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RNH1 (ribonuclease/angiogenin inhibitor 1)

Identity

Alias_namesRNH
ribonuclease/angiogenin inhibitor
Alias_symbol (synonym)RAI
Other alias
HGNC (Hugo) RNH1
LocusID (NCBI) 6050
Atlas_Id 45618
Location 11p15.5  [Link to chromosome band 11p15]
Location_base_pair Starts at 494512 and ends at 507283 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FN1 (2q35) / RNH1 (11p15.5)HBB (11p15.4) / RNH1 (11p15.5)RNH1 (11p15.5) / DEAF1 (11p15.5)
RNH1 (11p15.5) / HRAS (11p15.5)RNH1 (11p15.5) / LOC100507412 (-)RNH1 (11p15.5) / MYBPC1 (12q23.2)
RNH1 (11p15.5) / SCT (11p15.5)VPS37B (12q24.31) / RNH1 (11p15.5)RNH1 11p15.5 / DEAF1 11p15.5
RNH1 11p15.5 / HRAS 11p15.5RNH1 11p15.5 / MYBPC1 12q23.2RNH1 11p15.5 / SCT 11p15.5

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  t(11;11)(p15;p15) RNH1/DEAF1
t(11;11)(p15;p15) RNH1/SCT
t(11;11)(p15;p15) RNH1/HRAS
t(11;12)(p15;q23) RNH1/MYBPC1

External links

Nomenclature
HGNC (Hugo)RNH1   10074
Cards
Entrez_Gene (NCBI)RNH1  6050  ribonuclease/angiogenin inhibitor 1
AliasesRAI; RNH
GeneCards (Weizmann)RNH1
Ensembl hg19 (Hinxton)ENSG00000023191 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000023191 [Gene_View]  chr11:494512-507283 [Contig_View]  RNH1 [Vega]
ICGC DataPortalENSG00000023191
TCGA cBioPortalRNH1
AceView (NCBI)RNH1
Genatlas (Paris)RNH1
WikiGenes6050
SOURCE (Princeton)RNH1
Genetics Home Reference (NIH)RNH1
Genomic and cartography
GoldenPath hg38 (UCSC)RNH1  -     chr11:494512-507283 -  11p15.5   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RNH1  -     11p15.5   [Description]    (hg19-Feb_2009)
EnsemblRNH1 - 11p15.5 [CytoView hg19]  RNH1 - 11p15.5 [CytoView hg38]
Mapping of homologs : NCBIRNH1 [Mapview hg19]  RNH1 [Mapview hg38]
OMIM173320   
Gene and transcription
Genbank (Entrez)AB209196 AK027172 AK057144 AK308340 AK310173
RefSeq transcript (Entrez)NM_002939 NM_203383 NM_203384 NM_203385 NM_203386 NM_203387 NM_203388 NM_203389
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_187586
Consensus coding sequences : CCDS (NCBI)RNH1
Cluster EST : UnigeneHs.530687 [ NCBI ]
CGAP (NCI)Hs.530687
Alternative Splicing GalleryENSG00000023191
Gene ExpressionRNH1 [ NCBI-GEO ]   RNH1 [ EBI - ARRAY_EXPRESS ]   RNH1 [ SEEK ]   RNH1 [ MEM ]
Gene Expression Viewer (FireBrowse)RNH1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6050
GTEX Portal (Tissue expression)RNH1
Human Protein AtlasENSG00000023191-RNH1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13489   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP13489  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP13489
Splice isoforms : SwissVarP13489
PhosPhoSitePlusP13489
Domains : Interpro (EBI)L_dom-like    Leu-rich_rpt    Leu-rich_rpt_Cys-con_subtyp   
Domain families : Pfam (Sanger)LRR_6 (PF13516)   
Domain families : Pfam (NCBI)pfam13516   
Domain families : Smart (EMBL)LRR_CC (SM00367)  
Conserved Domain (NCBI)RNH1
DMDM Disease mutations6050
Blocks (Seattle)RNH1
PDB (SRS)1A4Y    1Z7X    2BEX    2Q4G   
PDB (PDBSum)1A4Y    1Z7X    2BEX    2Q4G   
PDB (IMB)1A4Y    1Z7X    2BEX    2Q4G   
PDB (RSDB)1A4Y    1Z7X    2BEX    2Q4G   
Structural Biology KnowledgeBase1A4Y    1Z7X    2BEX    2Q4G   
SCOP (Structural Classification of Proteins)1A4Y    1Z7X    2BEX    2Q4G   
CATH (Classification of proteins structures)1A4Y    1Z7X    2BEX    2Q4G   
SuperfamilyP13489
Human Protein Atlas [tissue]ENSG00000023191-RNH1 [tissue]
Peptide AtlasP13489
HPRD01412
IPIIPI00550069   IPI00975917   IPI00977939   IPI00984723   IPI00975857   IPI00983412   IPI00984516   IPI00977706   IPI00981363   IPI00979739   IPI00985085   
Protein Interaction databases
DIP (DOE-UCLA)P13489
IntAct (EBI)P13489
FunCoupENSG00000023191
BioGRIDRNH1
STRING (EMBL)RNH1
ZODIACRNH1
Ontologies - Pathways
QuickGOP13489
Ontology : AmiGOprotein binding  nucleoplasm  cytosol  mRNA catabolic process  ribonuclease inhibitor activity  angiogenin-PRI complex  negative regulation of catalytic activity  regulation of angiogenesis  extracellular exosome  
Ontology : EGO-EBIprotein binding  nucleoplasm  cytosol  mRNA catabolic process  ribonuclease inhibitor activity  angiogenin-PRI complex  negative regulation of catalytic activity  regulation of angiogenesis  extracellular exosome  
NDEx NetworkRNH1
Atlas of Cancer Signalling NetworkRNH1
Wikipedia pathwaysRNH1
Orthology - Evolution
OrthoDB6050
GeneTree (enSembl)ENSG00000023191
Phylogenetic Trees/Animal Genes : TreeFamRNH1
HOVERGENP13489
HOGENOMP13489
Homologs : HomoloGeneRNH1
Homology/Alignments : Family Browser (UCSC)RNH1
Gene fusions - Rearrangements
Fusion : MitelmanRNH1/DEAF1 [11p15.5/11p15.5]  
Fusion : MitelmanRNH1/HRAS [11p15.5/11p15.5]  [t(11;11)(p15;p15)]  
Fusion : MitelmanRNH1/MYBPC1 [11p15.5/12q23.2]  [t(11;12)(p15;q23)]  
Fusion : MitelmanRNH1/SCT [11p15.5/11p15.5]  [t(11;11)(p15;p15)]  
Fusion: TCGA_MDACCRNH1 11p15.5 DEAF1 11p15.5 BRCA
Fusion: TCGA_MDACCRNH1 11p15.5 HRAS 11p15.5 HNSC
Fusion: TCGA_MDACCRNH1 11p15.5 MYBPC1 12q23.2 PRAD
Fusion: TCGA_MDACCRNH1 11p15.5 SCT 11p15.5 BRCA
Fusion PortalRNH1 11p15.5 DEAF1 11p15.5 BRCA
Fusion PortalRNH1 11p15.5 HRAS 11p15.5 HNSC
Fusion PortalRNH1 11p15.5 MYBPC1 12q23.2 PRAD
Fusion PortalRNH1 11p15.5 SCT 11p15.5 BRCA
Fusion : QuiverRNH1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRNH1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNH1
dbVarRNH1
ClinVarRNH1
1000_GenomesRNH1 
Exome Variant ServerRNH1
ExAC (Exome Aggregation Consortium)ENSG00000023191
GNOMAD BrowserENSG00000023191
Genetic variants : HAPMAP6050
Genomic Variants (DGV)RNH1 [DGVbeta]
DECIPHERRNH1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRNH1 
Mutations
ICGC Data PortalRNH1 
TCGA Data PortalRNH1 
Broad Tumor PortalRNH1
OASIS PortalRNH1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRNH1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRNH1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RNH1
DgiDB (Drug Gene Interaction Database)RNH1
DoCM (Curated mutations)RNH1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RNH1 (select a term)
intoGenRNH1
Cancer3DRNH1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM173320   
Orphanet
DisGeNETRNH1
MedgenRNH1
Genetic Testing Registry RNH1
NextProtP13489 [Medical]
TSGene6050
GENETestsRNH1
Target ValidationRNH1
Huge Navigator RNH1 [HugePedia]
snp3D : Map Gene to Disease6050
BioCentury BCIQRNH1
ClinGenRNH1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6050
Chemical/Pharm GKB GenePA34447
Clinical trialRNH1
Miscellaneous
canSAR (ICR)RNH1 (select the gene name)
Probes
Litterature
PubMed67 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRNH1
EVEXRNH1
GoPubMedRNH1
iHOPRNH1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jun 18 19:42:56 CEST 2018
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