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RORB (RAR-related orphan receptor B)

Identity

Other namesNR1F2
ROR-BETA
RZR-BETA
RZRB
bA133M9.1
HGNC (Hugo) RORB
LocusID (NCBI) 6096
Atlas_Id 42143
Location 9q21.13
Location_base_pair Starts at 77112252 and ends at 77302117 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)RORB   10259
Cards
Entrez_Gene (NCBI)RORB  6096  RAR-related orphan receptor B
GeneCards (Weizmann)RORB
Ensembl hg19 (Hinxton)ENSG00000198963 [Gene_View]  chr9:77112252-77302117 [Contig_View]  RORB [Vega]
Ensembl hg38 (Hinxton)ENSG00000198963 [Gene_View]  chr9:77112252-77302117 [Contig_View]  RORB [Vega]
ICGC DataPortalENSG00000198963
TCGA cBioPortalRORB
AceView (NCBI)RORB
Genatlas (Paris)RORB
WikiGenes6096
SOURCE (Princeton)RORB
Genomic and cartography
GoldenPath hg19 (UCSC)RORB  -     chr9:77112252-77302117 +  9q21.13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RORB  -     9q21.13   [Description]    (hg38-Dec_2013)
EnsemblRORB - 9q21.13 [CytoView hg19]  RORB - 9q21.13 [CytoView hg38]
Mapping of homologs : NCBIRORB [Mapview hg19]  RORB [Mapview hg38]
OMIM601972   
Gene and transcription
Genbank (Entrez)AB307695 AK313431 AL118995 AL691650 BC051830
RefSeq transcript (Entrez)NM_006914
RefSeq genomic (Entrez)NC_000009 NC_018920 NT_008470 NW_004929366
Consensus coding sequences : CCDS (NCBI)RORB
Cluster EST : UnigeneHs.494178 [ NCBI ]
CGAP (NCI)Hs.494178
Alternative Splicing : Fast-db (Paris)GSHG0030192
Alternative Splicing GalleryENSG00000198963
Gene ExpressionRORB [ NCBI-GEO ]     RORB [ SEEK ]   RORB [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92753 (Uniprot)
NextProtQ92753  [Medical]  [Publications]
With graphics : InterProQ92753
Splice isoforms : SwissVarQ92753 (Swissvar)
Domaine pattern : Prosite (Expaxy)NUCLEAR_REC_DBD_1 (PS00031)    NUCLEAR_REC_DBD_2 (PS51030)   
Domains : Interpro (EBI)Nucl_hormone_rcpt_ligand-bd    Nucl_hrmn_rcpt_lig-bd_core    ROR_rcpt    Str_hrmn_rcpt    Znf_hrmn_rcpt    Znf_NHR/GATA   
Related proteins : CluSTrQ92753
Domain families : Pfam (Sanger)Hormone_recep (PF00104)    zf-C4 (PF00105)   
Domain families : Pfam (NCBI)pfam00104    pfam00105   
Domain families : Smart (EMBL)HOLI (SM00430)  ZnF_C4 (SM00399)  
DMDM Disease mutations6096
Blocks (Seattle)Q92753
Human Protein AtlasENSG00000198963
Peptide AtlasQ92753
HPRD09062
IPIIPI00023259   IPI00827604   
Protein Interaction databases
DIP (DOE-UCLA)Q92753
IntAct (EBI)Q92753
FunCoupENSG00000198963
BioGRIDRORB
IntegromeDBRORB
STRING (EMBL)RORB
Ontologies - Pathways
QuickGOQ92753
Ontology : AmiGOsequence-specific DNA binding transcription factor activity  steroid hormone receptor activity  ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity  protein binding  nucleus  nucleoplasm  regulation of transcription, DNA-templated  transcription initiation from RNA polymerase II promoter  visual perception  transcription factor binding  zinc ion binding  gene expression  intracellular receptor signaling pathway  intracellular receptor signaling pathway  amacrine cell differentiation  eye photoreceptor cell development  regulation of circadian rhythm  steroid hormone mediated signaling pathway  sequence-specific DNA binding  negative regulation of osteoblast differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  retinal rod cell development  retinal cone cell development  rhythmic process  retina development in camera-type eye  cellular response to retinoic acid  
Ontology : EGO-EBIsequence-specific DNA binding transcription factor activity  steroid hormone receptor activity  ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity  protein binding  nucleus  nucleoplasm  regulation of transcription, DNA-templated  transcription initiation from RNA polymerase II promoter  visual perception  transcription factor binding  zinc ion binding  gene expression  intracellular receptor signaling pathway  intracellular receptor signaling pathway  amacrine cell differentiation  eye photoreceptor cell development  regulation of circadian rhythm  steroid hormone mediated signaling pathway  sequence-specific DNA binding  negative regulation of osteoblast differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  retinal rod cell development  retinal cone cell development  rhythmic process  retina development in camera-type eye  cellular response to retinoic acid  
Pathways : KEGGCircadian rhythm   
Protein Interaction DatabaseRORB
DoCM (Curated mutations)RORB
Wikipedia pathwaysRORB
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerRORB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RORB
dbVarRORB
ClinVarRORB
1000_GenomesRORB 
Exome Variant ServerRORB
SNP (GeneSNP Utah)RORB
SNP : HGBaseRORB
Genetic variants : HAPMAPRORB
Genomic Variants (DGV)RORB [DGVbeta]
Mutations
ICGC Data PortalRORB 
TCGA Data PortalRORB 
Tumor PortalRORB
Somatic Mutations in Cancer : COSMICRORB 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)9:77112252-77302117
CONAN: Copy Number AnalysisRORB 
Mutations and Diseases : HGMDRORB
OMIM601972   
MedgenRORB
NextProtQ92753 [Medical]
GENETestsRORB
Disease Genetic AssociationRORB
Huge Navigator RORB [HugePedia]  RORB [HugeCancerGEM]
snp3D : Map Gene to Disease6096
DGIdb (Drug Gene Interaction db)RORB
BioCentury BCIQRORB
General knowledge
Homologs : HomoloGeneRORB
Homology/Alignments : Family Browser (UCSC)RORB
Phylogenetic Trees/Animal Genes : TreeFamRORB
Chemical/Protein Interactions : CTD6096
Chemical/Pharm GKB GenePA34631
Clinical trialRORB
Cancer Resource (Charite)ENSG00000198963
Other databases
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
CoreMineRORB
GoPubMedRORB
iHOPRORB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jun 27 12:13:24 CEST 2015

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