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RO60 (Ro60, Y RNA binding protein)

Identity

Alias (NCBI)RORNP
SSA2
TROVE2
HGNC (Hugo) RO60
HGNC Alias symbRo60
HGNC Previous nameSSA2
HGNC Previous nameSjogren syndrome antigen A2 (60kDa, ribonucleoprotein autoantigen SS-A/Ro)
 TROVE domain family, member 2
LocusID (NCBI) 6738
Atlas_Id 75207
Location 1q31.2  [Link to chromosome band 1q31]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;1)(q31;q32) TROVE2/CACNA1S


External links

Nomenclature
HGNC (Hugo)RO60   11313
Cards
Entrez_Gene (NCBI)RO60  6738  Ro60, Y RNA binding protein
AliasesRORNP; SSA2; TROVE2
GeneCards (Weizmann)RO60
Ensembl hg19 (Hinxton)ENSG00000116747 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000116747 [Gene_View]  ENSG00000116747 [Sequence]  - [Contig_View]  RO60 [Vega]
ICGC DataPortalENSG00000116747
TCGA cBioPortalRO60
AceView (NCBI)RO60
Genatlas (Paris)RO60
WikiGenes6738
SOURCE (Princeton)RO60
Genetics Home Reference (NIH)RO60
Genomic and cartography
GoldenPath hg38 (UCSC)RO60  -  
GoldenPath hg19 (UCSC)RO60  -  
GoldenPathRO60 - [CytoView hg19]  RO60 - [CytoView hg38]
ImmunoBaseENSG00000116747
genome Data Viewer NCBIRO60 [Mapview hg19]  
OMIM600063   
Gene and transcription
Genbank (Entrez)AH003763 AI433657 AK314594 AY205314 AY205315
RefSeq transcript (Entrez)NM_001042369 NM_001042370 NM_001173524 NM_001173525 NM_001331020 NM_004600
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RO60
Alternative Splicing GalleryENSG00000116747
Gene ExpressionRO60 [ NCBI-GEO ]   RO60 [ EBI - ARRAY_EXPRESS ]   RO60 [ SEEK ]   RO60 [ MEM ]
Gene Expression Viewer (FireBrowse)RO60 [ Firebrowse - Broad ]
GenevisibleExpression of RO60 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6738
GTEX Portal (Tissue expression)RO60
Human Protein AtlasENSG00000116747-RO60 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10155   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP10155  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP10155
Splice isoforms : SwissVarP10155
PhosPhoSitePlusP10155
Domaine pattern : Prosite (Expaxy)TROVE (PS50988)   
Domains : Interpro (EBI)TROVE2    TROVE_dom    TROVE_dom_sf    vWFA_dom_sf   
Domain families : Pfam (Sanger)TROVE (PF05731)   
Domain families : Pfam (NCBI)pfam05731   
Conserved Domain (NCBI)RO60
DMDM Disease mutations6738
Blocks (Seattle)RO60
SuperfamilyP10155
Human Protein Atlas [tissue]ENSG00000116747-RO60 [tissue]
Peptide AtlasP10155
HPRD15964
IPIIPI00019450   IPI00219287   IPI00760707   IPI00642416   IPI00646322   IPI00646813   IPI00642895   IPI00969077   IPI00966215   
Protein Interaction databases
DIP (DOE-UCLA)P10155
IntAct (EBI)P10155
FunCoupENSG00000116747
BioGRIDRO60
STRING (EMBL)RO60
ZODIACRO60
Ontologies - Pathways
QuickGOP10155
Ontology : AmiGOimmune system development  RNA binding  RNA binding  nucleoplasm  cytosol  transcription by RNA polymerase III  smoothened signaling pathway  response to UV  regulation of gene expression  U2 snRNA binding  cellular response to interferon-alpha  metal ion binding  cilium assembly  ribonucleoprotein complex  ribonucleoprotein complex  
Ontology : EGO-EBIimmune system development  RNA binding  RNA binding  nucleoplasm  cytosol  transcription by RNA polymerase III  smoothened signaling pathway  response to UV  regulation of gene expression  U2 snRNA binding  cellular response to interferon-alpha  metal ion binding  cilium assembly  ribonucleoprotein complex  ribonucleoprotein complex  
NDEx NetworkRO60
Atlas of Cancer Signalling NetworkRO60
Wikipedia pathwaysRO60
Orthology - Evolution
OrthoDB6738
GeneTree (enSembl)ENSG00000116747
Phylogenetic Trees/Animal Genes : TreeFamRO60
HOGENOMP10155
Homologs : HomoloGeneRO60
Homology/Alignments : Family Browser (UCSC)RO60
Gene fusions - Rearrangements
Fusion : QuiverRO60
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRO60 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RO60
dbVarRO60
ClinVarRO60
1000_GenomesRO60 
Exome Variant ServerRO60
GNOMAD BrowserENSG00000116747
Varsome BrowserRO60
Genetic variants : HAPMAP6738
Genomic Variants (DGV)RO60 [DGVbeta]
DECIPHERRO60 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRO60 
Mutations
ICGC Data PortalRO60 
TCGA Data PortalRO60 
Broad Tumor PortalRO60
OASIS PortalRO60 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDRO60
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RO60
DgiDB (Drug Gene Interaction Database)RO60
DoCM (Curated mutations)RO60 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RO60 (select a term)
intoGenRO60
Cancer3DRO60(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600063   
Orphanet
DisGeNETRO60
MedgenRO60
Genetic Testing Registry RO60
NextProtP10155 [Medical]
TSGene6738
GENETestsRO60
Target ValidationRO60
Huge Navigator RO60 [HugePedia]
snp3D : Map Gene to Disease6738
BioCentury BCIQRO60
ClinGenRO60
Clinical trials, drugs, therapy
Protein Interactions : CTD6738
Pharm GKB GenePA36137
Clinical trialRO60
Miscellaneous
canSAR (ICR)RO60 (select the gene name)
HarmonizomeRO60
DataMed IndexRO60
Probes
Litterature
PubMed63 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRO60
EVEXRO60
GoPubMedRO60
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 15:45:57 CEST 2020

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