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RNF217 (ring finger protein 217)

Identity

Alias_namesC6orf172
IBRDC1
chromosome 6 open reading frame 172
IBR domain containing 1
Alias_symbol (synonym)MGC26996
dJ84N20.1
Other aliasOSTL
HGNC (Hugo) RNF217
LocusID (NCBI) 154214
Atlas_Id 55518
Location 6q22.31  [Link to chromosome band 6q22]
Location_base_pair Starts at 124983364 and ends at 125092634 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ETV6 (12p13.2) / RNF217 (6q22.31)NKAIN2 (6q22.31) / RNF217 (6q22.31)RNF217 (6q22.31) / MRPS27 (5q13.2)
RNF217 (6q22.31) / PRDM1 (6q21)TRMT11 (6q22.32) / RNF217 (6q22.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;12)(q22;p13) ETV6/RNF217


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(6;6)(q21;q22) RNF217/PRDM1
TRMT11/RNF217 (6q22)


External links

Nomenclature
HGNC (Hugo)RNF217   21487
Cards
Entrez_Gene (NCBI)RNF217  154214  ring finger protein 217
AliasesC6orf172; IBRDC1; OSTL; dJ84N20.1
GeneCards (Weizmann)RNF217
Ensembl hg19 (Hinxton)ENSG00000146373 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146373 [Gene_View]  ENSG00000146373 [Sequence]  chr6:124983364-125092634 [Contig_View]  RNF217 [Vega]
ICGC DataPortalENSG00000146373
TCGA cBioPortalRNF217
AceView (NCBI)RNF217
Genatlas (Paris)RNF217
WikiGenes154214
SOURCE (Princeton)RNF217
Genetics Home Reference (NIH)RNF217
Genomic and cartography
GoldenPath hg38 (UCSC)RNF217  -     chr6:124983364-125092634 +  6q22.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RNF217  -     6q22.31   [Description]    (hg19-Feb_2009)
EnsemblRNF217 - 6q22.31 [CytoView hg19]  RNF217 - 6q22.31 [CytoView hg38]
Mapping of homologs : NCBIRNF217 [Mapview hg19]  RNF217 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AA782081 AK023584 AK057943 AK093417 AK122811
RefSeq transcript (Entrez)NM_001286398 NM_152553
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RNF217
Cluster EST : UnigeneHs.661833 [ NCBI ]
CGAP (NCI)Hs.661833
Alternative Splicing GalleryENSG00000146373
Gene ExpressionRNF217 [ NCBI-GEO ]   RNF217 [ EBI - ARRAY_EXPRESS ]   RNF217 [ SEEK ]   RNF217 [ MEM ]
Gene Expression Viewer (FireBrowse)RNF217 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)154214
GTEX Portal (Tissue expression)RNF217
Human Protein AtlasENSG00000146373-RNF217 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TC41   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TC41  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TC41
Splice isoforms : SwissVarQ8TC41
PhosPhoSitePlusQ8TC41
Domains : Interpro (EBI)E3_UB_ligase_RBR    IBR_dom    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)IBR (PF01485)   
Domain families : Pfam (NCBI)pfam01485   
Domain families : Smart (EMBL)IBR (SM00647)  
Conserved Domain (NCBI)RNF217
DMDM Disease mutations154214
Blocks (Seattle)RNF217
SuperfamilyQ8TC41
Human Protein Atlas [tissue]ENSG00000146373-RNF217 [tissue]
Peptide AtlasQ8TC41
HPRD17125
IPIIPI00152264   IPI00972968   IPI00032639   IPI00980433   IPI00985467   
Protein Interaction databases
DIP (DOE-UCLA)Q8TC41
IntAct (EBI)Q8TC41
FunCoupENSG00000146373
BioGRIDRNF217
STRING (EMBL)RNF217
ZODIACRNF217
Ontologies - Pathways
QuickGOQ8TC41
Ontology : AmiGOubiquitin ligase complex  protein polyubiquitination  protein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  cytoplasm  cytosol  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  integral component of membrane  ubiquitin conjugating enzyme binding  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  metal ion binding  ubiquitin protein ligase activity  
Ontology : EGO-EBIubiquitin ligase complex  protein polyubiquitination  protein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  cytoplasm  cytosol  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  integral component of membrane  ubiquitin conjugating enzyme binding  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  metal ion binding  ubiquitin protein ligase activity  
NDEx NetworkRNF217
Atlas of Cancer Signalling NetworkRNF217
Wikipedia pathwaysRNF217
Orthology - Evolution
OrthoDB154214
GeneTree (enSembl)ENSG00000146373
Phylogenetic Trees/Animal Genes : TreeFamRNF217
HOVERGENQ8TC41
HOGENOMQ8TC41
Homologs : HomoloGeneRNF217
Homology/Alignments : Family Browser (UCSC)RNF217
Gene fusions - Rearrangements
Fusion : QuiverRNF217
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRNF217 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNF217
dbVarRNF217
ClinVarRNF217
1000_GenomesRNF217 
Exome Variant ServerRNF217
ExAC (Exome Aggregation Consortium)ENSG00000146373
GNOMAD BrowserENSG00000146373
Varsome BrowserRNF217
Genetic variants : HAPMAP154214
Genomic Variants (DGV)RNF217 [DGVbeta]
DECIPHERRNF217 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRNF217 
Mutations
ICGC Data PortalRNF217 
TCGA Data PortalRNF217 
Broad Tumor PortalRNF217
OASIS PortalRNF217 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRNF217  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRNF217
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RNF217
DgiDB (Drug Gene Interaction Database)RNF217
DoCM (Curated mutations)RNF217 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RNF217 (select a term)
intoGenRNF217
Cancer3DRNF217(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETRNF217
MedgenRNF217
Genetic Testing Registry RNF217
NextProtQ8TC41 [Medical]
TSGene154214
GENETestsRNF217
Target ValidationRNF217
Huge Navigator RNF217 [HugePedia]
snp3D : Map Gene to Disease154214
BioCentury BCIQRNF217
ClinGenRNF217
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD154214
Chemical/Pharm GKB GenePA162401868
Clinical trialRNF217
Miscellaneous
canSAR (ICR)RNF217 (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRNF217
EVEXRNF217
GoPubMedRNF217
iHOPRNF217
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:36:03 CET 2018

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