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RORB (RAR related orphan receptor B)

Identity

Alias_namesRAR-related orphan receptor B
Alias_symbol (synonym)RZRB
NR1F2
ROR-BETA
HGNC (Hugo) RORB
LocusID (NCBI) 6096
Atlas_Id 42143
Location 9q21.13  [Link to chromosome band 9q21]
Location_base_pair Starts at 77112252 and ends at 77302117 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
RABEP1 (17p13.2) / RORB (9q21.13)RORB (9q21.13) / PISD (22q12.2)RABEP1 17p13.2 / RORB 9q21.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RORB   10259
Cards
Entrez_Gene (NCBI)RORB  6096  RAR related orphan receptor B
AliasesNR1F2; ROR-BETA; RZR-BETA; RZRB; 
bA133M9.1
GeneCards (Weizmann)RORB
Ensembl hg19 (Hinxton)ENSG00000198963 [Gene_View]  chr9:77112252-77302117 [Contig_View]  RORB [Vega]
Ensembl hg38 (Hinxton)ENSG00000198963 [Gene_View]  chr9:77112252-77302117 [Contig_View]  RORB [Vega]
ICGC DataPortalENSG00000198963
TCGA cBioPortalRORB
AceView (NCBI)RORB
Genatlas (Paris)RORB
WikiGenes6096
SOURCE (Princeton)RORB
Genetics Home Reference (NIH)RORB
Genomic and cartography
GoldenPath hg19 (UCSC)RORB  -     chr9:77112252-77302117 +  9q21.13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RORB  -     9q21.13   [Description]    (hg38-Dec_2013)
EnsemblRORB - 9q21.13 [CytoView hg19]  RORB - 9q21.13 [CytoView hg38]
Mapping of homologs : NCBIRORB [Mapview hg19]  RORB [Mapview hg38]
OMIM601972   
Gene and transcription
Genbank (Entrez)AB307695 AK313431 AL118995 AL691650 BC051830
RefSeq transcript (Entrez)NM_006914
RefSeq genomic (Entrez)NC_000009 NC_018920 NT_008470 NW_004929366
Consensus coding sequences : CCDS (NCBI)RORB
Cluster EST : UnigeneHs.494178 [ NCBI ]
CGAP (NCI)Hs.494178
Alternative Splicing GalleryENSG00000198963
Gene ExpressionRORB [ NCBI-GEO ]   RORB [ EBI - ARRAY_EXPRESS ]   RORB [ SEEK ]   RORB [ MEM ]
Gene Expression Viewer (FireBrowse)RORB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6096
GTEX Portal (Tissue expression)RORB
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92753   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92753  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92753
Splice isoforms : SwissVarQ92753
PhosPhoSitePlusQ92753
Domaine pattern : Prosite (Expaxy)NUCLEAR_REC_DBD_1 (PS00031)    NUCLEAR_REC_DBD_2 (PS51030)   
Domains : Interpro (EBI)Nucl_hrmn_rcpt_lig-bd    Nuclear_hrmn_rcpt    ROR_rcpt    Znf_hrmn_rcpt    Znf_NHR/GATA   
Domain families : Pfam (Sanger)Hormone_recep (PF00104)    zf-C4 (PF00105)   
Domain families : Pfam (NCBI)pfam00104    pfam00105   
Domain families : Smart (EMBL)HOLI (SM00430)  ZnF_C4 (SM00399)  
Conserved Domain (NCBI)RORB
DMDM Disease mutations6096
Blocks (Seattle)RORB
SuperfamilyQ92753
Human Protein AtlasENSG00000198963
Peptide AtlasQ92753
HPRD09062
IPIIPI00023259   IPI00827604   
Protein Interaction databases
DIP (DOE-UCLA)Q92753
IntAct (EBI)Q92753
FunCoupENSG00000198963
BioGRIDRORB
STRING (EMBL)RORB
ZODIACRORB
Ontologies - Pathways
QuickGOQ92753
Ontology : AmiGOtranscription factor activity, sequence-specific DNA binding  steroid hormone receptor activity  RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding  protein binding  nucleus  nucleoplasm  regulation of transcription, DNA-templated  transcription initiation from RNA polymerase II promoter  G-protein coupled receptor signaling pathway  brain development  visual perception  circadian rhythm  transcription factor binding  zinc ion binding  melatonin receptor activity  intracellular receptor signaling pathway  intracellular receptor signaling pathway  amacrine cell differentiation  eye photoreceptor cell development  regulation of circadian rhythm  steroid hormone mediated signaling pathway  sequence-specific DNA binding  negative regulation of osteoblast differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  retinal rod cell development  retinal cone cell development  retina development in camera-type eye  cellular response to retinoic acid  
Ontology : EGO-EBItranscription factor activity, sequence-specific DNA binding  steroid hormone receptor activity  RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding  protein binding  nucleus  nucleoplasm  regulation of transcription, DNA-templated  transcription initiation from RNA polymerase II promoter  G-protein coupled receptor signaling pathway  brain development  visual perception  circadian rhythm  transcription factor binding  zinc ion binding  melatonin receptor activity  intracellular receptor signaling pathway  intracellular receptor signaling pathway  amacrine cell differentiation  eye photoreceptor cell development  regulation of circadian rhythm  steroid hormone mediated signaling pathway  sequence-specific DNA binding  negative regulation of osteoblast differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  retinal rod cell development  retinal cone cell development  retina development in camera-type eye  cellular response to retinoic acid  
Pathways : KEGGCircadian rhythm   
NDEx NetworkRORB
Atlas of Cancer Signalling NetworkRORB
Wikipedia pathwaysRORB
Orthology - Evolution
OrthoDB6096
GeneTree (enSembl)ENSG00000198963
Phylogenetic Trees/Animal Genes : TreeFamRORB
HOVERGENQ92753
HOGENOMQ92753
Homologs : HomoloGeneRORB
Homology/Alignments : Family Browser (UCSC)RORB
Gene fusions - Rearrangements
Fusion : MitelmanRABEP1/RORB [17p13.2/9q21.13]  [t(9;17)(q21;p13)]  
Fusion: TCGARABEP1 17p13.2 RORB 9q21.13 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRORB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RORB
dbVarRORB
ClinVarRORB
1000_GenomesRORB 
Exome Variant ServerRORB
ExAC (Exome Aggregation Consortium)RORB (select the gene name)
Genetic variants : HAPMAP6096
Genomic Variants (DGV)RORB [DGVbeta]
DECIPHER (Syndromes)9:77112252-77302117  ENSG00000198963
CONAN: Copy Number AnalysisRORB 
Mutations
ICGC Data PortalRORB 
TCGA Data PortalRORB 
Broad Tumor PortalRORB
OASIS PortalRORB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRORB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRORB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RORB
DgiDB (Drug Gene Interaction Database)RORB
DoCM (Curated mutations)RORB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RORB (select a term)
intoGenRORB
Cancer3DRORB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601972   
Orphanet
MedgenRORB
Genetic Testing Registry RORB
NextProtQ92753 [Medical]
TSGene6096
GENETestsRORB
Huge Navigator RORB [HugePedia]
snp3D : Map Gene to Disease6096
BioCentury BCIQRORB
ClinGenRORB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6096
Chemical/Pharm GKB GenePA34631
Clinical trialRORB
Miscellaneous
canSAR (ICR)RORB (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRORB
EVEXRORB
GoPubMedRORB
iHOPRORB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Nov 18 19:50:13 CET 2016

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