ROBO4 (roundabout guidance receptor 4)

2007-02-01  

Identity

HGNC
LOCATION
11q24.2
LOCUSID
ALIAS
AOVD3,ECSM4,MRB

Other Information

Locus ID:

NCBI: 54538
MIM: 607528
HGNC: 17985
Ensembl: ENSG00000154133

Variants:

dbSNP: 54538
ClinVar: 54538
TCGA: ENSG00000154133
COSMIC: ROBO4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154133ENST00000306534Q8WZ75
ENSG00000154133ENST00000533054B4DYV8

Expression (GTEx)

0
50
100
150

References

Pubmed IDYearTitleCitations
203750032010Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenza.125
119449872002Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis.94
198553882009Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity.91
189483842009Active involvement of Robo1 and Robo4 in filopodia formation and endothelial cell motility mediated via WASP and other actin nucleation-promoting factors.47
158942872005Magic roundabout, a tumor endothelial marker: expression and signaling.46
182709762008Genetic analyses of roundabout (ROBO) axon guidance receptors in autism.34
182709762008Genetic analyses of roundabout (ROBO) axon guidance receptors in autism.34
166853772006Robo1/Robo4: differential expression of angiogenic markers in colorectal cancer.32
174961522007Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis.32
242729992014Slit2-Robo4 pathway modulates lipopolysaccharide-induced endothelial inflammation and its expression is dysregulated during endotoxemia.29

Citation

Dessen P

ROBO4 (roundabout guidance receptor 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45897/robo4