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RPA3 (replication protein A3)

Identity

Alias (NCBI)REPA3
RP-A p14
HGNC (Hugo) RPA3
HGNC Alias symbREPA3
HGNC Previous namereplication protein A3 (14kD)
 replication protein A3, 14kDa
LocusID (NCBI) 6119
Atlas_Id 42147
Location 7p21.3  [Link to chromosome band 7p21]
Location_base_pair Starts at 7636518 and ends at 7718607 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GNE (9p13.3) / RPA3 (7p21.3)RPA3 (7p21.3) / ME3 (11q14.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)RPA3   10291
Cards
Entrez_Gene (NCBI)RPA3    replication protein A3
AliasesREPA3; RP-A
GeneCards (Weizmann)RPA3
Ensembl hg19 (Hinxton)ENSG00000106399 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000106399 [Gene_View]  ENSG00000106399 [Sequence]  chr7:7636518-7718607 [Contig_View]  RPA3 [Vega]
ICGC DataPortalENSG00000106399
TCGA cBioPortalRPA3
AceView (NCBI)RPA3
Genatlas (Paris)RPA3
SOURCE (Princeton)RPA3
Genetics Home Reference (NIH)RPA3
Genomic and cartography
GoldenPath hg38 (UCSC)RPA3  -     chr7:7636518-7718607 -  7p21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RPA3  -     7p21.3   [Description]    (hg19-Feb_2009)
GoldenPathRPA3 - 7p21.3 [CytoView hg19]  RPA3 - 7p21.3 [CytoView hg38]
ImmunoBaseENSG00000106399
Genome Data Viewer NCBIRPA3 [Mapview hg19]  
OMIM179837   
Gene and transcription
Genbank (Entrez)AI243725 AK311842 BC005264 BC009868 BT007320
RefSeq transcript (Entrez)NM_002947
Consensus coding sequences : CCDS (NCBI)RPA3
Gene ExpressionRPA3 [ NCBI-GEO ]   RPA3 [ EBI - ARRAY_EXPRESS ]   RPA3 [ SEEK ]   RPA3 [ MEM ]
Gene Expression Viewer (FireBrowse)RPA3 [ Firebrowse - Broad ]
GenevisibleExpression of RPA3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6119
GTEX Portal (Tissue expression)RPA3
Human Protein AtlasENSG00000106399-RPA3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35244   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35244  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35244
PhosPhoSitePlusP35244
Domains : Interpro (EBI)NA-bd_OB-fold    Rfa2   
Domain families : Pfam (Sanger)Rep_fac-A_3 (PF08661)   
Domain families : Pfam (NCBI)pfam08661   
Conserved Domain (NCBI)RPA3
PDB (RSDB)1L1O    1QUQ    2PI2    2PQA    2Z6K    3KDF   
PDB Europe1L1O    1QUQ    2PI2    2PQA    2Z6K    3KDF   
PDB (PDBSum)1L1O    1QUQ    2PI2    2PQA    2Z6K    3KDF   
PDB (IMB)1L1O    1QUQ    2PI2    2PQA    2Z6K    3KDF   
Structural Biology KnowledgeBase1L1O    1QUQ    2PI2    2PQA    2Z6K    3KDF   
SCOP (Structural Classification of Proteins)1L1O    1QUQ    2PI2    2PQA    2Z6K    3KDF   
CATH (Classification of proteins structures)1L1O    1QUQ    2PI2    2PQA    2Z6K    3KDF   
SuperfamilyP35244
AlphaFold pdb e-kbP35244   
Human Protein Atlas [tissue]ENSG00000106399-RPA3 [tissue]
HPRD01567
Protein Interaction databases
DIP (DOE-UCLA)P35244
IntAct (EBI)P35244
BioGRIDRPA3
STRING (EMBL)RPA3
ZODIACRPA3
Ontologies - Pathways
QuickGOP35244
Ontology : AmiGOtelomere maintenance  double-strand break repair via homologous recombination  double-strand break repair via homologous recombination  damaged DNA binding  damaged DNA binding  single-stranded DNA binding  single-stranded DNA binding  protein binding  nucleoplasm  DNA replication factor A complex  DNA replication factor A complex  DNA replication  DNA replication  DNA replication  DNA replication initiation  transcription-coupled nucleotide-excision repair  base-excision repair  base-excision repair  base-excision repair, gap-filling  nucleotide-excision repair  nucleotide-excision repair  nucleotide-excision repair, preincision complex stabilization  nucleotide-excision repair, preincision complex assembly  nucleotide-excision repair, DNA incision, 3'-to lesion  nucleotide-excision repair, DNA incision, 5'-to lesion  nucleotide-excision repair, DNA gap filling  mismatch repair  mismatch repair  regulation of mitotic cell cycle  translesion synthesis  telomere maintenance via semi-conservative replication  nucleotide-excision repair, DNA incision  site of double-strand break  interstrand cross-link repair  regulation of cell population proliferation  error-prone translesion synthesis  DNA damage response, detection of DNA damage  error-free translesion synthesis  regulation of cellular response to heat  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBItelomere maintenance  double-strand break repair via homologous recombination  double-strand break repair via homologous recombination  damaged DNA binding  damaged DNA binding  single-stranded DNA binding  single-stranded DNA binding  protein binding  nucleoplasm  DNA replication factor A complex  DNA replication factor A complex  DNA replication  DNA replication  DNA replication  DNA replication initiation  transcription-coupled nucleotide-excision repair  base-excision repair  base-excision repair  base-excision repair, gap-filling  nucleotide-excision repair  nucleotide-excision repair  nucleotide-excision repair, preincision complex stabilization  nucleotide-excision repair, preincision complex assembly  nucleotide-excision repair, DNA incision, 3'-to lesion  nucleotide-excision repair, DNA incision, 5'-to lesion  nucleotide-excision repair, DNA gap filling  mismatch repair  mismatch repair  regulation of mitotic cell cycle  translesion synthesis  telomere maintenance via semi-conservative replication  nucleotide-excision repair, DNA incision  site of double-strand break  interstrand cross-link repair  regulation of cell population proliferation  error-prone translesion synthesis  DNA damage response, detection of DNA damage  error-free translesion synthesis  regulation of cellular response to heat  regulation of signal transduction by p53 class mediator  
Pathways : KEGGDNA replication    Nucleotide excision repair    Mismatch repair    Homologous recombination    Fanconi anemia pathway   
NDEx NetworkRPA3
Atlas of Cancer Signalling NetworkRPA3
Wikipedia pathwaysRPA3
Orthology - Evolution
OrthoDB6119
GeneTree (enSembl)ENSG00000106399
Phylogenetic Trees/Animal Genes : TreeFamRPA3
Homologs : HomoloGeneRPA3
Homology/Alignments : Family Browser (UCSC)RPA3
Gene fusions - Rearrangements
Fusion : QuiverRPA3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRPA3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RPA3
dbVarRPA3
ClinVarRPA3
MonarchRPA3
1000_GenomesRPA3 
Exome Variant ServerRPA3
GNOMAD BrowserENSG00000106399
Varsome BrowserRPA3
ACMGRPA3 variants
VarityP35244
Genomic Variants (DGV)RPA3 [DGVbeta]
DECIPHERRPA3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRPA3 
Mutations
ICGC Data PortalRPA3 
TCGA Data PortalRPA3 
Broad Tumor PortalRPA3
OASIS PortalRPA3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRPA3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRPA3
Mutations and Diseases : HGMDRPA3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRPA3
DgiDB (Drug Gene Interaction Database)RPA3
DoCM (Curated mutations)RPA3
CIViC (Clinical Interpretations of Variants in Cancer)RPA3
Cancer3DRPA3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM179837   
Orphanet
DisGeNETRPA3
MedgenRPA3
Genetic Testing Registry RPA3
NextProtP35244 [Medical]
GENETestsRPA3
Target ValidationRPA3
Huge Navigator RPA3 [HugePedia]
ClinGenRPA3
Clinical trials, drugs, therapy
MyCancerGenomeRPA3
Protein Interactions : CTDRPA3
Pharm GKB GenePA34653
PharosP35244
Clinical trialRPA3
Miscellaneous
canSAR (ICR)RPA3
HarmonizomeRPA3
DataMed IndexRPA3
Probes
Litterature
PubMed120 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRPA3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:29:25 CEST 2021

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