  serotonin metabolic process  metal ion binding  regulation of catalytic activity  ubiquitin protein ligase activity  
Ontology : EGO-EBIprotein polyubiquitination  nuclear envelope  integral component of membrane  adult behavior  intrinsic component of endoplasmic reticulum membrane  positive regulation of protein ubiquitination  ubiquitin conjugating enzyme binding  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  norepinephrine metabolic process  serotonin metabolic process  metal ion binding  regulation of catalytic activity  ubiquitin protein ligase activity  
NDEx NetworkRNF180
Atlas of Cancer Signalling NetworkRNF180
Wikipedia pathwaysRNF180
Orthology - Evolution
OrthoDB285671
GeneTree (enSembl)ENSG00000164197
Phylogenetic Trees/Animal Genes : TreeFamRNF180
Homologs : HomoloGeneRNF180
Homology/Alignments : Family Browser (UCSC)RNF180
Gene fusions - Rearrangements
Fusion : MitelmanCWC27/RNF180 [5q12.3/5q12.3]  
Fusion : QuiverRNF180
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRNF180 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNF180
dbVarRNF180
ClinVarRNF180
MonarchRNF180
1000_GenomesRNF180 
Exome Variant ServerRNF180
GNOMAD BrowserENSG00000164197
Varsome BrowserRNF180
ACMGRNF180 variants
VarityQ86T96
Genomic Variants (DGV)RNF180 [DGVbeta]
DECIPHERRNF180 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRNF180 
Mutations
ICGC Data PortalRNF180 
TCGA Data PortalRNF180 
Broad Tumor PortalRNF180
OASIS PortalRNF180 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRNF180  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRNF180
Mutations and Diseases : HGMDRNF180
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRNF180
DgiDB (Drug Gene Interaction Database)RNF180
DoCM (Curated mutations)RNF180
CIViC (Clinical Interpretations of Variants in Cancer)RNF180
Cancer3DRNF180
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616015   
Orphanet
DisGeNETRNF180
MedgenRNF180
Genetic Testing Registry RNF180
NextProtQ86T96 [Medical]
GENETestsRNF180
Target ValidationRNF180
Huge Navigator RNF180 [HugePedia]
ClinGenRNF180
Clinical trials, drugs, therapy
MyCancerGenomeRNF180
Protein Interactions : CTDRNF180
Pharm GKB GenePA134980027
PharosQ86T96
Clinical trialRNF180
Miscellaneous
canSAR (ICR)RNF180
HarmonizomeRNF180
DataMed IndexRNF180
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRNF180
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:29:14 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.