ROCK2 (Rho-associated, coiled-coil containing protein kinase 2)

Identity

Other names	KIAA0619
HGNC	ROCK2
Location	2p24
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	ROCK2   10252
Entrez_Gene	ROCK2  9475  Rho-associated, coiled-coil containing protein kinase 2
	Cards
GeneCards	ROCK2
Ensembl	ROCK2 [Search_View]   ENSG00000134318 [Gene_View]
Genatlas	ROCK2
GeneLynx	ROCK2
eGenome	ROCK2
euGene	9475
	Genomic and cartography
GoldenPath	ROCK2  -  2p24   chr2:11239229-11402162 -  2p25.1   [Description]    (hg18-March_2006)
Ensembl	ROCK2 - 2p25.1 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	ROCK2
	Gene and transcription
Genbank	AB014519 [ ENTREZ ]
Genbank	AK310358 [ ENTREZ ]
Genbank	BC111801 [ ENTREZ ]
Genbank	BG539531 [ ENTREZ ]
Genbank	CD652480 [ ENTREZ ]
RefSeq	NM_004850 [ SRS ]    NM_004850 [ ENTREZ ]
RefSeq	AC_000045 [ SRS ]    AC_000045 [ ENTREZ ]
RefSeq	AC_000134 [ SRS ]    AC_000134 [ ENTREZ ]
RefSeq	NC_000002 [ SRS ]    NC_000002 [ ENTREZ ]
RefSeq	NT_005334 [ SRS ]    NT_005334 [ ENTREZ ]
RefSeq	NW_001838766 [ SRS ]    NW_001838766 [ ENTREZ ]
RefSeq	NW_927719 [ SRS ]    NW_927719 [ ENTREZ ]
AceView	ROCK2 AceView - NCBI
Unigene	Hs.591600 [ SRS ]    Hs.591600 [ NCBI ]     HS591600 [ spliceNest ]
Fast-db	1391 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	O75116 [ SRS]    O75116 [ EXPASY ]     O75116 [ INTERPRO ]     O75116 [ UNIPROT ]
Prosite	PS51285 AGC_KINASE_CTER [ SRS ]    PS51285 AGC_KINASE_CTER [ Expasy ]
Prosite	PS50003 PH_DOMAIN [ SRS ]    PS50003 PH_DOMAIN [ Expasy ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00108 PROTEIN_KINASE_ST [ SRS ]    PS00108 PROTEIN_KINASE_ST [ Expasy ]
Prosite	PS00479 ZF_DAG_PE_1 [ SRS ]    PS00479 ZF_DAG_PE_1 [ Expasy ]
Prosite	PS50081 ZF_DAG_PE_2 [ SRS ]    PS50081 ZF_DAG_PE_2 [ Expasy ]
Interpro	IPR002219 DAG_PE_bd [ SRS ]    IPR002219 DAG_PE_bd [ EBI ]
Interpro	IPR000861 HR1-like_rho-bd [ SRS ]    IPR000861 HR1-like_rho-bd [ EBI ]
Interpro	IPR001849 PH [ SRS ]    IPR001849 PH [ EBI ]
Interpro	IPR000961 Pkinase_C [ SRS ]    IPR000961 Pkinase_C [ EBI ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR015008 Rho_bd [ SRS ]    IPR015008 Rho_bd [ EBI ]
Interpro	IPR015751 Rho_kinase [ SRS ]    IPR015751 Rho_kinase [ EBI ]
Interpro	IPR017442 Se/Thr_pkinase-rel [ SRS ]    IPR017442 Se/Thr_pkinase-rel [ EBI ]
Interpro	IPR008271 Ser_thr_pkin_AS [ SRS ]    IPR008271 Ser_thr_pkin_AS [ EBI ]
Interpro	IPR002290 Ser_thr_pkinase [ SRS ]    IPR002290 Ser_thr_pkinase [ EBI ]
CluSTr	O75116
Pfam	PF00130 C1_1 [ SRS ]    PF00130 C1_1 [ Sanger ]    pfam00130 [ NCBI-CDD ]
Pfam	PF02185 HR1 [ SRS ]    PF02185 HR1 [ Sanger ]    pfam02185 [ NCBI-CDD ]
Pfam	PF00169 PH [ SRS ]    PF00169 PH [ Sanger ]    pfam00169 [ NCBI-CDD ]
Pfam	PF00069 Pkinase [ SRS ]    PF00069 Pkinase [ Sanger ]    pfam00069 [ NCBI-CDD ]
Pfam	PF00433 Pkinase_C [ SRS ]    PF00433 Pkinase_C [ Sanger ]    pfam00433 [ NCBI-CDD ]
Pfam	PF08912 Rho_Binding [ SRS ]    PF08912 Rho_Binding [ Sanger ]    pfam08912 [ NCBI-CDD ]
Smart	SM00109 C1 [EMBL]
Smart	SM00233 PH [EMBL]
Smart	SM00133 S_TK_X [EMBL]
Smart	SM00220 S_TKc [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	O75116 ROCK2_HUMAN [ Domain structure ]   O75116 ROCK2_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	O75116
HPRD	04922
	Protein Interaction databases
DIP	O75116
IntAct	O75116
	Polymorphism : SNP, mutations, diseases
OMIM	604002    [ map ]
GENECLINICS	604002
SNP	ROCK2 [dbSNP-NCBI]
SNP	NM_004850 [SNP-NCI]
SNP	ROCK2 [GeneSNPs - Utah]  ROCK2] [HGBASE - SRS]
HAPMAP	ROCK2 [HAPMAP]
COSMIC	ROCK2 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	ROCK2
	General knowledge
Family Browser	ROCK2 [UCSC Family Browser]
SOURCE	NM_004850
SMD	Hs.591600
SAGE	Hs.591600
Enzyme	2.7.11.1 [ Enzyme-Expasy ]   2.7.11.1 [ Enzyme-SRS ]   2.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   2.7.11.1 [ WIT ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	cytokinesis [Amigo]  cytokinesis
GO	cytokinesis [Amigo]  cytokinesis
GO	protein serine/threonine kinase activity [Amigo]  protein serine/threonine kinase activity
GO	protein serine/threonine kinase activity [Amigo]  protein serine/threonine kinase activity
GO	structural molecule activity [Amigo]  structural molecule activity
GO	protein binding [Amigo]  protein binding
GO	protein binding [Amigo]  protein binding
GO	ATP binding [Amigo]  ATP binding
GO	intracellular [Amigo]  intracellular
GO	cytoplasm [Amigo]  cytoplasm
GO	plasma membrane [Amigo]  plasma membrane
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	intracellular signaling cascade [Amigo]  intracellular signaling cascade
GO	zinc ion binding [Amigo]  zinc ion binding
GO	transferase activity [Amigo]  transferase activity
GO	diacylglycerol binding [Amigo]  diacylglycerol binding
GO	actin cytoskeleton organization and biogenesis [Amigo]  actin cytoskeleton organization and biogenesis
GO	metal ion binding [Amigo]  metal ion binding
BIOCARTA	CCR3 signaling in Eosinophils    [Genes]
KEGG	Wnt signaling pathway
KEGG	TGF-beta signaling pathway
KEGG	Axon guidance
KEGG	Focal adhesion
KEGG	Leukocyte transendothelial migration
KEGG	Regulation of actin cytoskeleton
PubGene	ROCK2
TreeFam	ROCK2
CTD	9475 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	ROCK2 Related clones (RZPD - Berlin)
	PubMed
PubMed	29 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Sep 29 18:19:57 2008