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ROBO2 (roundabout guidance receptor 2)

Identity

Alias_namesroundabout (axon guidance receptor, Drosophila) homolog 2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
Alias_symbol (synonym)KIAA1568
Other aliasSAX3
HGNC (Hugo) ROBO2
LocusID (NCBI) 6092
Atlas_Id 54589
Location 3p12.3  [Link to chromosome band 3p12]
Location_base_pair Starts at 77040143 and ends at 77649963 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ASAP1 (8q24.21) / ROBO2 (3p12.3)CWC25 (17q12) / ROBO2 (3p12.3)KCTD12 (13q22.3) / ROBO2 (3p12.3)
ROBO2 (3p12.3) / CADM2 (3p12.1)ROBO2 (3p12.3) / ERLIN2 (8p11.23)ROBO2 (3p12.3) / GOLPH3 (5p13.3)
ROBO2 (3p12.3) / PAFAH2 (1p36.11)ROBO2 (3p12.3) / PSMD14 (2q24.2)ROBO2 (3p12.3) / ZFP1 (16q23.1)
USH2A (1q41) / ROBO2 (3p12.3)VPS72 (1q21.3) / ROBO2 (3p12.3)ROBO2 3p12.3 / ERLIN2 8p11.23
VPS72 1q21.3 / ROBO2 3p12.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]

Solid Tumors TT_t0103q21p12ID104390 TT_t0308p12p11ID106184 TT_t0312p12q15ID105610 TT_t0317p12q12ID105663

External links

Nomenclature
HGNC (Hugo)ROBO2   10250
Cards
Entrez_Gene (NCBI)ROBO2  6092  roundabout guidance receptor 2
AliasesSAX3
GeneCards (Weizmann)ROBO2
Ensembl hg19 (Hinxton)ENSG00000185008 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185008 [Gene_View]  ENSG00000185008 [Sequence]  chr3:77040143-77649963 [Contig_View]  ROBO2 [Vega]
ICGC DataPortalENSG00000185008
TCGA cBioPortalROBO2
AceView (NCBI)ROBO2
Genatlas (Paris)ROBO2
WikiGenes6092
SOURCE (Princeton)ROBO2
Genetics Home Reference (NIH)ROBO2
Genomic and cartography
GoldenPath hg38 (UCSC)ROBO2  -     chr3:77040143-77649963 +  3p12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ROBO2  -     3p12.3   [Description]    (hg19-Feb_2009)
GoldenPathROBO2 - 3p12.3 [CytoView hg19]  ROBO2 - 3p12.3 [CytoView hg38]
ImmunoBaseENSG00000185008
Mapping of homologs : NCBIROBO2 [Mapview hg19]  ROBO2 [Mapview hg38]
OMIM602431   610878   
Gene and transcription
Genbank (Entrez)AB046788 AF040991 AK074780 AK301176 BC064374
RefSeq transcript (Entrez)NM_001128929 NM_001290039 NM_001290040 NM_001290065 NM_002942
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ROBO2
Alternative Splicing GalleryENSG00000185008
Gene ExpressionROBO2 [ NCBI-GEO ]   ROBO2 [ EBI - ARRAY_EXPRESS ]   ROBO2 [ SEEK ]   ROBO2 [ MEM ]
Gene Expression Viewer (FireBrowse)ROBO2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6092
GTEX Portal (Tissue expression)ROBO2
Human Protein AtlasENSG00000185008-ROBO2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HCK4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HCK4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HCK4
Splice isoforms : SwissVarQ9HCK4
PhosPhoSitePlusQ9HCK4
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    IG_LIKE (PS50835)   
Domains : Interpro (EBI)FN3_dom    FN3_sf    Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_I-set    Ig_sub    Ig_sub2    Ig_V-set   
Domain families : Pfam (Sanger)fn3 (PF00041)    I-set (PF07679)   
Domain families : Pfam (NCBI)pfam00041    pfam07679   
Domain families : Smart (EMBL)FN3 (SM00060)  IG (SM00409)  IGc2 (SM00408)  IGv (SM00406)  
Conserved Domain (NCBI)ROBO2
DMDM Disease mutations6092
Blocks (Seattle)ROBO2
PDB (RSDB)1UEM    1UJT    2EDJ    5NOI    6I9S    6IAA   
PDB Europe1UEM    1UJT    2EDJ    5NOI    6I9S    6IAA   
PDB (PDBSum)1UEM    1UJT    2EDJ    5NOI    6I9S    6IAA   
PDB (IMB)1UEM    1UJT    2EDJ    5NOI    6I9S    6IAA   
Structural Biology KnowledgeBase1UEM    1UJT    2EDJ    5NOI    6I9S    6IAA   
SCOP (Structural Classification of Proteins)1UEM    1UJT    2EDJ    5NOI    6I9S    6IAA   
CATH (Classification of proteins structures)1UEM    1UJT    2EDJ    5NOI    6I9S    6IAA   
SuperfamilyQ9HCK4
Human Protein Atlas [tissue]ENSG00000185008-ROBO2 [tissue]
Peptide AtlasQ9HCK4
IPIIPI00385980   IPI00420043   IPI00939730   IPI00791479   IPI00900311   IPI00945364   IPI01025935   IPI00946902   IPI00945803   IPI00946940   
Protein Interaction databases
DIP (DOE-UCLA)Q9HCK4
IntAct (EBI)Q9HCK4
FunCoupENSG00000185008
BioGRIDROBO2
STRING (EMBL)ROBO2
ZODIACROBO2
Ontologies - Pathways
QuickGOQ9HCK4
Ontology : AmiGOmetanephros development  ureteric bud development  outflow tract septum morphogenesis  aortic valve morphogenesis  pulmonary valve morphogenesis  endocardial cushion formation  protein binding  plasma membrane  homophilic cell adhesion via plasma membrane adhesion molecules  axon guidance  axon guidance  central nervous system development  brain development  axon guidance receptor activity  axon guidance receptor activity  cell surface  integral component of membrane  axon midline choice point recognition  spinal cord development  olfactory bulb interneuron development  axolemma  retinal ganglion cell axon guidance  cellular response to hormone stimulus  positive regulation of Notch signaling pathway involved in heart induction  aorta development  identical protein binding  positive regulation of axonogenesis  negative regulation of negative chemotaxis  negative regulation of synapse assembly  ventricular septum morphogenesis  apoptotic process involved in luteolysis  extracellular exosome  
Ontology : EGO-EBImetanephros development  ureteric bud development  outflow tract septum morphogenesis  aortic valve morphogenesis  pulmonary valve morphogenesis  endocardial cushion formation  protein binding  plasma membrane  homophilic cell adhesion via plasma membrane adhesion molecules  axon guidance  axon guidance  central nervous system development  brain development  axon guidance receptor activity  axon guidance receptor activity  cell surface  integral component of membrane  axon midline choice point recognition  spinal cord development  olfactory bulb interneuron development  axolemma  retinal ganglion cell axon guidance  cellular response to hormone stimulus  positive regulation of Notch signaling pathway involved in heart induction  aorta development  identical protein binding  positive regulation of axonogenesis  negative regulation of negative chemotaxis  negative regulation of synapse assembly  ventricular septum morphogenesis  apoptotic process involved in luteolysis  extracellular exosome  
Pathways : KEGGAxon guidance   
NDEx NetworkROBO2
Atlas of Cancer Signalling NetworkROBO2
Wikipedia pathwaysROBO2
Orthology - Evolution
OrthoDB6092
GeneTree (enSembl)ENSG00000185008
Phylogenetic Trees/Animal Genes : TreeFamROBO2
HOGENOMQ9HCK4
Homologs : HomoloGeneROBO2
Homology/Alignments : Family Browser (UCSC)ROBO2
Gene fusions - Rearrangements
Fusion : MitelmanCWC25/ROBO2 [17q12/3p12.3]  [t(3;17)(p12;q12)]  
Fusion : MitelmanROBO2/ERLIN2 [3p12.3/8p11.23]  [t(3;8)(p12;p11)]  
Fusion : MitelmanVPS72/ROBO2 [1q21.3/3p12.3]  [t(1;3)(q21;p12)]  
Fusion PortalROBO2 3p12.3 ERLIN2 8p11.23 LUSC
Fusion PortalVPS72 1q21.3 ROBO2 3p12.3 LUAD
Fusion : QuiverROBO2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerROBO2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ROBO2
dbVarROBO2
ClinVarROBO2
1000_GenomesROBO2 
Exome Variant ServerROBO2
ExAC (Exome Aggregation Consortium)ENSG00000185008
GNOMAD BrowserENSG00000185008
Varsome BrowserROBO2
Genetic variants : HAPMAP6092
Genomic Variants (DGV)ROBO2 [DGVbeta]
DECIPHERROBO2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisROBO2 
Mutations
ICGC Data PortalROBO2 
TCGA Data PortalROBO2 
Broad Tumor PortalROBO2
OASIS PortalROBO2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICROBO2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DROBO2
Mutations and Diseases : HGMDROBO2
intOGen PortalROBO2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ROBO2
DgiDB (Drug Gene Interaction Database)ROBO2
DoCM (Curated mutations)ROBO2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ROBO2 (select a term)
intoGenROBO2
Cancer3DROBO2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602431    610878   
Orphanet20715   
DisGeNETROBO2
MedgenROBO2
Genetic Testing Registry ROBO2
NextProtQ9HCK4 [Medical]
TSGene6092
GENETestsROBO2
Target ValidationROBO2
Huge Navigator ROBO2 [HugePedia]
snp3D : Map Gene to Disease6092
BioCentury BCIQROBO2
ClinGenROBO2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6092
Chemical/Pharm GKB GenePA34621
Clinical trialROBO2
Miscellaneous
canSAR (ICR)ROBO2 (select the gene name)
DataMed IndexROBO2
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineROBO2
EVEXROBO2
GoPubMedROBO2
iHOPROBO2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Feb 19 17:06:29 CET 2020
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