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RNF8 (ring finger protein 8)

Identity

Alias_namesring finger protein (C3HC4 type) 8
ring finger protein 8
ring finger protein 8, E3 ubiquitin protein ligase
Alias_symbol (synonym)KIAA0646
Other aliashRNF8
HGNC (Hugo) RNF8
LocusID (NCBI) 9025
Atlas_Id 46867
Location 6p21.2  [Link to chromosome band 6p21]
Location_base_pair Starts at 37353972 and ends at 37394738 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PCBP1-AS1 (2p13.3) / RNF8 (6p21.2)TNIK (3q26.2) / RNF8 (6p21.2)ZFAND3 (6p21.2) / RNF8 (6p21.2)
ZFAND3 6p21.2 / RNF8 6p21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  ZFAND3/RNF8 (6p21)


External links

Nomenclature
HGNC (Hugo)RNF8   10071
Cards
Entrez_Gene (NCBI)RNF8  9025  ring finger protein 8
AliaseshRNF8
GeneCards (Weizmann)RNF8
Ensembl hg19 (Hinxton)ENSG00000112130 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112130 [Gene_View]  ENSG00000112130 [Sequence]  chr6:37353972-37394738 [Contig_View]  RNF8 [Vega]
ICGC DataPortalENSG00000112130
TCGA cBioPortalRNF8
AceView (NCBI)RNF8
Genatlas (Paris)RNF8
WikiGenes9025
SOURCE (Princeton)RNF8
Genetics Home Reference (NIH)RNF8
Genomic and cartography
GoldenPath hg38 (UCSC)RNF8  -     chr6:37353972-37394738 +  6p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RNF8  -     6p21.2   [Description]    (hg19-Feb_2009)
EnsemblRNF8 - 6p21.2 [CytoView hg19]  RNF8 - 6p21.2 [CytoView hg38]
Mapping of homologs : NCBIRNF8 [Mapview hg19]  RNF8 [Mapview hg38]
OMIM611685   
Gene and transcription
Genbank (Entrez)AB014546 AF334675 AK022075 AK222765 AK298319
RefSeq transcript (Entrez)NM_003958 NM_183078
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RNF8
Cluster EST : UnigeneHs.485278 [ NCBI ]
CGAP (NCI)Hs.485278
Alternative Splicing GalleryENSG00000112130
Gene ExpressionRNF8 [ NCBI-GEO ]   RNF8 [ EBI - ARRAY_EXPRESS ]   RNF8 [ SEEK ]   RNF8 [ MEM ]
Gene Expression Viewer (FireBrowse)RNF8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9025
GTEX Portal (Tissue expression)RNF8
Human Protein AtlasENSG00000112130-RNF8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO76064   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO76064  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO76064
Splice isoforms : SwissVarO76064
PhosPhoSitePlusO76064
Domaine pattern : Prosite (Expaxy)FHA_DOMAIN (PS50006)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)FHA_dom    RNF8    SMAD_FHA_dom_sf    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)FHA (PF00498)   
Domain families : Pfam (NCBI)pfam00498   
Domain families : Smart (EMBL)FHA (SM00240)  RING (SM00184)  
Conserved Domain (NCBI)RNF8
DMDM Disease mutations9025
Blocks (Seattle)RNF8
PDB (SRS)2CSW    2PIE    4AYC    4ORH    4WHV   
PDB (PDBSum)2CSW    2PIE    4AYC    4ORH    4WHV   
PDB (IMB)2CSW    2PIE    4AYC    4ORH    4WHV   
PDB (RSDB)2CSW    2PIE    4AYC    4ORH    4WHV   
Structural Biology KnowledgeBase2CSW    2PIE    4AYC    4ORH    4WHV   
SCOP (Structural Classification of Proteins)2CSW    2PIE    4AYC    4ORH    4WHV   
CATH (Classification of proteins structures)2CSW    2PIE    4AYC    4ORH    4WHV   
SuperfamilyO76064
Human Protein Atlas [tissue]ENSG00000112130-RNF8 [tissue]
Peptide AtlasO76064
HPRD11521
IPIIPI00022561   IPI00923427   IPI00375640   IPI00945358   IPI00946325   IPI00946038   IPI00946814   
Protein Interaction databases
DIP (DOE-UCLA)O76064
IntAct (EBI)O76064
FunCoupENSG00000112130
BioGRIDRNF8
STRING (EMBL)RNF8
ZODIACRNF8
Ontologies - Pathways
QuickGOO76064
Ontology : AmiGOubiquitin ligase complex  chromosome, telomeric region  chromatin binding  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  cytosol  double-strand break repair  double-strand break repair via nonhomologous end joining  double-strand break repair via nonhomologous end joining  ubiquitin-dependent protein catabolic process  cellular response to DNA damage stimulus  cell cycle  spermatid development  zinc ion binding  response to ionizing radiation  midbody  ubiquitin protein ligase binding  histone H2A ubiquitination  histone H2B ubiquitination  negative regulation of transcription elongation from RNA polymerase II promoter  spermatogenesis, exchange of chromosomal proteins  site of double-strand break  interstrand cross-link repair  histone binding  identical protein binding  protein homodimerization activity  ubiquitin binding  histone exchange  isotype switching  positive regulation of DNA repair  cell division  protein autoubiquitination  protein K63-linked ubiquitination  histone H2A K63-linked ubiquitination  histone H2A K63-linked ubiquitination  protein K48-linked ubiquitination  
Ontology : EGO-EBIubiquitin ligase complex  chromosome, telomeric region  chromatin binding  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  cytosol  double-strand break repair  double-strand break repair via nonhomologous end joining  double-strand break repair via nonhomologous end joining  ubiquitin-dependent protein catabolic process  cellular response to DNA damage stimulus  cell cycle  spermatid development  zinc ion binding  response to ionizing radiation  midbody  ubiquitin protein ligase binding  histone H2A ubiquitination  histone H2B ubiquitination  negative regulation of transcription elongation from RNA polymerase II promoter  spermatogenesis, exchange of chromosomal proteins  site of double-strand break  interstrand cross-link repair  histone binding  identical protein binding  protein homodimerization activity  ubiquitin binding  histone exchange  isotype switching  positive regulation of DNA repair  cell division  protein autoubiquitination  protein K63-linked ubiquitination  histone H2A K63-linked ubiquitination  histone H2A K63-linked ubiquitination  protein K48-linked ubiquitination  
NDEx NetworkRNF8
Atlas of Cancer Signalling NetworkRNF8
Wikipedia pathwaysRNF8
Orthology - Evolution
OrthoDB9025
GeneTree (enSembl)ENSG00000112130
Phylogenetic Trees/Animal Genes : TreeFamRNF8
HOVERGENO76064
HOGENOMO76064
Homologs : HomoloGeneRNF8
Homology/Alignments : Family Browser (UCSC)RNF8
Gene fusions - Rearrangements
Fusion : MitelmanZFAND3/RNF8 [6p21.2/6p21.2]  [t(6;6)(p21;p21)]  
Fusion PortalZFAND3 6p21.2 RNF8 6p21.2 BRCA
Fusion : QuiverRNF8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRNF8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNF8
dbVarRNF8
ClinVarRNF8
1000_GenomesRNF8 
Exome Variant ServerRNF8
ExAC (Exome Aggregation Consortium)ENSG00000112130
GNOMAD BrowserENSG00000112130
Varsome BrowserRNF8
Genetic variants : HAPMAP9025
Genomic Variants (DGV)RNF8 [DGVbeta]
DECIPHERRNF8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRNF8 
Mutations
ICGC Data PortalRNF8 
TCGA Data PortalRNF8 
Broad Tumor PortalRNF8
OASIS PortalRNF8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRNF8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRNF8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RNF8
DgiDB (Drug Gene Interaction Database)RNF8
DoCM (Curated mutations)RNF8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RNF8 (select a term)
intoGenRNF8
Cancer3DRNF8(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611685   
Orphanet
DisGeNETRNF8
MedgenRNF8
Genetic Testing Registry RNF8
NextProtO76064 [Medical]
TSGene9025
GENETestsRNF8
Target ValidationRNF8
Huge Navigator RNF8 [HugePedia]
snp3D : Map Gene to Disease9025
BioCentury BCIQRNF8
ClinGenRNF8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9025
Chemical/Pharm GKB GenePA34445
Clinical trialRNF8
Miscellaneous
canSAR (ICR)RNF8 (select the gene name)
Probes
Litterature
PubMed105 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRNF8
EVEXRNF8
GoPubMedRNF8
iHOPRNF8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:36:08 CET 2018

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