RNF40 (ring finger protein 40)

2003-10-01  

Identity

HGNC
LOCATION
16p11.2
LOCUSID
ALIAS
BRE1B,RBP95,STARING
FUSION GENES

Other Information

Locus ID:

NCBI: 9810
MIM: 607700
HGNC: 16867
Ensembl: ENSG00000103549

Variants:

dbSNP: 9810
ClinVar: 9810
TCGA: ENSG00000103549
COSMIC: RNF40

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103549ENST00000324685O75150
ENSG00000103549ENST00000357890O75150
ENSG00000103549ENST00000563683H3BP71
ENSG00000103549ENST00000563909H3BQ99
ENSG00000103549ENST00000565931I3L332
ENSG00000103549ENST00000565995H3BS50
ENSG00000103549ENST00000566811H3BUL6
ENSG00000103549ENST00000567365A0A087WTK2
ENSG00000103549ENST00000602784R4GN66

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Protein ubiquitinationREACTOMER-HSA-8852135
E3 ubiquitin ligases ubiquitinate target proteinsREACTOMER-HSA-8866654

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
163079232005Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation.192
121219822002Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation.46
223547492012Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability.43
218277562011RNF20-RNF40: A ubiquitin-driven link between gene expression and the DNA damage response.31
220310192011The H2B ubiquitin ligase RNF40 cooperates with SUPT16H to induce dynamic changes in chromatin structure during DNA double-strand break repair.28
207381732010Deficiency in Bre1 impairs homologous recombination repair and cell cycle checkpoint response to radiation damage in mammalian cells.22
221555692012Histone H2B ubiquitin ligases RNF20 and RNF40 in androgen signaling and prostate cancer cell growth.17
275576282016Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5.13
277981112016The RING finger domain E3 ubiquitin ligases BRCA1 and the RNF20/RNF40 complex in global loss of the chromatin mark histone H2B monoubiquitination (H2Bub1) in cell line models and primary high-grade serous ovarian cancer.7
303213252019Loss of RNF40 Decreases NF-κB Activity in Colorectal Cancer Cells and Reduces Colitis Burden in Mice.6

Citation

Dessen P

RNF40 (ring finger protein 40)

Atlas Genet Cytogenet Oncol Haematol. 2003-10-01

Online version: http://atlasgeneticsoncology.org/gene/42138/rnf40