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RNF216 (ring finger protein 216)

Identity

Alias_symbol (synonym)TRIAD3
UBCE7IP1
ZIN
Other aliasCAHH
U7I1
HGNC (Hugo) RNF216
LocusID (NCBI) 54476
Atlas_Id 53038
Location 7p22.1  [Link to chromosome band 7p22]
Location_base_pair Starts at 5620041 and ends at 5781730 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FBXL18 (7p22.1) / RNF216 (7p22.1)FBXO38 (5q32) / RNF216 (7p22.1)GNL2 (1p34.3) / RNF216 (7p22.1)
MT1X (16q13) / RNF216 (7p22.1)MTHFD1L (6q25.1) / RNF216 (7p22.1)PLCL1 (2q33.1) / RNF216 (7p22.1)
RNF216 (7p22.1) / BABAM1 (19p13.11)RNF216 (7p22.1) / COL5A2 (2q32.2)RNF216 (7p22.1) / EIF2AK1 (7p22.1)
RNF216 (7p22.1) / JAZF1 (7p15.2)RNF216 (7p22.1) / MTHFD1L (6q25.1)RNF216 (7p22.1) / RNF216 (7p22.1)
RNF216 (7p22.1) / ST14 (11q24.3)TNRC18 (7p22.1) / RNF216 (7p22.1)FBXL18 7p22.1 / RNF216 7p22.1
MTHFD1L 6q25.1 / RNF216 7p22.1RNF216 7p22.1 / EIF2AK1 7p22.1RNF216 7p22.1 / JAZF1 7p15.2
RNF216 7p22.1 / MTHFD1L 6q25.1RNF216 7p22.1 / ST14 11q24.3TNRC18 7p22.1 / RNF216 7p22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RNF216   21698
Cards
Entrez_Gene (NCBI)RNF216  54476  ring finger protein 216
AliasesCAHH; TRIAD3; U7I1; UBCE7IP1; 
ZIN
GeneCards (Weizmann)RNF216
Ensembl hg19 (Hinxton)ENSG00000011275 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000011275 [Gene_View]  chr7:5620041-5781730 [Contig_View]  RNF216 [Vega]
ICGC DataPortalENSG00000011275
TCGA cBioPortalRNF216
AceView (NCBI)RNF216
Genatlas (Paris)RNF216
WikiGenes54476
SOURCE (Princeton)RNF216
Genetics Home Reference (NIH)RNF216
Genomic and cartography
GoldenPath hg38 (UCSC)RNF216  -     chr7:5620041-5781730 -  7p22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RNF216  -     7p22.1   [Description]    (hg19-Feb_2009)
EnsemblRNF216 - 7p22.1 [CytoView hg19]  RNF216 - 7p22.1 [CytoView hg38]
Mapping of homologs : NCBIRNF216 [Mapview hg19]  RNF216 [Mapview hg38]
OMIM212840   609948   
Gene and transcription
Genbank (Entrez)AF228527 AF513717 AF513718 AK000916 AK024787
RefSeq transcript (Entrez)NM_019011 NM_207111 NM_207116
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RNF216
Cluster EST : UnigeneHs.733601 [ NCBI ]
CGAP (NCI)Hs.733601
Alternative Splicing GalleryENSG00000011275
Gene ExpressionRNF216 [ NCBI-GEO ]   RNF216 [ EBI - ARRAY_EXPRESS ]   RNF216 [ SEEK ]   RNF216 [ MEM ]
Gene Expression Viewer (FireBrowse)RNF216 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54476
GTEX Portal (Tissue expression)RNF216
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NWF9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NWF9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NWF9
Splice isoforms : SwissVarQ9NWF9
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   
PhosPhoSitePlusQ9NWF9
Domains : Interpro (EBI)IBR_dom   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)IBR (SM00647)  
Conserved Domain (NCBI)RNF216
DMDM Disease mutations54476
Blocks (Seattle)RNF216
SuperfamilyQ9NWF9
Human Protein AtlasENSG00000011275
Peptide AtlasQ9NWF9
HPRD15550
IPIIPI00413022   IPI00375632   IPI00410033   IPI00979344   IPI00926713   IPI00927136   
Protein Interaction databases
DIP (DOE-UCLA)Q9NWF9
IntAct (EBI)Q9NWF9
FunCoupENSG00000011275
BioGRIDRNF216
STRING (EMBL)RNF216
ZODIACRNF216
Ontologies - Pathways
QuickGOQ9NWF9
Ontology : AmiGOprotein binding  nucleus  nucleoplasm  cytosol  cytosol  apoptotic process  viral process  negative regulation of type I interferon production  regulation of interferon-beta production  proteasome-mediated ubiquitin-dependent protein catabolic process  metal ion binding  regulation of defense response to virus by host  ubiquitin protein ligase activity  protein K48-linked ubiquitination  
Ontology : EGO-EBIprotein binding  nucleus  nucleoplasm  cytosol  cytosol  apoptotic process  viral process  negative regulation of type I interferon production  regulation of interferon-beta production  proteasome-mediated ubiquitin-dependent protein catabolic process  metal ion binding  regulation of defense response to virus by host  ubiquitin protein ligase activity  protein K48-linked ubiquitination  
NDEx NetworkRNF216
Atlas of Cancer Signalling NetworkRNF216
Wikipedia pathwaysRNF216
Orthology - Evolution
OrthoDB54476
GeneTree (enSembl)ENSG00000011275
Phylogenetic Trees/Animal Genes : TreeFamRNF216
HOVERGENQ9NWF9
HOGENOMQ9NWF9
Homologs : HomoloGeneRNF216
Homology/Alignments : Family Browser (UCSC)RNF216
Gene fusions - Rearrangements
Fusion : MitelmanMTHFD1L/RNF216 [6q25.1/7p22.1]  [t(6;7)(q25;p22)]  
Fusion : MitelmanRNF216/EIF2AK1 [7p22.1/7p22.1]  [t(7;7)(p22;p22)]  
Fusion : MitelmanRNF216/JAZF1 [7p22.1/7p15.2]  [t(7;7)(p15;p22)]  
Fusion : MitelmanRNF216/MTHFD1L [7p22.1/6q25.1]  [t(6;7)(q25;p22)]  
Fusion : MitelmanRNF216/ST14 [7p22.1/11q24.3]  [t(7;11)(p22;q24)]  
Fusion : MitelmanTNRC18/RNF216 [7p22.1/7p22.1]  [t(7;7)(p22;p22)]  
Fusion: TCGAMTHFD1L 6q25.1 RNF216 7p22.1 HNSC
Fusion: TCGARNF216 7p22.1 EIF2AK1 7p22.1 KIRC
Fusion: TCGARNF216 7p22.1 JAZF1 7p15.2 LUAD
Fusion: TCGARNF216 7p22.1 MTHFD1L 6q25.1 HNSC
Fusion: TCGARNF216 7p22.1 ST14 11q24.3 BRCA
Fusion: TCGATNRC18 7p22.1 RNF216 7p22.1 BRCA LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRNF216 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNF216
dbVarRNF216
ClinVarRNF216
1000_GenomesRNF216 
Exome Variant ServerRNF216
ExAC (Exome Aggregation Consortium)RNF216 (select the gene name)
Genetic variants : HAPMAP54476
Genomic Variants (DGV)RNF216 [DGVbeta]
DECIPHERRNF216 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRNF216 
Mutations
ICGC Data PortalRNF216 
TCGA Data PortalRNF216 
Broad Tumor PortalRNF216
OASIS PortalRNF216 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRNF216  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRNF216
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RNF216
DgiDB (Drug Gene Interaction Database)RNF216
DoCM (Curated mutations)RNF216 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RNF216 (select a term)
intoGenRNF216
Cancer3DRNF216(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM212840    609948   
Orphanet1437   
MedgenRNF216
Genetic Testing Registry RNF216
NextProtQ9NWF9 [Medical]
TSGene54476
GENETestsRNF216
Target ValidationRNF216
Huge Navigator RNF216 [HugePedia]
snp3D : Map Gene to Disease54476
BioCentury BCIQRNF216
ClinGenRNF216
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54476
Chemical/Pharm GKB GenePA162401829
Clinical trialRNF216
Miscellaneous
canSAR (ICR)RNF216 (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRNF216
EVEXRNF216
GoPubMedRNF216
iHOPRNF216
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:53:34 CEST 2017

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