RPA4 (replication protein A4)

2007-02-01 Affiliation

Identity

HGNC

RPA4

LOCATION

Xq21.33

LOCUSID

29935

ALIAS

HSU24186

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 29935
MIM: 300767
HGNC: 30305
Ensembl: ENSG00000204086

Variants:

dbSNP: 29935
ClinVar: 29935
TCGA: ENSG00000204086
COSMIC: RPA4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000204086	ENST00000373040	Q13156

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
DNA replication	KEGG	ko03030
Nucleotide excision repair	KEGG	ko03420
Mismatch repair	KEGG	ko03430
Homologous recombination	KEGG	ko03440
DNA replication	KEGG	hsa03030
Nucleotide excision repair	KEGG	hsa03420
Mismatch repair	KEGG	hsa03430
Homologous recombination	KEGG	hsa03440
Fanconi anemia pathway	KEGG	ko03460
Fanconi anemia pathway	KEGG	hsa03460
RPA complex	KEGG	hsa_M00288
RPA complex	KEGG	M00288
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
Mitotic G1-G1/S phases	REACTOME	R-HSA-453279
G1/S Transition	REACTOME	R-HSA-69206
Activation of the pre-replicative complex	REACTOME	R-HSA-68962
M/G1 Transition	REACTOME	R-HSA-68874
DNA Replication Pre-Initiation	REACTOME	R-HSA-69002
DNA Replication	REACTOME	R-HSA-69306

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
15929725	2005	Preferential localization of hyperphosphorylated replication protein A to double-strand break repair and checkpoint complexes upon DNA damage.	36
18676680	2008	Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.	32
19692168	2010	Genetic susceptibility to distinct bladder cancer subphenotypes.	25
19942684	2010	A naturally occurring human RPA subunit homolog does not support DNA replication or cell-cycle progression.	14
19996105	2010	An alternative form of replication protein a expressed in normal human tissues supports DNA repair.	12
19170196	2009	Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.	5

Citation

Dessen P

RPA4 (replication protein A4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43989/rpa4