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RORA (RAR related orphan receptor A)

Identity

Alias_namesRAR-related orphan receptor A
Alias_symbol (synonym)RZRA
ROR1
ROR2
ROR3
NR1F1
Other aliasRZR-ALPHA
HGNC (Hugo) RORA
LocusID (NCBI) 6095
Atlas_Id 42142
Location 15q22.2  [Link to chromosome band 15q22]
Location_base_pair Starts at 60488284 and ends at 60592508 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANXA2 (15q22.2) / RORA (15q22.2)MRO (18q21.2) / RORA (15q22.2)RORA (15q22.2) / ADGRB3 (6q12)
RORA (15q22.2) / ALMS1 (2p13.1)RORA (15q22.2) / ARNT2 (15q25.1)RORA (15q22.2) / CLSTN2 (3q23)
RORA (15q22.2) / KLK3 (19q13.33)RORA (15q22.2) / NUP210L (1q21.3)RORA (15q22.2) / STARD9 (15q15.2)
RORA 15q22.2 / ALMS1 2p13.1RORA 15q22.2 / ARNT2 15q25.1RORA 15q22.2 / CLSTN2 3q23
RORA 15q22.2 / NUP210L 1q21.3RORA 15q22.2 / STARD9 15q15.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 6 ]
  t(1;15)(q21;q22) RORA/NUP210L
t(2;15)(p13;q22) RORA/ALMS1
t(3;15)(q23;q22) RORA/CLSTN2
t(15;15)(q15;q22) RORA/STARD9
ANXA2/RORA (15q22)
t(15;15)(q22;q25) RORA/ARNT2


External links

Nomenclature
HGNC (Hugo)RORA   10258
Cards
Entrez_Gene (NCBI)RORA  6095  RAR related orphan receptor A
AliasesNR1F1; ROR1; ROR2; ROR3; 
RZR-ALPHA; RZRA
GeneCards (Weizmann)RORA
Ensembl hg19 (Hinxton)ENSG00000069667 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000069667 [Gene_View]  ENSG00000069667 [Sequence]  chr15:60488284-60592508 [Contig_View]  RORA [Vega]
ICGC DataPortalENSG00000069667
TCGA cBioPortalRORA
AceView (NCBI)RORA
Genatlas (Paris)RORA
WikiGenes6095
SOURCE (Princeton)RORA
Genetics Home Reference (NIH)RORA
Genomic and cartography
GoldenPath hg38 (UCSC)RORA  -     chr15:60488284-60592508 -  15q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RORA  -     15q22.2   [Description]    (hg19-Feb_2009)
EnsemblRORA - 15q22.2 [CytoView hg19]  RORA - 15q22.2 [CytoView hg38]
Mapping of homologs : NCBIRORA [Mapview hg19]  RORA [Mapview hg38]
OMIM600825   
Gene and transcription
Genbank (Entrez)AB209916 AB307694 AK055969 AL530219 AL532048
RefSeq transcript (Entrez)NM_002943 NM_134260 NM_134261 NM_134262
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RORA
Cluster EST : UnigeneHs.560343 [ NCBI ]
CGAP (NCI)Hs.560343
Alternative Splicing GalleryENSG00000069667
Gene ExpressionRORA [ NCBI-GEO ]   RORA [ EBI - ARRAY_EXPRESS ]   RORA [ SEEK ]   RORA [ MEM ]
Gene Expression Viewer (FireBrowse)RORA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6095
GTEX Portal (Tissue expression)RORA
Human Protein AtlasENSG00000069667-RORA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35398   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35398  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35398
Splice isoforms : SwissVarP35398
PhosPhoSitePlusP35398
Domaine pattern : Prosite (Expaxy)NR_LBD (PS51843)    NUCLEAR_REC_DBD_1 (PS00031)    NUCLEAR_REC_DBD_2 (PS51030)   
Domains : Interpro (EBI)NHR_like_dom_sf    Nucl_hrmn_rcpt_lig-bd    Nuclear_hrmn_rcpt    ROR_rcpt    Znf_hrmn_rcpt    Znf_NHR/GATA   
Domain families : Pfam (Sanger)Hormone_recep (PF00104)    zf-C4 (PF00105)   
Domain families : Pfam (NCBI)pfam00104    pfam00105   
Domain families : Smart (EMBL)HOLI (SM00430)  ZnF_C4 (SM00399)  
Conserved Domain (NCBI)RORA
DMDM Disease mutations6095
Blocks (Seattle)RORA
PDB (SRS)1N83    1S0X    4S15   
PDB (PDBSum)1N83    1S0X    4S15   
PDB (IMB)1N83    1S0X    4S15   
PDB (RSDB)1N83    1S0X    4S15   
Structural Biology KnowledgeBase1N83    1S0X    4S15   
SCOP (Structural Classification of Proteins)1N83    1S0X    4S15   
CATH (Classification of proteins structures)1N83    1S0X    4S15   
SuperfamilyP35398
Human Protein Atlas [tissue]ENSG00000069667-RORA [tissue]
Peptide AtlasP35398
HPRD02896
IPIIPI00018225   IPI00107635   IPI00218544   IPI00243584   IPI01021884   
Protein Interaction databases
DIP (DOE-UCLA)P35398
IntAct (EBI)P35398
FunCoupENSG00000069667
BioGRIDRORA
STRING (EMBL)RORA
ZODIACRORA
Ontologies - Pathways
QuickGOP35398
Ontology : AmiGORNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II proximal promoter sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcription corepressor binding  transcription coactivator binding  transcription coactivator binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding  angiogenesis  DNA binding  DNA-binding transcription factor activity  steroid hormone receptor activity  nuclear receptor activity  protein binding  nucleus  nucleoplasm  regulation of transcription, DNA-templated  transcription initiation from RNA polymerase II promoter  xenobiotic metabolic process  nitric oxide biosynthetic process  beta-catenin binding  transcription factor binding  oxysterol binding  oxysterol binding  zinc ion binding  regulation of smoothened signaling pathway  positive regulation of vascular endothelial growth factor production  regulation of glucose metabolic process  regulation of steroid metabolic process  cytokine-mediated signaling pathway  cerebellar Purkinje cell differentiation  cerebellar granule cell precursor proliferation  intracellular receptor signaling pathway  circadian regulation of gene expression  cellular response to sterol  cellular response to sterol  cholesterol homeostasis  muscle cell differentiation  positive regulation of circadian rhythm  regulation of macrophage activation  negative regulation of I-kappaB kinase/NF-kappaB signaling  steroid hormone mediated signaling pathway  sequence-specific DNA binding  negative regulation of fat cell differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  cGMP metabolic process  negative regulation of inflammatory response  negative regulation of inflammatory response  regulation of transcription involved in cell fate commitment  triglyceride homeostasis  cellular response to interleukin-1  cellular response to tumor necrosis factor  cellular response to hypoxia  T-helper 17 cell differentiation  transcription factor activity, direct ligand regulated sequence-specific DNA binding  
Ontology : EGO-EBIRNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II proximal promoter sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcription corepressor binding  transcription coactivator binding  transcription coactivator binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding  angiogenesis  DNA binding  DNA-binding transcription factor activity  steroid hormone receptor activity  nuclear receptor activity  protein binding  nucleus  nucleoplasm  regulation of transcription, DNA-templated  transcription initiation from RNA polymerase II promoter  xenobiotic metabolic process  nitric oxide biosynthetic process  beta-catenin binding  transcription factor binding  oxysterol binding  oxysterol binding  zinc ion binding  regulation of smoothened signaling pathway  positive regulation of vascular endothelial growth factor production  regulation of glucose metabolic process  regulation of steroid metabolic process  cytokine-mediated signaling pathway  cerebellar Purkinje cell differentiation  cerebellar granule cell precursor proliferation  intracellular receptor signaling pathway  circadian regulation of gene expression  cellular response to sterol  cellular response to sterol  cholesterol homeostasis  muscle cell differentiation  positive regulation of circadian rhythm  regulation of macrophage activation  negative regulation of I-kappaB kinase/NF-kappaB signaling  steroid hormone mediated signaling pathway  sequence-specific DNA binding  negative regulation of fat cell differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  cGMP metabolic process  negative regulation of inflammatory response  negative regulation of inflammatory response  regulation of transcription involved in cell fate commitment  triglyceride homeostasis  cellular response to interleukin-1  cellular response to tumor necrosis factor  cellular response to hypoxia  T-helper 17 cell differentiation  transcription factor activity, direct ligand regulated sequence-specific DNA binding  
Pathways : KEGGCircadian rhythm    Inflammatory bowel disease (IBD)   
NDEx NetworkRORA
Atlas of Cancer Signalling NetworkRORA
Wikipedia pathwaysRORA
Orthology - Evolution
OrthoDB6095
GeneTree (enSembl)ENSG00000069667
Phylogenetic Trees/Animal Genes : TreeFamRORA
HOVERGENP35398
HOGENOMP35398
Homologs : HomoloGeneRORA
Homology/Alignments : Family Browser (UCSC)RORA
Gene fusions - Rearrangements
Fusion : MitelmanANXA2/RORA [15q22.2/15q22.2]  [t(15;15)(q22;q22)]  
Fusion : MitelmanRORA/ALMS1 [15q22.2/2p13.1]  [t(2;15)(p13;q22)]  
Fusion : MitelmanRORA/ARNT2 [15q22.2/15q25.1]  [t(15;15)(q22;q25)]  
Fusion : MitelmanRORA/CLSTN2 [15q22.2/3q23]  [t(3;15)(q23;q22)]  
Fusion : MitelmanRORA/NUP210L [15q22.2/1q21.3]  [t(1;15)(q21;q22)]  
Fusion : MitelmanRORA/STARD9 [15q22.2/15q15.2]  [t(15;15)(q15;q22)]  
Fusion PortalRORA 15q22.2 ALMS1 2p13.1 BRCA
Fusion PortalRORA 15q22.2 ARNT2 15q25.1 BRCA
Fusion PortalRORA 15q22.2 CLSTN2 3q23 LGG
Fusion PortalRORA 15q22.2 NUP210L 1q21.3 BRCA
Fusion PortalRORA 15q22.2 STARD9 15q15.2 PRAD
Fusion : QuiverRORA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRORA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RORA
dbVarRORA
ClinVarRORA
1000_GenomesRORA 
Exome Variant ServerRORA
ExAC (Exome Aggregation Consortium)ENSG00000069667
GNOMAD BrowserENSG00000069667
Varsome BrowserRORA
Genetic variants : HAPMAP6095
Genomic Variants (DGV)RORA [DGVbeta]
DECIPHERRORA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRORA 
Mutations
ICGC Data PortalRORA 
TCGA Data PortalRORA 
Broad Tumor PortalRORA
OASIS PortalRORA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRORA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRORA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RORA
DgiDB (Drug Gene Interaction Database)RORA
DoCM (Curated mutations)RORA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RORA (select a term)
intoGenRORA
Cancer3DRORA(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600825   
Orphanet
DisGeNETRORA
MedgenRORA
Genetic Testing Registry RORA
NextProtP35398 [Medical]
TSGene6095
GENETestsRORA
Target ValidationRORA
Huge Navigator RORA [HugePedia]
snp3D : Map Gene to Disease6095
BioCentury BCIQRORA
ClinGenRORA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6095
Chemical/Pharm GKB GenePA34630
Clinical trialRORA
Miscellaneous
canSAR (ICR)RORA (select the gene name)
Probes
Litterature
PubMed140 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRORA
EVEXRORA
GoPubMedRORA
iHOPRORA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:49:48 CEST 2018

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