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ROR1 (receptor tyrosine kinase like orphan receptor 1)

Identity

Alias_namesNTRKR1
Other aliasdJ537F10.1
HGNC (Hugo) ROR1
LocusID (NCBI) 4919
Atlas_Id 43475
Location 1p31.3  [Link to chromosome band 1p31]
Location_base_pair Starts at 63774019 and ends at 64143369 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CACHD1 (1p31.3) / ROR1 (1p31.3)ROR1 (1p31.3) / SNAP25 (20p12.2)CACHD1 1p31.3 / ROR1 1p31.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ROR1   10256
Cards
Entrez_Gene (NCBI)ROR1  4919  receptor tyrosine kinase like orphan receptor 1
AliasesNTRKR1; dJ537F10.1
GeneCards (Weizmann)ROR1
Ensembl hg19 (Hinxton)ENSG00000185483 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185483 [Gene_View]  chr1:63774019-64143369 [Contig_View]  ROR1 [Vega]
ICGC DataPortalENSG00000185483
TCGA cBioPortalROR1
AceView (NCBI)ROR1
Genatlas (Paris)ROR1
WikiGenes4919
SOURCE (Princeton)ROR1
Genetics Home Reference (NIH)ROR1
Genomic and cartography
GoldenPath hg38 (UCSC)ROR1  -     chr1:63774019-64143369 +  1p31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ROR1  -     1p31.3   [Description]    (hg19-Feb_2009)
EnsemblROR1 - 1p31.3 [CytoView hg19]  ROR1 - 1p31.3 [CytoView hg38]
Mapping of homologs : NCBIROR1 [Mapview hg19]  ROR1 [Mapview hg38]
OMIM602336   
Gene and transcription
Genbank (Entrez)AK000776 AK308088 AK309189 BC006374 BC080541
RefSeq transcript (Entrez)NM_001083592 NM_005012
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ROR1
Cluster EST : UnigeneHs.128753 [ NCBI ]
CGAP (NCI)Hs.128753
Alternative Splicing GalleryENSG00000185483
Gene ExpressionROR1 [ NCBI-GEO ]   ROR1 [ EBI - ARRAY_EXPRESS ]   ROR1 [ SEEK ]   ROR1 [ MEM ]
Gene Expression Viewer (FireBrowse)ROR1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4919
GTEX Portal (Tissue expression)ROR1
Human Protein AtlasENSG00000185483-ROR1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ01973   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ01973  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ01973
Splice isoforms : SwissVarQ01973
PhosPhoSitePlusQ01973
Domaine pattern : Prosite (Expaxy)FZ (PS50038)    IG_LIKE (PS50835)    KRINGLE_1 (PS00021)    KRINGLE_2 (PS50070)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)   
Domains : Interpro (EBI)Frizzled_dom    Ig-like_dom    Ig-like_fold    Ig_I-set    Ig_sub    Ig_sub2    Kinase-like_dom    Kringle    Kringle-like    Kringle_CS    Prot_kinase_dom    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS    Tyr_kinase_rcpt_ROR   
Domain families : Pfam (Sanger)Fz (PF01392)    I-set (PF07679)    Kringle (PF00051)    Pkinase_Tyr (PF07714)   
Domain families : Pfam (NCBI)pfam01392    pfam07679    pfam00051    pfam07714   
Domain families : Smart (EMBL)IG (SM00409)  IGc2 (SM00408)  KR (SM00130)  
Conserved Domain (NCBI)ROR1
DMDM Disease mutations4919
Blocks (Seattle)ROR1
SuperfamilyQ01973
Human Protein Atlas [tissue]ENSG00000185483-ROR1 [tissue]
Peptide AtlasQ01973
HPRD03821
IPIIPI00010405   IPI00472950   IPI01013136   IPI00644416   
Protein Interaction databases
DIP (DOE-UCLA)Q01973
IntAct (EBI)Q01973
FunCoupENSG00000185483
BioGRIDROR1
STRING (EMBL)ROR1
ZODIACROR1
Ontologies - Pathways
QuickGOQ01973
Ontology : AmiGOstress fiber  transmembrane receptor protein tyrosine kinase activity  protein binding  ATP binding  cytoplasm  plasma membrane  integral component of plasma membrane  transmembrane receptor protein tyrosine kinase signaling pathway  cell surface  astrocyte development  Wnt-protein binding  peptidyl-tyrosine phosphorylation  receptor complex  Wnt signaling pathway, planar cell polarity pathway  coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway  
stress fiber  transmembrane receptor protein tyrosine kinase activity  protein binding  ATP binding  cytoplasm  plasma membrane  integral component of plasma membrane  transmembrane receptor protein tyrosine kinase signaling pathway  cell surface  astrocyte development  Wnt-protein binding  peptidyl-tyrosine phosphorylation  receptor complex  Wnt signaling pathway, planar cell polarity pathway  coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway  
NDEx NetworkROR1
Atlas of Cancer Signalling NetworkROR1
Wikipedia pathwaysROR1
Orthology - Evolution
OrthoDB4919
GeneTree (enSembl)ENSG00000185483
Phylogenetic Trees/Animal Genes : TreeFamROR1
HOVERGENQ01973
HOGENOMQ01973
Homologs : HomoloGeneROR1
Homology/Alignments : Family Browser (UCSC)ROR1
Gene fusions - Rearrangements
Fusion : MitelmanCACHD1/ROR1 [1p31.3/1p31.3]  [t(1;1)(p31;p31)]  
Fusion: TCGA_MDACCCACHD1 1p31.3 ROR1 1p31.3 OV
Tumor Fusion PortalROR1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerROR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ROR1
dbVarROR1
ClinVarROR1
1000_GenomesROR1 
Exome Variant ServerROR1
ExAC (Exome Aggregation Consortium)ENSG00000185483
GNOMAD BrowserENSG00000185483
Genetic variants : HAPMAP4919
Genomic Variants (DGV)ROR1 [DGVbeta]
DECIPHERROR1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisROR1 
Mutations
ICGC Data PortalROR1 
TCGA Data PortalROR1 
Broad Tumor PortalROR1
OASIS PortalROR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICROR1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDROR1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ROR1
DgiDB (Drug Gene Interaction Database)ROR1
DoCM (Curated mutations)ROR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ROR1 (select a term)
intoGenROR1
Cancer3DROR1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602336   
Orphanet
DisGeNETROR1
MedgenROR1
Genetic Testing Registry ROR1
NextProtQ01973 [Medical]
TSGene4919
GENETestsROR1
Target ValidationROR1
Huge Navigator ROR1 [HugePedia]
snp3D : Map Gene to Disease4919
BioCentury BCIQROR1
ClinGenROR1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4919
Chemical/Pharm GKB GenePA34628
Clinical trialROR1
Miscellaneous
canSAR (ICR)ROR1 (select the gene name)
Probes
Litterature
PubMed66 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineROR1
EVEXROR1
GoPubMedROR1
iHOPROR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:32:50 CET 2017

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