RNMT (RNA guanine-7 methyltransferase)

2015-10-01  

Identity

HGNC
LOCATION
18p11.21
LOCUSID
ALIAS
CMT1,CMT1c,MET,Met,RG7MT1,cm1p,hCMT1,hMet
FUSION GENES

Other Information

Locus ID:

NCBI: 8731
MIM: 603514
HGNC: 10075
Ensembl: ENSG00000101654

Variants:

dbSNP: 8731
ClinVar: 8731
TCGA: ENSG00000101654
COSMIC: RNMT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101654ENST00000262173O43148
ENSG00000101654ENST00000383314O43148
ENSG00000101654ENST00000543302O43148
ENSG00000101654ENST00000588457K7EP06
ENSG00000101654ENST00000589866O43148
ENSG00000101654ENST00000591746K7EPP5
ENSG00000101654ENST00000592764O43148
ENSG00000101654ENST00000593007K7ERH6

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Transcription of the HIV genomeREACTOMER-HSA-167172
RNA Pol II CTD phosphorylation and interaction with CE during HIV infectionREACTOMER-HSA-167160
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Pol II CTD phosphorylation and interaction with CEREACTOMER-HSA-77075
mRNA CappingREACTOMER-HSA-72086

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
247636122014Genome-wide study of hypomethylated and induced genes in patients with liver cancer unravels novel anticancer targets.31
191611602009An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).30
269426772016CDK1-Cyclin B1 Activates RNMT, Coordinating mRNA Cap Methylation with G1 Phase Transcription.20
238630842013Human cap methyltransferase (RNMT) N-terminal non-catalytic domain mediates recruitment to transcription initiation sites.15
157676702005Human mRNA cap methyltransferase: alternative nuclear localization signal motifs ensure nuclear localization required for viability.14
289817152017RNA guanine-7 methyltransferase catalyzes the methylation of cytoplasmically recapped RNAs.10
242004672014RAM function is dependent on Kapβ2-mediated nuclear entry.9
297192632018mRNA Cap Methyltransferase, RNMT-RAM, Promotes RNA Pol II-Dependent Transcription.8
278994232017MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase.6

Citation

Dessen P

RNMT (RNA guanine-7 methyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2015-10-01

Online version: http://atlasgeneticsoncology.org/gene/55481/rnmt