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RNF216 (ring finger protein 216)

Identity

Alias (NCBI)CAHH
TRIAD3
U7I1
UBCE7IP1
ZIN
HGNC (Hugo) RNF216
HGNC Alias symbTRIAD3
UBCE7IP1
ZIN
LocusID (NCBI) 54476
Atlas_Id 53038
Location 7p22.1  [Link to chromosome band 7p22]
Location_base_pair Starts at 5620047 and ends at 5781663 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FBXL18 (7p22.1) / RNF216 (7p22.1)FBXO38 (5q32) / RNF216 (7p22.1)GNL2 (1p34.3) / RNF216 (7p22.1)
MT1X (16q13) / RNF216 (7p22.1)MTHFD1L (6q25.1) / RNF216 (7p22.1)PLCL1 (2q33.1) / RNF216 (7p22.1)
RNF216 (7p22.1) / BABAM1 (19p13.11)RNF216 (7p22.1) / COL5A2 (2q32.2)RNF216 (7p22.1) / EIF2AK1 (7p22.1)
RNF216 (7p22.1) / JAZF1 (7p15.2)RNF216 (7p22.1) / MTHFD1L (6q25.1)RNF216 (7p22.1) / RNF216 (7p22.1)
RNF216 (7p22.1) / ST14 (11q24.3)TNRC18 (7p22.1) / RNF216 (7p22.1)FBXL18 7p22.1 / RNF216 7p22.1
MTHFD1L 6q25.1 / RNF216 7p22.1RNF216 7p22.1 / EIF2AK1 7p22.1RNF216 7p22.1 / JAZF1 7p15.2
RNF216 7p22.1 / MTHFD1L 6q25.1RNF216 7p22.1 / ST14 11q24.3TNRC18 7p22.1 / RNF216 7p22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)RNF216   21698
Cards
Entrez_Gene (NCBI)RNF216    ring finger protein 216
AliasesCAHH; TRIAD3; U7I1; UBCE7IP1; 
ZIN
GeneCards (Weizmann)RNF216
Ensembl hg19 (Hinxton)ENSG00000011275 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000011275 [Gene_View]  ENSG00000011275 [Sequence]  chr7:5620047-5781663 [Contig_View]  RNF216 [Vega]
ICGC DataPortalENSG00000011275
TCGA cBioPortalRNF216
AceView (NCBI)RNF216
Genatlas (Paris)RNF216
SOURCE (Princeton)RNF216
Genetics Home Reference (NIH)RNF216
Genomic and cartography
GoldenPath hg38 (UCSC)RNF216  -     chr7:5620047-5781663 -  7p22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RNF216  -     7p22.1   [Description]    (hg19-Feb_2009)
GoldenPathRNF216 - 7p22.1 [CytoView hg19]  RNF216 - 7p22.1 [CytoView hg38]
ImmunoBaseENSG00000011275
Genome Data Viewer NCBIRNF216 [Mapview hg19]  
OMIM212840   609948   
Gene and transcription
Genbank (Entrez)AF228527 AF513717 AF513718 AK000916 AK024787
RefSeq transcript (Entrez)NM_001377156 NM_019011 NM_207111 NM_207116
Consensus coding sequences : CCDS (NCBI)RNF216
Gene ExpressionRNF216 [ NCBI-GEO ]   RNF216 [ EBI - ARRAY_EXPRESS ]   RNF216 [ SEEK ]   RNF216 [ MEM ]
Gene Expression Viewer (FireBrowse)RNF216 [ Firebrowse - Broad ]
GenevisibleExpression of RNF216 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54476
GTEX Portal (Tissue expression)RNF216
Human Protein AtlasENSG00000011275-RNF216 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NWF9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NWF9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NWF9
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9NWF9
Domaine pattern : Prosite (Expaxy)TRIAD (PS51873)   
Domains : Interpro (EBI)IBR_dom    TRIAD_supradom    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)IBR (SM00647)  
Conserved Domain (NCBI)RNF216
SuperfamilyQ9NWF9
AlphaFold pdb e-kbQ9NWF9   
Human Protein Atlas [tissue]ENSG00000011275-RNF216 [tissue]
HPRD15550
Protein Interaction databases
DIP (DOE-UCLA)Q9NWF9
IntAct (EBI)Q9NWF9
BioGRIDRNF216
STRING (EMBL)RNF216
ZODIACRNF216
Ontologies - Pathways
QuickGOQ9NWF9
Ontology : AmiGOprotein binding  nucleus  nucleoplasm  cytosol  cytosol  apoptotic process  negative regulation of type I interferon production  regulation of interferon-beta production  proteasome-mediated ubiquitin-dependent protein catabolic process  metal ion binding  regulation of defense response to virus by host  ubiquitin protein ligase activity  protein K48-linked ubiquitination  Schaffer collateral - CA1 synapse  postsynaptic endocytic zone  glutamatergic synapse  protein catabolic process, modulating synaptic transmission  
Ontology : EGO-EBIprotein binding  nucleus  nucleoplasm  cytosol  cytosol  apoptotic process  negative regulation of type I interferon production  regulation of interferon-beta production  proteasome-mediated ubiquitin-dependent protein catabolic process  metal ion binding  regulation of defense response to virus by host  ubiquitin protein ligase activity  protein K48-linked ubiquitination  Schaffer collateral - CA1 synapse  postsynaptic endocytic zone  glutamatergic synapse  protein catabolic process, modulating synaptic transmission  
NDEx NetworkRNF216
Atlas of Cancer Signalling NetworkRNF216
Wikipedia pathwaysRNF216
Orthology - Evolution
OrthoDB54476
GeneTree (enSembl)ENSG00000011275
Phylogenetic Trees/Animal Genes : TreeFamRNF216
Homologs : HomoloGeneRNF216
Homology/Alignments : Family Browser (UCSC)RNF216
Gene fusions - Rearrangements
Fusion : MitelmanMTHFD1L/RNF216 [6q25.1/7p22.1]  
Fusion : MitelmanRNF216/EIF2AK1 [7p22.1/7p22.1]  
Fusion : MitelmanRNF216/JAZF1 [7p22.1/7p15.2]  
Fusion : MitelmanRNF216/MTHFD1L [7p22.1/6q25.1]  
Fusion : MitelmanRNF216/ST14 [7p22.1/11q24.3]  
Fusion : MitelmanTNRC18/RNF216 [7p22.1/7p22.1]  
Fusion : QuiverRNF216
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRNF216 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNF216
dbVarRNF216
ClinVarRNF216
MonarchRNF216
1000_GenomesRNF216 
Exome Variant ServerRNF216
GNOMAD BrowserENSG00000011275
Varsome BrowserRNF216
ACMGRNF216 variants
VarityQ9NWF9
Genomic Variants (DGV)RNF216 [DGVbeta]
DECIPHERRNF216 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRNF216 
Mutations
ICGC Data PortalRNF216 
TCGA Data PortalRNF216 
Broad Tumor PortalRNF216
OASIS PortalRNF216 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRNF216  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRNF216
Mutations and Diseases : HGMDRNF216
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRNF216
DgiDB (Drug Gene Interaction Database)RNF216
DoCM (Curated mutations)RNF216
CIViC (Clinical Interpretations of Variants in Cancer)RNF216
Cancer3DRNF216
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM212840    609948   
Orphanet1437   
DisGeNETRNF216
MedgenRNF216
Genetic Testing Registry RNF216
NextProtQ9NWF9 [Medical]
GENETestsRNF216
Target ValidationRNF216
Huge Navigator RNF216 [HugePedia]
ClinGenRNF216
Clinical trials, drugs, therapy
MyCancerGenomeRNF216
Protein Interactions : CTDRNF216
Pharm GKB GenePA162401829
PharosQ9NWF9
Clinical trialRNF216
Miscellaneous
canSAR (ICR)RNF216
HarmonizomeRNF216
DataMed IndexRNF216
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRNF216
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:29:16 CEST 2021

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