RNF20 (ring finger protein 20)

2007-04-01  

Identity

HGNC
LOCATION
9q31.1
LOCUSID
ALIAS
BRE1,BRE1A,hBRE1
FUSION GENES

Other Information

Locus ID:

NCBI: 56254
MIM: 607699
HGNC: 10062
Ensembl: ENSG00000155827

Variants:

dbSNP: 56254
ClinVar: 56254
TCGA: ENSG00000155827
COSMIC: RNF20

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000155827ENST00000374819C9JXC9
ENSG00000155827ENST00000389120Q5VTR2
ENSG00000155827ENST00000466817C9J0A5
ENSG00000155827ENST00000479306C9JWJ4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Protein ubiquitinationREACTOMER-HSA-8852135
E3 ubiquitin ligases ubiquitinate target proteinsREACTOMER-HSA-8866654

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
125355392003Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter.220
163079232005Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation.192
163079232005Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation.192
125355382003A conserved RING finger protein required for histone H2B monoubiquitination and cell size control.190
128762942003The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p.185
182995612008Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers.167
188320712008The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression.135
213625482011Regulation of homologous recombination by RNF20-dependent H2B ubiquitination.132
163375992005The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions.122
215963122011RNF20 inhibits TFIIS-facilitated transcriptional elongation to suppress pro-oncogenic gene expression.46

Citation

Dessen P

RNF20 (ring finger protein 20)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46758/rnf20