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RNLS (renalase, FAD dependent amine oxidase)

Identity

Alias (NCBI)C10orf59
RENALASE
HGNC (Hugo) RNLS
HGNC Alias symbFLJ11218
renalase
HGNC Previous nameC10orf59
HGNC Previous namechromosome 10 open reading frame 59
LocusID (NCBI) 55328
Atlas_Id 54588
Location 10q23.31  [Link to chromosome band 10q23]
Location_base_pair Starts at 88273864 and ends at 88583325 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MGEA5 (10q24.32) / RNLS (10q23.31)NFIA (1p31.3) / RNLS (10q23.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(10;10)(q23;q24) MGEA5/RNLS


External links

 

Nomenclature
HGNC (Hugo)RNLS   25641
Cards
Entrez_Gene (NCBI)RNLS    renalase, FAD dependent amine oxidase
AliasesC10orf59; RENALASE
GeneCards (Weizmann)RNLS
Ensembl hg19 (Hinxton)ENSG00000184719 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184719 [Gene_View]  ENSG00000184719 [Sequence]  chr10:88273864-88583325 [Contig_View]  RNLS [Vega]
ICGC DataPortalENSG00000184719
TCGA cBioPortalRNLS
AceView (NCBI)RNLS
Genatlas (Paris)RNLS
SOURCE (Princeton)RNLS
Genetics Home Reference (NIH)RNLS
Genomic and cartography
GoldenPath hg38 (UCSC)RNLS  -     chr10:88273864-88583325 -  10q23.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RNLS  -     10q23.31   [Description]    (hg19-Feb_2009)
GoldenPathRNLS - 10q23.31 [CytoView hg19]  RNLS - 10q23.31 [CytoView hg38]
ImmunoBaseENSG00000184719
Genome Data Viewer NCBIRNLS [Mapview hg19]  
OMIM609360   
Gene and transcription
Genbank (Entrez)AA854849 AK002080 AK296262 BC005364 BM978857
RefSeq transcript (Entrez)NM_001031709 NM_018363
Consensus coding sequences : CCDS (NCBI)RNLS
Gene ExpressionRNLS [ NCBI-GEO ]   RNLS [ EBI - ARRAY_EXPRESS ]   RNLS [ SEEK ]   RNLS [ MEM ]
Gene Expression Viewer (FireBrowse)RNLS [ Firebrowse - Broad ]
GenevisibleExpression of RNLS in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55328
GTEX Portal (Tissue expression)RNLS
Human Protein AtlasENSG00000184719-RNLS [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5VYX0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5VYX0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5VYX0
PhosPhoSitePlusQ5VYX0
Domains : Interpro (EBI)Amino_oxidase    FAD/NAD-bd_sf    RNLS   
Domain families : Pfam (Sanger)Amino_oxidase (PF01593)   
Domain families : Pfam (NCBI)pfam01593   
Conserved Domain (NCBI)RNLS
PDB (RSDB)3QJ4   
PDB Europe3QJ4   
PDB (PDBSum)3QJ4   
PDB (IMB)3QJ4   
Structural Biology KnowledgeBase3QJ4   
SCOP (Structural Classification of Proteins)3QJ4   
CATH (Classification of proteins structures)3QJ4   
SuperfamilyQ5VYX0
AlphaFold pdb e-kbQ5VYX0   
Human Protein Atlas [tissue]ENSG00000184719-RNLS [tissue]
HPRD07742
Protein Interaction databases
DIP (DOE-UCLA)Q5VYX0
IntAct (EBI)Q5VYX0
BioGRIDRNLS
STRING (EMBL)RNLS
ZODIACRNLS
Ontologies - Pathways
QuickGOQ5VYX0
Ontology : AmiGOresponse to ischemia  protein binding  extracellular region  extracellular region  extracellular region  extracellular space  negative regulation of heart rate  oxidoreductase activity, acting on NAD(P)H  oxidoreductase activity, acting on NAD(P)H  NAD biosynthesis via nicotinamide riboside salvage pathway  negative regulation of blood pressure  epinephrine binding  NADH binding  response to epinephrine  monoamine oxidase activity  response to salt  
Ontology : EGO-EBIresponse to ischemia  protein binding  extracellular region  extracellular region  extracellular region  extracellular space  negative regulation of heart rate  oxidoreductase activity, acting on NAD(P)H  oxidoreductase activity, acting on NAD(P)H  NAD biosynthesis via nicotinamide riboside salvage pathway  negative regulation of blood pressure  epinephrine binding  NADH binding  response to epinephrine  monoamine oxidase activity  response to salt  
NDEx NetworkRNLS
Atlas of Cancer Signalling NetworkRNLS
Wikipedia pathwaysRNLS
Orthology - Evolution
OrthoDB55328
GeneTree (enSembl)ENSG00000184719
Phylogenetic Trees/Animal Genes : TreeFamRNLS
Homologs : HomoloGeneRNLS
Homology/Alignments : Family Browser (UCSC)RNLS
Gene fusions - Rearrangements
Fusion : MitelmanNFIA/RNLS [1p31.3/10q23.31]  
Fusion : QuiverRNLS
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRNLS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNLS
dbVarRNLS
ClinVarRNLS
MonarchRNLS
1000_GenomesRNLS 
Exome Variant ServerRNLS
GNOMAD BrowserENSG00000184719
Varsome BrowserRNLS
ACMGRNLS variants
VarityQ5VYX0
Genomic Variants (DGV)RNLS [DGVbeta]
DECIPHERRNLS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRNLS 
Mutations
ICGC Data PortalRNLS 
TCGA Data PortalRNLS 
Broad Tumor PortalRNLS
OASIS PortalRNLS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRNLS  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRNLS
Mutations and Diseases : HGMDRNLS
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRNLS
DgiDB (Drug Gene Interaction Database)RNLS
DoCM (Curated mutations)RNLS
CIViC (Clinical Interpretations of Variants in Cancer)RNLS
Cancer3DRNLS
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609360   
Orphanet
DisGeNETRNLS
MedgenRNLS
Genetic Testing Registry RNLS
NextProtQ5VYX0 [Medical]
GENETestsRNLS
Target ValidationRNLS
Huge Navigator RNLS [HugePedia]
ClinGenRNLS
Clinical trials, drugs, therapy
MyCancerGenomeRNLS
Protein Interactions : CTDRNLS
Pharm GKB GenePA165549084
PharosQ5VYX0
Clinical trialRNLS
Miscellaneous
canSAR (ICR)RNLS
HarmonizomeRNLS
DataMed IndexRNLS
Probes
Litterature
PubMed77 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRNLS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:29:20 CEST 2021

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