Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

RNF4 (ring finger protein 4)

Identity

Alias_symbol (synonym)RES4-26
SNURF
SLX5
Other alias
HGNC (Hugo) RNF4
LocusID (NCBI) 6047
Atlas_Id 42137
Location 4p16.3  [Link to chromosome band 4p16]
Location_base_pair Starts at 2471180 and ends at 2517586 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
RNF4 (4p16.3) / DCTD (4q35.1)STK24 (13q32.2) / RNF4 (4p16.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RNF4   10067
Cards
Entrez_Gene (NCBI)RNF4  6047  ring finger protein 4
AliasesRES4-26; SLX5; SNURF
GeneCards (Weizmann)RNF4
Ensembl hg19 (Hinxton)ENSG00000063978 [Gene_View]  chr4:2471180-2517586 [Contig_View]  RNF4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000063978 [Gene_View]  chr4:2471180-2517586 [Contig_View]  RNF4 [Vega]
ICGC DataPortalENSG00000063978
TCGA cBioPortalRNF4
AceView (NCBI)RNF4
Genatlas (Paris)RNF4
WikiGenes6047
SOURCE (Princeton)RNF4
Genetics Home Reference (NIH)RNF4
Genomic and cartography
GoldenPath hg19 (UCSC)RNF4  -     chr4:2471180-2517586 +  4p16.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RNF4  -     4p16.3   [Description]    (hg38-Dec_2013)
EnsemblRNF4 - 4p16.3 [CytoView hg19]  RNF4 - 4p16.3 [CytoView hg38]
Mapping of homologs : NCBIRNF4 [Mapview hg19]  RNF4 [Mapview hg38]
OMIM602850   
Gene and transcription
Genbank (Entrez)AB000468 AK128038 AK307372 AK309509 AK311314
RefSeq transcript (Entrez)NM_001185009 NM_001185010 NM_002938
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_006051 NW_004929314
Consensus coding sequences : CCDS (NCBI)RNF4
Cluster EST : UnigeneHs.66394 [ NCBI ]
CGAP (NCI)Hs.66394
Alternative Splicing GalleryENSG00000063978
Gene ExpressionRNF4 [ NCBI-GEO ]   RNF4 [ EBI - ARRAY_EXPRESS ]   RNF4 [ SEEK ]   RNF4 [ MEM ]
Gene Expression Viewer (FireBrowse)RNF4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6047
GTEX Portal (Tissue expression)RNF4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78317   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP78317  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP78317
Splice isoforms : SwissVarP78317
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
PhosPhoSitePlusP78317
Domaine pattern : Prosite (Expaxy)ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)zf-RING_2 (PF13639)   
Domain families : Pfam (NCBI)pfam13639   
Domain families : Smart (EMBL)RING (SM00184)  
Conserved Domain (NCBI)RNF4
DMDM Disease mutations6047
Blocks (Seattle)RNF4
PDB (SRS)2EA6    2XEU    4PPE   
PDB (PDBSum)2EA6    2XEU    4PPE   
PDB (IMB)2EA6    2XEU    4PPE   
PDB (RSDB)2EA6    2XEU    4PPE   
Structural Biology KnowledgeBase2EA6    2XEU    4PPE   
SCOP (Structural Classification of Proteins)2EA6    2XEU    4PPE   
CATH (Classification of proteins structures)2EA6    2XEU    4PPE   
SuperfamilyP78317
Human Protein AtlasENSG00000063978
Peptide AtlasP78317
HPRD04167
IPIIPI00297694   IPI00965645   IPI01012670   IPI00968079   IPI00965666   IPI00967026   IPI00966161   IPI00966685   IPI00966103   IPI00967571   IPI00967218   IPI00965860   
Protein Interaction databases
DIP (DOE-UCLA)P78317
IntAct (EBI)P78317
FunCoupENSG00000063978
BioGRIDRNF4
STRING (EMBL)RNF4
ZODIACRNF4
Ontologies - Pathways
QuickGOP78317
Ontology : AmiGODNA binding  transcription factor activity, sequence-specific DNA binding  transcription coactivator activity  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  cytoplasm  transcription, DNA-templated  transcription factor binding  zinc ion binding  protein ubiquitination  PML body  ligase activity  androgen receptor signaling pathway  nucleosome binding  SUMO polymer binding  SUMO polymer binding  negative regulation of protein sumoylation  SUMO-targeted ubiquitin ligase complex  identical protein binding  proteasome-mediated ubiquitin-dependent protein catabolic process  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  response to arsenic-containing substance  androgen receptor binding  protein autoubiquitination  ubiquitin protein ligase activity  ubiquitin protein ligase activity  protein K63-linked ubiquitination  protein K48-linked ubiquitination  protein K11-linked ubiquitination  protein K6-linked ubiquitination  regulation of spindle assembly  regulation of kinetochore assembly  
Ontology : EGO-EBIDNA binding  transcription factor activity, sequence-specific DNA binding  transcription coactivator activity  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  cytoplasm  transcription, DNA-templated  transcription factor binding  zinc ion binding  protein ubiquitination  PML body  ligase activity  androgen receptor signaling pathway  nucleosome binding  SUMO polymer binding  SUMO polymer binding  negative regulation of protein sumoylation  SUMO-targeted ubiquitin ligase complex  identical protein binding  proteasome-mediated ubiquitin-dependent protein catabolic process  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  response to arsenic-containing substance  androgen receptor binding  protein autoubiquitination  ubiquitin protein ligase activity  ubiquitin protein ligase activity  protein K63-linked ubiquitination  protein K48-linked ubiquitination  protein K11-linked ubiquitination  protein K6-linked ubiquitination  regulation of spindle assembly  regulation of kinetochore assembly  
NDEx NetworkRNF4
Atlas of Cancer Signalling NetworkRNF4
Wikipedia pathwaysRNF4
Orthology - Evolution
OrthoDB6047
GeneTree (enSembl)ENSG00000063978
Phylogenetic Trees/Animal Genes : TreeFamRNF4
HOVERGENP78317
HOGENOMP78317
Homologs : HomoloGeneRNF4
Homology/Alignments : Family Browser (UCSC)RNF4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRNF4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNF4
dbVarRNF4
ClinVarRNF4
1000_GenomesRNF4 
Exome Variant ServerRNF4
ExAC (Exome Aggregation Consortium)RNF4 (select the gene name)
Genetic variants : HAPMAP6047
Genomic Variants (DGV)RNF4 [DGVbeta]
DECIPHER (Syndromes)4:2471180-2517586  ENSG00000063978
CONAN: Copy Number AnalysisRNF4 
Mutations
ICGC Data PortalRNF4 
TCGA Data PortalRNF4 
Broad Tumor PortalRNF4
OASIS PortalRNF4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRNF4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRNF4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RNF4
DgiDB (Drug Gene Interaction Database)RNF4
DoCM (Curated mutations)RNF4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RNF4 (select a term)
intoGenRNF4
Cancer3DRNF4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602850   
Orphanet
MedgenRNF4
Genetic Testing Registry RNF4
NextProtP78317 [Medical]
TSGene6047
GENETestsRNF4
Huge Navigator RNF4 [HugePedia]
snp3D : Map Gene to Disease6047
BioCentury BCIQRNF4
ClinGenRNF4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6047
Chemical/Pharm GKB GenePA34439
Clinical trialRNF4
Miscellaneous
canSAR (ICR)RNF4 (select the gene name)
Probes
Litterature
PubMed67 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRNF4
EVEXRNF4
GoPubMedRNF4
iHOPRNF4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:25:25 CET 2017

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.