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ROBO2 (roundabout guidance receptor 2)

Identity

Alias_namesroundabout (axon guidance receptor, Drosophila) homolog 2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
Alias_symbol (synonym)KIAA1568
Other aliasSAX3
HGNC (Hugo) ROBO2
LocusID (NCBI) 6092
Atlas_Id 54589
Location 3p12.3  [Link to chromosome band 3p12]
Location_base_pair Starts at 77147163 and ends at 77699114 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ASAP1 (8q24.21) / ROBO2 (3p12.3)CWC25 (17q12) / ROBO2 (3p12.3)KCTD12 (13q22.3) / ROBO2 (3p12.3)
ROBO2 (3p12.3) / CADM2 (3p12.1)ROBO2 (3p12.3) / ERLIN2 (8p11.23)ROBO2 (3p12.3) / GOLPH3 (5p13.3)
ROBO2 (3p12.3) / PAFAH2 (1p36.11)ROBO2 (3p12.3) / PSMD14 (2q24.2)ROBO2 (3p12.3) / ZFP1 (16q23.1)
USH2A (1q41) / ROBO2 (3p12.3)VPS72 (1q21.3) / ROBO2 (3p12.3)ROBO2 3p12.3 / ERLIN2 8p11.23
VPS72 1q21.3 / ROBO2 3p12.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ROBO2   10250
Cards
Entrez_Gene (NCBI)ROBO2  6092  roundabout guidance receptor 2
AliasesSAX3
GeneCards (Weizmann)ROBO2
Ensembl hg19 (Hinxton)ENSG00000185008 [Gene_View]  chr3:77147163-77699114 [Contig_View]  ROBO2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000185008 [Gene_View]  chr3:77147163-77699114 [Contig_View]  ROBO2 [Vega]
ICGC DataPortalENSG00000185008
TCGA cBioPortalROBO2
AceView (NCBI)ROBO2
Genatlas (Paris)ROBO2
WikiGenes6092
SOURCE (Princeton)ROBO2
Genetics Home Reference (NIH)ROBO2
Genomic and cartography
GoldenPath hg19 (UCSC)ROBO2  -     chr3:77147163-77699114 +  3p12.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ROBO2  -     3p12.3   [Description]    (hg38-Dec_2013)
EnsemblROBO2 - 3p12.3 [CytoView hg19]  ROBO2 - 3p12.3 [CytoView hg38]
Mapping of homologs : NCBIROBO2 [Mapview hg19]  ROBO2 [Mapview hg38]
OMIM602431   610878   
Gene and transcription
Genbank (Entrez)AB046788 AF040991 AK074780 AK301176 BC064374
RefSeq transcript (Entrez)NM_001128929 NM_001290039 NM_001290040 NM_001290065 NM_002942
RefSeq genomic (Entrez)NC_000003 NC_018914 NG_027734 NT_022517 NW_004929310
Consensus coding sequences : CCDS (NCBI)ROBO2
Cluster EST : UnigeneHs.13305 [ NCBI ]
CGAP (NCI)Hs.13305
Alternative Splicing GalleryENSG00000185008
Gene ExpressionROBO2 [ NCBI-GEO ]   ROBO2 [ EBI - ARRAY_EXPRESS ]   ROBO2 [ SEEK ]   ROBO2 [ MEM ]
Gene Expression Viewer (FireBrowse)ROBO2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6092
GTEX Portal (Tissue expression)ROBO2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HCK4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HCK4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HCK4
Splice isoforms : SwissVarQ9HCK4
PhosPhoSitePlusQ9HCK4
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    IG_LIKE (PS50835)   
Domains : Interpro (EBI)FN3_dom    Ig-like_dom    Ig-like_fold    Ig_I-set    Ig_sub2    Robo2   
Domain families : Pfam (Sanger)fn3 (PF00041)    I-set (PF07679)   
Domain families : Pfam (NCBI)pfam00041    pfam07679   
Domain families : Smart (EMBL)FN3 (SM00060)  IGc2 (SM00408)  
Conserved Domain (NCBI)ROBO2
DMDM Disease mutations6092
Blocks (Seattle)ROBO2
PDB (SRS)1UEM    1UJT    2EDJ   
PDB (PDBSum)1UEM    1UJT    2EDJ   
PDB (IMB)1UEM    1UJT    2EDJ   
PDB (RSDB)1UEM    1UJT    2EDJ   
Structural Biology KnowledgeBase1UEM    1UJT    2EDJ   
SCOP (Structural Classification of Proteins)1UEM    1UJT    2EDJ   
CATH (Classification of proteins structures)1UEM    1UJT    2EDJ   
SuperfamilyQ9HCK4
Human Protein AtlasENSG00000185008
Peptide AtlasQ9HCK4
IPIIPI00385980   IPI00420043   IPI00939730   IPI00791479   IPI00900311   IPI00945364   IPI01025935   IPI00946902   IPI00945803   IPI00946940   
Protein Interaction databases
DIP (DOE-UCLA)Q9HCK4
IntAct (EBI)Q9HCK4
FunCoupENSG00000185008
BioGRIDROBO2
STRING (EMBL)ROBO2
ZODIACROBO2
Ontologies - Pathways
QuickGOQ9HCK4
Ontology : AmiGOmetanephros development  ureteric bud development  protein binding  homophilic cell adhesion via plasma membrane adhesion molecules  axon guidance  central nervous system development  brain development  axon guidance receptor activity  axon guidance receptor activity  cell surface  integral component of membrane  axon midline choice point recognition  olfactory bulb interneuron development  axolemma  retinal ganglion cell axon guidance  cellular response to hormone stimulus  Roundabout signaling pathway  identical protein binding  positive regulation of axonogenesis  negative regulation of negative chemotaxis  negative regulation of synapse assembly  apoptotic process involved in luteolysis  extracellular exosome  
Ontology : EGO-EBImetanephros development  ureteric bud development  protein binding  homophilic cell adhesion via plasma membrane adhesion molecules  axon guidance  central nervous system development  brain development  axon guidance receptor activity  axon guidance receptor activity  cell surface  integral component of membrane  axon midline choice point recognition  olfactory bulb interneuron development  axolemma  retinal ganglion cell axon guidance  cellular response to hormone stimulus  Roundabout signaling pathway  identical protein binding  positive regulation of axonogenesis  negative regulation of negative chemotaxis  negative regulation of synapse assembly  apoptotic process involved in luteolysis  extracellular exosome  
Pathways : KEGGAxon guidance   
NDEx NetworkROBO2
Atlas of Cancer Signalling NetworkROBO2
Wikipedia pathwaysROBO2
Orthology - Evolution
OrthoDB6092
GeneTree (enSembl)ENSG00000185008
Phylogenetic Trees/Animal Genes : TreeFamROBO2
HOVERGENQ9HCK4
HOGENOMQ9HCK4
Homologs : HomoloGeneROBO2
Homology/Alignments : Family Browser (UCSC)ROBO2
Gene fusions - Rearrangements
Fusion : MitelmanCWC25/ROBO2 [17q12/3p12.3]  [t(3;17)(p12;q12)]  
Fusion : MitelmanROBO2/ERLIN2 [3p12.3/8p11.23]  [t(3;8)(p12;p11)]  
Fusion : MitelmanVPS72/ROBO2 [1q21.3/3p12.3]  [t(1;3)(q21;p12)]  
Fusion: TCGAROBO2 3p12.3 ERLIN2 8p11.23 LUSC
Fusion: TCGAVPS72 1q21.3 ROBO2 3p12.3 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerROBO2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ROBO2
dbVarROBO2
ClinVarROBO2
1000_GenomesROBO2 
Exome Variant ServerROBO2
ExAC (Exome Aggregation Consortium)ROBO2 (select the gene name)
Genetic variants : HAPMAP6092
Genomic Variants (DGV)ROBO2 [DGVbeta]
DECIPHER (Syndromes)3:77147163-77699114  ENSG00000185008
CONAN: Copy Number AnalysisROBO2 
Mutations
ICGC Data PortalROBO2 
TCGA Data PortalROBO2 
Broad Tumor PortalROBO2
OASIS PortalROBO2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICROBO2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDROBO2
intOGen PortalROBO2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ROBO2
DgiDB (Drug Gene Interaction Database)ROBO2
DoCM (Curated mutations)ROBO2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ROBO2 (select a term)
intoGenROBO2
Cancer3DROBO2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602431    610878   
Orphanet20715   
MedgenROBO2
Genetic Testing Registry ROBO2
NextProtQ9HCK4 [Medical]
TSGene6092
GENETestsROBO2
Huge Navigator ROBO2 [HugePedia]
snp3D : Map Gene to Disease6092
BioCentury BCIQROBO2
ClinGenROBO2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6092
Chemical/Pharm GKB GenePA34621
Clinical trialROBO2
Miscellaneous
canSAR (ICR)ROBO2 (select the gene name)
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineROBO2
EVEXROBO2
GoPubMedROBO2
iHOPROBO2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:25:29 CET 2017

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