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RNGTT (RNA guanylyltransferase and 5'-phosphatase)

Identity

Other aliasCAP1A
HCE
HCE1
hCAP
HGNC (Hugo) RNGTT
LocusID (NCBI) 8732
Atlas_Id 57550
Location 6q15  [Link to chromosome band 6q15]
Location_base_pair Starts at 88609897 and ends at 88963629 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FAM219A (9p13.3) / RNGTT (6q15)GNPDA1 (5q31.3) / RNGTT (6q15)LOC389831 () / RNGTT (6q15)
RNGTT (6q15) / BACH2 (6q15)RNGTT (6q15) / RNGTT (6q15)RNGTT (6q15) / ZMYM4 (1p34.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(5;6)(q31;q15) GNPDA1/RNGTT
t(6;6)(p22;q15) JARID2/RNGTT


External links

Nomenclature
HGNC (Hugo)RNGTT   10073
Cards
Entrez_Gene (NCBI)RNGTT  8732  RNA guanylyltransferase and 5'-phosphatase
AliasesCAP1A; HCE; HCE1; hCAP
GeneCards (Weizmann)RNGTT
Ensembl hg19 (Hinxton)ENSG00000111880 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111880 [Gene_View]  ENSG00000111880 [Sequence]  chr6:88609897-88963629 [Contig_View]  RNGTT [Vega]
ICGC DataPortalENSG00000111880
TCGA cBioPortalRNGTT
AceView (NCBI)RNGTT
Genatlas (Paris)RNGTT
WikiGenes8732
SOURCE (Princeton)RNGTT
Genetics Home Reference (NIH)RNGTT
Genomic and cartography
GoldenPath hg38 (UCSC)RNGTT  -     chr6:88609897-88963629 -  6q15   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RNGTT  -     6q15   [Description]    (hg19-Feb_2009)
EnsemblRNGTT - 6q15 [CytoView hg19]  RNGTT - 6q15 [CytoView hg38]
Mapping of homologs : NCBIRNGTT [Mapview hg19]  RNGTT [Mapview hg38]
OMIM603512   
Gene and transcription
Genbank (Entrez)AB009022 AB009023 AB009024 AB012142 AB012143
RefSeq transcript (Entrez)NM_001286426 NM_001286428 NM_003800
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RNGTT
Cluster EST : UnigeneHs.627135 [ NCBI ]
CGAP (NCI)Hs.627135
Alternative Splicing GalleryENSG00000111880
Gene ExpressionRNGTT [ NCBI-GEO ]   RNGTT [ EBI - ARRAY_EXPRESS ]   RNGTT [ SEEK ]   RNGTT [ MEM ]
Gene Expression Viewer (FireBrowse)RNGTT [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8732
GTEX Portal (Tissue expression)RNGTT
Human Protein AtlasENSG00000111880-RNGTT [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60942   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60942  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60942
Splice isoforms : SwissVarO60942
Catalytic activity : Enzyme3.1.3.33 [ Enzyme-Expasy ]   3.1.3.333.1.3.33 [ IntEnz-EBI ]   3.1.3.33 [ BRENDA ]   3.1.3.33 [ KEGG ]   
PhosPhoSitePlusO60942
Domaine pattern : Prosite (Expaxy)TYR_PHOSPHATASE_1 (PS00383)    TYR_PHOSPHATASE_2 (PS50056)   
Domains : Interpro (EBI)Dual-sp_phosphatase_cat-dom    mRNA_cap_enz_bifunc    mRNA_cap_enzyme    mRNA_cap_enzyme_C    NA-bd_OB-fold    Prot-tyrosine_phosphatase-like    Tyr_Pase_AS    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)DSPc (PF00782)    mRNA_cap_C (PF03919)    mRNA_cap_enzyme (PF01331)   
Domain families : Pfam (NCBI)pfam00782    pfam03919    pfam01331   
Conserved Domain (NCBI)RNGTT
DMDM Disease mutations8732
Blocks (Seattle)RNGTT
PDB (SRS)2C46    3S24   
PDB (PDBSum)2C46    3S24   
PDB (IMB)2C46    3S24   
PDB (RSDB)2C46    3S24   
Structural Biology KnowledgeBase2C46    3S24   
SCOP (Structural Classification of Proteins)2C46    3S24   
CATH (Classification of proteins structures)2C46    3S24   
SuperfamilyO60942
Human Protein Atlas [tissue]ENSG00000111880-RNGTT [tissue]
Peptide AtlasO60942
IPIIPI00000104   IPI00219610   IPI00219612   IPI01014591   IPI01015903   IPI00219611   
Protein Interaction databases
DIP (DOE-UCLA)O60942
IntAct (EBI)O60942
FunCoupENSG00000111880
BioGRIDRNGTT
STRING (EMBL)RNGTT
ZODIACRNGTT
Ontologies - Pathways
QuickGOO60942
Ontology : AmiGOmRNA guanylyltransferase activity  mRNA guanylyltransferase activity  polynucleotide 5'-phosphatase activity  protein tyrosine phosphatase activity  protein binding  GTP binding  nucleus  nucleoplasm  transcription by RNA polymerase II  7-methylguanosine mRNA capping  7-methylguanosine mRNA capping  7-methylguanosine mRNA capping  RNA processing  protein tyrosine/serine/threonine phosphatase activity  RNA guanylyltransferase activity  viral process  peptidyl-tyrosine dephosphorylation  triphosphatase activity  polynucleotide 5' dephosphorylation  
Ontology : EGO-EBImRNA guanylyltransferase activity  mRNA guanylyltransferase activity  polynucleotide 5'-phosphatase activity  protein tyrosine phosphatase activity  protein binding  GTP binding  nucleus  nucleoplasm  transcription by RNA polymerase II  7-methylguanosine mRNA capping  7-methylguanosine mRNA capping  7-methylguanosine mRNA capping  RNA processing  protein tyrosine/serine/threonine phosphatase activity  RNA guanylyltransferase activity  viral process  peptidyl-tyrosine dephosphorylation  triphosphatase activity  polynucleotide 5' dephosphorylation  
Pathways : KEGGmRNA surveillance pathway   
NDEx NetworkRNGTT
Atlas of Cancer Signalling NetworkRNGTT
Wikipedia pathwaysRNGTT
Orthology - Evolution
OrthoDB8732
GeneTree (enSembl)ENSG00000111880
Phylogenetic Trees/Animal Genes : TreeFamRNGTT
HOVERGENO60942
HOGENOMO60942
Homologs : HomoloGeneRNGTT
Homology/Alignments : Family Browser (UCSC)RNGTT
Gene fusions - Rearrangements
Fusion : QuiverRNGTT
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRNGTT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNGTT
dbVarRNGTT
ClinVarRNGTT
1000_GenomesRNGTT 
Exome Variant ServerRNGTT
ExAC (Exome Aggregation Consortium)ENSG00000111880
GNOMAD BrowserENSG00000111880
Varsome BrowserRNGTT
Genetic variants : HAPMAP8732
Genomic Variants (DGV)RNGTT [DGVbeta]
DECIPHERRNGTT [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRNGTT 
Mutations
ICGC Data PortalRNGTT 
TCGA Data PortalRNGTT 
Broad Tumor PortalRNGTT
OASIS PortalRNGTT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRNGTT  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRNGTT
BioMutasearch RNGTT
DgiDB (Drug Gene Interaction Database)RNGTT
DoCM (Curated mutations)RNGTT (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RNGTT (select a term)
intoGenRNGTT
Cancer3DRNGTT(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603512   
Orphanet
DisGeNETRNGTT
MedgenRNGTT
Genetic Testing Registry RNGTT
NextProtO60942 [Medical]
TSGene8732
GENETestsRNGTT
Target ValidationRNGTT
Huge Navigator RNGTT [HugePedia]
snp3D : Map Gene to Disease8732
BioCentury BCIQRNGTT
ClinGenRNGTT
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8732
Chemical/Pharm GKB GenePA34446
Clinical trialRNGTT
Miscellaneous
canSAR (ICR)RNGTT (select the gene name)
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRNGTT
EVEXRNGTT
GoPubMedRNGTT
iHOPRNGTT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:36:09 CET 2018

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