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RPA1 (replication protein A1)

Identity

Alias (NCBI)HSSB
MST075
REPA1
RF-A
RP-A
RPA70
HGNC (Hugo) RPA1
HGNC Alias symbREPA1
RPA70
HSSB
RF-A
RP-A
HGNC Previous namereplication protein A1 (70kD)
 replication protein A1, 70kDa
LocusID (NCBI) 6117
Atlas_Id 42145
Location 17p13.3  [Link to chromosome band 17p13]
Location_base_pair Starts at 1830005 and ends at 1900082 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ALK (2p23.2) / RPA1 (17p13.3)ATP6V1D (14q23.3) / RPA1 (17p13.3)CARD8 (19q13.33) / RPA1 (17p13.3)
ENO1 (1p36.23) / RPA1 (17p13.3)RPA1 (17p13.3) / RPA1 (17p13.3)SMYD4 (17p13.3) / RPA1 (17p13.3)
TNRC6A (16p12.1) / RPA1 (17p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)RPA1   10289
Cards
Entrez_Gene (NCBI)RPA1    replication protein A1
AliasesHSSB; MST075; REPA1; RF-A; 
RP-A; RPA70
GeneCards (Weizmann)RPA1
Ensembl hg19 (Hinxton)ENSG00000132383 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000132383 [Gene_View]  ENSG00000132383 [Sequence]  chr17:1830005-1900082 [Contig_View]  RPA1 [Vega]
ICGC DataPortalENSG00000132383
TCGA cBioPortalRPA1
AceView (NCBI)RPA1
Genatlas (Paris)RPA1
SOURCE (Princeton)RPA1
Genetics Home Reference (NIH)RPA1
Genomic and cartography
GoldenPath hg38 (UCSC)RPA1  -     chr17:1830005-1900082 +  17p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RPA1  -     17p13.3   [Description]    (hg19-Feb_2009)
GoldenPathRPA1 - 17p13.3 [CytoView hg19]  RPA1 - 17p13.3 [CytoView hg38]
ImmunoBaseENSG00000132383
Genome Data Viewer NCBIRPA1 [Mapview hg19]  
OMIM179835   
Gene and transcription
Genbank (Entrez)AA311833 AB209732 AF167994 AK289704 AW966691
RefSeq transcript (Entrez)NM_001355120 NM_001355121 NM_002945
Consensus coding sequences : CCDS (NCBI)RPA1
Gene ExpressionRPA1 [ NCBI-GEO ]   RPA1 [ EBI - ARRAY_EXPRESS ]   RPA1 [ SEEK ]   RPA1 [ MEM ]
Gene Expression Viewer (FireBrowse)RPA1 [ Firebrowse - Broad ]
GenevisibleExpression of RPA1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6117
GTEX Portal (Tissue expression)RPA1
Human Protein AtlasENSG00000132383-RPA1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP27694   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP27694  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP27694
PhosPhoSitePlusP27694
Domains : Interpro (EBI)NA-bd_OB-fold    NA-bd_OB_tRNA    Rep_factor-A_C    Rep_factor-A_N    REPA_OB_2    Rfa1   
Domain families : Pfam (Sanger)Rep-A_N (PF04057)    Rep_fac-A_C (PF08646)    REPA_OB_2 (PF16900)    tRNA_anti-codon (PF01336)   
Domain families : Pfam (NCBI)pfam04057    pfam08646    pfam16900    pfam01336   
Conserved Domain (NCBI)RPA1
PDB (RSDB)1EWI    1FGU    1JMC    1L1O    2B29    2B3G    4IJH    4IJL    4IPC    4IPD    4IPG    4IPH    4LUO    4LUV    4LUZ    4LW1    4LWC    4NB3    4O0A    4R4C    4R4I    4R4O    4R4Q    4R4T    5E7N    5EAY    5N85    5N8A   
PDB Europe1EWI    1FGU    1JMC    1L1O    2B29    2B3G    4IJH    4IJL    4IPC    4IPD    4IPG    4IPH    4LUO    4LUV    4LUZ    4LW1    4LWC    4NB3    4O0A    4R4C    4R4I    4R4O    4R4Q    4R4T    5E7N    5EAY    5N85    5N8A   
PDB (PDBSum)1EWI    1FGU    1JMC    1L1O    2B29    2B3G    4IJH    4IJL    4IPC    4IPD    4IPG    4IPH    4LUO    4LUV    4LUZ    4LW1    4LWC    4NB3    4O0A    4R4C    4R4I    4R4O    4R4Q    4R4T    5E7N    5EAY    5N85    5N8A   
PDB (IMB)1EWI    1FGU    1JMC    1L1O    2B29    2B3G    4IJH    4IJL    4IPC    4IPD    4IPG    4IPH    4LUO    4LUV    4LUZ    4LW1    4LWC    4NB3    4O0A    4R4C    4R4I    4R4O    4R4Q    4R4T    5E7N    5EAY    5N85    5N8A   
Structural Biology KnowledgeBase1EWI    1FGU    1JMC    1L1O    2B29    2B3G    4IJH    4IJL    4IPC    4IPD    4IPG    4IPH    4LUO    4LUV    4LUZ    4LW1    4LWC    4NB3    4O0A    4R4C    4R4I    4R4O    4R4Q    4R4T    5E7N    5EAY    5N85    5N8A   
SCOP (Structural Classification of Proteins)1EWI    1FGU    1JMC    1L1O    2B29    2B3G    4IJH    4IJL    4IPC    4IPD    4IPG    4IPH    4LUO    4LUV    4LUZ    4LW1    4LWC    4NB3    4O0A    4R4C    4R4I    4R4O    4R4Q    4R4T    5E7N    5EAY    5N85    5N8A   
CATH (Classification of proteins structures)1EWI    1FGU    1JMC    1L1O    2B29    2B3G    4IJH    4IJL    4IPC    4IPD    4IPG    4IPH    4LUO    4LUV    4LUZ    4LW1    4LWC    4NB3    4O0A    4R4C    4R4I    4R4O    4R4Q    4R4T    5E7N    5EAY    5N85    5N8A   
SuperfamilyP27694
AlphaFold pdb e-kbP27694   
Human Protein Atlas [tissue]ENSG00000132383-RPA1 [tissue]
HPRD01565
Protein Interaction databases
DIP (DOE-UCLA)P27694
IntAct (EBI)P27694
BioGRIDRPA1
STRING (EMBL)RPA1
ZODIACRPA1
Ontologies - Pathways
QuickGOP27694
Ontology : AmiGOtelomere maintenance  telomere maintenance  double-strand break repair via homologous recombination  double-strand break repair via homologous recombination  chromosome, telomeric region  damaged DNA binding  damaged DNA binding  single-stranded DNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  DNA replication factor A complex  DNA replication factor A complex  DNA replication factor A complex  DNA replication  DNA replication  DNA-dependent DNA replication  DNA unwinding involved in DNA replication  DNA replication initiation  DNA repair  transcription-coupled nucleotide-excision repair  base-excision repair  base-excision repair, gap-filling  nucleotide-excision repair  nucleotide-excision repair  nucleotide-excision repair, preincision complex stabilization  nucleotide-excision repair, preincision complex assembly  nucleotide-excision repair, DNA incision, 3'-to lesion  nucleotide-excision repair, DNA incision, 5'-to lesion  nucleotide-excision repair, DNA gap filling  mismatch repair  DNA recombination  cellular response to DNA damage stimulus  telomere maintenance via telomerase  PML body  PML body  translesion synthesis  telomere maintenance via semi-conservative replication  nucleotide-excision repair, DNA incision  protein localization to chromosome  interstrand cross-link repair  error-prone translesion synthesis  DNA damage response, detection of DNA damage  single-stranded telomeric DNA binding  metal ion binding  meiotic cell cycle  error-free translesion synthesis  site of DNA damage  G-rich strand telomeric DNA binding  G-rich strand telomeric DNA binding  regulation of cellular response to heat  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBItelomere maintenance  telomere maintenance  double-strand break repair via homologous recombination  double-strand break repair via homologous recombination  chromosome, telomeric region  damaged DNA binding  damaged DNA binding  single-stranded DNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  DNA replication factor A complex  DNA replication factor A complex  DNA replication factor A complex  DNA replication  DNA replication  DNA-dependent DNA replication  DNA unwinding involved in DNA replication  DNA replication initiation  DNA repair  transcription-coupled nucleotide-excision repair  base-excision repair  base-excision repair, gap-filling  nucleotide-excision repair  nucleotide-excision repair  nucleotide-excision repair, preincision complex stabilization  nucleotide-excision repair, preincision complex assembly  nucleotide-excision repair, DNA incision, 3'-to lesion  nucleotide-excision repair, DNA incision, 5'-to lesion  nucleotide-excision repair, DNA gap filling  mismatch repair  DNA recombination  cellular response to DNA damage stimulus  telomere maintenance via telomerase  PML body  PML body  translesion synthesis  telomere maintenance via semi-conservative replication  nucleotide-excision repair, DNA incision  protein localization to chromosome  interstrand cross-link repair  error-prone translesion synthesis  DNA damage response, detection of DNA damage  single-stranded telomeric DNA binding  metal ion binding  meiotic cell cycle  error-free translesion synthesis  site of DNA damage  G-rich strand telomeric DNA binding  G-rich strand telomeric DNA binding  regulation of cellular response to heat  regulation of signal transduction by p53 class mediator  
Pathways : BIOCARTAHypoxia and p53 in the Cardiovascular system [Genes]   
Pathways : KEGGDNA replication    Nucleotide excision repair    Mismatch repair    Homologous recombination    Fanconi anemia pathway   
NDEx NetworkRPA1
Atlas of Cancer Signalling NetworkRPA1
Wikipedia pathwaysRPA1
Orthology - Evolution
OrthoDB6117
GeneTree (enSembl)ENSG00000132383
Phylogenetic Trees/Animal Genes : TreeFamRPA1
Homologs : HomoloGeneRPA1
Homology/Alignments : Family Browser (UCSC)RPA1
Gene fusions - Rearrangements
Fusion : QuiverRPA1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRPA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RPA1
dbVarRPA1
ClinVarRPA1
MonarchRPA1
1000_GenomesRPA1 
Exome Variant ServerRPA1
GNOMAD BrowserENSG00000132383
Varsome BrowserRPA1
ACMGRPA1 variants
VarityP27694
Genomic Variants (DGV)RPA1 [DGVbeta]
DECIPHERRPA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRPA1 
Mutations
ICGC Data PortalRPA1 
TCGA Data PortalRPA1 
Broad Tumor PortalRPA1
OASIS PortalRPA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRPA1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRPA1
Mutations and Diseases : HGMDRPA1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRPA1
DgiDB (Drug Gene Interaction Database)RPA1
DoCM (Curated mutations)RPA1
CIViC (Clinical Interpretations of Variants in Cancer)RPA1
Cancer3DRPA1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM179835   
Orphanet
DisGeNETRPA1
MedgenRPA1
Genetic Testing Registry RPA1
NextProtP27694 [Medical]
GENETestsRPA1
Target ValidationRPA1
Huge Navigator RPA1 [HugePedia]
ClinGenRPA1
Clinical trials, drugs, therapy
MyCancerGenomeRPA1
Protein Interactions : CTDRPA1
Pharm GKB GenePA34651
PharosP27694
Clinical trialRPA1
Miscellaneous
canSAR (ICR)RPA1
HarmonizomeRPA1
DataMed IndexRPA1
Probes
Litterature
PubMed405 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRPA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:29:24 CEST 2021

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