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ROR1 (receptor tyrosine kinase-like orphan receptor 1)

Identity

Other namesMGC99659
NTRKR1
dJ537F10.1
HGNC (Hugo) ROR1
Location 1p31.3
Location_base_pair Starts at 64012278 and ends at 64381640 bp from pter ( according to hg18-March_2006)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ROR1   10256
Entrez_Gene (NCBI)ROR1  4919  receptor tyrosine kinase-like orphan receptor 1
Cards
GeneCards (Weizmann)ROR1
Ensembl (Hinxton)ENSG00000185483 [Gene_View]  ROR1 [Vega]
AceView (NCBI)ROR1
Genatlas (Paris)ROR1
euGene (Indiana)4919
SOURCE (Stanford)NM_001083592 NM_005012
Gene Expression (Array Express) ENSG00000185483
Genomic and cartography
GoldenPath (UCSC)ROR1  -  1p31.3   chr1:64012278-64381640 +  1p31.3   [Description]    (hg18-March_2006)
EnsemblROR1 - 1p31.3 [CytoView]
Mapping of homologs : NCBIROR1 [Mapview]
OMIM602336   
Gene and transcription
Gene : Genbank (Entrez)AK308088 AK309189 BC006374 BC080541 BC128386
Reference sequence (RefSeq transcript) :SRSNM_001083592 NM_005012
Reference transcript : EntrezNM_001083592 NM_005012
RefSeq genomic : SRSAC_000044 AC_000133 NC_000001 NT_032977 NW_001838579 NW_921351
RefSeq genomic : EntrezAC_000044 AC_000133 NC_000001 NT_032977 NW_001838579 NW_921351
Consensus coding sequences : CCDS NCBIROR1
Cluster EST : UnigeneHs.654491 [ SRS ] Hs.654491 [ NCBI ]
Alternative Splicing : Fast-db (Paris)16396
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtQ01973 (SRS) Q01973 (Expasy) Q01973 (Uniprot)
With graphics : InterProQ01973
Splice isoforms : VarSplice FASTAQ01973(VarSplice FASTA)
Domaine pattern : Prosite (SRS)FZ (PS50038)    IG_LIKE (PS50835)    KRINGLE_1 (PS00021)    KRINGLE_2 (PS50070)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)   
Domain pattern : Prosite (Expaxy)FZ (PS50038)    IG_LIKE (PS50835)    KRINGLE_1 (PS00021)    KRINGLE_2 (PS50070)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)   
Domains : Interpro (SRS)Frizzled-like_dom    Ig-like    Ig_I-set    Ig_sub2    Kinase-like_dom    Kringle    Kringle-like    Kringle_CS    Kringle_sub    Prot_kinase_cat_dom    Tyr_kinase_rcpt_ROR_subgr    Tyr_prot_kinase    Tyr_prot_kinase_AS    Tyr_prot_kinase_cat_dom    Tyr_prot_kinase_subgr_cat_dom   
Domains : Interpro (EBI)Frizzled-like_dom    Ig-like    Ig_I-set    Ig_sub2    Kinase-like_dom    Kringle    Kringle-like    Kringle_CS    Kringle_sub    Prot_kinase_cat_dom    Tyr_kinase_rcpt_ROR_subgr    Tyr_prot_kinase    Tyr_prot_kinase_AS    Tyr_prot_kinase_cat_dom    Tyr_prot_kinase_subgr_cat_dom   
Related proteins : CluSTrQ01973
Domain families : Pfam SRSFz (PF01392)    I-set (PF07679)    Kringle (PF00051)    Pkinase_Tyr (PF07714)   
Domain families : Pfam SangerFz (PF01392)    I-set (PF07679)    Kringle (PF00051)    Pkinase_Tyr (PF07714)   
Domain families : Pfam NCBIpfam01392    pfam07679    pfam00051    pfam07714   
Domain families : Smart EMBLIGc2 (SM00408)  KR (SM00130)  TyrKc (SM00219)  
Blocks (Seattle)Q01973
Crystal structure of protein : PDB SRS
Crystal structure of protein : PDBSum
Crystal structure of protein : IMB
Crystal structure of protein : PDB RSDB
HPRD03821
Protein Interaction databases
DIP (DOE-UCLA)Q01973
IntAct (EBI)Q01973
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBIROR1
SNP : GeneSNP UtahROR1
SNP : HGBaseROR1
Genetic variants : HAPMAPROR1
Somatic Mutations in Cancer : COSMICROR1 
Mutations and Diseases : HGMDROR1
Hereditary diseases : OMIM602336   
Hereditary diseases : GENETests602336   
Diseases : Genetic AssociationROR1
General knowledge
Homologs : HomoloGeneROR1
Homology/Alignments : Family Browser UCSCROR1
Phylogenetic Trees/Animal Genes : TreeFamROR1
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.1 [ Enzyme-SRS ]   2.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   
Chemical/Protein Interactions : CTD4919
Keywords Ontology : AmiGOnucleotide binding  transmembrane receptor protein tyrosine kinase activity  receptor activity  protein binding  ATP binding  cytoplasm  plasma membrane  integral to plasma membrane  protein amino acid phosphorylation  transmembrane receptor protein tyrosine kinase signaling pathway  transferase activity  
Keywords Ontology : EGO-EBInucleotide binding  transmembrane receptor protein tyrosine kinase activity  receptor activity  protein binding  ATP binding  cytoplasm  plasma membrane  integral to plasma membrane  protein amino acid phosphorylation  transmembrane receptor protein tyrosine kinase signaling pathway  transferase activity  
Pathways : BIOCARTA
Pathways : KEGG
Other databases
Probes
Probes : ImagenesROR1 Related clones (RZPD - Berlin)
Literature
PubMed13 Pubmed reference(s) in Entrez
PubGeneROR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated03-2009Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 27 10:34:55 CET 2010
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