Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

RPA1 (replication protein A1)

Identity

Alias_namesreplication protein A1 (70kD)
replication protein A1, 70kDa
Alias_symbol (synonym)REPA1
RPA70
HSSB
RF-A
RP-A
Other aliasMST075
HGNC (Hugo) RPA1
LocusID (NCBI) 6117
Atlas_Id 42145
Location 17p13.3  [Link to chromosome band 17p13]
Location_base_pair Starts at 1733273 and ends at 1802848 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ALK (2p23.2) / RPA1 (17p13.3)ATP6V1D (14q23.3) / RPA1 (17p13.3)CARD8 (19q13.33) / RPA1 (17p13.3)
ENO1 (1p36.23) / RPA1 (17p13.3)RPA1 (17p13.3) / RPA1 (17p13.3)SMYD4 (17p13.3) / RPA1 (17p13.3)
TNRC6A (16p12.1) / RPA1 (17p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RPA1   10289
Cards
Entrez_Gene (NCBI)RPA1  6117  replication protein A1
AliasesHSSB; MST075; REPA1; RF-A; 
RP-A; RPA70
GeneCards (Weizmann)RPA1
Ensembl hg19 (Hinxton)ENSG00000132383 [Gene_View]  chr17:1733273-1802848 [Contig_View]  RPA1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000132383 [Gene_View]  chr17:1733273-1802848 [Contig_View]  RPA1 [Vega]
ICGC DataPortalENSG00000132383
TCGA cBioPortalRPA1
AceView (NCBI)RPA1
Genatlas (Paris)RPA1
WikiGenes6117
SOURCE (Princeton)RPA1
Genetics Home Reference (NIH)RPA1
Genomic and cartography
GoldenPath hg19 (UCSC)RPA1  -     chr17:1733273-1802848 +  17p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RPA1  -     17p13.3   [Description]    (hg38-Dec_2013)
EnsemblRPA1 - 17p13.3 [CytoView hg19]  RPA1 - 17p13.3 [CytoView hg38]
Mapping of homologs : NCBIRPA1 [Mapview hg19]  RPA1 [Mapview hg38]
OMIM179835   
Gene and transcription
Genbank (Entrez)AB209732 AF167994 AK289704 BC018126 HQ258560
RefSeq transcript (Entrez)NM_002945
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010718 NW_004929405
Consensus coding sequences : CCDS (NCBI)RPA1
Cluster EST : UnigeneHs.461925 [ NCBI ]
CGAP (NCI)Hs.461925
Alternative Splicing GalleryENSG00000132383
Gene ExpressionRPA1 [ NCBI-GEO ]   RPA1 [ EBI - ARRAY_EXPRESS ]   RPA1 [ SEEK ]   RPA1 [ MEM ]
Gene Expression Viewer (FireBrowse)RPA1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6117
GTEX Portal (Tissue expression)RPA1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP27694   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP27694  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP27694
Splice isoforms : SwissVarP27694
PhosPhoSitePlusP27694
Domains : Interpro (EBI)NA-bd_OB-fold    NA-bd_OB_tRNA    Rep_factor-A_C    Rep_factor-A_N    REPA_OB_2    Rfa1   
Domain families : Pfam (Sanger)Rep-A_N (PF04057)    Rep_fac-A_C (PF08646)    REPA_OB_2 (PF16900)    tRNA_anti-codon (PF01336)   
Domain families : Pfam (NCBI)pfam04057    pfam08646    pfam16900    pfam01336   
Conserved Domain (NCBI)RPA1
DMDM Disease mutations6117
Blocks (Seattle)RPA1
PDB (SRS)1EWI    1FGU    1JMC    1L1O    2B29    2B3G    4IJH    4IJL    4IPC    4IPD    4IPG    4IPH    4LUO    4LUV    4LUZ    4LW1    4LWC    4NB3    4O0A    4R4C    4R4I    4R4O    4R4Q    4R4T    5E7N    5EAY   
PDB (PDBSum)1EWI    1FGU    1JMC    1L1O    2B29    2B3G    4IJH    4IJL    4IPC    4IPD    4IPG    4IPH    4LUO    4LUV    4LUZ    4LW1    4LWC    4NB3    4O0A    4R4C    4R4I    4R4O    4R4Q    4R4T    5E7N    5EAY   
PDB (IMB)1EWI    1FGU    1JMC    1L1O    2B29    2B3G    4IJH    4IJL    4IPC    4IPD    4IPG    4IPH    4LUO    4LUV    4LUZ    4LW1    4LWC    4NB3    4O0A    4R4C    4R4I    4R4O    4R4Q    4R4T    5E7N    5EAY   
PDB (RSDB)1EWI    1FGU    1JMC    1L1O    2B29    2B3G    4IJH    4IJL    4IPC    4IPD    4IPG    4IPH    4LUO    4LUV    4LUZ    4LW1    4LWC    4NB3    4O0A    4R4C    4R4I    4R4O    4R4Q    4R4T    5E7N    5EAY   
Structural Biology KnowledgeBase1EWI    1FGU    1JMC    1L1O    2B29    2B3G    4IJH    4IJL    4IPC    4IPD    4IPG    4IPH    4LUO    4LUV    4LUZ    4LW1    4LWC    4NB3    4O0A    4R4C    4R4I    4R4O    4R4Q    4R4T    5E7N    5EAY   
SCOP (Structural Classification of Proteins)1EWI    1FGU    1JMC    1L1O    2B29    2B3G    4IJH    4IJL    4IPC    4IPD    4IPG    4IPH    4LUO    4LUV    4LUZ    4LW1    4LWC    4NB3    4O0A    4R4C    4R4I    4R4O    4R4Q    4R4T    5E7N    5EAY   
CATH (Classification of proteins structures)1EWI    1FGU    1JMC    1L1O    2B29    2B3G    4IJH    4IJL    4IPC    4IPD    4IPG    4IPH    4LUO    4LUV    4LUZ    4LW1    4LWC    4NB3    4O0A    4R4C    4R4I    4R4O    4R4Q    4R4T    5E7N    5EAY   
SuperfamilyP27694
Human Protein AtlasENSG00000132383
Peptide AtlasP27694
HPRD01565
IPIIPI00020127   IPI00742854   
Protein Interaction databases
DIP (DOE-UCLA)P27694
IntAct (EBI)P27694
FunCoupENSG00000132383
BioGRIDRPA1
STRING (EMBL)RPA1
ZODIACRPA1
Ontologies - Pathways
QuickGOP27694
Ontology : AmiGOG1/S transition of mitotic cell cycle  telomere maintenance via recombination  telomere maintenance  double-strand break repair via homologous recombination  nuclear chromosome, telomeric region  damaged DNA binding  single-stranded DNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  DNA replication factor A complex  DNA replication factor A complex  DNA replication  DNA replication  DNA-dependent DNA replication  DNA repair  transcription-coupled nucleotide-excision repair  base-excision repair  nucleotide-excision repair  nucleotide-excision repair, preincision complex stabilization  nucleotide-excision repair, preincision complex assembly  nucleotide-excision repair, DNA incision, 3'-to lesion  nucleotide-excision repair, DNA incision, 5'-to lesion  nucleotide-excision repair, DNA gap filling  mismatch repair  mismatch repair  DNA recombination  PML body  PML body  protein sumoylation  translesion synthesis  nucleotide-excision repair, DNA incision  interstrand cross-link repair  error-prone translesion synthesis  DNA damage response, detection of DNA damage  metal ion binding  error-free translesion synthesis  regulation of cellular response to heat  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  telomere maintenance via recombination  telomere maintenance  double-strand break repair via homologous recombination  nuclear chromosome, telomeric region  damaged DNA binding  single-stranded DNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  DNA replication factor A complex  DNA replication factor A complex  DNA replication  DNA replication  DNA-dependent DNA replication  DNA repair  transcription-coupled nucleotide-excision repair  base-excision repair  nucleotide-excision repair  nucleotide-excision repair, preincision complex stabilization  nucleotide-excision repair, preincision complex assembly  nucleotide-excision repair, DNA incision, 3'-to lesion  nucleotide-excision repair, DNA incision, 5'-to lesion  nucleotide-excision repair, DNA gap filling  mismatch repair  mismatch repair  DNA recombination  PML body  PML body  protein sumoylation  translesion synthesis  nucleotide-excision repair, DNA incision  interstrand cross-link repair  error-prone translesion synthesis  DNA damage response, detection of DNA damage  metal ion binding  error-free translesion synthesis  regulation of cellular response to heat  regulation of signal transduction by p53 class mediator  
Pathways : BIOCARTAHypoxia and p53 in the Cardiovascular system [Genes]   
Pathways : KEGGDNA replication    Nucleotide excision repair    Mismatch repair    Homologous recombination    Fanconi anemia pathway   
NDEx NetworkRPA1
Atlas of Cancer Signalling NetworkRPA1
Wikipedia pathwaysRPA1
Orthology - Evolution
OrthoDB6117
GeneTree (enSembl)ENSG00000132383
Phylogenetic Trees/Animal Genes : TreeFamRPA1
HOVERGENP27694
HOGENOMP27694
Homologs : HomoloGeneRPA1
Homology/Alignments : Family Browser (UCSC)RPA1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRPA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RPA1
dbVarRPA1
ClinVarRPA1
1000_GenomesRPA1 
Exome Variant ServerRPA1
ExAC (Exome Aggregation Consortium)RPA1 (select the gene name)
Genetic variants : HAPMAP6117
Genomic Variants (DGV)RPA1 [DGVbeta]
DECIPHER (Syndromes)17:1733273-1802848  ENSG00000132383
CONAN: Copy Number AnalysisRPA1 
Mutations
ICGC Data PortalRPA1 
TCGA Data PortalRPA1 
Broad Tumor PortalRPA1
OASIS PortalRPA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRPA1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRPA1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RPA1
DgiDB (Drug Gene Interaction Database)RPA1
DoCM (Curated mutations)RPA1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RPA1 (select a term)
intoGenRPA1
Cancer3DRPA1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM179835   
Orphanet
MedgenRPA1
Genetic Testing Registry RPA1
NextProtP27694 [Medical]
TSGene6117
GENETestsRPA1
Huge Navigator RPA1 [HugePedia]
snp3D : Map Gene to Disease6117
BioCentury BCIQRPA1
ClinGenRPA1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6117
Chemical/Pharm GKB GenePA34651
Clinical trialRPA1
Miscellaneous
canSAR (ICR)RPA1 (select the gene name)
Probes
Litterature
PubMed243 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRPA1
EVEXRPA1
GoPubMedRPA1
iHOPRPA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:25:31 CET 2017

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.