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RNF43 (ring finger protein 43)

Identity

Other namesRNF124
URCC
HGNC (Hugo) RNF43
LocusID (NCBI) 54894
Atlas_Id 40600
Location 17q22
Location_base_pair Starts at 56429861 and ends at 56494943 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CDK5RAP3 (17q21.32) / RNF43 (17q22)RNF43 (17q22) / HSF5 (17q22)RNF43 (17q22) / LRPPRC (2p21)
RNF43 (17q22) / STAG1 (3q22.3)CDK5RAP3 17q21.32 / RNF43 17q22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RNF43   18505
Cards
Entrez_Gene (NCBI)RNF43  54894  ring finger protein 43
GeneCards (Weizmann)RNF43
Ensembl hg19 (Hinxton)ENSG00000108375 [Gene_View]  chr17:56429861-56494943 [Contig_View]  RNF43 [Vega]
Ensembl hg38 (Hinxton)ENSG00000108375 [Gene_View]  chr17:56429861-56494943 [Contig_View]  RNF43 [Vega]
ICGC DataPortalENSG00000108375
TCGA cBioPortalRNF43
AceView (NCBI)RNF43
Genatlas (Paris)RNF43
WikiGenes54894
SOURCE (Princeton)RNF43
Genomic and cartography
GoldenPath hg19 (UCSC)RNF43  -     chr17:56429861-56494943 -  17q22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RNF43  -     17q22   [Description]    (hg38-Dec_2013)
EnsemblRNF43 - 17q22 [CytoView hg19]  RNF43 - 17q22 [CytoView hg38]
Mapping of homologs : NCBIRNF43 [Mapview hg19]  RNF43 [Mapview hg38]
OMIM612482   
Gene and transcription
Genbank (Entrez)AB081837 AK000322 AK291027 AK296769 AK298789
RefSeq transcript (Entrez)NM_001305544 NM_001305545 NM_017763
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_042894 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)RNF43
Cluster EST : UnigeneHs.584916 [ NCBI ]
CGAP (NCI)Hs.584916
Alternative Splicing : Fast-db (Paris)GSHG0013604
Alternative Splicing GalleryENSG00000108375
Gene ExpressionRNF43 [ NCBI-GEO ]   RNF43 [ EBI - ARRAY_EXPRESS ]   RNF43 [ SEEK ]   RNF43 [ MEM ]
Gene Expression Viewer (FireBrowse)RNF43 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)54894
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ68DV7 (Uniprot)
NextProtQ68DV7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ68DV7
Splice isoforms : SwissVarQ68DV7 (Swissvar)
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
PhosPhoSitePlusQ68DV7
Domaine pattern : Prosite (Expaxy)ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)Znf_RING    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)zf-RING_2 (PF13639)   
Domain families : Pfam (NCBI)pfam13639   
Domain families : Smart (EMBL)RING (SM00184)  
DMDM Disease mutations54894
Blocks (Seattle)RNF43
PDB (SRS)4KNG   
PDB (PDBSum)4KNG   
PDB (IMB)4KNG   
PDB (RSDB)4KNG   
Structural Biology KnowledgeBase4KNG   
SCOP (Structural Classification of Proteins)4KNG   
CATH (Classification of proteins structures)4KNG   
SuperfamilyQ68DV7
Human Protein AtlasENSG00000108375
Peptide AtlasQ68DV7
HPRD07896
IPIIPI00744070   IPI00930434   IPI00930238   IPI00930185   
Protein Interaction databases
DIP (DOE-UCLA)Q68DV7
IntAct (EBI)Q68DV7
FunCoupENSG00000108375
BioGRIDRNF43
STRING (EMBL)RNF43
ZODIACRNF43
Ontologies - Pathways
QuickGOQ68DV7
Ontology : AmiGOubiquitin-protein transferase activity  frizzled binding  protein binding  nuclear envelope  endoplasmic reticulum membrane  plasma membrane  integral component of plasma membrane  zinc ion binding  Wnt signaling pathway  protein ubiquitination  ligase activity  negative regulation of Wnt signaling pathway  Wnt receptor catabolic process  Wnt receptor catabolic process  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  ubiquitin protein ligase activity  stem cell proliferation  
Ontology : EGO-EBIubiquitin-protein transferase activity  frizzled binding  protein binding  nuclear envelope  endoplasmic reticulum membrane  plasma membrane  integral component of plasma membrane  zinc ion binding  Wnt signaling pathway  protein ubiquitination  ligase activity  negative regulation of Wnt signaling pathway  Wnt receptor catabolic process  Wnt receptor catabolic process  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  ubiquitin protein ligase activity  stem cell proliferation  
NDEx Network
Atlas of Cancer Signalling NetworkRNF43
Wikipedia pathwaysRNF43
Orthology - Evolution
OrthoDB54894
GeneTree (enSembl)ENSG00000108375
Phylogenetic Trees/Animal Genes : TreeFamRNF43
Homologs : HomoloGeneRNF43
Homology/Alignments : Family Browser (UCSC)RNF43
Gene fusions - Rearrangements
Fusion: TCGACDK5RAP3 17q21.32 RNF43 17q22 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerRNF43 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNF43
dbVarRNF43
ClinVarRNF43
1000_GenomesRNF43 
Exome Variant ServerRNF43
ExAC (Exome Aggregation Consortium)RNF43 (select the gene name)
SNP (GeneSNP Utah)RNF43
SNP : HGBaseRNF43
Genetic variants : HAPMAPRNF43
Genomic Variants (DGV)RNF43 [DGVbeta]
Mutations
ICGC Data PortalRNF43 
TCGA Data PortalRNF43 
Broad Tumor PortalRNF43
OASIS PortalRNF43 [ Somatic mutations - Copy number]
Cancer Gene: CensusRNF43 
Somatic Mutations in Cancer : COSMICRNF43 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RNF43
DgiDB (Drug Gene Interaction Database)RNF43
DoCM (Curated mutations)RNF43 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RNF43 (select a term)
intoGenRNF43
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)17:56429861-56494943
CONAN: Copy Number AnalysisRNF43 
Mutations and Diseases : HGMDRNF43
OMIM612482   
MedgenRNF43
Genetic Testing Registry RNF43
NextProtQ68DV7 [Medical]
TSGene54894
GENETestsRNF43
Huge Navigator RNF43 [HugePedia]  RNF43 [HugeCancerGEM]
snp3D : Map Gene to Disease54894
BioCentury BCIQRNF43
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54894
Chemical/Pharm GKB GenePA34441
Clinical trialRNF43
Miscellaneous
canSAR (ICR)RNF43 (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRNF43
GoPubMedRNF43
iHOPRNF43
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Apr 16 18:02:31 CEST 2016

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