ROMO1 (reactive oxygen species modulator 1)

2008-05-01  

Identity

HGNC
LOCATION
20q11.22
LOCUSID
ALIAS
C20orf52,MTGM,MTGMP,bA353C18.2
FUSION GENES

Other Information

Locus ID:

NCBI: 140823
MIM: 618894
HGNC: 16185
Ensembl: ENSG00000125995

Variants:

dbSNP: 140823
ClinVar: 140823
TCGA: ENSG00000125995
COSMIC: ROMO1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125995ENST00000336695P60602
ENSG00000125995ENST00000374072P60602
ENSG00000125995ENST00000374077P60602
ENSG00000125995ENST00000374078P60602
ENSG00000125995ENST00000397416P60602

Expression (GTEx)

0
50
100
150
200

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
202036912010TNF-alpha-induced ROS production triggering apoptosis is directly linked to Romo1 and Bcl-X(L).68
244731952014ROMO1 is an essential redox-dependent regulator of mitochondrial dynamics.30
199046092010Serum deprivation-induced reactive oxygen species production is mediated by Romo1.27
175374042007Drug resistance to 5-FU linked to reactive oxygen species modulator 1.24
183133942008A critical role for Romo1-derived ROS in cell proliferation.22
195357342009The novel conserved mitochondrial inner-membrane protein MTGM regulates mitochondrial morphology and cell proliferation.21
188361792008Replicative senescence induced by Romo1-derived reactive oxygen species.19
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
238678222013Romo1 expression contributes to oxidative stress-induced death of lung epithelial cells.14
195139052009Mitochondrial reactive oxygen species originating from Romo1 exert an important role in normal cell cycle progression by regulating p27(Kip1) expression.11

Citation

Dessen P

ROMO1 (reactive oxygen species modulator 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/50117/romo1