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RNPEP (arginyl aminopeptidase)

Identity

Alias_namesarginyl aminopeptidase (aminopeptidase B)
Other aliasAP-B
APB
HGNC (Hugo) RNPEP
LocusID (NCBI) 6051
Atlas_Id 55685
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 201983330 and ends at 202006147 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LRCH1 (13q14.13) / RNPEP (1q32.1)PRR4 (12p13.2) / RNPEP (1q32.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RNPEP   10078
Cards
Entrez_Gene (NCBI)RNPEP  6051  arginyl aminopeptidase
AliasesAP-B; APB
GeneCards (Weizmann)RNPEP
Ensembl hg19 (Hinxton)ENSG00000176393 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000176393 [Gene_View]  chr1:201983330-202006147 [Contig_View]  RNPEP [Vega]
ICGC DataPortalENSG00000176393
TCGA cBioPortalRNPEP
AceView (NCBI)RNPEP
Genatlas (Paris)RNPEP
WikiGenes6051
SOURCE (Princeton)RNPEP
Genetics Home Reference (NIH)RNPEP
Genomic and cartography
GoldenPath hg38 (UCSC)RNPEP  -     chr1:201983330-202006147 +  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RNPEP  -     1q32.1   [Description]    (hg19-Feb_2009)
EnsemblRNPEP - 1q32.1 [CytoView hg19]  RNPEP - 1q32.1 [CytoView hg38]
Mapping of homologs : NCBIRNPEP [Mapview hg19]  RNPEP [Mapview hg38]
OMIM602675   
Gene and transcription
Genbank (Entrez)AJ242586 AJ296161 AK026644 AK097372 AK129946
RefSeq transcript (Entrez)NM_001319182 NM_001319183 NM_001319184 NM_020216
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RNPEP
Cluster EST : UnigeneHs.497391 [ NCBI ]
CGAP (NCI)Hs.497391
Alternative Splicing GalleryENSG00000176393
Gene ExpressionRNPEP [ NCBI-GEO ]   RNPEP [ EBI - ARRAY_EXPRESS ]   RNPEP [ SEEK ]   RNPEP [ MEM ]
Gene Expression Viewer (FireBrowse)RNPEP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6051
GTEX Portal (Tissue expression)RNPEP
Human Protein AtlasENSG00000176393-RNPEP [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H4A4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H4A4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H4A4
Splice isoforms : SwissVarQ9H4A4
Catalytic activity : Enzyme3.4.11.6 [ Enzyme-Expasy ]   3.4.11.63.4.11.6 [ IntEnz-EBI ]   3.4.11.6 [ BRENDA ]   3.4.11.6 [ KEGG ]   
PhosPhoSitePlusQ9H4A4
Domaine pattern : Prosite (Expaxy)ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)ARM-type_fold    M1_LTA4H    Pept_M1_aminopeptidase-B    Peptidase_M1    Peptidase_M1_C    Peptidase_M1_N   
Domain families : Pfam (Sanger)Leuk-A4-hydro_C (PF09127)    Peptidase_M1 (PF01433)   
Domain families : Pfam (NCBI)pfam09127    pfam01433   
Domain families : Smart (EMBL)Leuk-A4-hydro_C (SM01263)  
Conserved Domain (NCBI)RNPEP
DMDM Disease mutations6051
Blocks (Seattle)RNPEP
SuperfamilyQ9H4A4
Human Protein Atlas [tissue]ENSG00000176393-RNPEP [tissue]
Peptide AtlasQ9H4A4
HPRD04055
IPIIPI00642211   IPI00646984   IPI00647400   IPI00647859   IPI00642164   
Protein Interaction databases
DIP (DOE-UCLA)Q9H4A4
IntAct (EBI)Q9H4A4
FunCoupENSG00000176393
BioGRIDRNPEP
STRING (EMBL)RNPEP
ZODIACRNPEP
Ontologies - Pathways
QuickGOQ9H4A4
Ontology : AmiGOaminopeptidase activity  aminopeptidase activity  epoxide hydrolase activity  extracellular region  extracellular region  extracellular space  plasma membrane  plasma membrane  proteolysis  proteolysis  metalloexopeptidase activity  zinc ion binding  zinc ion binding  secretory granule  peptide binding  peptide catabolic process  negative regulation of blood pressure  metalloaminopeptidase activity  extracellular exosome  
Ontology : EGO-EBIaminopeptidase activity  aminopeptidase activity  epoxide hydrolase activity  extracellular region  extracellular region  extracellular space  plasma membrane  plasma membrane  proteolysis  proteolysis  metalloexopeptidase activity  zinc ion binding  zinc ion binding  secretory granule  peptide binding  peptide catabolic process  negative regulation of blood pressure  metalloaminopeptidase activity  extracellular exosome  
NDEx NetworkRNPEP
Atlas of Cancer Signalling NetworkRNPEP
Wikipedia pathwaysRNPEP
Orthology - Evolution
OrthoDB6051
GeneTree (enSembl)ENSG00000176393
Phylogenetic Trees/Animal Genes : TreeFamRNPEP
HOVERGENQ9H4A4
HOGENOMQ9H4A4
Homologs : HomoloGeneRNPEP
Homology/Alignments : Family Browser (UCSC)RNPEP
Gene fusions - Rearrangements
Fusion: Tumor Portal RNPEP
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRNPEP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNPEP
dbVarRNPEP
ClinVarRNPEP
1000_GenomesRNPEP 
Exome Variant ServerRNPEP
ExAC (Exome Aggregation Consortium)ENSG00000176393
GNOMAD BrowserENSG00000176393
Genetic variants : HAPMAP6051
Genomic Variants (DGV)RNPEP [DGVbeta]
DECIPHERRNPEP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRNPEP 
Mutations
ICGC Data PortalRNPEP 
TCGA Data PortalRNPEP 
Broad Tumor PortalRNPEP
OASIS PortalRNPEP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRNPEP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRNPEP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RNPEP
DgiDB (Drug Gene Interaction Database)RNPEP
DoCM (Curated mutations)RNPEP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RNPEP (select a term)
intoGenRNPEP
Cancer3DRNPEP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602675   
Orphanet
MedgenRNPEP
Genetic Testing Registry RNPEP
NextProtQ9H4A4 [Medical]
TSGene6051
GENETestsRNPEP
Target ValidationRNPEP
Huge Navigator RNPEP [HugePedia]
snp3D : Map Gene to Disease6051
BioCentury BCIQRNPEP
ClinGenRNPEP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6051
Chemical/Pharm GKB GenePA34451
Clinical trialRNPEP
Miscellaneous
canSAR (ICR)RNPEP (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRNPEP
EVEXRNPEP
GoPubMedRNPEP
iHOPRNPEP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 13:09:04 CET 2017

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