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RNF41 (ring finger protein 41)

Identity

Alias (NCBI)FLRF
NRDP1
SBBI03
HGNC (Hugo) RNF41
HGNC Alias symbSBBI03
NRDP1
HGNC Previous namering finger protein 41, E3 ubiquitin protein ligase
LocusID (NCBI) 10193
Atlas_Id 47099
Location 12q13.3  [Link to chromosome band 12q13]
Location_base_pair Starts at 56202504 and ends at 56221969 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RNF41 (12q13.2)::CS (12q13.3)RNF41 (12q13.2)::LARP4 (12q13.12)RNF41 (12q13.2)::MYO1C (17p13.3)
RNF41 (12q13.2)::PRIM1 (12q13.3)RNF41 12q13.2::MYO1C 17p13.3RNF41 12q13.2::PRIM1 12q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)RNF41   18401
Cards
Entrez_Gene (NCBI)RNF41    ring finger protein 41
AliasesFLRF; NRDP1; SBBI03
GeneCards (Weizmann)RNF41
Ensembl hg19 (Hinxton)ENSG00000181852 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000181852 [Gene_View]  ENSG00000181852 [Sequence]  chr12:56202504-56221969 [Contig_View]  RNF41 [Vega]
ICGC DataPortalENSG00000181852
TCGA cBioPortalRNF41
AceView (NCBI)RNF41
Genatlas (Paris)RNF41
SOURCE (Princeton)RNF41
Genetics Home Reference (NIH)RNF41
Genomic and cartography
GoldenPath hg38 (UCSC)RNF41  -     chr12:56202504-56221969 -  12q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RNF41  -     12q13.3   [Description]    (hg19-Feb_2009)
GoldenPathRNF41 - 12q13.3 [CytoView hg19]  RNF41 - 12q13.3 [CytoView hg38]
ImmunoBaseENSG00000181852
Genome Data Viewer NCBIRNF41 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AF077599 AK300752 AK304576 AK314811 AL080105
RefSeq transcript (Entrez)NM_001242826 NM_005785 NM_194358 NM_194359
Consensus coding sequences : CCDS (NCBI)RNF41
Gene ExpressionRNF41 [ NCBI-GEO ]   RNF41 [ EBI - ARRAY_EXPRESS ]   RNF41 [ SEEK ]   RNF41 [ MEM ]
Gene Expression Viewer (FireBrowse)RNF41 [ Firebrowse - Broad ]
GenevisibleExpression of RNF41 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10193
GTEX Portal (Tissue expression)RNF41
Human Protein AtlasENSG00000181852-RNF41 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H4P4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H4P4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H4P4
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9H4P4
Domaine pattern : Prosite (Expaxy)ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)    ZF_SIAH (PS51081)   
Domains : Interpro (EBI)NRDP1    NRDP1_C    TRAF-like    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS    Znf_SIAH   
Domain families : Pfam (Sanger)USP8_interact (PF08941)   
Domain families : Pfam (NCBI)pfam08941   
Domain families : Smart (EMBL)RING (SM00184)  
Conserved Domain (NCBI)RNF41
PDB (RSDB)2FZP    2GWF   
PDB Europe2FZP    2GWF   
PDB (PDBSum)2FZP    2GWF   
PDB (IMB)2FZP    2GWF   
Structural Biology KnowledgeBase2FZP    2GWF   
SCOP (Structural Classification of Proteins)2FZP    2GWF   
CATH (Classification of proteins structures)2FZP    2GWF   
SuperfamilyQ9H4P4
AlphaFold pdb e-kbQ9H4P4   
Human Protein Atlas [tissue]ENSG00000181852-RNF41 [tissue]
HPRD11520
Protein Interaction databases
DIP (DOE-UCLA)Q9H4P4
IntAct (EBI)Q9H4P4
BioGRIDRNF41
STRING (EMBL)RNF41
ZODIACRNF41
Ontologies - Pathways
QuickGOQ9H4P4
Ontology : AmiGOprotein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  erythropoietin receptor binding  interleukin-3 receptor binding  protein binding  cytosol  autophagy  zinc ion binding  negative regulation of cell population proliferation  proteasomal protein catabolic process  protein ubiquitination  protein domain specific binding  negative regulation of cell migration  receptor tyrosine kinase binding  small GTPase binding  identical protein binding  regulation of MAPK cascade  regulation of lymphocyte differentiation  regulation of myeloid cell differentiation  positive regulation of protein catabolic process  perinuclear region of cytoplasm  protein autoubiquitination  regulation of protein kinase B signaling  ubiquitin protein ligase activity  ubiquitin protein ligase activity  endoplasmic reticulum tubular network  endoplasmic reticulum tubular network  extrinsic apoptotic signaling pathway  negative regulation of mitophagy  regulation of reactive oxygen species metabolic process  positive regulation of reactive oxygen species metabolic process  
Ontology : EGO-EBIprotein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  erythropoietin receptor binding  interleukin-3 receptor binding  protein binding  cytosol  autophagy  zinc ion binding  negative regulation of cell population proliferation  proteasomal protein catabolic process  protein ubiquitination  protein domain specific binding  negative regulation of cell migration  receptor tyrosine kinase binding  small GTPase binding  identical protein binding  regulation of MAPK cascade  regulation of lymphocyte differentiation  regulation of myeloid cell differentiation  positive regulation of protein catabolic process  perinuclear region of cytoplasm  protein autoubiquitination  regulation of protein kinase B signaling  ubiquitin protein ligase activity  ubiquitin protein ligase activity  endoplasmic reticulum tubular network  endoplasmic reticulum tubular network  extrinsic apoptotic signaling pathway  negative regulation of mitophagy  regulation of reactive oxygen species metabolic process  positive regulation of reactive oxygen species metabolic process  
Pathways : KEGGKEGG_ENDOCYTOSIS   
NDEx NetworkRNF41
Atlas of Cancer Signalling NetworkRNF41
Wikipedia pathwaysRNF41
Orthology - Evolution
OrthoDB10193
GeneTree (enSembl)ENSG00000181852
Phylogenetic Trees/Animal Genes : TreeFamRNF41
Homologs : HomoloGeneRNF41
Homology/Alignments : Family Browser (UCSC)RNF41
Gene fusions - Rearrangements
Fusion : MitelmanRNF41::MYO1C [12q13.2/17p13.3]  
Fusion : MitelmanRNF41::PRIM1 [12q13.2/12q13.3]  
Fusion : QuiverRNF41
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRNF41 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNF41
dbVarRNF41
ClinVarRNF41
MonarchRNF41
1000_GenomesRNF41 
Exome Variant ServerRNF41
GNOMAD BrowserENSG00000181852
Varsome BrowserRNF41
ACMGRNF41 variants
VarityQ9H4P4
Genomic Variants (DGV)RNF41 [DGVbeta]
DECIPHERRNF41 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRNF41 
Mutations
ICGC Data PortalRNF41 
TCGA Data PortalRNF41 
Broad Tumor PortalRNF41
OASIS PortalRNF41 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRNF41  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRNF41
Mutations and Diseases : HGMDRNF41
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRNF41
DgiDB (Drug Gene Interaction Database)RNF41
DoCM (Curated mutations)RNF41
CIViC (Clinical Interpretations of Variants in Cancer)RNF41
Cancer3DRNF41
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETRNF41
MedgenRNF41
Genetic Testing Registry RNF41
NextProtQ9H4P4 [Medical]
GENETestsRNF41
Target ValidationRNF41
Huge Navigator RNF41 [HugePedia]
ClinGenRNF41
Clinical trials, drugs, therapy
MyCancerGenomeRNF41
Protein Interactions : CTDRNF41
Pharm GKB GenePA134875033
PharosQ9H4P4
Clinical trialRNF41
Miscellaneous
canSAR (ICR)RNF41
HarmonizomeRNF41
ARCHS4RNF41
DataMed IndexRNF41
Probes
Litterature
PubMed83 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRNF41
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:56:33 CET 2022

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