ROR1 (receptor tyrosine kinase like orphan receptor 1)

2006-10-01  

Identity

HGNC
LOCATION
1p31.3
LOCUSID
ALIAS
NTRKR1,dJ537F10.1
FUSION GENES

Other Information

Locus ID:

NCBI: 4919
MIM: 602336
HGNC: 10256
Ensembl: ENSG00000185483

Variants:

dbSNP: 4919
ClinVar: 4919
TCGA: ENSG00000185483
COSMIC: ROR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185483ENST00000371079Q01973
ENSG00000185483ENST00000371080Q01973
ENSG00000185483ENST00000545203A0A0A0MTJ5

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
PCP/CE pathwayREACTOMER-HSA-4086400
WNT5A-dependent internalization of FZD2, FZD5 and ROR2REACTOMER-HSA-5140745

References

Pubmed IDYearTitleCitations
194880442009Genome-wide association study of bipolar disorder in European American and African American individuals.162
236204052013Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells.151
182870272008Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a.117
224036102012ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growth.99
207027782010The B-cell tumor-associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor.89
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
182232142008Unique cell surface expression of receptor tyrosine kinase ROR1 in human B-cell chronic lymphocytic leukemia.81
241040622013Hypoxia induces phenotypic plasticity and therapy resistance in melanoma via the tyrosine kinase receptors ROR1 and ROR2.75
185462922008Ror1, a cell surface receptor tyrosine kinase is expressed in chronic lymphocytic leukemia and may serve as a putative target for therapy.71
281142692017A ROR1-HER3-lncRNA signalling axis modulates the Hippo-YAP pathway to regulate bone metastasis.71

Citation

Dessen P

ROR1 (receptor tyrosine kinase like orphan receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43475/ror1