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ROS1 (ROS proto-oncogene 1 , receptor tyrosine kinase)

Identity

Other namesMCF3
ROS
c-ros-1
HGNC (Hugo) ROS1
LocusID (NCBI) 6098
Location 6q22.1
Location_base_pair Starts at 117609530 and ends at 117747018 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas)

Solid Tumors ProstateOverviewID5041

External links

Nomenclature
HGNC (Hugo)ROS1   10261
Cards
Entrez_Gene (NCBI)ROS1  6098  ROS proto-oncogene 1 , receptor tyrosine kinase
GeneCards (Weizmann)ROS1
Ensembl (Hinxton)ENSG00000047936 [Gene_View]  chr6:117609530-117747018 [Contig_View]  ROS1 [Vega]
ICGC DataPortalENSG00000047936
cBioPortalROS1
AceView (NCBI)ROS1
Genatlas (Paris)ROS1
WikiGenes6098
SOURCE (Princeton)NM_002944
Genomic and cartography
GoldenPath (UCSC)ROS1  -  6q22.1   chr6:117609530-117747018 -  6q22.1   [Description]    (hg19-Feb_2009)
EnsemblROS1 - 6q22.1 [CytoView]
Mapping of homologs : NCBIROS1 [Mapview]
OMIM165020   
Gene and transcription
Genbank (Entrez)BC144556 BC166687 M13880 M34353
RefSeq transcript (Entrez)NM_002944
RefSeq genomic (Entrez)AC_000138 NC_000006 NC_018917 NG_033929 NT_025741 NW_001838990 NW_004929328
Consensus coding sequences : CCDS (NCBI)ROS1
Cluster EST : UnigeneHs.1041 [ NCBI ]
CGAP (NCI)Hs.1041
Alternative Splicing : Fast-db (Paris)GSHG0026874
Alternative Splicing GalleryENSG00000047936
Gene ExpressionROS1 [ NCBI-GEO ]     ROS1 [ SEEK ]   ROS1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08922 (Uniprot)
NextProtP08922  [Medical]
With graphics : InterProP08922
Splice isoforms : SwissVarP08922 (Swissvar)
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.12.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_II (PS00239)   
Domains : Interpro (EBI)6-blade_b-propeller_TolB-like [organisation]   Fibronectin_type3 [organisation]   Ig-like_fold [organisation]   Kinase-like_dom [organisation]   LDLR_classB_rpt [organisation]   Prot_kinase_dom [organisation]   Protein_kinase_ATP_BS [organisation]   Ser-Thr/Tyr_kinase_cat_dom [organisation]   Tyr_kinase_AS [organisation]   Tyr_kinase_cat_dom [organisation]   Tyr_kinase_rcpt_2_CS [organisation]  
Related proteins : CluSTrP08922
Domain families : Pfam (Sanger)fn3 (PF00041)    Pkinase_Tyr (PF07714)   
Domain families : Pfam (NCBI)pfam00041    pfam07714   
Domain families : Smart (EMBL)FN3 (SM00060)  LY (SM00135)  TyrKc (SM00219)  
DMDM Disease mutations6098
Blocks (Seattle)P08922
PDB (SRS)3ZBF   
PDB (PDBSum)3ZBF   
PDB (IMB)3ZBF   
PDB (RSDB)3ZBF   
Human Protein AtlasENSG00000047936 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP08922
HPRD01295
IPIIPI00288965   IPI00647703   IPI00647258   
Protein Interaction databases
DIP (DOE-UCLA)P08922
IntAct (EBI)P08922
FunCoupENSG00000047936
BioGRIDROS1
InParanoidP08922
Interologous Interaction database P08922
IntegromeDBROS1
STRING (EMBL)ROS1
Ontologies - Pathways
Ontology : AmiGOcolumnar/cuboidal epithelial cell development  protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  protein binding  ATP binding  plasma membrane  protein phosphorylation  transmembrane receptor protein tyrosine kinase signaling pathway  spermatogenesis  cell proliferation  negative regulation of gene expression  regulation of phosphate transport  membrane  integral component of membrane  cell growth  peptidyl-tyrosine phosphorylation  peptidyl-tyrosine phosphorylation  protein phosphatase binding  cell differentiation  regulation of TOR signaling  regulation of ERK1 and ERK2 cascade  
Ontology : EGO-EBIcolumnar/cuboidal epithelial cell development  protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  protein binding  ATP binding  plasma membrane  protein phosphorylation  transmembrane receptor protein tyrosine kinase signaling pathway  spermatogenesis  cell proliferation  negative regulation of gene expression  regulation of phosphate transport  membrane  integral component of membrane  cell growth  peptidyl-tyrosine phosphorylation  peptidyl-tyrosine phosphorylation  protein phosphatase binding  cell differentiation  regulation of TOR signaling  regulation of ERK1 and ERK2 cascade  
Protein Interaction DatabaseROS1
Wikipedia pathwaysROS1
Gene fusion - rearrangments
Rearrangement : COSMICCD74 [5q32]  -  ROS1 [6q22.1]  
  [COSF1200] [COSF1201] [COSF1202] [COSF1203] [COSF1478] 
Rearrangement : COSMICEZR [6q25.3]  -  ROS1 [6q22.1]  
  [COSF1267] [COSF1268] 
Rearrangement : COSMICGOPC [6q22.1]  -  ROS1 [6q22.1]  
  [COSF1139] [COSF1140] [COSF1188] [COSF1210] [COSF1243] [COSF1251] [COSF1295] 
Rearrangement : COSMICLRIG3 [12q14.1]  -  ROS1 [6q22.1]  
  [COSF1269] [COSF1270] 
Rearrangement : COSMICSDC4 [20q13.12]  -  ROS1 [6q22.1]  
  [COSF1265] [COSF1266] [COSF1278] [COSF1279] [COSF1280] 
Rearrangement : COSMICSLC34A2 [4p15.2]  -  ROS1 [6q22.1]  
  [COSF1196] [COSF1197] [COSF1198] [COSF1259] [COSF1260] [COSF1261] 
Rearrangement : COSMICTPM3 [1q21.3]  -  ROS1 [6q22.1]  
  [COSF1273] [COSF1274] 
Rearrangement : TICdbCD74 [5q32]  -  ROS1 [14q13.3]
Rearrangement : TICdbGOPC [6q22.1]  -  ROS1 [3q27.3]
Rearrangement : TICdbSLC34A2 [4p15.2]  -  ROS1 [12p13.31]
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)ROS1
snp3D : Map Gene to Disease6098
SNP (GeneSNP Utah)ROS1
SNP : HGBaseROS1
Genetic variants : HAPMAPROS1
Exome VariantROS1
1000_GenomesROS1 
ICGC programENSG00000047936 
Cancer Gene: CensusROS1 
Somatic Mutations in Cancer : COSMICROS1 
CONAN: Copy Number AnalysisROS1 
Mutations and Diseases : HGMDROS1
Genomic VariantsROS1  ROS1 [DGVbeta]
dbVarROS1
ClinVarROS1
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM165020   
MedgenROS1
GENETestsROS1
Disease Genetic AssociationROS1
Huge Navigator ROS1 [HugePedia]  ROS1 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneROS1
Homology/Alignments : Family Browser (UCSC)ROS1
Phylogenetic Trees/Animal Genes : TreeFamROS1
Chemical/Protein Interactions : CTD6098
Chemical/Pharm GKB GenePA34633
Clinical trialROS1
Cancer Resource (Charite)ENSG00000047936
Other databases
Probes
Litterature
PubMed66 Pubmed reference(s) in Entrez
CoreMineROS1
iHOPROS1
OncoSearchROS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jul 26 14:46:18 CEST 2014

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