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ROBO3 (roundabout guidance receptor 3)

Identity

Alias_namesHGPPS
roundabout (axon guidance receptor, Drosophila) homolog 3
horizontal gaze palsy with progressive scoliosis
roundabout, axon guidance receptor, homolog 3 (Drosophila)
Alias_symbol (synonym)RBIG1
FLJ21044
HGPS
HGNC (Hugo) ROBO3
LocusID (NCBI) 64221
Atlas_Id 52146
Location 11q24.2  [Link to chromosome band 11q24]
Location_base_pair Starts at 124735305 and ends at 124751370 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ROBO3 (11q24.2) / ROBO3 (11q24.2)ROBO3 (11q24.2) / SCARB1 (12q24.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ROBO3   13433
Cards
Entrez_Gene (NCBI)ROBO3  64221  roundabout guidance receptor 3
AliasesHGPPS; HGPS; RBIG1; RIG1
GeneCards (Weizmann)ROBO3
Ensembl hg19 (Hinxton)ENSG00000154134 [Gene_View]  chr11:124735305-124751370 [Contig_View]  ROBO3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000154134 [Gene_View]  chr11:124735305-124751370 [Contig_View]  ROBO3 [Vega]
ICGC DataPortalENSG00000154134
TCGA cBioPortalROBO3
AceView (NCBI)ROBO3
Genatlas (Paris)ROBO3
WikiGenes64221
SOURCE (Princeton)ROBO3
Genetics Home Reference (NIH)ROBO3
Genomic and cartography
GoldenPath hg19 (UCSC)ROBO3  -     chr11:124735305-124751370 +  11q24.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ROBO3  -     11q24.2   [Description]    (hg38-Dec_2013)
EnsemblROBO3 - 11q24.2 [CytoView hg19]  ROBO3 - 11q24.2 [CytoView hg38]
Mapping of homologs : NCBIROBO3 [Mapview hg19]  ROBO3 [Mapview hg38]
OMIM607313   608630   
Gene and transcription
Genbank (Entrez)AK024697 AK225076 AK291045 AK295475 AK298792
RefSeq transcript (Entrez)NM_022370
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_016214 NT_033899 NW_004929381
Consensus coding sequences : CCDS (NCBI)ROBO3
Cluster EST : UnigeneHs.435621 [ NCBI ]
CGAP (NCI)Hs.435621
Alternative Splicing GalleryENSG00000154134
Gene ExpressionROBO3 [ NCBI-GEO ]   ROBO3 [ EBI - ARRAY_EXPRESS ]   ROBO3 [ SEEK ]   ROBO3 [ MEM ]
Gene Expression Viewer (FireBrowse)ROBO3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64221
GTEX Portal (Tissue expression)ROBO3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96MS0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96MS0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96MS0
Splice isoforms : SwissVarQ96MS0
PhosPhoSitePlusQ96MS0
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    IG_LIKE (PS50835)   
Domains : Interpro (EBI)FN3_dom    Ig-like_dom    Ig-like_fold    Ig_I-set    Ig_sub2    Robo3   
Domain families : Pfam (Sanger)fn3 (PF00041)    I-set (PF07679)   
Domain families : Pfam (NCBI)pfam00041    pfam07679   
Domain families : Smart (EMBL)FN3 (SM00060)  IGc2 (SM00408)  
Conserved Domain (NCBI)ROBO3
DMDM Disease mutations64221
Blocks (Seattle)ROBO3
SuperfamilyQ96MS0
Human Protein AtlasENSG00000154134
Peptide AtlasQ96MS0
HPRD10554
IPIIPI00418275   IPI00007176   IPI01010817   
Protein Interaction databases
DIP (DOE-UCLA)Q96MS0
IntAct (EBI)Q96MS0
FunCoupENSG00000154134
BioGRIDROBO3
STRING (EMBL)ROBO3
ZODIACROBO3
Ontologies - Pathways
QuickGOQ96MS0
Ontology : AmiGOaxon guidance  integral component of membrane  axon midline choice point recognition  axon  Roundabout signaling pathway  
Ontology : EGO-EBIaxon guidance  integral component of membrane  axon midline choice point recognition  axon  Roundabout signaling pathway  
Pathways : KEGGAxon guidance   
NDEx NetworkROBO3
Atlas of Cancer Signalling NetworkROBO3
Wikipedia pathwaysROBO3
Orthology - Evolution
OrthoDB64221
GeneTree (enSembl)ENSG00000154134
Phylogenetic Trees/Animal Genes : TreeFamROBO3
HOVERGENQ96MS0
HOGENOMQ96MS0
Homologs : HomoloGeneROBO3
Homology/Alignments : Family Browser (UCSC)ROBO3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerROBO3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ROBO3
dbVarROBO3
ClinVarROBO3
1000_GenomesROBO3 
Exome Variant ServerROBO3
ExAC (Exome Aggregation Consortium)ROBO3 (select the gene name)
Genetic variants : HAPMAP64221
Genomic Variants (DGV)ROBO3 [DGVbeta]
DECIPHER (Syndromes)11:124735305-124751370  ENSG00000154134
CONAN: Copy Number AnalysisROBO3 
Mutations
ICGC Data PortalROBO3 
TCGA Data PortalROBO3 
Broad Tumor PortalROBO3
OASIS PortalROBO3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICROBO3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDROBO3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ROBO3
DgiDB (Drug Gene Interaction Database)ROBO3
DoCM (Curated mutations)ROBO3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ROBO3 (select a term)
intoGenROBO3
Cancer3DROBO3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607313    608630   
Orphanet552   
MedgenROBO3
Genetic Testing Registry ROBO3
NextProtQ96MS0 [Medical]
TSGene64221
GENETestsROBO3
Huge Navigator ROBO3 [HugePedia]
snp3D : Map Gene to Disease64221
BioCentury BCIQROBO3
ClinGenROBO3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64221
Chemical/Pharm GKB GenePA134896648
Clinical trialROBO3
Miscellaneous
canSAR (ICR)ROBO3 (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineROBO3
EVEXROBO3
GoPubMedROBO3
iHOPROBO3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Nov 18 19:50:11 CET 2016

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