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ROBO2 (roundabout guidance receptor 2)

Identity

Alias (NCBI)SAX3
HGNC (Hugo) ROBO2
HGNC Alias symbKIAA1568
HGNC Previous nameroundabout (axon guidance receptor, Drosophila) homolog 2
 roundabout, axon guidance receptor, homolog 2 (Drosophila)
LocusID (NCBI) 6092
Atlas_Id 54589
Location 3p12.3  [Link to chromosome band 3p12]
Location_base_pair Starts at 77040099 and ends at 77649963 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ASAP1 (8q24.21) / ROBO2 (3p12.3)CWC25 (17q12) / ROBO2 (3p12.3)KCTD12 (13q22.3) / ROBO2 (3p12.3)
ROBO2 (3p12.3) / CADM2 (3p12.1)ROBO2 (3p12.3) / ERLIN2 (8p11.23)ROBO2 (3p12.3) / GOLPH3 (5p13.3)
ROBO2 (3p12.3) / PAFAH2 (1p36.11)ROBO2 (3p12.3) / PSMD14 (2q24.2)ROBO2 (3p12.3) / ZFP1 (16q23.1)
USH2A (1q41) / ROBO2 (3p12.3)VPS72 (1q21.3) / ROBO2 (3p12.3)ROBO2 3p12.3 / ERLIN2 8p11.23
VPS72 1q21.3 / ROBO2 3p12.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ROBO2   10250
Cards
Entrez_Gene (NCBI)ROBO2    roundabout guidance receptor 2
AliasesSAX3
GeneCards (Weizmann)ROBO2
Ensembl hg19 (Hinxton)ENSG00000185008 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185008 [Gene_View]  ENSG00000185008 [Sequence]  chr3:77040099-77649963 [Contig_View]  ROBO2 [Vega]
ICGC DataPortalENSG00000185008
TCGA cBioPortalROBO2
AceView (NCBI)ROBO2
Genatlas (Paris)ROBO2
SOURCE (Princeton)ROBO2
Genetics Home Reference (NIH)ROBO2
Genomic and cartography
GoldenPath hg38 (UCSC)ROBO2  -     chr3:77040099-77649963 +  3p12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ROBO2  -     3p12.3   [Description]    (hg19-Feb_2009)
GoldenPathROBO2 - 3p12.3 [CytoView hg19]  ROBO2 - 3p12.3 [CytoView hg38]
ImmunoBaseENSG00000185008
Genome Data Viewer NCBIROBO2 [Mapview hg19]  
OMIM602431   610878   
Gene and transcription
Genbank (Entrez)AB046788 AF040991 AK074780 AK301176 BC064374
RefSeq transcript (Entrez)NM_001128929 NM_001290039 NM_001290040 NM_001290065 NM_001378190 NM_001378191 NM_001378192 NM_001378193 NM_001378194 NM_001378195 NM_001378196 NM_001378197 NM_001378198 NM_001378199 NM_001378200 NM_001378201 NM_001378202 NM_001378203 NM_001394212 NM_001394213 NM_001394214 NM_002942
Consensus coding sequences : CCDS (NCBI)ROBO2
Gene ExpressionROBO2 [ NCBI-GEO ]   ROBO2 [ EBI - ARRAY_EXPRESS ]   ROBO2 [ SEEK ]   ROBO2 [ MEM ]
Gene Expression Viewer (FireBrowse)ROBO2 [ Firebrowse - Broad ]
GenevisibleExpression of ROBO2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6092
GTEX Portal (Tissue expression)ROBO2
Human Protein AtlasENSG00000185008-ROBO2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HCK4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HCK4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HCK4
PhosPhoSitePlusQ9HCK4
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    IG_LIKE (PS50835)   
Domains : Interpro (EBI)FN3_dom    FN3_sf    Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_I-set    Ig_sub    Ig_sub2    Ig_V-set   
Domain families : Pfam (Sanger)fn3 (PF00041)    I-set (PF07679)   
Domain families : Pfam (NCBI)pfam00041    pfam07679   
Domain families : Smart (EMBL)FN3 (SM00060)  IG (SM00409)  IGc2 (SM00408)  IGv (SM00406)  
Conserved Domain (NCBI)ROBO2
PDB (RSDB)1UEM    1UJT    2EDJ    5NOI    6I9S    6IAA   
PDB Europe1UEM    1UJT    2EDJ    5NOI    6I9S    6IAA   
PDB (PDBSum)1UEM    1UJT    2EDJ    5NOI    6I9S    6IAA   
PDB (IMB)1UEM    1UJT    2EDJ    5NOI    6I9S    6IAA   
Structural Biology KnowledgeBase1UEM    1UJT    2EDJ    5NOI    6I9S    6IAA   
SCOP (Structural Classification of Proteins)1UEM    1UJT    2EDJ    5NOI    6I9S    6IAA   
CATH (Classification of proteins structures)1UEM    1UJT    2EDJ    5NOI    6I9S    6IAA   
SuperfamilyQ9HCK4
AlphaFold pdb e-kbQ9HCK4   
Human Protein Atlas [tissue]ENSG00000185008-ROBO2 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q9HCK4
IntAct (EBI)Q9HCK4
BioGRIDROBO2
STRING (EMBL)ROBO2
ZODIACROBO2
Ontologies - Pathways
QuickGOQ9HCK4
Ontology : AmiGOmetanephros development  ureteric bud development  outflow tract septum morphogenesis  aortic valve morphogenesis  pulmonary valve morphogenesis  endocardial cushion formation  protein binding  plasma membrane  homophilic cell adhesion via plasma membrane adhesion molecules  axon guidance  axon guidance  central nervous system development  brain development  axon guidance receptor activity  axon guidance receptor activity  cell surface  integral component of membrane  axon midline choice point recognition  spinal cord development  olfactory bulb interneuron development  axolemma  retinal ganglion cell axon guidance  cellular response to hormone stimulus  positive regulation of Notch signaling pathway involved in heart induction  aorta development  identical protein binding  positive regulation of axonogenesis  negative regulation of negative chemotaxis  negative regulation of synapse assembly  ventricular septum morphogenesis  apoptotic process involved in luteolysis  extracellular exosome  
Ontology : EGO-EBImetanephros development  ureteric bud development  outflow tract septum morphogenesis  aortic valve morphogenesis  pulmonary valve morphogenesis  endocardial cushion formation  protein binding  plasma membrane  homophilic cell adhesion via plasma membrane adhesion molecules  axon guidance  axon guidance  central nervous system development  brain development  axon guidance receptor activity  axon guidance receptor activity  cell surface  integral component of membrane  axon midline choice point recognition  spinal cord development  olfactory bulb interneuron development  axolemma  retinal ganglion cell axon guidance  cellular response to hormone stimulus  positive regulation of Notch signaling pathway involved in heart induction  aorta development  identical protein binding  positive regulation of axonogenesis  negative regulation of negative chemotaxis  negative regulation of synapse assembly  ventricular septum morphogenesis  apoptotic process involved in luteolysis  extracellular exosome  
Pathways : KEGGAxon guidance   
NDEx NetworkROBO2
Atlas of Cancer Signalling NetworkROBO2
Wikipedia pathwaysROBO2
Orthology - Evolution
OrthoDB6092
GeneTree (enSembl)ENSG00000185008
Phylogenetic Trees/Animal Genes : TreeFamROBO2
Homologs : HomoloGeneROBO2
Homology/Alignments : Family Browser (UCSC)ROBO2
Gene fusions - Rearrangements
Fusion : MitelmanCWC25/ROBO2 [17q12/3p12.3]  
Fusion : MitelmanROBO2/ERLIN2 [3p12.3/8p11.23]  
Fusion : MitelmanVPS72/ROBO2 [1q21.3/3p12.3]  
Fusion : QuiverROBO2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerROBO2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ROBO2
dbVarROBO2
ClinVarROBO2
MonarchROBO2
1000_GenomesROBO2 
Exome Variant ServerROBO2
GNOMAD BrowserENSG00000185008
Varsome BrowserROBO2
ACMGROBO2 variants
VarityQ9HCK4
Genomic Variants (DGV)ROBO2 [DGVbeta]
DECIPHERROBO2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisROBO2 
Mutations
ICGC Data PortalROBO2 
TCGA Data PortalROBO2 
Broad Tumor PortalROBO2
OASIS PortalROBO2 [ Somatic mutations - Copy number]
Cancer Gene: CensusROBO2 
Somatic Mutations in Cancer : COSMICROBO2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DROBO2
Mutations and Diseases : HGMDROBO2
intOGen PortalROBO2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaROBO2
DgiDB (Drug Gene Interaction Database)ROBO2
DoCM (Curated mutations)ROBO2
CIViC (Clinical Interpretations of Variants in Cancer)ROBO2
Cancer3DROBO2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602431    610878   
Orphanet20715   
DisGeNETROBO2
MedgenROBO2
Genetic Testing Registry ROBO2
NextProtQ9HCK4 [Medical]
GENETestsROBO2
Target ValidationROBO2
Huge Navigator ROBO2 [HugePedia]
ClinGenROBO2
Clinical trials, drugs, therapy
MyCancerGenomeROBO2
Protein Interactions : CTDROBO2
Pharm GKB GenePA34621
PharosQ9HCK4
Clinical trialROBO2
Miscellaneous
canSAR (ICR)ROBO2
HarmonizomeROBO2
DataMed IndexROBO2
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXROBO2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:29:22 CEST 2021

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