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RO60 (Ro60, Y RNA binding protein)

Identity

Alias (NCBI)RORNP
SSA2
TROVE2
HGNC (Hugo) RO60
HGNC Alias symbRo60
HGNC Previous nameSSA2
HGNC Previous nameSjogren syndrome antigen A2 (60kDa, ribonucleoprotein autoantigen SS-A/Ro)
 TROVE domain family, member 2
LocusID (NCBI) 6738
Atlas_Id 75207
Location 1q31.2  [Link to chromosome band 1q31]
Location_base_pair Starts at 193059874 and ends at 193085985 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute



External links

 

Nomenclature
HGNC (Hugo)RO60   11313
Cards
Entrez_Gene (NCBI)RO60    Ro60, Y RNA binding protein
AliasesRORNP; SSA2; TROVE2
GeneCards (Weizmann)RO60
Ensembl hg19 (Hinxton)ENSG00000116747 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000116747 [Gene_View]  ENSG00000116747 [Sequence]  chr1:193059874-193085985 [Contig_View]  RO60 [Vega]
ICGC DataPortalENSG00000116747
TCGA cBioPortalRO60
AceView (NCBI)RO60
Genatlas (Paris)RO60
SOURCE (Princeton)RO60
Genetics Home Reference (NIH)RO60
Genomic and cartography
GoldenPath hg38 (UCSC)RO60  -     chr1:193059874-193085985 +  1q31.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RO60  -     1q31.2   [Description]    (hg19-Feb_2009)
GoldenPathRO60 - 1q31.2 [CytoView hg19]  RO60 - 1q31.2 [CytoView hg38]
ImmunoBaseENSG00000116747
Genome Data Viewer NCBIRO60 [Mapview hg19]  
OMIM600063   
Gene and transcription
Genbank (Entrez)AH003763 AI433657 AK314594 AY205314 AY205315
RefSeq transcript (Entrez)NM_001042369 NM_001042370 NM_001173524 NM_001173525 NM_001331020 NM_004600
Consensus coding sequences : CCDS (NCBI)RO60
Gene ExpressionRO60 [ NCBI-GEO ]   RO60 [ EBI - ARRAY_EXPRESS ]   RO60 [ SEEK ]   RO60 [ MEM ]
Gene Expression Viewer (FireBrowse)RO60 [ Firebrowse - Broad ]
GenevisibleExpression of RO60 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6738
GTEX Portal (Tissue expression)RO60
Human Protein AtlasENSG00000116747-RO60 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10155   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP10155  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP10155
PhosPhoSitePlusP10155
Domaine pattern : Prosite (Expaxy)TROVE (PS50988)   
Domains : Interpro (EBI)TROVE2    TROVE_dom    TROVE_dom_sf    vWFA_dom_sf   
Domain families : Pfam (Sanger)TROVE (PF05731)   
Domain families : Pfam (NCBI)pfam05731   
Conserved Domain (NCBI)RO60
SuperfamilyP10155
AlphaFold pdb e-kbP10155   
Human Protein Atlas [tissue]ENSG00000116747-RO60 [tissue]
HPRD15964
Protein Interaction databases
DIP (DOE-UCLA)P10155
IntAct (EBI)P10155
BioGRIDRO60
STRING (EMBL)RO60
ZODIACRO60
Ontologies - Pathways
QuickGOP10155
Ontology : AmiGOimmune system development  RNA binding  RNA binding  nucleoplasm  cytosol  transcription by RNA polymerase III  smoothened signaling pathway  response to UV  regulation of gene expression  U2 snRNA binding  cellular response to interferon-alpha  metal ion binding  cilium assembly  ribonucleoprotein complex  ribonucleoprotein complex  
Ontology : EGO-EBIimmune system development  RNA binding  RNA binding  nucleoplasm  cytosol  transcription by RNA polymerase III  smoothened signaling pathway  response to UV  regulation of gene expression  U2 snRNA binding  cellular response to interferon-alpha  metal ion binding  cilium assembly  ribonucleoprotein complex  ribonucleoprotein complex  
NDEx NetworkRO60
Atlas of Cancer Signalling NetworkRO60
Wikipedia pathwaysRO60
Orthology - Evolution
OrthoDB6738
GeneTree (enSembl)ENSG00000116747
Phylogenetic Trees/Animal Genes : TreeFamRO60
Homologs : HomoloGeneRO60
Homology/Alignments : Family Browser (UCSC)RO60
Gene fusions - Rearrangements
Fusion : QuiverRO60
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRO60 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RO60
dbVarRO60
ClinVarRO60
MonarchRO60
1000_GenomesRO60 
Exome Variant ServerRO60
GNOMAD BrowserENSG00000116747
Varsome BrowserRO60
ACMGRO60 variants
VarityP10155
Genomic Variants (DGV)RO60 [DGVbeta]
DECIPHERRO60 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRO60 
Mutations
ICGC Data PortalRO60 
TCGA Data PortalRO60 
Broad Tumor PortalRO60
OASIS PortalRO60 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDRO60
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRO60
DgiDB (Drug Gene Interaction Database)RO60
DoCM (Curated mutations)RO60
CIViC (Clinical Interpretations of Variants in Cancer)RO60
Cancer3DRO60
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600063   
Orphanet
DisGeNETRO60
MedgenRO60
Genetic Testing Registry RO60
NextProtP10155 [Medical]
GENETestsRO60
Target ValidationRO60
Huge Navigator RO60 [HugePedia]
ClinGenRO60
Clinical trials, drugs, therapy
MyCancerGenomeRO60
Protein Interactions : CTDRO60
Pharm GKB GenePA36137
PharosP10155
Clinical trialRO60
Miscellaneous
canSAR (ICR)RO60
HarmonizomeRO60
DataMed IndexRO60
Probes
Litterature
PubMed77 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRO60
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:19:02 CEST 2021

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